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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

SCIENCE CHINA-CHEMISTRY 2025年 1-8页

作者： Zhang, Li Qiu, Shuhai Hu, Shunlong Xu, Hanren sun, xuwen Jiang, Wei Qu, Da-Hui Wang, Zhaohui East China Univ Sci & Technol Feringa Nobel Prize Scientist Joint Res Ctr Key Lab Adv Mat & Joint Int Res Lab Precis Chem & Sch Chem & Mol EngnInst Fine ChemFrontiers Sci C Shanghai 200237 Peoples R China Tsinghua Univ Dept Chem Key Lab Organ Optoelect & Mol Engn Beijing 100084 Peoples R China

Organic donor-acceptor cocrystals of pi-conjugated molecues have shown diverse applications in materials science. However, most cocrystals exist in neutral forms dominated by pi-pi interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops (DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular pi-pi interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of pi-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

关键词： n-doped carbon nanohoop donor-acceptor cocrystal charge transfer interaction ionic state

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A highly sensitive one-step nanobody-based immunoassay to specifically detect antibodies against fowl adenovirus serotype 4

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POULTRY SCIENCE 2025年第4期104卷 104970页

作者： Ji, Pinpin Zhang, Hao Xiri, Yangzong Li, Ziling Liu, Zhixiang Dan, Miao Li, Xiaoxuan sun, xuwen Zhao, Qin sun, Yani Northwest A&F Univ Coll Vet Med Dept Prevent Vet Med Yangling 712100 Shaanxi Peoples R China Minist Agr Sci Observing & Expt Stn Vet Pharmacol & Diagnost Yangling 712100 Shaanxi Peoples R China

Hepatitis-hydropericardium syndrome, caused by fowl adenovirus serotype 4 (FAdV-4), has resulted in significant economic damage to the poultry industry. To monitor viral exposure and vaccine efficacy, some traditional antibody-based immunoassays have been developed for detecting anti-FAdV-4 antibodies. However, these assays have some drawbacks including multi-step operations and higher production cost. Recently, nanobodies are regarded as a promising tool for developing immunoassays. In the study, 23 nanobodies against FAdV-4 were screened and expressed with horseradish peroxidase (HRP) in the HEK293T cells. Then, the FAdV-4-Nb28-HRP fusion protein was selected for developing competitive enzyme-linked immunoassays (cELISA) to detect antiFAdV-4 antibodies in the chicken sera. The optimal concentrations and dilutions for the coating antigen, fusion protein and testing sera were determined to be 400 ng/well, 1:80 and 1:20, respectively. After the coated plates were vacuumized and stored, the operation of cELISA to detect clinical chicken sera was only one-step and the full time was 75 min. The cELISA also exhibited high sensitivity, specificity, reproducibility and good agreement with the commercial ELISA kit. When the sequential sera from the challenged chickens were tested, the cELISA showed superior sensitivity compared with the commercial ELISA kit. Moreover, epitope mapping revealed that the nanobody specifically recognized the sites GLN235 ASN236 SER238 of the fiber-1 protein, highly conserved among different FAdV-4 isolates and different from the FAdV-1 and-8. The results indicated that cELISA can specifically detect anti-FAdV-4 antibodies. Collectively, the developed one-step nanobody-based cELISA is an ideal method for epidemiological investigation and vaccine immune evaluation of FAdV-4.

关键词： Nanobody One-step competitive ELISA FAdV-4 antibodies Fiber-1 protein

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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

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Science China Chemistry 2025年

作者： Li Zhang Shuhai Qiu Shunlong Hu Hanren Xu xuwen sun Wei Jiang Da-Hui Qu Zhaohui Wang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materi-obiology and Dynamic Chemistry Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University

Organic donor-acceptor cocrystals of π-conjugated molecues have shown diverse applications in materials science. However,most cocrystals exist in neutral forms dominated by π-π interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops(DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular π-π interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of π-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

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Why they don't trust the media: The Chinese public's perception and evaluation of news media in the social media era, taking the Liu Xuezhou incident as an example

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GLOBAL MEDIA AND CHINA 2024年第4期9卷 521-541页

作者： Ye, Xiaoyan sun, xuwen Qufu Normal Univ Qufu Peoples R China Shenzhen Univ Shenzhen Peoples R China

With the advent of the post-pandemic era characterised by increasing social uncertainty, the public is placing higher demands on the trust in news media. According to the 2023 Edelman Trust Barometer, the image of the media in the public's mind is deteriorating. Why don't they trust the media? What are the reasons given by the public when the media is denounced as unscrupulous? Taking the Liu Xuezhou incident as a typical case, the study extracts key elements from 5,225 related microblog texts, identifies the main topics of public discussion with the help of LDA topic modelling, clarifies the referential dimension of unscrupulous media with the help of pointwise mutual information, and analyzes netizens' evaluations related to different referential levels of the media through visual semantic networks, which can help formulate dialectical thinking on media trust in the context of China in the era of social media.

关键词： LDA topic modelling media trust positive trust social media

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Analysis and Design of Adversarial Virtual Simulation Training System 21

Analysis and Design of Adversarial Virtual Simulation Traini...

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13th International Conference on Computer Modeling and Simulation, ICCMS 2021

作者： sun, xuwen Li, Shixiong Xing, Yu Dalian Naval Academy China China Coast Guard Academy China

ISBN: (纸本)9781450389792

In order to improve the high degree of close to training reality for college teaching and training, an antagonistic virtual simulation training system is constructed by analyzing and designing. First, the basic process of antagonistic training is analyzed for preparation, training implantation, and training evaluation, then the process is modeled, and modeled. And then, functional requirements of adversarial virtual simulation training is analyzed and studied, after which, the technical architecture is designed, and core technique is discussed. The study lays a foundation for the design and implementation of the antagonistic virtual simulation training system in future. © 2021 ACM.

关键词： E-learning

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Engineering of Charge-Transfer State to Modify Photophysical Properties in N,N′-Diaryl-dihydrodibenzo[a,c]phenazine

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JOURNAL OF PHYSICAL CHEMISTRY C 2024年第36期128卷 15124-15131页

作者： sun, xuwen Cong, Muyu Jin, Xin Su, Jianhua Zhang, Zhiyun East China Univ Sci & Technol Feringa Nobel Prize Scientist Ctr Materiobiol & Dy Key Lab Adv Mat Shanghai 200237 Peoples R China East China Univ Sci & Technol Feringa Nobel Prize Scientist Ctr Materiobiol & Dy Joint Int Res Lab Precis Chem & Mol Engn Shanghai 200237 Peoples R China

Herein, we explored the charge transfer (CT) effect on the excited-state structural and electronic evolution of N,N '-diphenyl-dihydrodibenzo[a,c]phenazine (DPAC) featuring various electron-donating groups (EDGs). Upon photoexcitation, DPAC molecules undergo a sequential multistep structural transformation along the Franck-Condon (FC) state, CT-controlled bent state (responsible for E1 & horbar;420 nm), and twisted state (responsible for E2 & horbar;600 nm). By introducing different EDGs to the DPAC core, we can fine-tune the balance between the inherent decay of the CT-controlled bent state and its progression into the twisted state by adjusting the CT effect. As the electron-donating ability of the EDG increases, the strong CT effect can produce a "deep" (stable) CT-controlled bent state, in which the transformation of the excited molecular skeleton from bent into twisted was partly suppressed. This research provides valuable insights into organic chromophores' excited-state structural and electronic evolution, revealing how competitive decay pathways are contingent upon the CT effect.

关键词： Charge transfer

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Analysis on Operational Capability Evaluation of Ship Formations' anti-submaring Firing System 7

Analysis on Operational Capability Evaluation of Ship Format...

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7th International Symposium on Computational Intelligence and Design (ISCID)

作者： Deng, Ke Long, Fei sun, xuwen Xu, Jia Dalian Naval Acad Dalian 116018 Peoples R China Naval Engn Univ Wuhan 430000 Peoples R China

ISBN: (纸本)9781479970056

Anti-submarine is either the main role for ship formations or an associate for other war missions. In this paper, a model is proposed for evaluating the firing ability of ship formations to fire against submarines, which is based on a four-dimension characterization and a two-layer gray fuzzy evaluation method. This evaluation should be a vital reference for improving the ship formations' anti-submarine ability.

关键词： operation capability evaluation firing system anti-submarine

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Vibration-induced emission: Dynamic multiple intrinsic luminescence

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COORDINATION CHEMISTRY REVIEWS 2022年 472卷

作者： Zhang, Zhiyun Jin, Xin sun, xuwen Su, Jianhua Qu, Da -Hui East China Univ Sci & Technol Frontiers Ctr Materiobiol & Dynam Chem Sch Chem & Mol Engn Key Lab Adv Mat 130 Meilong Rd Shanghai 200237 Peoples R China East China Univ Sci & Technol Feringa Nobel Prize Scientist Joint Res Ctr Frontiers Ctr Materiobiol & Dynam Chem Sch Chem & Mol Engn 130 Meilong Rd Shanghai 200237 Peoples R China

pi-Conjugated molecules exhibit prosperous excited-state processes and tunable luminescence proper-ties, as the key building blocks for fabricating smart luminescent materials. In this review, we focus on the vibration-induced emission (VIE) of saddle-shaped dihydrophenazine (DHP) derivatives, which involves dynamic conformation changes of photoexcited molecules to planar configuration in charge of the large Stokes-shifted emission. By modifying the rigid-flexible fused skeleton of DHP, a continuously tunable emission over a wide range can be achieved through the dynamic bent-to-planar transformations of a single-molecule entity. The interplay of aromaticity and steric hindrance was proposed as the regu-lation mechanism, and applied to clarify how the luminescence characteristics were affected by the intramolecular steric hindrance and ring tension. By taking advantage of the VIE phenomenon, i.e., dra-matic structural/electronic responses and sensitive vibration-degree-dependent emissions, donor -bridge-acceptor systems with conformation-dependent electron/energy donors were fabricated, and the output of colorful fluorescent signals visible to the naked eye were realized in response to minor inter-/intra-molecular stimulations. Furthermore, the VIE phenomenon of DHPs brings new possibilities for obtaining different conductance features as one molecule changes its conformation in the metal- molecule-metal junction arrangement. This review includes the recent progress in VIE research as well as our perspectives on future directions.(c) 2022 Elsevier B.V. All rights reserved.

关键词： Dihydrophenazine Vibration-induced emission Luminescence-structure relationships Dynamic multiple emission Photoconductance

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Research on Architecture of Surface Vessels Decision-making Model System Based on Distributed Consultation Decision 5

Research on Architecture of Surface Vessels Decision-making ...

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5th IEEE International Conference on Software Engineering and Service Science (ICSESS)

作者： Ma, Zhengwei sun, xuwen Yang, Mei Li, Kan Long, Fei Dalian Naval Acad Dalian 116018 Peoples R China

ISBN: (纸本)9781479932795

According to the fact that the decision-making of surface vessels is more and more complicated, based on the military process of decision-making of surface vessels, using soft engineering, from the view of system science, this article expounds the complexity of the command architecture and decision-making of surface vessels, then analyzes the process of consultation decision, at last, it establishes the architecture of shipboard decision-making model based on the distributed consultation decision,. It is very useful not only for furthering the theoretical system of shipboard decision-making, but also for the research on warfare software.

关键词： formation of ships distributed consultation decision (DCD) soft engineering architecture component

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GluR1 Phosphorylation and Persistent Expression of Levodopa-induced Motor Response Alterations in the Hemi-Parkinsonian Rat

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NEUROCHEMICAL RESEARCH 2011年第6期36卷 1135-1144页

作者： Ba, Maowen Kong, Min Yu, Guoping sun, xuwen Liu, Zhuli Wang, Xiaotong Qingdao Med Univ Yuhuangding Hosp Dept Neurol Yantai 264000 Shandong Peoples R China Yantaishan Hosp Dept Neurol Yantai 264000 Shandong Peoples R China

The phosphorylation of glutamate receptor 1 (GluR1) has been increasingly implicated in the formation and maintenance of plastic responses. To investigate molecular mechanisms that underlie the persisting alterations in motor response occurring with levodopa treatment of parkinsonian patients, we evaluated the time course of these changes in relation to the phosphorylation of GluR1 in 6-hydroxydopamine (6-OHDA) lesioned animals. Three weeks of twice-daily levodopa administration to rats shortened the duration of the rotational responses and increased the peak turning responses, which lasted at least 7 days after withdrawal of chronic levodopa treatment. The shortened response duration and increased peak turning, resembling human wearing-off fluctuations and dyskinesia, were associated with a marked increase in Ser-845 phosphorylated GluR1 (pGluR1S845) immunoreactivity in lesioned striatum in response to levodopa treatment. The time course of changes in GluR1 phosphorylation correlated with the time course of changes in motor behavior after withdrawal of chronic levodopa therapy. Our immunostaining data showed that these changes were confined to parvalbumin-positive neurons where GluR1 are exclusively expressed. Both the altered motor response and the degree of pGluR1S845 were attenuated by the intrastriatal administration of protein kinase A (PKA) inhibitor Rp-cAMPS or GluR1 antisense oligonucleotides. The results suggest that Ser-845 GluR1 phosphorylation within parvalbumin-positive neurons contributes to the persistence of the motor response alterations produced by chronic intermittent dopaminergic stimulation.

关键词： GluR1 Phosphorylation Protein kinase A Motor response alterations Parkinson's disease

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