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Risk prevention of different forms of gestational diabetes mellitus based on energy metabolism prior to diagnosis

TECHNOLOGY AND HEALTH CARE 2022年第1_suppl期30卷 S285-S292页

作者： Lu, Jiayu Jiang, Hongqing Zhang, song Yang, Yimin Hao, Dongmei Li, xuwen Chen, Aiqing Shao, Jing Liu, Xiaohong Yang, Lin Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing Peoples R China Haidian Maternal & Children Hlth Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively. OBJECTIVE: GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively. METHODS: By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences. RESULTS: For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy. CONCLUSION: The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

关键词： Diabetes mellitus in the second trimester diagnosis of diabetes mellitus in the third trimester energy metabolism

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Controlled Anodic Decomposition Pathway of Supramolecular Lithium Borate for Rationally Tuned Interphase Chemistry

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025年第19期64卷 e202500425页

作者： Zhou, Haiyu Hou, Wenhui Zhu, Da Zhou, Pan Peng, xuwen Liu, Zhi Yan, Shuaishuai Lu, Yang Ou, Yu Liu, Fengxiang Xia, Yingchun Liu, Hao Cao, Qingbin song, Xuan Guo, Decai Xu, Hong Liu, Kai Tsinghua Univ Dept Chem Engn State Key Lab Chem Engn Beijing 100084 Peoples R China Tsinghua Univ Inst Nucl & New Energy Technol Beijing 100084 Peoples R China SINOPEC Dalian Res Inst Petr & Petrochem 96 Nankai RdTieshan St Dalian 116045 Liaoning Peoples R China

The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium metal batteries. However, developing well-tailored electrolyte additives with rationally controlled interfacial chemistry remains highly challenging. Here, two lithium borates: lithium (2-methoxy-15-crown-5)trifluoroborate (C-LiMCFB) and lithium (15-methoxy-2,5,8,11,14-pentaoxahexadecan)trifluoroborate (L-LiMCFB), incorporating cyclic 15-crown-5 (15C5) and linear pentaethylene glycol monomethyl ether (PEGME) as respective host groups tethered to the boron center are designed and synthesized. In C-LiMCFB, the supramolecular polydentate chelation/de-chelation of the 15C5 with Li+ can sequentially deactivate/activate the anodic decomposition of the C & horbar;O bonds, therefore leading to the controlled cleavage pathway of B & horbar;O and C & horbar;O bonds. The controlled interfacial chemistry leads to the formation of a uniform CEI layer, rich in lithium boron-oxygen clusters interwoven with LiF, on the NCM811 surface. This novel CEI configuration demonstrates an exceptional balance of mechanical robustness, adhesiveness, and toughness, providing highly desirable protection for the NCM811 cathode. The discovery of these novel supramolecular boron-based lithium salts not only unlocks supramolecular chemistry for rational electrolyte tuning but also provides a deeper understanding of the CEI formation mechanism in high-energy lithium metal batteries.

关键词： Battery electrolytes Energy storage Lithium metal batteries Supramolecular chemistry

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IVDETR: A Multi-Source Image Pig Detection Method Based on Cross-Domain Feature Fusion

IVDETR: A Multi-Source Image Pig Detection Method Based on C...

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Pattern Recognition and Artificial Intelligence (PRAI), International Conference on

作者： Rui song Hao Li Mengzhen Huang Zihan Huang Peng Li xuwen He School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

ISBN: (数字)9798350350890

ISBN: (纸本)9798350350906

In large-scale centralised pig farming, object detection algorithms can accurately track and monitor each pig. However, a significant proportion of current detection methods are based on visible images, and the colour differences between different pig breeds limit the applicability of the models. Furthermore, complex background interference, low illumination conditions, or high illumination intensity noise in visible scenes can likewise lead to reduced accuracy during detection. Therefore, we propose a cross-domain encoder based on the self-attention and design the IVDETR model, which integrates features from infrared and visible light images for pig object detection. In order to facilitate the training and evaluation of the model, we constructed a comprehensive, standardised infrared-visible light dataset for the first time. The experimental outcomes demonstrated that the detection accuracy was increased from 0.939 to 0.998 in a real pig breeding environment.

关键词： Training Accuracy Noise Lighting Object detection Feature extraction Pattern recognition Detection algorithms Monitoring Farming

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Interphasial Chemistry Design for Seamless Lithium Deposition in Anode-Free Lithium Metal Batteries

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ADVANCED MATERIALS 2025年

作者： song, Xuan Liu, Cheng Zhang, Aiyuan Ding, Li Zeng, Tianyou Lu, Yang Ou, Yu Hou, Wenhui Zhou, Pan Cao, Qingbin Yan, Shuaishuai Liu, Zhi Peng, xuwen Zhou, Haiyu Xia, Yingchun Zhang, Weili Liu, Hao Liu, Kai Tsinghua Univ Dept Chem Engn Beijing 100084 Peoples R China China Acad Space Technol Beijing 100094 Peoples R China Beijing Mingyuan Space Elect Informat Technol Co L Beijing 100080 Peoples R China Tsinghua Univ Hefei Inst Publ Safety Res Hefei 230601 Peoples R China

Anode-free lithium metal batteries (AFLMBs) are promising due to ultrahigh energy density, reduced manufacturing costs, and enhanced safety through active lithium elimination. However, their practical implementation remains challenged by unstable electrode-electrolyte interfaces and the resulting rapid active species depletion. Herein, an ultrathin ion-conducting membrane (ICM) is designed, featuring uniformly distributed rigid benzenesulfonimide anionic groups and flexible lithiophilic groups containing ether oxygen groups. The constrained benzenesulfonimide anions enable exceptional charge separation and reduced spatial resistance, boosting lithium-ion mobility, while the integrated lithophilic network directs lateral lithium deposition through ionic nanochannels. This ICM layer effectively promotes the enrichment of anions at the interface and constructs stable anion-derived solid electrolyte interphases (SEI). Meanwhile, ICM layers with electron-insulating and ion-conducting properties can further prevent side reactions, and suppress dendritic Li growth acting as a natural shield, resulting in seamless lithium deposition. Specifically, the Li||Cu coin cells with ICM achieve 99.82% Coulombic efficiency. The AFLMBs assembled with ICM-coated copper foil (ICM Cu) and NCM811 deliver an energy density of 495 Wh kg-1 with 80.72% capacity retention after 100 cycles. The interphasial chemistry design strategy provides insights into the precise interfacial engineering to realize high-performance, high-safety battery systems and facilitates their development for practical applications.

关键词： anode-free lithium metal batteries dendrite suppression interphasial chemistry ion-conducting membranes solid electrolyte interphases

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Leather Defect Detection Algorithm Based on an Improved YOLOv5s

Leather Defect Detection Algorithm Based on an Improved YOLO...

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Pattern Recognition and Artificial Intelligence (PRAI), International Conference on

作者： xuwen He Hao Li Yifan Liu Rui song Yuchen Zhao Xiao Ou School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

ISBN: (数字)9798350350890

ISBN: (纸本)9798350350906

In the field of intelligent manufacturing, the realization of efficient and accurate automated surface defect detection is particularly critical for enhancing product quality, especially in the leather industry, which holds a significant position in global trade. Traditional defect detection methods encounter challenges in handling complex scenes and identifying minute defects. However, the advent of deep learning technologies has provided a new pathway to address these issues. This paper is dedicated to innovative research on the precise localization and detailed classification of leather surface defects through the enhancement of deep learning models, aiming to overcome the limitations of existing technologies and improve the accuracy and efficiency of detection. By extending the YOLOv5s model, this study has developed the CMR-YOLO algorithm. This algorithm integrates the Channel Attention mechanism (CA), an improved Multi-Dimensional Precision Intersection over Union (MPDIoU), and the Cross Stage Partial Residual feature enhancement module (C3R). These enhancements not only improve the classification accuracy but also bolster the model's stability and robustness in complex scenes. Through the comprehensive application of these techniques, the CMR-YOLO algorithm demonstrates improved performance in categorizing different types of leather defects, particularly effective in handling diverse defect characteristics and accurately classifying various defects. Compared to the traditional YOLOv5s, the CMR-YOLO algorithm also exhibits improved accuracy in defect classification, with the mAP50 increasing from 62.5% to 79.5%, effectively enhancing the overall performance of leather defect detection. These research outcomes not only achieve technological breakthroughs but also provide significant technical support for quality control and intelligent manufacturing in the leather goods industry.

关键词： YOLO Industries Deep learning Accuracy Attention mechanisms Prediction algorithms Robustness Classification algorithms Manufacturing Defect detection

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

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NANO LETTERS 2025年第7期25卷 2949-2959页

作者： Zhang, Shilin You, Haoyu Fan, Hongrui Chen, Yun song, Haolin Zhao, Zhenhao Chen, Qinjun Wang, Yu Tian, Zonghua Wu, Yuxing Zhou, Zheng Guo, Yun Su, Boyu Li, xuwen Jia, Ru Fang, Mingzhu Jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Key Lab Smart Drug Delivery State Key Lab Med NeurobiolMinist Educ Shanghai 201203 Peoples R China Fudan Univ Frontiers Ctr Brain Sci Sch Pharm MOE Shanghai 201203 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China Fujian Med Univ Binhai Campus Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Fuzhou 350212 Peoples R China

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8+ T cells inward. Additionally, the overactivated TGF-beta/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy. In this work, a type of enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) and pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral enamine N-oxides can trigger transcytosis and then respond to hypoxia and acidic microenvironments, turning the surface charge of the nanoparticles to a positive charge and enhancing penetration. The released galunisertib inhibits the TGF-beta/SMAD signaling pathway, reshapes the matrix, activates antitumor immunity, and combines with gemcitabine (Gem) to kill tumor cells.

关键词： Drug delivery system transcytosis tumor penetration enamine N-oxide TGF-beta/SMAD signalingpathway

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Tunable Band Gaps and High Carrier Mobilities in Germanene by Si Doping in the Presence of an External Electric Field: Field Effect Transistors

SSRN

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SSRN 2023年

作者： Xiao, Meixia Yin, xuwen song, Haiyang Lv, Ying Xiao, Beibei College of New Energy Xi′an Shiyou University Xi′an710065 China School of Materials Science and Engineering Xi′an Shiyou University Xi′an710065 China School of Energy and Power Engineering Jiangsu University of Science and Technology Zhenjiang212003 China

We have systematically investigated the electronic properties of Si doping germanene under external electric fields by the first-principle calculations. The results show that a wide range of linearly tunable and sizable direct band gaps for the Ge31Si1 and Ge28Si4 systems (3~1048 meV and 6~716 meV) are merely determined by the strength of the electric field. More importantly, the high carrier mobilities of the stable Ge31Si1 and Ge28Si4 systems are largely retained under external electric field. The mechanism of charge transfer confirms the p-type semiconductor properties in the Si doping germanene systems. These results indicate that the electronic properties of Si doping germanene can be effectively modulated under the external electric field, providing a potential application in novel electronic devices, such as Field effect transistors. © 2023, The Authors. All rights reserved.

关键词： Energy gap

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A molecularly imprinted electrochemiluminescence sensor based on ZnO@CdTe for the detection of mevastatin

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MICROCHEMICAL JOURNAL 2024年 203卷

作者： Li, Huiling Tian, Li Yang, Shuning Li, Chao Li, Ruidan song, Yujia Guo, Yanjia Li, xuwen Changchun Normal Univ Coll chem Changchun 130032 Peoples R China Jilin Univ Coll Chem Changchun 130012 Peoples R China

In this paper, CdTe quantum dots with near-infrared fluorescence (NIR) and hexagonal prism-shaped ZnO were synthesized, and the composites were characterized for their performance. A sensitive molecularly imprinted electrochemiluminescence (ECL) sensor for the determination of mevastatin was constructed based on ZnO@CdTe and molecularly imprinted polymer (MIP). The highest ECL intensity of the system was obtained by ZnO@CdTe as the main luminophores reacted with the co-reactant K2S2O8. The ECL response generated by the reaction of ZnO@CdTe and K2S2O8 was used as the basic signal detection platform. The MIP was prepared by the electropolymerization process on the above platform, which laid the foundation for forming the mevastatin cavities with specific recognition sites. In addition, the response mechanism was investigated, and the determination conditions were optimized. The ECL intensity change values (Delta I) of the sensor showed a good linear relationship with the logarithm of mevastatin concentration in the range of 2.0 x 10-11 to 2.0 x 10-6 mol L-1, and the limit of detection was 6.7 x 10-12 mol L-1 (S/N = 3). This method obtained satisfactory results in the detection of mevastatin in tablets.

关键词： Molecularly-imprinted ZnO@CdTe Mevastatin Electrochemiluminescence

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Low-level laser activates Wnt/β-catenin signaling pathway-promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1

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SKIN RESEARCH AND TECHNOLOGY 2024年第6期30卷 e13807页

作者： BangHong, Jiang YuKun, Wang Ao, Shi Tao, Sun PeiJun, song xuwen, Li Lin, Li ZhuYou, Xiong Li, Zhang Bengbu Med Coll Affiliated Hosp 1 Dept Plast Surg Bengbu Peoples R China Lanzhou Univ Hosp & Clin Med Sch 2 Lanzhou Peoples R China Bengbu Med Coll Affiliated Hosp 1 Dept Neurosurg Bengbu Peoples R China

BackgroundThe objective of this study is to investigate the mechanism by which low-level laser stimulation promotes the proliferation of intraepithelial hair follicle stem cells (HFSCs) in wounds. This research aims to expand the applications of laser treatment, enhance wound repair methods, and establish a theoretical and experimental foundation for achieving accelerated wound *** experimental approach involved irradiating a cell model with low-level laser to assess the proliferation of HFSCs and examine alterations in the expression of proteins related to the Wnt/beta-catenin signaling pathway. A mouse back wound model was established to investigate the effects of low-level laser irradiation on wound healing rate, wound microenvironment, and the proliferation of HFSCs in relation to the Wnt/beta-catenin signaling *** research findings indicate that low-level laser light effectively activates the Wnt signaling pathway, leading to the increased accumulation of core protein beta-catenin and the upregulation of key downstream gene Lef 1. Consequently, this regulatory mechanism facilitates various downstream biological effects, including the notable promotion of HFSC proliferation and differentiation into skin appendages and epithelial tissues. As a result, the process of wound healing is significantly *** levels of laser activates the Wnt signalling pathway, promotes the regeneration of hair follicle stem cells and accelerates wound healing.

关键词： carcinogenesis low-level laser stem cells Wnt/beta-catenin pathway wound healing

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Mesoporous Palladium-Boron-Sulfur Alloy Nanospheres for Efficient Hydrogen Evolution

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INORGANIC CHEMISTRY 2021年第7期60卷 4380-4384页

作者： Guo, xuwen Chen, Zhichao Huang, Yanping Lv, Hao Wang, Yaru Sun, Lizhi song, Kai Liu, Ben Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab New Power Batteries Nanjing 210023 Peoples R China Shenzhen RELX Technol Co Ltd Shenzhen 518108 Peoples R China Sichuan Univ Coll Chem Chengdu 610064 Peoples R China Changchun Normal Univ Sch Life Sci Changchun 130032 Peoples R China Sichuan Univ Sch Chem Engn Ctr Engn Expt Teaching Chengdu 610065 Peoples R China

Ternary noble metal-metalloid-nonmetal PdBS alloy mesoporous nanospheres (MSs) with three-dimensional central-radial pore channels were prepared for an electrocatalytic hydrogen evolution reaction. The synthesis was performed via precise control in the reduction and nucleation growth of ternary PdBS alloy MSs along confined cylinder mesophases assembled by amphiphilic dioctadecyldimethylammonium chloride. The resultant PdBS alloy MSs disclosed a remarkably improved electrocatalytic performance due to their structural and compositional synergies. This finding extended our knowledge on the rational design and targeted synthesis of novel noble metal-metalloid-nonmetal alloys with desired structures and morphologies for catalysis and other applications.

关键词： Palladium Alloys Genetics Evolution reactions Transmission electron microscopy

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