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A self-enhanced chemiexcited PDT system for targeted and efficient treatment of deeply seated tumors

INORGANIC CHEMISTRY FRONTIERS 2024年第17期11卷 5598-5611页

作者： Da, xuwen Xu, Yunli Wang, Lei Liu, Xiulian peng, Yatong Wu, Yao Zhou, Wanpeng Wang, Wentao Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Univ Chinese Acad Sci Wenzhou Inst Wenzhou 325000 Peoples R China

Traditional photodynamic therapy (PDT) is almost ineffective against deeply seated tumors due to the limited penetration depth of external light. The development of chemiexcited PDT is promising to address this issue, but it is still challenging to construct simple, efficient and targeted chemiexcited PDT systems. In this work, CPPO (bio(3,5,6-trichloro-2-n-pentyloxycarbonylphenyl) oxalate) and [Ru(phen)2(PIP-OCH3)](PF6)2 (Ru3, where phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) with efficient photocatalytic NADH (reduced nicotinamide adenine dinucleotide) oxidation were co-encapsulated with DSPE-PEG 2000 to form Ru3/CPPO@PEG nanoparticles (NP3). Once internalized by cancer cells, Ru3 can be excited with the chemical energy produced by the reaction between CPPO and endogenous H2O2. The subsequent oxidation of intracellular NADH and generation of H2O2in situ by excited Ru3 will further promote the sustained occurrence of the chemical reaction, realizing self-enhanced chemiexcited PDT. NP3 could effectively deplete intracellular NADH, inhibit ATP synthesis, increase the H2O2 content, and produce reactive oxygen species (ROS) within cancer cells, thus exhibiting efficient chemiexcited PDT activity against various cancer cells. Notably, minimal cytotoxicity was observed towards normal cells. Good therapeutic effects against subcutaneously implanted and lung metastatic tumors were also observed for NP3. The current findings may provide new insights for development of novel chemiexcited PDT. NP3 with H2O2 supplementation and self-enhanced chemiexcited PDT system are developed, exhibiting efficient chemiexcited PDT activity towards subcutaneously implanted and lung metastatic tumors, providing new insights for development of novel chemiexcited PDT.

关键词： Photodynamic therapy

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A Two-level Learning Approach for Achieving the Sustainable Development of Service Ecosystem

A Two-level Learning Approach for Achieving the Sustainable ...

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IEEE International Conference on Web Services (IEEE ICWS)

作者： peng, Chao Xue, Xiao Zhang, xuwen Ji, Peilin Shen, Yifan Fang, Li Feng, Zhiyong Tianjin Univ Coll Intelligence & Comp Tianjin Peoples R China Tianjin Key Lab Healthy Habitat & Mart Technol Tianjin Peoples R China Xian Univ Finance & Econ Sch Informat Xian Peoples R China

ISBN: (纸本)9798350368567;9798350368550

The governance of service ecosystem needs to balance efficiency and fairness to promote the sustainable development of the system, making it an important topic. However, service entities in the service ecosystem have autonomy and engage in dynamic game with governance strategies, leading to governance challenges. To address this issue, we model the governance process as a repeated sequential game between the governance algorithm and service entities, and propose a novel two-level learning algorithm. This algorithm considers the learning evolution of service entities and the co-evolutionary of the governance algorithm, using reinforcement learning to learn effective governance strategies while also considering the response function of service entities to balance efficiency and fairness. Combining the ideas of bilevel optimization and online learning, this algorithm effectively balances exploration (understanding the service entities' responses function) and exploitation (choosing efficient actions). We apply the algorithm to a classic service ecosystem, the ride-hailing service system, and empirically demonstrate its effectiveness in the governance task of order dispatching.

关键词： Service Ecosystem Governance Reinforcement Learning Balancing Efficiency and Fairness

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Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV

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VIROLOGY JOURNAL 2024年第1期21卷 1-12页

作者： Chen, Suling Xu, Yuyuan Jiang, Yuanhui Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Minist Educ Key Lab Infect Dis Res South China Guangzhou Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

BackgroundThe global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise in the post era of antiretroviral therapy (ART). Nevertheless, there are no validated predictive models available for assessing the risk of MetS in this specific *** study included PLWH who participated in annual follow-ups at Southern Medical University Nanfang Hospital from September 2022 to November 2023. Participants enrolled in this study were divided into the training set and validation set based on the follow-up duration. We employed both multivariate logistic regression and lasso regression to develop three distinct prediction models. Subsequently, the optimal model was determined through comprehensive analyses, including receiver operating characteristic (ROC) curve analysis, calibration curve, and decision curve analysis (DCA). Ultimately, we generated a nomogram for the optimal model and analyzed the correlation between the model score and the components of *** total of 1017 participants were included in this study, with 814 in the training set and 203 in the validation set. The ultimate prediction model of MetS risk in PLWH incorporated five factors: age, CD8 + T cell counts, controlled attenuation parameter (CAP), gamma-glutamyl transferase (gamma-GT) and lactate dehydrogenase (LDH). The area under the ROC curve (AUC) of the model in the training set and validation set was 0.849 and 0.834, respectively. Furthermore, we revealed a significant correlation between the model score and the MetS components. Additionally, the model score revealed significant group differences in MetS and related metabolic *** study established a potential model for predicting MetS in PLWH.

关键词： HIV/AIDS Metabolic syndrome Clinical prediction model Nomogram Clinical endocrinology

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Ru(II)-base d aggregation-induce d emission (AIE) agents with efficient 1 O2 generation, photo-catalytic NADH oxidation and anticancer activity

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CHINESE CHEMICAL LETTERS 2025年第5期36卷

作者： Xu, Yunli Da, xuwen Wang, Lei peng, Yatong Zhou, Wanpeng Liu, Xiulian Wu, Yao Wang, Wentao Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Univ Chinese Acad Sci Wenzhou Inst Wenzhou 325000 Peoples R China

Photodynamic therapy (PDT) has received much attention in recent years. However, traditional photosensitizers (PSs) applied in PDT usually suffer from aggregation-caused quenching (ACQ) effect in H2 O, single and inefficient photochemical mechanism of action (MoA), poor cancer targeting ability, etc . In this work, two novel Ru(II)-based aggregation-induced emission (AIE) agents (Ru1 and Ru2) were developed. Both complexes exhibited long triplet excited lifetimes and nearly 100 % singlet oxygen quantum yields in H2 O. In addition, Ru1 and Ru2 displayed potent photo-catalytic reduced nicotinamide adenine dinucleotide (NADH) oxidation activity with turnover frequency (TOF) values of about 1779 and 20 0 0 h-1 , respectively. Therefore, both Ru1 and Ru2 showed efficient PDT activity towards a series of cancer cells. Moreover, Ru2 was further loaded in bovine serum albumin (BSA) to enhance the tumor targeting ability in vivo , and the obtained Ru2@BSA could selectively accumulate in tumor tissues and effectively inhibit tumor growth on a 4T1 tumor-bearing mouse model. So far as we know, this work represents the first report about Ru(II) AIE agents that possess high singlet oxygen quantum yields and also potent photocatalytic NADH oxidation activity, and may provide new ideas for rational design of novel PSs with efficient PDT activity. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

关键词： Ru(II) complexes Aggregation-induced emission Photo-catalytic NADH oxidation Photodynamic therapy Turnover frequency

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Estimated Pulse Wave Velocity as a Novel Non-Invasive Biomarker for Metabolic Syndrome Among People Living with HIV

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DIABETES METABOLIC SYNDROME AND OBESITY 2024年 17卷 1999-2010页

作者： Chen, Suling Jiang, Yuanhui Lin, Xiaoli Chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

Purpose: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel and convenient predictor for early detection of MetS in PLWH. Patients and Methods: A total of 485 PLWH were enrolled. These participants were categorized into two groups based on the estimated pulse wave velocity (ePWV) level. Demographic and clinical data were collected to investigate the correlation between ePWV and MetS. Results: The cohort of 485 PLWH was categorized into high-ePWV and low-ePWV groups based on ePWV cutoff value of 10 m/s. We observed significant differences in components of MetS including triglycerides (TG, P < 0.05), HDL cholesterol (HDL-C, P < 0.01), systolic blood pressure (SBP, P < 0.001), diastolic blood pressure (DBP, P < 0.05), and fasting plasma glucose (FPG, P < 0.001) between the two groups. Furthermore, we employed receiver operating characteristic (ROC) curves to demonstrate the effectiveness of ePWV as a predictive indicator for MetS in PLWH (AUC = 0.739, P < 0.001). According to the ROC curve, the optimal cut-off value of ePWV was 7.4 m/s, and its sensitivity and specificity in diagnosing MetS in PLWH were 79.03% and 64.07%, respectively. Although the 7.4 m/s cutoff increased the false positive rate compared to the traditional cutoff, it significantly reduced the rate of missed diagnoses, effectively identifying 79.03% of PLWH with MetS. Conclusion: ePWV is a non-invasive and convenient novel biomarker with predictive capabilities for MetS in PLWH.

关键词： HIV/AIDS highly active antiretroviral therapy metabolic syndrome estimated pulse wave velocity

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Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis

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CLINICAL AND EXPERIMENTAL HYPERTENSION 2022年第5期44卷 451-458页

作者： Qian, Zhe Li, Zhuohong peng, Jie Gao, Qiqing Cai, Shaohang Xu, xuwen Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 Guangzhou Ave North Guangdong Kguangzhou GD Peoples R China

Background To investigate the association between hypertension and clinical outcomes, including in-hospital mortality, intensive care unit (ICU) admission, and invasive ventilation in patients with coronavirus disease 2019 (COVID-19) pneumonia. Methods We implemented a systematic search of PubMed for articles that assessed clinical outcomes of hypertensive patients infected with SARS-CoV-2. The primary outcomes evaluated included: in-hospital mortality, ICU admission, and the use of invasive ventilation. Results A total of 18 studies were included, involving 13,293 patients and covering from January 25, 2020, to April 20, 2020. The relationship between hypertension and prognosis in COVID-19 patients was evaluated. Results showed that hypertension was a risk factor for in-hospital mortality in COVID-19 patients (RR: 2.20, 95% CI, 1.83-2.65, P < .001). Moreover, patients with hypertension were more likely to be admitted to ICU (RR: 1.86, 95% CI, 1.13-3.07, P = .001) and to use invasive ventilation (RR: 2.99, 95% CI, 1.73-5.17, P < .001). Conclusions Among COVID-19 patients, those combined with hypertension had a significantly higher risk of in-hospital deaths, admission to ICU, and need for invasive ventilation.

关键词： COVID-19 epidemiology hypertension respiratory infections virology

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Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions

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Chinese Chemical Letters 2023年第12期34卷 440-445页

作者： xuwen Da Xiulian Liu Chao Li Yatong peng Yao Jian Wanpeng Zhou Yunli Xu Yao Wu Xuesong Wang Qianxiong Zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Photo-catalytic oxidation of intracellular nicotinamide adenine dinucleotide(2'-phosphate)(NAD(P)H)has attracted much attention for cancer ***,the general oxygen-dependent mechanism heavily depresses the efficacy in hypoxic *** solve this problem,herein platinum nanoparticles(Pt NPs)with catalase-like(CAT-like)and catalytic H_(2)evolution activities were introduced as a powerful assistant to enhance the photo-catalytic NAD(P)H oxidation of Ru1([Ru(phen)2(PIP-OCH_(3))]^(2+),phen=1,10-phenanthroline,PIP-OCH_(3)=2-(4-methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline)under hypoxic and even oxygen-free ***,Pt NPs can transform the original and in situ formed H_(2)O_(2)once again into O_(2)by the CAT-like activity,thus relieving tumor hypoxia and realizing cyclic utilization(at least in part)of the precious oxygen in ***,Pt NPs can also be served as H_(2)evolution catalysts while using Ru1 as the photosensitizer and NAD(P)H as the electron and proton *** this process,NAD(P)H is oxidized without the participation of oxygen,which can provide an effective way even under oxygen-free *** co-encapsulation of Rul and Pt NPs in bovine serum albumin(BSA)with tumor targeting ability,the resultant Ru/Pt@BSA could photo-catalyze intracellular NAD(P)H oxidation under hypoxic conditions(3%O_(2)),and exhibited an efficient and selective anticancer activity both in vitro and in *** results may provide new sights for efficient and targeted cancer treatment underhypoxic conditions.

关键词： Hypoxic Cancer treatment Photo-catalytic oxidation NAD(P)H Cyclic utilization of oxygen Pt nanoparticle

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A highly positively charged Ru(II) complex with photo-labile ligands for selective and efficient photo-inactivation of intracellular aureus

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JOURNAL OF INORGANIC BIOCHEMISTRY 2025年 268卷 112908页

作者： Xu, Yunli Da, xuwen Jian, Yao Zhou, Wanpeng Wu, Aifeng Wu, Yao peng, Yatong Liu, Xiulian Shi, Yu Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Due to the protection afforded by host cells, intracellular Staphylococcus aureus (S. aureus), particularly methicillin-resistant S. aureus (MRSA), poses a significantly greater challenge to eliminate compared to the extracellular counterparts. It is highly desirable to develop novel antibacterial agents which are capable of selectively and efficiently eradicating intracellular bacteria, including drug-resistant strains, while being less prone to induce bacterial resistance. In this work, two Ru(II) complexes (Ru1 and Ru2) with photo-labile ligands were designed and synthesized. Both Ru1 and Ru2 could covalently bind to DNA after photo-induced ligand dissociation. Compared to Ru1, the incorporation of a triphenylamine group adorned with two positively charged cationic pyridine units significantly boosts the DNA binding constant, bacterial binding/uptake level, and subsequently, the antibacterial activity of Ru2. Ru2 could selectively photo-inactivate intracellular S. aureus and MRSA, being more efficient than vancomycin both in vitro and in vivo. Interestingly, after 20 days' treatment at sublethal concentrations, S. aureus cells exhibited no obvious drug resistance towards Ru2 upon irradiation. Such appealing results may provide new sights for developing novel antibacterial agents against intractable intracellular pathogens and also prevalent drug resistance.

关键词： Ru(II) complexes Photo-induced ligand dissociation Intracellular bacteria DNA binding Drug resistance

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HClO-responsive dinuclear Ru(II) complexes for selective imaging and efficient photo-inactivation of intracellular bacteria

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CHINESE CHEMICAL LETTERS 2025年第6期36卷

作者： Zhou, Wanpeng Da, xuwen Xu, Yunli peng, Yatong Liu, Xiulian Wu, Yao Shi, Yu Wu, Aifeng Yao, Yishan Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Key Lab Photochem Convers & Optoelect Mat Tech Inst Phys & Chem Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Beijing Inst Pharmacol & Toxicol Beijing 100850 Peoples R China

Intracellular bacteria (ICB), cloaked by the protective barriers of host cells, pose a formidable challenge to selective and efficient eradication. The employment of activatable photosensitizers based antibacterial photodynamic therapy (aPDT) holds significant potential for selective imaging and photo-inactivation of ICB while minimizing side effects on normal cells. Drawing inspiration from the elevated hypochlorous acid (HClO) levels in ICB infected phagocytes, herein we firstly designed and synthesized a series of HClOresponsive dinuclear Ru(II) complexes (Ru1-Ru3) to achieve such a goal. Initially, the luminescence, 1 O2 generation and aPDT activity of these Ru(II) complexes were suppressed due to the quenching effect of the azo group, but were recovered after reaction with HClO in solutions or within ICB infected phagocytes. The detailed results revealed that Ru1 and Ru3 could not only selectively visualize ICB, but also demonstrated remarkable aPDT activity against ICB, surpassing vancomycin both in vitro and in vivo . (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

关键词： Intracellular bacteria HClO-responsive Ru(II) complexes Antibacterial photodynamic therapy Selective imaging and photo-inactivation

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“家校社”协同育人纾解教育焦虑的理与道

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教学与管理 2025年第9期 26-32页

作者：彭亮徐文彬南京晓庄学院教师教育学院南京211171 南京师范大学课程与教学研究所南京210097

作为一种社会心态,教育焦虑渗透在“家校社”这些主体的行动之中,表现为家长“愈战愈勇”的行动逻辑、学校“规避失败”的行动逻辑以及社会“合谋助推”的行动逻辑。然而,这些行动逻辑或将导致“人际间信任的退隐”“理想与现实的渐行... 详细信息

作为一种社会心态,教育焦虑渗透在“家校社”这些主体的行动之中,表现为家长“愈战愈勇”的行动逻辑、学校“规避失败”的行动逻辑以及社会“合谋助推”的行动逻辑。然而,这些行动逻辑或将导致“人际间信任的退隐”“理想与现实的渐行渐远”以及“学习和生活意义的背离”等悖反的结果,这些悖反的结果不仅让教育偏离其正常的轨道,而且使得个人、家庭和社会陷入更加困窘的境地。基于此,在“家校社”协同育人之下,社会层面需要通过“多重保障”来提供必需的支撑;学校教育需要回归育人的本真以使其“谨言慎行”;而家庭则需重塑相关的观念以使家庭教育发生“成人自觉”的转变。藉由这些转变和调整,希冀教育焦虑下的社会、学校和家庭能够以有限合理性原则来筹划各自的行为,以为孩子的未来谋划一片真正属于他们的教育蓝天。

关键词：教育焦虑 “家校社” 行动逻辑行动悖反协同育人

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