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Glutathione promoted Fenton degradation: a cocatalyst based on the -HS/-S-S- cycle with hydroxyl radicals

ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY 2020年第3期6卷 515-522页

作者： Da, xuwen tang, Daojian Wang, Ling Ma, Jiahai Univ Chinese Acad Sci Sch Chem Sci Beijing 100049 Peoples R China Chinese Acad Sci Inst Proc Engn Key Lab Green Proc & Engn Beijing Key Lab Ionic Liquids Clean Proc Beijing 100190 Peoples R China

Glutathione, a kind of tripeptide with a thiol group, was introduced into the traditional Fenton system. It was found that target pollutant degradation is greatly improved when adding glutathione into the Fenton system, due to it accelerating the Fe(II)/Fe(III) cycle, thus generating more hydroxyl radicals. The variation of the concentrations of Fe(II) and H2O2 and the generation of HO center dot were monitored to verify the catalytic action of glutathione. Operating variables such as pH, molar ratios and different atmospheres were examined, and cyclic degradation experiments were performed to explore the stability of catalysts. Electrospray ionization mass spectrometry (ESI-MS) was used to determine the transformation of different forms of glutathione to explore the catalytic mechanism. More importantly, it was found that other thiol compounds can also promote the Fenton degradation through a cycle of thiol compounds and their oxidized forms. In conclusion, it is a cocatalyst based on the -HS/-S-S- cycle with hydroxyl radicals, which has not been reported previously.

关键词： Molar ratio

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Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii

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PARASITES & VECTORS 2023年第1期16卷 409-409页

作者： He, Kai Wang, Qiangqiang Gao, xuwen tang, Tao Ding, Huiyong Long, Shaojun China Agr Univ Natl Anim Protozoa Lab Beijing 100193 Peoples R China China Agr Univ Sch Vet Med Beijing 100193 Peoples R China China Agr Univ Sch Vet Med Natl KeyLab Vet Publ Hlth Safety Beijing 100193 Peoples R China

Background The protozoan parasite Toxoplasma gondii encodes a dozen Rab proteins, which are parts of the small GTPase superfamily and regulate intracellular membrane trafficking. Our previous study showed that depletion of Rab1B caused severe defects regarding parasite growth and morphological structure, yet early defects of endocytic trafficking and vesicle sorting to the rhoptry in T. gondii are not expected to have a strong effect. To understand this discrepancy, we performed an integrated analysis at the level of transcriptomics and *** In the study, tetracycline-inducible TATi/Ty-Rab1B parasite line treated with ATc at three different time points (0, 18 and 24 h) was used. We first observed the morphological changes caused by Rab1B depletion via transmission electron technology. Then, high-throughput transcriptome along with non-targeted metabolomics were performed to analyze the RNA expression and metabolite changes in the Rab1B-depleted parasite. The essential nature of Rab1B in the parasite was revealed by the integrated omics *** Transmission electron micrographs showed a strong disorganization of endo-membranes in the Rab1B-depleted parasites. Our deep analysis of transcriptome and metabolome identified 2181 and 2374 differentially expressed genes (DEGs) and 30 and 83 differentially expressed metabolites (DEMs) at 18 and 24 h of induction in the tetracycline-inducible parasite line, respectively. These DEGs included key genes associated with crucial organelles that contain the rhoptry, microneme, endoplasmic reticulum and Golgi apparatus. The analysis of qRT-PCR verified some of the key DEGs identified by RNA-Seq, supporting that the key vesicular regulator Rab1B was involved in biogenesis of multiple parasite organelles. Functional enrichment analyses revealed pathways related to central carbon metabolisms and lipid metabolisms, such as the TCA cycle, glycerophospholipid metabolism and fatty acid biosynthesis and elongation.

关键词： Toxoplasma gondii Transcriptome Metabolome Rab family proteins

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Distribution of bound-PAH residues and their correlations with the bacterial community at different depths of soil from an abandoned chemical plant site

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JOURNAL OF HAZARDOUS MATERIALS 2023年第1期453卷 131328页

作者： tang, Lei Zhao, Xuqiang Chen, xuwen Jiang, Yi Gudda, Fredrick Wang, Yunhao Ling, Wanting Nanjing Agr Univ Coll Resources & Environm Sci Inst Organ Contaminant Control & Soil Remediat Nanjing 210095 Peoples R China Huazhong Agr Univ Coll Resources & Environm State Key Lab Agr Microbiol Wuhan 430070 Peoples R China

The situ pollutant residue and microbial characteristics in contaminated environments are crucial for ecological restoration and soil utilization. This work reported the variation of polycyclic aromatic hydrocarbon (PAH) residues and the bacterial community at different depths in an aged-abandoned site. These results unveiled that over 90% of low molecular weight (LMW) and medium molecular weight (MMW), 52.84-76.88% of high mo-lecular weight (HMW) bound-PAH (BP) residues were sequestrated in humin (HM). The stresses of PAH and soil depth enhanced the frequency of bacteria associations, especially positive associations. We enriched and cultured PAH degradation bacteria (PDB) from the sampling site mainly consisting of Pseudomonas and Acinetobacter, which were originally 0.39-0.52% abundant in the sampling site. The abundances of PDB and PAH-degradation genes (PDGs) were higher at shallower depths and increased with high PAH concentration. Simultaneously, Pearson correlation analysis and experimental verification found that the process of PAH binding with SOM limited the further increase of PDB and PDGs in PAH-contaminated sites. These findings may illustrate possible ecological risks of contaminated soils and provide guidance for the isolation and application of PDB.

关键词： Vertical distribution PAH residues Bacterial communication Degradation gene Ecosystem risks

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Erosion wear resistance mechanism of erosion ripples

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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE 2022年第19期236卷 10359-10369页

作者： Zhang, Yan Zhao, xuwen Wang, Qi Wang, Tianqi tang, Yuling Tianjin Univ Sci & Technol Tianjin Key Lab Integrated Design & On Line Monit Tianjin Peoples R China Tianjin Univ Sci & Technol Coll Mech Engn Tianjin Peoples R China

Erosion ripples widely exist on natural and industrial surfaces suffering gas-solid flow erosion. During the steady state of erosion ripples formation, the material removal and plastic flow rate of the material basically reach a dynamic equilibrium. In this state, the erosion rate of the surface material is steady and at a low level. In this paper, the relationship between erosion ripples and the erosion characteristics of surface materials was explored by experimental and simulation methods. Under the conditions of air pressures of 0.3, 0.4 and 0.5 MPa and erosion angles of 30 degrees, 40 degrees and 50 degrees, several erosion ripples were prepared on the surface of 1060 aluminium alloy samples by sandblasting. According to the obtained morphological parameters and orthogonal test design, rippled samples with rectangular, triangular and semicircular groove sections were designed. The effect of morphology parameters on the erosion resistance of the sample was analysed by a sandblasting test. The results showed that the rippled samples have lower erosion rates than the plate sample. The cross-sectional shape of grooves is the most obviously affected factor. The velocity distribution and surface pressure distribution on the surface of rippled and plate samples were analysed by FLUENT software, and the results showed that the low-speed reflow vortex will be formed in grooves of erosion ripples that can change the near-wall flow field conditions. The differential pressure generated on two sides of the ridge between adjacent grooves, as well as the area decrease of erosion caused by the "shaded effect," may be the cause of the erosion resistance. The results of this study can provide new insight into the active erosive wear resistance method of mechanical components.

关键词： erosive wear erosion ripple gas-solid flow sandblasting near-wall flow field

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东西部协作赋能共同富裕:生成逻辑、作用机理及显著优势

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陕西行政学院学报 2024年第4期38卷 5-11页

作者：刘旭雯唐霄广西大学马克思主义学院南宁530004

共同富裕作为社会主义的本质要求,是实现中国式现代化的必经之路。东西部协作是推动全国各族人民共同富裕的必然要求。从生成逻辑上看,东西部协作赋能共同富裕是对马克思主义民族理论的继承与创新,是“先富后富”理论的直观表达,是扎实... 详细信息

共同富裕作为社会主义的本质要求,是实现中国式现代化的必经之路。东西部协作是推动全国各族人民共同富裕的必然要求。从生成逻辑上看,东西部协作赋能共同富裕是对马克思主义民族理论的继承与创新,是“先富后富”理论的直观表达,是扎实推动共同富裕的重要力量。从作用机理上看,其高度契合性表现在东西部协作在帮助西部地区增收中缩小贫富差距,在促进文化交融中丰富精神文化,在动员社会参与中积聚力量,在不断推进社会公平中实现共富。从显著优势上看,东西部协作赋能共同富裕的过程中充分发挥社会主义制度集中力量办大事的优势,始终坚持以人民为中心的根本动力,将促进人的自由全面发展作为唯一价值遵循。

关键词：东西部协作共同富裕中国式现代化显著优势

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负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响研究

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中国医学创新 2018年第5期15卷 102-105页

作者：唐绪文湖北省潜江市中医院湖北潜江433100

目的:探讨分析负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响。方法:选取2016年9月-2017年9月本院收治的四肢创伤患者90例,按照随机数字表法分为对照组与研究组,每组45例。对照组施以常规的换药治疗方法,研究组施以负... 详细信息

目的:探讨分析负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响。方法:选取2016年9月-2017年9月本院收治的四肢创伤患者90例,按照随机数字表法分为对照组与研究组,每组45例。对照组施以常规的换药治疗方法,研究组施以负压封闭引流技术进行治疗,观察比较两组临床疗效、创面面积变化、住院费用与住院时间、创面愈合情况以及并发症发生情况。结果:治疗后,研究组治疗有效率明显优于对照组,差异有统计学意义(P<0.05),且研究组创面面积大幅度减小,住院时间也明显缩短,住院费用也大大减少,与对照组比较差异均有统计学意义(P<0.05);治疗后,研究组创面愈合情况显著优于对照组,且并发症发生情况比对照组少,差异均有统计学意义(P<0.05)。结论:应用负压封闭引流技术对四肢创伤患者进行治疗,可以有效提高临床疗效,降低并发症发生率,安全可靠,值得临床推广应用。

关键词：负压封闭引流技术四肢创伤临床效果创面愈合

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Principles for waste concrete recycling and basic problems of recycled concrete

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CHINESE SCIENCE BULLETIN-CHINESE 2023年第5期68卷 510-523页

作者： Xiao, Jianzhuang Zhang, Hanghua tang, Yuxiang Lu, Zhenyuan Ye, Taohua Duan, Zhenhua Sui, Tongbo Xiao, xuwen Tongji Univ Coll Civil Engn Dept Bldg Engineer Shanghai 200092 Peoples R China Tongji Univ State Key Lab Disaster Reduct Civil Engineer Shanghai 200092 Peoples R China Tongji Univ Key Lab Adv Civil Engn Mat Minist Educ Shanghai 201804 Peoples R China Tongji Univ Key Lab Performance Evolut & Control Engn Struct Minist Educ Shanghai 200092 Peoples R China Sinoma Int Engn Co Ltd Beijing 100102 Peoples R China

The discovery and development of contemporary concrete have made substantial contributions to the industrial revolution and urbanization over the last two centuries. The tremendous use of concrete results in a large amount of solid waste and considerable carbon emissions. The effort on waste concrete recycling is significant and vital in light of the national strategy of "carbon peaking and neutrality". The previous research on the recycled concrete focused on the traditional ideas of aggregate substitution and parameter modification to normal concrete. However, new ideas for waste concrete recycling and low-carbon application of recycled concrete should be further investigated. The theory and methods of concrete composition, decomposition, and recycling are examined. In general, the synthesis of concrete necessitates managing the characteristics of raw ingredients to increase overall performance. A mature concrete synthesis system was established by the steady physical qualities of sand and gravels, the hydration reaction of cementitious materials, and scientific combination design. Furthermore, the changes in the physical qualities of concrete components provide a theoretical foundation for crushing and sieving to produce recycled materials. To make recycled concrete (RC), recycled aggregates (RAs) and recycled powder are employed. However, the use of RC is complicated by the uncertainty of raw material sources, variations in the hydration process and microstructures, and discrepancies in basic attributes. Multi-way modification strategies have been developed to improve the qualities of RAs and RC to realize the conversion of difficult-to-control wastes into controllable recycled materials. The qualities of RC are improved and the variability of these features is reduced by incorporating artificial intelligence technologies into the mixture design of RC based on big data. In addition, three criteria for the preparation of RC are proposed, including a safe applicat

关键词： waste concrete recycling recycled concrete recycled aggregate recycled powder full recycled aggregate concrete mixture design for recycling

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A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex and Xilinx Ultrascale+ MPSoC DUAL VOLTAGE MECHANISM 2021

A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex an...

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2021 10th International Conference on Computing and Pattern Recognition

作者： Chenyun Li xuwen Li Changjiang tang Qiang Wu Beijing University of Technology China

ISBN: (纸本)9781450390439

Since the semiconductor technology has entered the age of 90 nm, the static power consumption of the chip has increased rapidly. For edge computing devices, the waste of power can not be ignored. This paper uses the relationship between power consumption and power supply voltage of FPGA and DSP, analyzes the characteristics of the traditional scheme, and designs a hardware circuit according to the different mechanisms of reducing static power consumption of FPGA and DSP According to the design of FPGA and DSP core power supply voltage compatibility, the system realizes the requirement of FPGA and DSP for power supply voltage amplitude and realizes dynamic control of power supply voltage. After verification and comparison, FPGA and DSP can realize the adjustment of performance power consumption and stable operation under the power system.

关键词： FPGA DSP POWER CONSUMPTION

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma

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ADVANCED MATERIALS 2025年第15期37卷 e2418053页

作者： You, Haoyu Zhang, Shilin Zhang, Yiwen Chen, Qinjun Wu, Yuxing Zhou, Zheng Zhao, Zhenhao Su, Boyu Li, xuwen Guo, Yun Chen, Yun tang, Weiyi Liu, Bing Fan, Hongrui Geng, Shuo Fang, Mingzhu Li, Fangxin Liu, Guangna Jiang, Chen Sun, Tao Fudan Univ Sch Pharm State Key Lab Med Neurobiol Minhang HospInnovat Ctr New Drug Dev Immune Infla Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Orthoped Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB. Therefore, to enhance the in vivo safety and targeting capability of OMVs, we introduced engineered OMVs to reduce toxicity and further constructed a modularly assembled nanoplatform by performing simple peptide modifications. This nanoplatform demonstrates satisfactory biosafety and is able to continuously cross the BBB and target GBM with the assistance of Angiopep-2. Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenicity of GBM, ultimately overcoming GBM immune resistance to enhance the efficacy of immunotherapy. This OMVs-based nanoplatform provides a new paradigm and insights into the development of immunotherapy for GBM.

关键词： engineering technology glioblastoma immune resistance immunotherapy outer membrane vesicles

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Molecular simulation studies on the water/methane two-phase flow in a cylindrical silica nanopore: Formation mechanisms of water lock and implications for gas hydrate exploitation

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FUEL 2023年第Part1期333卷

作者： Zheng, Chao Guo, Guang-Jun Qin, xuwen Dong, Yanhui Lu, Cheng Peng, Bo tang, Wei Bian, Hang Chinese Acad Sci Inst Geol & Geophys Key Lab Petr Resource Res Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Guangzhou Marine Geol Survey Guangzhou 511458 Peoples R China Natl Engn Res Ctr Gas Hydrate Explorat & Dev Guangzhou 511458 Peoples R China Chinese Acad Sci Inst Geol & Geophys Key Lab Shale Gas & Geoengn Beijing 100029 Peoples R China China Geol Survey Ctr Oil & Nat Gas Resource Explorat Beijing 100083 Peoples R China China Univ Geosci Sch Energy Resources Beijing 100083 Peoples R China

The water/gas two-phase flow is a frequently encountered question in the percolation field, and is especially important for the exploitation of natural gas hydrates because their decomposition products are exactly liquid water and natural gas. We studied the water/methane two-phase flow in a hydrophilic cylindrical nanopore by performing molecular simulations, and obtained high-quality nanoflows under different water saturation (Sw) thanks to the newly established nano-manometer method to control pressure difference accurately. With increasing Sw, the methane flow decreases almost linearly until a sudden stop when Sw >= 0.52. The formation of the water lock accounting for this phenomenon is observed clearly, and the larger Sw, the earlier formation of the water lock as well as the longer water lock. Based on careful data analysis, a water lock model and its formation mechanism are newly proposed with two pieces of strong evidence - the continuous reduction of the surface area of the water/gas interface when the water lock forms and the existence of maximum thickness of water film for different Sw. Thus, the competition between the surface tension of the water/gas interface and the adsorption of the water/wall interface controls the development of the water lock. These findings are very helpful for un-derstanding the two-phase percolation and optimizing the gas production and water removal schemes during hydrate exploitation. In addition, the nano-manometer can be widely used in other nanoflow simulations for measuring the local pressure accurately.

关键词： Water methane two-phase flow Cylindrical nanopore Nano -manometer Relative permeability Water lock Natural gas hydrates

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