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Arbidol/IFN-a2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study

MICROBES AND INFECTION 2020年第4-5期22卷 200-205页

作者： Xu, Ping Huang, Jianping Fan, Zhao Huang, Wendi Qi, Minghua Lin, xuwen song, Weidong Yi, Li Peking Univ Shenzhen Hosp Dept Resp & Crit Care Med Shenzhen 518036 Guangdong Peoples R China Hubei Jianli People Hosp Dept Infect Dis Jingzhou 433300 Hubei Peoples R China Peking Univ Dept Emergency Shenzhen Hosp Shenzhen Guangdong Peoples R China Peking Univ Dept Neurol Shenzhen Hosp 1120 Lianhua Rd Futian Area Shenzhen 518036 Guangdong Peoples R China

The spread of COVID-19 is accelerating. At present, there is no specific antiviral drugs for COVID-19 outbreak. This is a multicenter retrospective cohort study of patients with laboratory-confirmed COVID-19 infection pneumonia from 3 hospitals in Hubei and Guangdong province, 141 adults (aged ≥18 years) without ventilation were included. Combined group patients were given Arbidol and IFN-α2b, monotherapy group patients inhaled IFN-α2b for 10-14 days. Of 141 COVID-19 patients, baseline clinical and laboratory characteristics were similar between combined group and monotherapy group, that 30% of the patients leucocytes counts were below the normal range and 36.4% of the patients experienced lymphocytopenia. The duration of viral RNA of respiratory tract in the monotherapy group was not longer than that in the combined therapy group. There was no significant differences between two groups. The absorption of pneumonia in the combined group was faster than that in the monotherapy group. We inferred that Arbidol/IFN - 2 b therapy can be used as an effective method to improve the COVID-19 pneumonia of mild patients, although it helpless with accelerating the virus clearance. These results should be verified in a larger prospective randomized environment.

关键词： COVID-19 2019-nCoV Pneumonia Arbidol IFN-α2b Treatment RNA

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Investigation of anionic group effects on the shale inhibition performance of fatty acid-based ionic liquids and their inhibition mechanism

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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2022年第0期636卷 128135-128135页

作者： Jia, Han Wang, Shaoyan Wang, Zhe Wang, Qiang Jia, Haidong song, Lin Qin, xuwen Fan, Fangning Li, Zhe Huang, Pan China Univ Petr East China Key Lab Unconvent Oil & Gas Dev Minist Educ Qingdao 266580 Peoples R China China Univ Petr East China Shandong Key Lab Oilfield Chem Sch Petr Engn Qingdao 266580 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

Ionic liquids (ILs) have been introduced as novel high-performance shale inhibitors. The inhibition performance and mechanism of the cation groups in ILs have been widely investigated, whereas the effects of the anionic groups in ILs on the inhibitory capacity have rarely been reported. In this work, a series of fatty acid-based ionic liquids (FAILs) with different anionic groups, methyltrioctylammonium octanoate ([N8881][C8:0]), methyltrioctylammonium laurate ([N8881][C12:0]), and methyltrioctylammonium palmitate ([N8881][C16:0]), were synthesized to evaluate their inhibition ability via the sodium bentonite (Na-Bent) immersion test, the linear swelling test, and the shale hot-rolling recovery test. Compared with the traditional inhibitor KCl (2 wt%), FAIL [N8881][C8:0] showed greater inhibition performance at a much lower concentration (0.1 wt%). The inhibition mechanism of FAILs was further analysed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential measurements, and contact angle measurements. It was speculated that the best inhibition ability and thermal stability of [N8881][C8:0] should be attributed to the intensive interaction and the sizematching effect between cationic and anionic groups. The present study provided novel insight into the research and development of high-efficiency shale inhibitors.

关键词： Shale inhibitor Fatty acid-based ionic liquids Size-matching effect Intermolecular interaction Inhibition mechanism

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竖向分布钢筋不连续的装配式剪力墙结构振动台试验研究

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建筑结构学报 2022年第7期43卷 91-99页

作者：蔡琪宋晓滨肖绪文顾祥林张士前廖显东苏群山同济大学土木工程学院上海200092 中国建筑股份有限公司北京100029 中国建筑第八工程局有限公司上海200122 河南省第二建设集团有限公司河南郑州451464

为研究竖向分布钢筋不连续的装配式剪力墙结构抗震性能,设计了1个缩尺比为1/2的四层模型结构,并对其开展振动台试验。试验中考虑了7度多遇至9度罕遇等地震烈度(0.035g~0.62g),并进行了峰值加速度0.80g的El Centro波破坏加载。研究结果表... 详细信息

为研究竖向分布钢筋不连续的装配式剪力墙结构抗震性能,设计了1个缩尺比为1/2的四层模型结构,并对其开展振动台试验。试验中考虑了7度多遇至9度罕遇等地震烈度(0.035g~0.62g),并进行了峰值加速度0.80g的El Centro波破坏加载。研究结果表明:在7度罕遇地震作用下,模型结构处于弹性状态,最大层间位移角仅1/991;模型结构进入塑性阶段后(8度罕遇和9度罕遇地震作用),现浇边缘构件产生水平裂缝并跨越竖向拼缝向预制墙体发展,模型结构频率和阻尼比大幅变化,最大层间位移角为1/125;在峰值加速度0.80g的El Centro波作用下,模型结构发生典型的压弯破坏,一层现浇边缘构件混凝土局部压坏,钢筋压曲,但未发生整体破坏或倒塌;模型结构的1阶频率和阻尼比分别降低58.3%和增大163.2%,层间位移角达1/87;该剪力墙结构整体变形呈弯曲型,其现浇边缘构件和预制墙体具有良好的协同工作能力,抗震性能良好。

关键词：装配式剪力墙竖向分布钢筋不连续振动台试验抗震性能

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Prediction of hypertensive disorders in pregnancy based on placental growth factor

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S165-S170页

作者： Xu, Qi Sun, Ge Zhang, song Liu, Guoli Yang, Lin Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei Liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

关键词： Model accuracy placental growth factor logistic regression

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A study of a fetal heart rate calculation system based on R-R interval

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S187-S195页

作者： Zhang, Yisong Zhang, song Yang, Lin Yang, Yimin Li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal electrocardiogram (FECG) can be obtained in a non-invasive manner to monitor fetal growth status. OBJECTIVE: In this study, a fetal heart rate (FHR) calculation system was proposed, which consists of the FECG recorder (MF-HOLTER) and the FECG monitoring software (FECG-MS). The abdomen electrocardiogram (AECG) of pregnant woman is acquired through the MF-HOLTER. The FECG-MS packs the AECG data and calls the FECG separation algorithm to obtain the separated FECG and the fetal QRS (FQRS) position. The FHR is further obtained by calculating the R-R interval value. At the same time, this study proposed a FQRS position correction algorithm to calculate the correct FHR values. METHOD: In order to verify the accuracy of the FHR calculation, the ECG signal of FLUKE's PS320 FETAL SIMULATOR and clinical data were simultaneously tested. RESULTS: The accuracy rate is over 98% in processing the simulator's data. In processing clinical data, the FHR values obtained by both the system proposed in this study and Monica AN24 are very close, and the difference is less than 1 bpm. CONCLUSION: The results show that the FHR calculation system is accurate and stable, and has a positive application value and prospect.

关键词： Fetal ECG fetal heart rate R-R interval fetal QRS position correction

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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, song Yang, Lin Liu, Guoli Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei Liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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Reconciling the Cooperative-Competitive Patterns among Tumor and Immune Cells for Triple-Negative Breast Cancer Treatment Using Multimodule Nanocomplexes

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ADVANCED MATERIALS 2024年第26期36卷 2312219-2312219页

作者： Li, xuwen Guo, Qin Chen, Qinjun Chu, Yongchao Zhang, Yiwen Chen, Hongyi Zhao, Zhenhao Wang, Yu Luo, Yifan Li, Chufeng You, Haoyu song, Haolin Su, Boyu Jalili, Kiyumars Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Sahand Univ Technol Fac Polymer Engn POB 51317-11111 Tabriz Iran Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition-cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models. A multimodule nanocomplex dual targeting tumor-associated macrophages (TAMs) and tumor cells is devised to reconcile cooperative-competitive patterns among multiple cells through metabolic-immune regulation. The reversion of metabolic disequilibrium-immunosuppression tumor microenvironment is observed in TNBC models after treatment, contributing to the tumor remission. image

关键词： bacterial outer membrane CD24 l-arginine metabolic regulation T cell activation tumor-associated macrophages repolarization

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带窗洞的竖向分布钢筋不连接装配整体式剪力墙的受力性能分析

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建筑结构 2023年第5期53卷 30-35页

作者：宋晓滨蔡琪肖绪文曹志伟李厂张士前同济大学土木工程学院建筑工程系上海200092 中国建筑股份有限公司北京100029 中国建筑第八工程局有限公司上海200112

为探究带窗洞的竖向分布钢筋不连接装配整体式剪力墙(SGBL装配整体式剪力墙)的受力性能,采用ABAQUS软件建立SGBL装配整体式剪力墙精细化有限元模型。有限元模型采用Cohesive接触和弹簧单元模拟预制墙板与后浇混凝土的拼缝,模拟所得荷载... 详细信息

为探究带窗洞的竖向分布钢筋不连接装配整体式剪力墙(SGBL装配整体式剪力墙)的受力性能,采用ABAQUS软件建立SGBL装配整体式剪力墙精细化有限元模型。有限元模型采用Cohesive接触和弹簧单元模拟预制墙板与后浇混凝土的拼缝,模拟所得荷载-位移曲线及破坏模式与文献中试验结果均吻合良好。在此基础上,对比了带窗洞SGBL装配整体式剪力墙与带窗洞现浇剪力墙受力性能的差异,并讨论了轴压比和洞口偏心等参数对带窗洞SGBL装配整体式剪力墙的承载力和刚度的影响。结果表明:通过适当增加边缘现浇段竖向钢筋,带窗洞SGBL装配整体式剪力墙可拥有等同带窗洞现浇剪力墙的承载力。此外,轴压比对两类开洞剪力墙受力性能影响均较小,洞口偏心对带窗洞SGBL装配整体式剪力墙的承载力影响较小,当洞口偏心率小于20%时,洞口偏心对刚度的影响小于8%。

关键词： SGBL装配整体式剪力墙带窗洞剪力墙竖向分布钢筋不连接抗侧性能有限元分析

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国家通用语言文字教育教学与铸牢中华民族共同体意识协同共进研究

语言与文化研究

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语言与文化研究 2024年第6期32卷 107-110页

作者：宋娇娇尹绪文席楷轩新疆理工学院阿克苏843000

国家通用语言文字承载着中华文化的语言符号系统,推广与普及国家通用语言文字是铸牢中华民族共同体意识的必然要求。高校作为师生双向沟通交流的共同场域,要充分发挥课堂教学“主渠道”的作用,从宏观到微观深入构建国家通用语言文字教... 详细信息

国家通用语言文字承载着中华文化的语言符号系统,推广与普及国家通用语言文字是铸牢中华民族共同体意识的必然要求。高校作为师生双向沟通交流的共同场域,要充分发挥课堂教学“主渠道”的作用,从宏观到微观深入构建国家通用语言文字教育教学模式,促进学生自觉规范地运用国家通用语言文字,培育各族学生厚植中华民族情感。鉴于此,本文以新疆理工学院为例,将在铸牢中华民族共同体意识融入国家通用语言文字教育教学的实践做法基础上,探讨分析其面临的困境并提出对策建议,从而实现国家通用语言文字教育教学与铸牢中华民族共同体意识之间的有效协同与融合发展。

关键词：新建高校国家通用语言文字共同体意识协同共进

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Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis

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INTERNATIONAL IMMUNOPHARMACOLOGY 2024年 140卷 112790页

作者： Zhang, Xin Yao, Jie Xie, Mei Liang, Yiran Lin, xuwen song, Jialin Bao, Xinyu Ma, Xidong Wang, Yuanyong Zhang, Yinguang Liu, Yiming Han, Wenya Pan, Lei Xue, Xinying Shandong Second Med Univ Sch Clin Med Weifang 261000 Shandong Peoples R China Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Resp & Crit Care Beijing 100835 Peoples R China Air Force Mil Med Univ Tangdu Hosp Dept Thorac Surg Xian 710038 Shanxi Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Thorac Surg Beijing 100070 Peoples R China Hubei Univ Med Taihe Hosp Dept Resp & Crit Care Med Shiyan 442000 Peoples R China

Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates formed in non-lymphoid tissues, including cancers, and are loci for the generation of in situ anti-tumor immune responses, which play a crucial role in cancer control. The state of TLS presence in cancer and its composition can significantly impact the treatment response and prognosis of patients. TLSs have the potential to serve as predictive and prognostic biomarkers for cancer. However, the mechanisms underlying TLS formation in cancer and how the essential components of TLSs affect cancer are not fully understood. In this review, we summarized TLS formation in cancer, the value of the TLS in different states of existence, and its key constituents for cancer prediction and prognosis. Finally, we discussed the impact of cancer treatment on TLSs.

关键词： Tertiary lymphoid structure Cancer Prediction Prognosis Biomarker

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