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Dynamic design method of digital twin process model driven by knowledge-evolution machining features

INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH 2022年第7期60卷 2312-2330页

作者： Liu, Jinfeng Zhao, peng Jing, xuwen Cao, Xuwu Sheng, Sushan Zhou, Honggen Liu, Xiaojun Feng, Feng Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Peoples R China Shaanxi Diesel Engine Heavy Ind Co Ltd Xingping Peoples R China

Machining plan is the core of guiding manufacturing production and is regarded as one of the keys to ensure the quality of product processing. Existing process design methods are inefficient to quickly handle the machining plan changed induced by the unpredictable events in real-time production. It inevitably causes time and economic losses for the enterprise. In order to express the evolutionary characteristics of product processing, the construction method of digital twin process model (DTPM) is proposed based on the knowledge-evolution machining features. Three key technologies include correlation structure of process knowledge, expression method of the evolution geometric features and the association mechanism between two are solved. On this basis, the construction framework of DTPM is illustrated. Then, the organisation and management mechanism of multi-source heterogeneous data is discussed in detail. At last, a case study of the complex machined part is researched, the results show that the processing time reduced by about 7% and the processing stability improved by 40%. Meanwhile, the implementation scheme, application process and effect of this case are described in detail to provide reference for enterprises.

关键词： Digital twin process knowledge machining features dynamic evolution

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aMAP Score as a Predictor for Long-Term Outcomes in Patients with HBV-Related Acute-on-Chronic Liver Failure

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INTERNATIONAL JOURNAL OF GENERAL MEDICINE 2022年 15卷 407-415页

作者： Sun, Yunqing Li, Zhuohong Liao, Guichan Xia, Muye Xu, xuwen Cai, Shaohang peng, Jie Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou Guangdong Peoples R China

Background and Aim: The long-term outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remain not well known. This study aimed to investigate whether aMAP score can predict re-hospitalization, hepatocellular carcinoma (HCC) occurrence and long-term mortality in patients with HBV-ACLF. Methods: A total of 82 patients diagnosed with HBV-ACLF and survived over 6 months were enrolled. The median follow-up period was 105 (75.9, 134.1) months. The Cox proportional hazards or logistic regression analysis was used to determine independent risk factors. Cumulative incidence of HCC and survival rate were evaluated using Kaplan-Meier analysis. Results: Multivariate analysis identified that the aMAP risk score was an independent predictor of re-hospitalization (odds ratio [OR] = 1.112, 95% confidence interval [CI]: 1.021-1.211, p = 0.015), hepatocellular carcinoma occurrence (hazards ratio [HR] = 2.277, 95% CI: 1.014-5.114, p = 0.046) and mortality (HR = 1.366, 95% CI: 1.040-1.794, p = 0.025). High-risk aMAP scores were associated with higher risk of HCC occurrence and mortality. Conclusion: A higher aMAP score was an independent risk predictor of re-hospitalization, HCC occurrence and mortality, respectively, in HBV-ACLF patients who survived over 6 months, which can be applicable for early risk stratification and clinical decision.

关键词： acute-on-chronic liver failure chronic hepatitis B virus infection re-hospitalization hepatocellular carcinoma mortality prognosis

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Decreased intestinal abundance of Akkermansia muciniphila is associated with metabolic disorders among people living with HIV

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ANNALS OF MEDICINE 2025年第1期57卷 2474730页

作者： Qian, Zhe Chen, Suling Liao, Xiaoyang Xie, Jingfang Xu, Yuyuan Zhong, Huiqun Ou, Lang Zuo, Xiang Xu, xuwen peng, Jie Wu, Jian Cai, Shaohang Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Elderly Resp 2 Guangzhou 510030 Peoples R China Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Geriatr Guangzhou Peoples R China Univ South China Affiliated Nanhua Hosp Dept Hepatobiliary Surg Hengyang Peoples R China Southern Med Univ Nanfang Hosp Dept Gen Surg Div Hepatobiliopancreat Surg Guangzhou Peoples R China South China Univ Technol Sch Med Guangzhou Peoples R China

BackgroundPrevious studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic *** total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. Akkermansia abundance in stool samples was measured using RT-qPCR, and Pearson correlation and logistic regression were applied for *** sequencing revealed a significant decline in gut Akkermansia abundance in PLWHIV with NAFLD. STAMP analysis of public datasets confirmed this decline after HIV infection, while KEGG pathway analysis identified enrichment of metabolism-related genes. A prospective cohort study with 103 PLWHIV followed for 48 weeks validated these findings. Akkermansia abundance was significantly lower in participants with NAFLD, overweight, and hyperlipidemia at baseline, and it emerged as an independent predictor of NAFLD and overweight. Negative correlations were observed between Akkermansia abundance and both CAP values and body mass index (BMI) at baseline and at week 48. At the 48-week follow-up, Akkermansia remained a predictive marker for *** abundance was reduced in PLWHIV with metabolic disorders and served as a predictive biomarker for NAFLD progression over 48 weeks of ART.

关键词： HIV gut microbiota metabolic diseases NAFLD overweight Akkermansia muciniphila

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A Study on Genotype-by-Environment Interaction Analysis for Agronomic Traits of Maize Genotypes Across Huang-Huai-Hai Region in China

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 57-81页

作者： Haiwang Yue Jianwei Wei Junliang Xie Shuping Chen Haicheng peng Hongmei Cao Junzhou Bu xuwen Jiang Dryland Farming Institute Hebei Academy of Agriculture and Forestry SciencesHebei Provincial Key Laboratory of Crops Drought Resistance ResearchHengshui053000China Soil and Fertilizer Workstation of Hengshui Agriculture and Rural Bureau Hengshui053000China Maize Research Institute/College of Agronomy Qingdao Agricultural UniversityQingdao266109China

Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food *** this study,28 nationally approved maize hybrids were evaluated across 24 different climatic conditions for two consecutive years(2018-2019).The purpose of this study was to select high-yield with stable genotypes and identify important agronomic traits for maize breeding program *** results of this study showed that the genotypeenvironment interaction effects of the 12 evaluated agronomic traits was highly significant(P<0.001).We introduced a novel multi-trait genotype-ideotype distance index(MGIDI)to select genotypes based on multiple agronomic *** selection process exhibited by this method is unique and easy to understand,so the MGIDI index will have more and more important applications in future multi-environment trials(METs)*** genotypes selected by the MGIDI index were G22,G10,G12 and G1 as the high yielding and stable *** parents of these selected genotypes have the ability to play a greater role as the basic germplasm in the breeding process.A new form of genotype(G)main effects and genotype(G)-by-environment(E)interaction(GGE)technician,genotypeyieldtrait(GYT)biplot,based on multiple traits for genotypes selection was also applied in this *** GYT biplot ranked genotypes by combining grain yield with other evaluated agronomic traits,and displayed the distribution of their traits,namely strengths and weaknesses.

关键词： GEI MGIDI GYT biplot AMMI model GGE

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Adhesive Coacervates: Adhesive Coacervates Driven by Hydrogen-Bonding Interaction (Small 43/2020)

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Small 2020年第43期16卷

作者： Qiongyao peng Jingsi Chen Zicheng Zeng Tao Wang Li Xiang xuwen peng Jifang Liu Hongbo Zeng Department of Chemical and Materials Engineering University of Alberta Edmonton Alberta T6G 1H9 Canada The Fifth Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong 510700 China

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Improved formation and evolution models for hydrate flow barriers in water-dominated systems based on flowloop experiments

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CHEMICAL ENGINEERING SCIENCE 2024年 297卷

作者： Kong, Qingwen Qin, xuwen Ji, peng Wang, Zhiyuan Zhang, Jianbo Fu, Weiqi Sun, Baojiang China Univ Petr East China Sch Petr Engn Qingdao Peoples R China China Geol Survey Aero Geophys Survey & Remote Sensing Ctr Nat Resou Beijing Peoples R China CNPC Offshore Engn Co Ltd Tianjin Branch Tianjin Peoples R China Natl Engn Res Ctr Oil & Gas Drilling & Complet Tec Qingdao Peoples R China China Univ Min & Technol State Key Lab Coal Resources & Safe Min Xuzhou Peoples R China

During gas hydrate and deep -water oil and gas exploitation, hydrate flow barriers in water -dominated systems represent a critical safety issue. In this study, hydrate formation and blockage were investigated using flowloop and focused beam reflectance measurement. An improved hydrate kinetic model suitable for cooling conditions was established considering various bubble behaviors. The special large aggregate size range was defined as 150 - 500 mu m. A new hydrate aggregation -blockage evolution model is proposed based on three significant events: large aggregate appearance, large aggregate blockage, and particle and small aggregate blockage. The results show that a critical initial flow velocity of 0.65 +/- 0.07 m/s determines whether large hydrate aggregates appear immediately at the onset of hydrate formation. Moreover, the prediction error for the flow velocity drop at significant events was less than +/- 9.1 %. Based on these results, two main hydrate blockage mechanisms in waterdominated systems are revealed.

关键词： Gas hydrate Hydrate formation Blockage Bubbly flow Significant events

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XGB-SEGA coupled energy saving method for wastewater treatment plants

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APPLIED WATER SCIENCE 2024年第2期14卷 29页

作者： Wang, Zijian Zhou, xuwen Wang, Hao Huang, Zehan Ji, Jiantao peng, Zhaoxu Jiang, Kun Beijing Univ Technol Fac Architecture Civil & Transportat Engn Beijing 100124 Peoples R China Zhengzhou Univ Sch Water Conservancy & Transportat Zhengzhou 450001 Peoples R China Harbin Inst Technol Sch Civil & Environm Engn Shenzhen 518055 Peoples R China Cent Plains Environm Protect Co Ltd Zhengzhou 450001 Peoples R China Zhengzhou Univ Sch Ecol & Environm Zhengzhou 450001 Peoples R China CSD Water Serv CO Ltd Beijing 100124 Peoples R China

To reduce the amount of energy consumed in wastewater treatment plants, nine methods were used to select the key operation parameters that affected energy consumption according to daily operation records, and an intelligent operation management system based on a genetic algorithm was constructed by mapping the relationships between energy consumption and the key operation parameters. The results showed that the prediction and management of energy consumption could be achieved by incorporating the strengthened elastic genetic algorithm into the extreme gradient boosting model. The main parameters affecting energy consumption were the influent flow rate, effluent total nitrogen, NH4+-N loading rate, etc., and the energy consumption could be reduced by 13-27% (with an average of 22%). The parameters were all selected from the daily operation records of the wastewater treatment plant, and no additional complex data acquisition system was needed to collect specific parameters. This study provided a cost-effective strategy to reduce energy consumption in wastewater treatment plants.

关键词： Energy saving Extreme gradient boosting (XGB) Genetic algorithm optimization Carbon neutrality Wastewater treatment

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DNA mismatch repair in HIV-Associated Lymphoma: Lost in Translation?

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JOURNAL OF INFECTION 2024年第3期88卷 106112-106112页

作者： Jiang, Yuanhui Chen, Suling Xia, Muye Xu, xuwen peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China

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IVDETR: A Multi-Source Image Pig Detection Method Based on Cross-Domain Feature Fusion

IVDETR: A Multi-Source Image Pig Detection Method Based on C...

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Pattern Recognition and Artificial Intelligence (PRAI), International Conference on

作者： Rui Song Hao Li Mengzhen Huang Zihan Huang peng Li xuwen He School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

ISBN: (数字)9798350350890

ISBN: (纸本)9798350350906

In large-scale centralised pig farming, object detection algorithms can accurately track and monitor each pig. However, a significant proportion of current detection methods are based on visible images, and the colour differences between different pig breeds limit the applicability of the models. Furthermore, complex background interference, low illumination conditions, or high illumination intensity noise in visible scenes can likewise lead to reduced accuracy during detection. Therefore, we propose a cross-domain encoder based on the self-attention and design the IVDETR model, which integrates features from infrared and visible light images for pig object detection. In order to facilitate the training and evaluation of the model, we constructed a comprehensive, standardised infrared-visible light dataset for the first time. The experimental outcomes demonstrated that the detection accuracy was increased from 0.939 to 0.998 in a real pig breeding environment.

关键词： Training Accuracy Noise Lighting Object detection Feature extraction Pattern recognition Detection algorithms Monitoring Farming

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A tumor-targeted multifunctional nanosystem with light-triggered NO generation for synergistic photodynamic/gas therapy

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INORGANICA CHIMICA ACTA 2024年 567卷

作者： peng, Yatong Da, xuwen Zhou, Wanpeng Xu, Yunli Wu, Yao Liu, Xiulian Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment. Nevertheless, PDT alone still faces a considerable challenge in efficiently eliminating cancer cells, and combination with other therapeutic strategies can significantly improve anticancer efficacy. Herein, a multifunctional nanosystem (Ru-PArg-HA) composed of biocompatible and tumor-targeted hyaluronic acid (HA), a photosensitizer [Ru(phen)(2)(PIP-OCH3)](2+) (termed Ru, phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1H-imidazo[4,5-f] [1,10] phenanthroline) and a NO donor poly-L-arginine (PArg), was fabricated via electrostatic interactions. Under 470 nm light irradiation, Ru-PArg-HA could not only catalyze 1,4-dihydronicotinamide adenine dinucleotide (NADH) oxidation to produce H2O2, but also could generate a large amount of reactive oxygen species (ROS, including O-1(2) and O-2(center dot-)) for PDT therapy. The light-driven production of O-1(2) and H2O2 could further convert PArg into nitric oxide (NO), enabling synergistic gas therapy. The experimental outcomes demonstrated that Ru-PArg-HA exhibited much enhanced anticancer activity compared to traditional mono-modal PDT. This finding provides new inspiration for the development of multifunctional nanosystems with efficient and targeted anti-cancer activity.

关键词： Photodynamic therapy Gas therapy Ru(II) photosensitizer Nitric oxide Tumor-targeted

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