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FETAL MOVEMENT SIGNAL DETECTION METHOD BASED ON MULTIPLE PRESSURE SENSORS

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第5期21卷 2140024-2140024页

作者： Liu, Jianli Li, xuwen Zhang, song Zhang, Qiang Yang, Lin Yang, Yimin Hao, Dongmei Beijing Univ Technol Fac Environm & Life Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100024 Peoples R China

Objective: Fetal movement (FM) is one of the objective phenomena of fetal life. The decrease of FM is a clinical indicator of fetal hypoxia. A fetal motion detection method is based on multiple pressure sensors and multi features. Methods: Collecting the abdominal data of pregnant women using multi-pressure sensors, preprocessing the signal with a digital filter, extracting the time-frequency characteristics of FM signal. The designed classifier is used for recognition of the extracted features. Results: The detection system used for FM time series can provide reliable results with a detection rate of 93.0% and a positive rate is 75.9%. Conclusion: The portable detection system proposed in this paper is a good alternative that will optimize medical use, professionals and hospital resources and has potential application prospects in the field of home electronic medical treatment.

关键词： Fetal movement detection pressure sensor classifier

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CHANGES IN GAUSSIAN MODELING PARAMETERS OF PPG PULSE DURING HEALTHY PREGNANCY

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第5期21卷 2140001-2140001页

作者： Meng, Yu Yang, Lin Zhang, song Wu, Guanghui Liu, Xiaohong Hao, Dongmei Yang, Yimin Li, xuwen Beijing Univ Technol Fac Environm & Life Beijing 100024 Peoples R China Capital Med Univ Beijing Anzhen Hosp Beijing Inst Heart Lung & Blood Vessel Dis Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

We used Gaussian modeling to depict the changes in finger photoplethysmographic (PPG) pulse during pregnancy in healthy women. We enrolled 70 healthy pregnant women and recorded their PPG pulses in 11-13 gestational weeks, 20-22 gestational weeks, and 37-39 gestational weeks. Three independent positive Gaussian functions were utilized to decompose the pulses, and each Gaussian function extracted three key parameters: the peak amplitude (H), the peak position (T), and the half-width (W). The method of ANOVA and post-hoc multiple comparisons of mathematical statistics were utilized to study the differences of these parameters between the three trimesters. We found that in the first trimester H-1 increased significantly (H-1 : 49.7 +/- 10.3 versus 52.9 +/- 6.9, p < 0.05). T-2 and T-3 increased in the first trimester (T-2 : 28.1 +/- 2.8 versus 28.4 +/- 2.2, p > 0.05;T-3: 54.3 +/- 4.2 versus 56.3 +/- 4.3, p < 0.01), then decreased significantly (T-2 : 28.4 +/- 2.2 versus 27.3 +/- 2.2, T-3: 56.3 +/- 4.3 versus 54.7 +/- 5.2, p < 0.05). H-1 is associated with cardiac output, and T-2 and T-3 are associated with peripheral vascular resistance. The results of this study were consistent with the conclusion that healthy pregnant women exhibited high flow state of the cardiovascular system and their peripheral vascular resistance decreased first and then gradually recovered during pregnancy. This study indicated that PPG pulse could also reflect the changes in the maternal cardiovascular system during pregnancy.

关键词： PPG pulse healthy pregnant women Gaussian modeling parameters

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川西坳陷须三段致密砂岩优质储层特征及控制因素

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中国地质 2022年第1期49卷 298-310页

作者：付振柯王晓龙饶松徐雯卓俊驰张玲衣佳栋长江大学油气资源与勘探技术教育部重点实验室湖北武汉430100 长江大学非常规油气湖北省协同创新中心湖北武汉430100 中国石油化工股份有限公司西南油气分公司勘探开发研究院四川成都610041

【研究目的】致密砂岩优质储层发育特征及控制因素已成为川西坳陷开展源储一体的常规与非常规油气协同勘探的重难点问题;探讨致密砂岩储层特征与致密气成藏的关系。【研究方法】运用地球化学、地球物理和沉积学等分析方法,对晚三叠世须... 详细信息

【研究目的】致密砂岩优质储层发育特征及控制因素已成为川西坳陷开展源储一体的常规与非常规油气协同勘探的重难点问题;探讨致密砂岩储层特征与致密气成藏的关系。【研究方法】运用地球化学、地球物理和沉积学等分析方法,对晚三叠世须三段致密储层发育特征进行研究。【研究结果】分析测试数据揭示须家河组须三段储层的孔隙度分布在1.11%~5.70%,渗透率分布在(0.0017~0.45)×10^(-3)μm^(2),属于致密储层范畴。基于砂岩粒度大小,川西坳陷须三段致密储层识别出3类优质储层,即以石英砂岩和岩屑石英砂岩为主的粗砂,以岩屑砂岩、岩屑石英砂岩和长石岩屑砂岩为主的中砂和细砂。研究区粗砂较少发育,厚度较大的中砂和细砂在中亚段和上亚段的三角洲前缘相中部、高位体系域中晚期与低位体系域早期较发育,属于低孔低渗—特低孔特低渗致密储层,储集空间以次生孔隙、微孔隙和微裂缝为主。【结论】致密砂岩优质储层发育主要受岩性、沉积、层序和成岩作用协同控制。岩性控制优质储层的发育类型,沉积和层序控制优质储层的发育位置,成岩作用控制优质储层的形成;致密砂岩储层特征与致密气成藏的关系。

关键词：非常规油气致密砂岩粒度储存油气勘查工程晚三叠世须家河组川西坳陷四川

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Predictive models of hypertensive disorders in pregnancy based on support vector machine algorithm

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S181-S186页

作者： Yang, Lin Sun, Ge Wang, Anran Jiang, Hongqing Zhang, song Yang, Yimin Li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Beijing Peoples R China Chinese Acad Med Sci Inst Med Informat Beijing 100020 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The risk factors of hypertensive disorders in pregnancy (HDP) could be summarized into three categories: clinical epidemiological factors, hemodynamic factors and biochemical factors. OBJECTIVE: To establish models for early prediction and intervention of HDP. METHODS: This study used the three types of risk factors and support vector machine (SVM) to establish prediction models of HDP at different gestational weeks. RESULTS: The average accuracy of the model was gradually increased when the pregnancy progressed, especially in the late pregnancy 28-34 weeks and >= 35 weeks, it reached more than 92%. CONCLUSION: Multi-risk factors combined with dynamic gestational weeks' prediction of HDP based on machine learning was superior to static and single-class conventional prediction methods. Multiple continuous tests could be performed from early pregnancy to late pregnancy.

关键词： Support vector machine algorithm machine learning model research

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Identification of genetic loci associated with rough dwarf disease resistance in maize by integrating GWAS and linkage mapping

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PLANT SCIENCE 2022年 315卷 111100-111100页

作者： Zhao, Meiai Liu, Shuangshuang Pei, Yuhe Jiang, xuwen Jaqueth, Jennifer S. Li, Bailin Han, Jing Jeffers, Daniel Wang, Jiabo song, Xiyun Qingdao Agr Univ Coll Life Sci Key Lab Plant Biotechnol Univ Shandong Prov Qingdao 266109 Peoples R China Qingdao Agr Univ Coll Agron Key Lab Qingdao Major Crop Germplasm Resource Inn Qingdao 266109 Peoples R China Corteva Agrisci 7300 NW 62nd Ave Johnston IA 50131 USA Shandong Denghai Pioneer Jinan 254000 Shandong Peoples R China Yunnan Acad Agr Sci Yunnan Off Kunming 650205 Yunnan Peoples R China Southwest Minzu Univ Minist Educ Key Lab Qinghai Tibetan Plateau Anim Genet Resour Chengdu 160041 Sichuan Peoples R China

Maize rough dwarf disease (MRDD) is a viral disease that causes substantial yield loss, especially in China's summer planted maize area. Discovery of resistance genes would help in developing high-yielding resistant maize hybrids. Genome-wide association studies (GWASs) have advanced quickly and are now a powerful tool for dissecting complex genetic architectures. In this study, the disease severity index (DSI) of 292 maize inbred lines and an F6 linkage population were investigated across multiple environments for two years. Using the genotypes obtained from the Maize SNP 50K chip, a GWAS was performed with four analytical models. The results showed that 22 SNPs distributed on chromosomes 1, 3, 4, 6, 7 and 8 were significantly associated with resistance to MRDD (P<0.0001). The SNPs on chromosomes 3, 6 and 8 were consistent with the quantitative trait locus (QTL) regions from linkage mapping in an RIL population. Candidate genes identified by GWAS included an LRR receptor-like serine/threonine-protein kinase (GRMZM2G141288), and a DRE-binding protein (GRMZM2G006745). In addition, we performed an allele variation analysis of the SNP loci selected by GWAS and linkage mapping and found that the main alleles of the two SNP loci PZE_101170408 and PZE_106082685 on chromosome 1 differed in terms of disease-resistant materials and disease-susceptible materials. The identified SNPs and genes provide useful information for MRDD-related gene cloning and insights on the underlying disease resistance mechanisms, and they can be used in marker-assisted breeding to develop MRDD-resistant maize.

关键词： Maize MRDD GWAS Linkage mapping Candidate genes

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基于元分析的预制装配式建筑隐含碳排放评估

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建筑科学 2024年第12期40卷 8-17页

作者：卢昱杰杨晓露李佩娴宋广翰何凌云肖建庄肖绪文同济大学土木工程学院上海200092 同济大学工程结构性能演化与控制教育部重点实验室上海200092 同济大学建筑与城市规划学院上海200092 高密度人居环境生态与节能教育部重点实验室(同济大学) 上海200092

建筑行业将推广装配式建筑作为实现“双碳”目标的重要途径之一,但现有研究多关注单体案例,缺乏对装配式建筑普适减排效果的理解与分析。本文筛选出62个具有详细数据的预制装配式建筑文献案例,统一系统边界为建筑物化阶段(建材生产、运... 详细信息

建筑行业将推广装配式建筑作为实现“双碳”目标的重要途径之一,但现有研究多关注单体案例,缺乏对装配式建筑普适减排效果的理解与分析。本文筛选出62个具有详细数据的预制装配式建筑文献案例,统一系统边界为建筑物化阶段(建材生产、运输和现场施工),采用元分析方法研究了碳核算方法与建筑特征两方面共8个维度对预制装配式建筑碳排放的影响。结果显示,案例间的单位面积隐含碳差异较大。仅考虑物化阶段,钢结构建筑的单位面积隐含碳均值约为预制混凝土建筑的1.9倍;建筑层数与建筑类型对单位面积隐含碳无显著影响。相较于现浇混凝土建筑,装配式钢结构和预制混凝土建筑均可减少隐含碳排放,平均减碳率为12.54%。为切实有效减少隐含碳排放,预制混凝土建筑应提升工厂预制水平、减少预制构件运输距离、优化现场施工工艺,钢结构建筑可考虑利用高性能钢结构以减少钢材用量。

关键词：预制装配式元分析碳足迹减排全寿命分析

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面动脉穿支筋膜蒂皮瓣与任意皮瓣修复面中部皮肤肿瘤切除后缺损的疗效比较

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中华全科医学 2023年第4期21卷 576-580页

作者：宋培军李旭文李薇王怀谷霍继武张硕徐静蚌埠医学院第一附属医院整形烧伤科安徽蚌埠233004

目的探讨面中部皮肤肿瘤切除后采用面动脉穿支筋膜蒂皮瓣修复缺损的临床应用价值。方法选取2019年1月—2021年12月于蚌埠医学院第一附属医院整形烧伤科治疗的40例面中部皮肤肿瘤患者,根据术中切除肿瘤后遗留创面的大小及位置分为观察... 详细信息

目的探讨面中部皮肤肿瘤切除后采用面动脉穿支筋膜蒂皮瓣修复缺损的临床应用价值。方法选取2019年1月—2021年12月于蚌埠医学院第一附属医院整形烧伤科治疗的40例面中部皮肤肿瘤患者,根据术中切除肿瘤后遗留创面的大小及位置分为观察组和对照组,每组各20例,观察组行面动脉穿支筋膜蒂皮瓣修复术,而对照组行传统皮瓣修复术,比较2组患者皮瓣修复后皮瓣的色泽评分、美观度评分、功能评分、术后瘢痕宽度、瘢痕弹性、瘢痕的平整度、瘢痕颜色以及术后6个月患者的效果满意度。结果观察组患者术后6个月在皮瓣的色泽评价(7.54±0.17)、美观评价(7.85±1.17)以及功能评价(8.20±0.89)评分方面均高于对照组患者术后6个月在皮瓣的色泽评价(4.85±1.73)、美观评价(5.23±1.50)以及功能评价(6.00±0.93),均P<0.05;观察组患者在瘢痕宽度(0.40±0.13)、瘢痕弹性(0.33±0.12)以及瘢痕平整度(0.24±0.09)以及瘢痕颜色评分(0.20±0.06)方面低于对照组在瘢痕宽度(0.58±0.18)、瘢痕弹性(0.57±0.13)、瘢痕平整度(0.38±0.16)以及瘢痕颜色评分(0.36±0.08);观察组的总体满意度(95%)高于对照组(65%);差异均有统计学意义(P<0.05)。结论在面部皮肤肿瘤术后组织缺损皮瓣修复手术中,相较于传统的任意皮瓣修复术,面动脉穿支筋膜蒂皮瓣修复术可使患者在术后外形及功能方面获得更大的满意度,具有较高的临床应用价值。

关键词：面动脉穿支筋膜蒂皮瓣肿瘤组织缺损

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慢性心力衰竭患者居家液体摄入管理影响因素的质性研究

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护理学杂志 2025年第5期40卷 94-98页

作者：鲁欢欢徐苏梦杨静徐冬梅周媛宋海燕殷徐雯顾则娟南京医科大学护理学院江苏南京211166 南京中医药大学护理学院南京医科大学第一附属医院

目的探讨居家慢性心力衰竭患者居家液体摄入管理影响因素,为制订居家干预方案提供参考。方法采用描述性质性研究,基于Pender健康促进模式,对20例慢性心力衰竭出院患者进行半结构式访谈,采用内容分析法进行资料分析、主题提练。结果提炼... 详细信息

目的探讨居家慢性心力衰竭患者居家液体摄入管理影响因素,为制订居家干预方案提供参考。方法采用描述性质性研究,基于Pender健康促进模式,对20例慢性心力衰竭出院患者进行半结构式访谈,采用内容分析法进行资料分析、主题提练。结果提炼2个主题及8个亚主题,促进因素为感知液体管理益处,参与主动健康行为,积极发挥自我效能,自护时间投入增加;障碍因素为居家应对行为不佳,记忆力减退,消极认知与延迟就医,内外部支持削弱。结论引导慢性心力衰竭患者树立正确液体摄入管理认知,激励居家患者发挥自我效能,落实居家液体摄入管理,同时加强“医院-社区-家庭”联动,持续追踪患者疾病轨迹。

关键词：慢性心力衰竭居家液体摄入管理决定因素 Pender健康促进模式质性研究

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CLINICAL AND TRANSLATIONAL MEDICINE 2024年第3期14卷 e1613页

作者： Lin, xuwen Xie, Mei Yao, Jie Ma, Xidong Qin, Lin Zhang, Xu-Mei song, Jialin Bao, Xinyu Zhang, Xin Zhang, Yinguang Liu, Yiming Han, Wenya Liang, Yiran Jing, Ying Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Resp & Crit Care Beijing Peoples R China Capital Med Univ Beijing Chest Hosp TB & Thorac Tumor Inst Dept Endoscop Diag & Treatment Beijing Peoples R China Weifang Med Univ Dept Pathol Affiliated Hosp Weifang Shandong Peoples R China Weifang Med Coll Dept Resp & Crit Care Weifang Shandong Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Thorac Surg Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Thorac Surg Beijing Peoples R China Hubei Univ Med Taihe Hosp Dept Resp & Crit Care Shiyan Peoples R China Fudan Univ Ctr Intelligent Med Greater Bay Area Inst Precis Med Guangzhou Sch Life Sci Guangzhou Guangdong Peoples R China Fudan Univ Greater Bay Area Inst Precis Med Guangzhou Ctr Intelligent Med Sch Life Sci Guangzhou 511462 Guangdong Peoples R China Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China

The emergence of immune checkpoint inhibitors (ICIs) has heralded a transformative era in the therapeutic landscape of non-small cell lung cancer (NSCLC). While ICIs have demonstrated clinical efficacy in a portion of patients with NSCLC, these treatments concurrently precipitate a spectrum of immune-related adverse events (irAEs), encompassing mild to severe manifestations, collectively posing a risk of significant organ damage. Consequently, there exists an imperative to augment our comprehension of the pathophysiological underpinnings of irAEs and to formulate more efficacious preventive and ameliorative strategies. In this comprehensive review, we delineate the clinical presentation of organ-specific irAEs in patients with NSCLC and provide an in-depth analysis of recent advancements in understanding the mechanisms driving ICI-induced toxicity. Furthermore, we discuss potential strategies and targets for ameliorating these irAEs. Ultimately, this review aims to furnish valuable insights to guide further research endeavours in the context of irAEs in NSCLC patients. Immunotherapy not only revolutionises lung cancer treatment but also poses serious toxicity risks. Elucidating irAE mechanisms in NSCLC: T/B-cell dysregulation, cytokine imbalances, autoantibody production, genetic predispositions and gut microbiome alterations. Highlighting precise irAE interventions in NSCLC: corticosteroids, targeted immunosuppressants, monoclonal antibodies targeting lymphocytes, cytokine inhibitors and signalling pathway modulators. image

关键词： immune checkpoint inhibitors immune-related adverse events mechanism non-small cell lung cancer

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Effect of a closed-loop medication order executive system on safe medication administration at a tertiary hospital: a quasi-experimental study

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THERAPEUTIC ADVANCES IN DRUG SAFETY 2024年 15卷

作者： Yin, xuwen song, Haiyan Lu, Jieyu Yang, Jing Wang, Rong Lin, Zheng Jiang, Shudi Yuan, Hui Wang, Xumei Xu, Dongmei Gao, Chunhong Zhou, Yuan Xu, Jiayi Chen, Chen Gu, Chenyu Diao, Qingqing Li, Fang Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Sch Nursing Nanjing Peoples R China

Background: Closed-loop electronic medication management systems are effective measures for preventing medication errors (MEs). However, there is limited evidence supporting this, and few studies have evaluated the long-term effects of these systems on safe medication. Objective: To evaluate the long-term effects of implementing a closed-loop medication order executive system on the safe clinical use of medications. Design: A quasi-experimental design. Method: Data from 2017 to 2023 were extracted and retrospectively analyzed. The primary outcome indicator was the ME rate. Secondary outcome indicators were the accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing. The autoregressive integrated moving average (ARIMA) model in time-series analysis was used to evaluate the level and trend changes in ME rates using SPSS 25.0 before and after system implementation. Root cause analysis and descriptive statistics were used to assess changes in types, stages, and causes of ME rates. The independent samples t-test was used to analyze secondary outcomes. Results: Overall, 295 MEs were reported with a mean of 0.26 +/- 0.26 ME rates per month during 2017-2023. The ARIMA model showed a decrease in the average level of ME rates after system implementation, with no statistically significant decrease in the long term, and a significant drop in the ME rate in the short and medium term (p < 0.01). Nurses' administration accounted for more than 60% of errors post-implementation, and lack of communication was a prominent factor. The accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing all increased after implementation. Conclusion: Adopting a closed-loop executive system is beneficial for ensuring patient medication safety, but a single integrated system does not completely eliminate MEs. Optimizing system functionalities and applying structured handoff tools are r

关键词： closed-loop electronic medication management system medication error patient safety

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