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Biomimetic Dendrimer-Peptide Conjugates for Early Multi-Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation

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ADVANCED MATERIALS 2021年第26期33卷 2100746-2100746页

作者： Liu, Peixin Zhang, Tongyu Chen, Qinjun Li, Chao Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Zhao, Zhenhao Luo, Yifan Li, xuwen song, Haolin Su, Boyu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery Minist Educ State Key Lab Med Neurobiol Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Dept Pharmaceut Sch Pharm Shanghai 201203 Peoples R China

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on beta-amyloid (A beta) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting A beta phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease A beta burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

关键词： Alzheimer&apos s disease antioxidant ability glial cell activation inflammatory responses multi‐ target treatments synergistic function

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An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters

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BIOMED RESEARCH INTERNATIONAL 2020年第0期2020卷 000-000页

作者： Sun, Ge Yang, Lin Wang, Weiwei Zhang, song Luo, Zhichang Wu, Guanghui Liu, Xiaohong Hao, Dongmei Yang, Yimin Li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Chinese Acad Med Sci Fuwai Hosp Beijing 100037 Peoples R China Capital Med Univ Beijing Inst Heart Lung & Blood Vessel Dis Beijing Anzhen Hosp Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904,P <= 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443,P<0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.

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Identification of unhealthy Panax notoginseng from different geographical origins by means of multi-label classification

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2019年 222卷 117243-000页

作者： Yang, Xiaodong song, Jie Wu, Xin Xie, Lin Liu, xuwen Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China

Root-knot nematode is a common plant-parasitic pest with a highly destructive that infects more than 2000 plant species. Panax notoginseng (P. notoginseng) is one of the most susceptible traditional medicine. More importantly, it is difficult to distinguish the powders of P. notoginseng infected with root-knot nematode from those of healthy P. notoginseng due to the color and shape are same after being ground into powder. In this paper, Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) was used to identify P. notoginseng samples. Multiplicative scatter correction (MSC) was applied to preprocess the spectral data. Competitive adaptive reweighted sampling (CARS) and successive projection algorithm (SPA) were employed to select feature variables. Density-based spatial clustering of application with noise (DBSCAN) was adopted to discover groups within the data. Also, we found that the geographical origin is a pivotal factor to consider when identifying unhealthy P. notoginseng. Therefore, we introduced a novel multi-label classification (MLC) method to identify healthy and unhealthy P. notoginseng powders from three different geographical origins. In addition, binary relevance method (BR), classifier chain (CC), ensembles of classifier chains (ECC), and multilayer perceptron classifier (MLPC) were applied to create classification models, ECC exhibits superior performance in particular. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Panax notoginseng Root-knot nematode Geographical origin Multi-label classification

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政府质量对公民参与倾向的影响:一个有调节的中介模型

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江苏社会科学 2019年第4期 128-136,259页

作者：宋典芮国强丁叙文苏州大学政治与公共管理学院

本文通过调查问卷收集了政府质量、政府信任等变量的数据,运用回归分析方法,深度剖析了政府质量、政府信任以及社会责任感影响公民参与倾向的机制和原理。研究表明:政府质量和政府信任是影响公民参与倾向的关键变量,对公民参与倾向有直... 详细信息

本文通过调查问卷收集了政府质量、政府信任等变量的数据,运用回归分析方法,深度剖析了政府质量、政府信任以及社会责任感影响公民参与倾向的机制和原理。研究表明:政府质量和政府信任是影响公民参与倾向的关键变量,对公民参与倾向有直接影响。另外,个体社会责任感不仅会负向调节政府信任与公民参与倾向之间的关系,还会削弱政府信任在政府质量与公民参与倾向之间的中介作用。研究结论揭示了政府质量发挥治理作用的复杂机制,为政府质量理论的发展提供了微观理论基础。

关键词：政府质量政府信任公民参与倾向社会责任感

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糖浸种对盐胁迫玉米种子萌发和幼苗生长的影响

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种子 2021年第8期40卷 51-56页

作者：张成冉徐广海宋朝玉伊祖涛江绪文孙鹏张海艳青岛农业大学农学院山东青岛266109 青岛市农业科学研究院山东青岛266071 山东登海华玉种业有限公司山东莱州261411

以耐盐玉米品种伟科702和盐敏感玉米品种蠡玉16为试验材料,在150 mmol·L^(-1) NaCl胁迫下,采用不同浓度(5、10、15 g·L^(-1))外源糖(葡萄糖、果糖、蔗糖、壳聚糖、海藻糖)浸种处理,分析外源糖对玉米种子发芽指标、幼苗生长、... 详细信息

以耐盐玉米品种伟科702和盐敏感玉米品种蠡玉16为试验材料,在150 mmol·L^(-1) NaCl胁迫下,采用不同浓度(5、10、15 g·L^(-1))外源糖(葡萄糖、果糖、蔗糖、壳聚糖、海藻糖)浸种处理,分析外源糖对玉米种子发芽指标、幼苗生长、叶绿素含量、SOD活性、POD活性和MDA含量的影响。结果表明,外源糖处理后两个品种的发芽势、发芽率、最终发芽率、发芽指数、生物量、叶绿素含量、SOD活性和POD活性均显著增大,且随着糖浓度的增加呈先升高后下降的趋势,浓度为10 g·L^(-1)时最高;平均发芽时间和MDA含量减小,且随着糖浓度的增加呈先下降后上升的趋势,浓度为10 g·L^(-1)时最低。不同糖处理间比较,果糖处理的各项指标显著优于其他糖处理。因此,外源糖浸种能有效改善盐胁迫下玉米幼苗生长状况,10 g·L^(-1)果糖的改善效果最好。

关键词：玉米盐胁迫糖种子萌发幼苗生长抗氧化酶

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Medium-temperature furnace baking of 1.3 GHz 9-cell superconducting cavities at IHEP

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SUPERCONDUCTOR SCIENCE & TECHNOLOGY 2021年第9期34卷 095005-095005页

作者： He, Feisi Pan, Weimin Sha, Peng Zhai, Jiyuan Mi, Zhenghui Dai, xuwen Jin, song Zhang, Zhanjun Dong, Chao Liu, Baiqi Zhao, Hui Ge, Rui Zhao, Jianbing Mu, Zhihui Du, Lei Sun, Liangrui Zhang, Liang Yang, Conglai Zheng, Xiaobing Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Chinese Acad Sci Inst High Energy Phys Key Lab Particle Accelerat Phys & Technol Beijing 100049 Peoples R China Chinese Acad Sci Ctr Superconducting RF & Cryogen Inst High Energy Phys Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Recently, heat treatment in the range of 250 degrees C-500 degrees C has been attempted with the aim of improving the quality factor (Q) of superconducting radio-frequency (SRF) cavities worldwide. Herein, medium-temperature (mid-T) furnace baking experiments were conducted at the Institute of High Energy Physics to obtain higher Q values. First, 1.3 GHz 1-cell cavities received mid-T furnace baking at different temperatures, resulting in not only the improvement of Q but also an anti-Q-slope behavior. Furthermore, mid-T furnace baking was applied to six 1.3 GHz 9-cell cavities, all of which indicated higher Q and anti-Q-slope behavior. The average Q was 3.8 x 10(10) at 16 MV m(-1). The maximum gradients of the 9-cell cavities were 22.7-26.5 MV m(-1). Finally, the mid-T furnace baked 1.3 GHz 9-cell cavities were welded with helium vessel, with no degradation in the vertical tests. In addition, the mid-T furnace baking process was simplified in comparison with European X-ray Free Electron Laser and Linear Coherent Light Source because of the cancellation of light electro-polishing. This simplification is beneficial in the mass production of SRF cavities with high Q, which are widely adopted in free electron lasers and high-energy colliders.

关键词： superconducting cavity quality factor gradient medium-temperature furnace baking vertical test

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赞比亚医疗器械现状及挑战

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中国医疗设备 2022年第5期37卷 146-149,165页

作者： Taizya Kapenda 廉翠婷杨琳郝冬梅杨益民李旭雯张松北京工业大学环境与生命学部智能化生理测量与临床转化北京市国际科研合作基地北京100124

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废... 详细信息

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废更新提供参考。赞比亚卫生部通过赞比亚药品监督管理局制定的医疗设备相关政策、计划、资源、规范和指南,明确了在医疗器械部署过程中各环节应遵循的规定制度。本文分析了赞比亚医疗器械管理所面临的挑战:医疗设备缺乏、人力资源缺乏、规划与预算不足,以及设备采购、安装、调试、维护的难题,并提出相应解决办法,如建立医疗设备委员会,采用临床工程人员对医疗设备进行统一管理的方式,以保障临床医护人员以及患者的安全。赞比亚管理和维护医疗设备的能力仍然有限,导致管理和维修能力的增长大大落后于医疗设备的部署,这些既是赞比亚与他国合作的方向,也是自身需要改进的部分。本研究可为提高赞比亚医疗设备服务水平、缓解医疗压力提供参考。

关键词：赞比亚医疗器械政策法规器械管理挑战

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Modeling Hydro-Dynamics in a Harbor Area in the Daishan Island, China

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WATER 2019年第2期11卷 192页

作者： Li, Yuting song, Zhiyao Peng, Guoqiang Fang, xuwen Li, Ruijie Chen, Peng Hong, Haoyuan Nanjing Normal Univ Key Lab Virtual Geog Environm Nanjing 210023 Jiangsu Peoples R China State Key Lab Cultivat Base Geog Environm Evolut Nanjing 210023 Jiangsu Peoples R China Jiangsu Ctr Collaborat Innovat Geog Informat Reso Nanjing 210023 Jiangsu Peoples R China Anhui Transport Survey & Design Inst Co Ltd Hefei 230000 Anhui Peoples R China Hohai Univ Key Lab Coastal Disaster & Def Minist Educ Nanjing 210098 Jiangsu Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Jiangsu Peoples R China

This study presents an incorporation and application of a two-dimensional, unstructured-grid hydrodynamic model with a suspended sediment transport module in Daishan, China. The model is verified with field measurement data from 2017: water level, flow velocities and suspended sediment concentration (SSC). In the application on the Daishan, the performance of the hydrodynamic model has been satisfactorily validated against observed variations of available measurement stations. Coupled with the hydrodynamic model, a sediment transport model has been developed and tested. The simulations agreed quantitatively with the observations. The validated model was applied to the construction of breakwaters and docks under a different plan. The model can calculate the flow field and siltation situation under different breakwater settings. After we have analyzed the impact of existing breakwater layout schemes and sediment transport, a reasonable plan will be selected. The results show that the sea area near the north of Yanwo Shan and Dongken Shan has a large flow velocity exceeding 2.0 m/s and the flow velocity within the isobath of 5 m is small, within 0.6 m/s. According to the sediment calculation, the dock project is feasible. However, the designed width of the fairway should be increased to ensure the navigation safety of the ship according to variation characteristics of cross flow velocity in channel.

关键词： suspended sediment concentration numerical simulation breakwater the dock project

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Metabolomic study of natrin-induced apoptosis in SMMC-7721 hepatocellular carcinoma cells by ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2019年第0期124卷 1264-1273页

作者： Lu, Shiyin Lu, Rigang song, Hui Wu, Jinxia Liu, xuwen Zhou, Xiaoling Yang, Jianqing Zhang, Hongye Tang, Chaoling Guo, Hongwei Hu, Jian Mao, Guifu Lin, Hanmei Su, Zhiheng Zheng, Hua Guangxi Med Univ Pharmaceut Coll Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Pharm Liuzhou Peoples R China Guangxi Inst Food & Drug Control Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Gastroenterol Liuzhou Peoples R China Guangxi Tradit Chinese Med Univ Affiliated Hosp 1 Gynaecol Nanning Peoples R China Guangxi Med Univ Med Sci Res Ctr Nanning Peoples R China

Natrin, a new member of the cysteine-rich secretory protein (CRISP) family purified from the snake venom of Naja naja atra, has been demonstrated to have anticancer activity. However, the underlying molecular mechanisms need further elucidation. In this study, MU was used to evaluate cell viability. Apoptotic cells were analyzed by employing a transmission electron microscope (TEM). Metabolomic study of the metabolic perturbations caused by natrin-induced apoptosis in differentiated SMMC-7721 cells was performed for the first time by using integrative ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/IDF MS). To investigate the possible mechanism in the mitochondria] pathway of natrin-induced apoptosis, we measured apoptosis-related mRNA changes using real-time fluorescent quantitative PCR (FQ-PCR). Cell proliferation was significantly inhibited after treatment with natrin in a dose dependent manner. Principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) clearly demonstrated that metabolic profiles were affected by natrin. The results of multivariate statistical analysis showed that a total of 13 metabolites were characterized as potential biomarkers highly implicated in natrin-induced apoptosis, which corresponded to fluctuations of five pathways, including sphingolipid metabolism, fatty acid biosynthesis, fatty acid metabolism, glycerophospholipid metabolism and glycosphingolipid biosynthesis. Furthermore, natrin-induced apoptosis showed an increase in the Bax/Bcl-2 ratio in the mitochondrial pathway compared with controls. This study illustrated that rapid and holistic cell metabolomics combining molecular biological approaches might be a powerful tool for evaluating the underlying mechanisms of natrin-induced apoptosis, which would help to deepen specific insights into the anti-hepatoma mechanisms of natrin and facilitate the clinical application of natrin in the future.

关键词： Metabolomics Natrin Hepatocellular carcinoma (HCC) Apoptosis UPLC-QtrOF MS

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Improving identification ability of adulterants in powdered Panax notoginseng using particle swarm optimization and data fusion

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INFRARED PHYSICS & TECHNOLOGY 2019年 103卷 103101-000页

作者： Yang, Xiaodong song, Jie Peng, Lin Gao, Lutao Liu, xuwen Xie, Lin Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China Yunnan Agr Univ Coll Big Data Kunming 650201 Yunnan Peoples R China

Panax notoginseng (P. notoginseng) is frequently targeted for adulteration with lower-grade P. notoginseng because of its high price. This paper presents a novel method to improve the identification ability of adulterants using spectroscopic techniques and chemometrics. P. notoginseng powder of different grades were blended at different percentages (0-100%), in which the minimum blend ratio was 0.5%. NIR (12,497-4000 cm(-1)) and FT-MIR (4000-400 cm(-1)) spectra of samples were acquired. The wavenumbers of 7099-4200 cm(-1), 3600-2750 cm(-1), and 1750-400 cm(-1) were selected manually as characteristic spectra, which included 3706 variables. Then principal component analysis (PCA) was used to further reduce the data dimension of characteristic spectra, and the first nine principal components (PCs) were applied to build classification models of 14 (the ratio of 0.5% excluded) and 15 kinds of blend ratios. Finally, Support vector machine (SVM) was built for classification of adulterants of different blend ratio. The accuracy of prediction set is 92.46% and 91.79%, respectively. On this basis, particle swarm optimization (PSO) was applied to optimize the parameters of SVM, and the accuracy of prediction set increased to 96.65% and 96.97%, respectively. The results demonstrate that the application of data fusion of NIR and FT-MIR spectra combined with SVM optimized by PSO can improve the identification ability of adulterants in powdered P. notoginseng.

关键词： Panax notoginseng Adulteration PCA PSO SVM

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