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Association of rs1059004 polymorphism in the OLIG2 locus with functional brain network in first-episode negative schizophrenia

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PSYCHIATRY RESEARCH-NEUROIMAGING 2020年 303卷 111130-111130页

作者： Lv, Yahui wu, Sijia Lin, Yanyan Wang, xuwen Wang, Jijun Cai, Suping Huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Shanghai 200030 Peoples R China

Schizophrenia has often been viewed as a disorder of connectivity. The single nucleotide polymorphism rs1059004 in the oligodendrocyte lineage transcription factor 2 gene locus has been reported to be associated with schizophrenia. We measured the functional connectivity and functional brain network topology properties in 49 schizophrenic patients and 47 healthy controls. We compared the strength and diversity of the functional connectivity and topological properties of functional networks between different genotypes. The correlations among functional connectivity, topological properties and behavioral performances were also investigated in this study. We found that the connectivity strength of schizophrenic patients carrying the risk A allele was generally decreased whereas connectivity diversity was increased. Regarding topological properties, all groups showed small-world properties, the nodal efficiency showed significant differences in the right precuneus and left middle temporal pole between different genotypes in schizophrenic patients. Moreover, the nodal efficiency in the left middle temporal pole was positively correlated with the neuropsychological assessment battery results of the schizophrenic patients who were homozygous for the C allele. Our results elucidate the contribution of rs1059004 to the functional brain network, and may help enhance the present understanding of the role of risk gene in the functional dysconnectivity of schizophrenia.

关键词： Schizophrenia Oligodendrocyte lineage transcription factor 2 Functional connectivity Functional network Graph theoretical analysis

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On-Orbit Estimation and Calibration of GPS Antenna Geometry Offsets for Attitude Determination of LEO Satellites

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IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES 2018年第3期E101A卷 644-648页

作者： Hou, Huiling Hu, Weisheng wu, Kang Liang, xuwen Chinese Acad Sci Shanghai Inst Microsyst & Informat Technol Shanghai Peoples R China Chinese Acad Sci Shanghai Engn Ctr Microsatellites Shanghai Peoples R China Univ Chinese Acad Sci Beijing Peoples R China

In this letter, a novel on-orbit estimation and calibration method of GPS antenna geometry offsets for attitude determination of LEO satellites is proposed. Both baseline vectors in the NED coordinate system are achieved epoch-by-epoch firstly. Then multiple epochs' baseline vectors are united to compute all the offsets via an UKF for a certain long time. After on-orbit estimation and calibration, instantaneous and accurate attitude can be achieved. Numerical results show that the proposed method can obtain the offsets of each baseline in all directions with high accuracy estimation and small STDs, and effective attitudes can be achieved after antenna geometry calibration using the estimated offsets. The high accuracy give the proposed scheme a strong practical-oriented ability.

关键词： offset estimation calibration attitude determination LEO satellites

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Parameter identification for mixed fractional Brownian motions with the drift parameter

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PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 2019年 536卷 120942-000页

作者： Cai, Chunhao Cheng, xuwen Xiao, Weilin wu, Xiang Shanghai Univ Econ & Finance Sch Math Shanghai Peoples R China Zhejiang Univ Sch Management Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Finance & Econ Sch Finance Hangzhou 300018 Zhejiang Peoples R China

This paper deals with the problem of estimating the unknown parameters in the drift mixed fractional Brownian motion based on discrete-sampled observations. We construct two different estimators for the drift parameter based on the approximation by random walks of the driving noise and prove the consistency of these two estimators. Some numerical simulations are also presented to illustrate the performance of these maximum likelihood estimators. Empirical examples are given to illustrate the potential applications of these proposed estimators. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Maximum likelihood estimation Mixed fractional Brownian motions Euler-Murayama scheme Donsker type approximation

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基于LoRa自组网的电能采集系统设计与实现

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计算机测量与控制 2023年第3期31卷 235-240,261页

作者：陈德富刘小湖周旭文邱宝象吴华君屈亮亮浙江工业大学信息工程学院杭州310023 万向钱潮股份有限公司杭州311215

为了实现用电设备运行状况的远程监测,需要对设备运行时的电能参数进行采集并上报至云平台;针对上述目的,本项目设计了一种基于LoRa自组网技术的电能采集系统,整个系统主要由数据采集节点和集中器组成;数据采集节点采用RN8209电能计量... 详细信息

为了实现用电设备运行状况的远程监测,需要对设备运行时的电能参数进行采集并上报至云平台;针对上述目的,本项目设计了一种基于LoRa自组网技术的电能采集系统,整个系统主要由数据采集节点和集中器组成;数据采集节点采用RN8209电能计量芯片实现负载电能数据的精确采集,并通过LoRa通信模块将数据发送至集中器;集中器采用了基于NB-IoT通信模块和LoRa通信模块的双模组设计,通过LoRa模块接收节点上报的数据,并通过NB-IoT模块转发至物联网云平台;本系统利用LoRa载波侦听技术设计了基于CSMA/CA的星型自组网络,实现了节点与集中器间的无线通信,适用于低成本、小规模的远程电能数据采集系统;通过实验验证,该方案的数据采集功能、LoRa自组网通信功能和NB-IoT通信功能均能够正常实现,达到了设计目标。

关键词：电能采集 RN8209 LoRa通信 CSMA/CA 载波侦听星型自组网

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矛盾纠纷调处化解标准化实践路径研究与建议——以湖州市吴兴区社会综合治理省级标准化战略重大试点为例

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中国质量与标准导报 2022年第3期 103-105,111页

作者：郑玲陈旭文吴新惠陆芸陈群浙江蓝箭万帮标准技术有限公司浙江省方大标准信息有限公司湖州市吴兴区社会矛盾纠纷调处化解中心

标准化对完善社会矛盾纠纷多元预防调处化解综合机制,提升地方社会矛盾纠纷调处化解工作系统规范性和调处效率具有重要作用。本文以吴兴区社会综合治理省级标准化战略重大试点标准体系构建与实践经验为基础,对“顶层设计体系化、资源管... 详细信息

标准化对完善社会矛盾纠纷多元预防调处化解综合机制,提升地方社会矛盾纠纷调处化解工作系统规范性和调处效率具有重要作用。本文以吴兴区社会综合治理省级标准化战略重大试点标准体系构建与实践经验为基础,对“顶层设计体系化、资源管理标准化、调处机制链条化、调处人员职业化、统筹研判数字化”的标准化实践路径进行研究总结,为全国社会矛盾纠纷调处化解标准化长效发展提供经验与借鉴。

关键词：矛盾纠纷调处化解社会治理标准化

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基于5G网络的工业产品识别系统设计

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江西科学 2022年第2期40卷 341-345页

作者：林若波姚亮谢扬陈旭文吴容冰许泽波揭阳职业技术学院广东揭阳522000 广东伟兴电子科技有限公司广东揭阳522000

针对工业产品识别准确度的不足,提出一种基于5G网络的工业产品识别系统框架。在传统卷积神经网络CNN基础上,提出DNN深度神经网络算法,并引入控制参数k_(p)实现采集数据的变换特征映射;基于5G网络传输和加密,实现实时数据传输和保密通信... 详细信息

针对工业产品识别准确度的不足,提出一种基于5G网络的工业产品识别系统框架。在传统卷积神经网络CNN基础上,提出DNN深度神经网络算法,并引入控制参数k_(p)实现采集数据的变换特征映射;基于5G网络传输和加密,实现实时数据传输和保密通信;基于云平台,使用Pytorch进行物体识别的匹配运算;最后开发了一套基于5G网络的工业产品识别与溯源平台,验证本设计的实用性。结果表明,本系统对于工业产品识别具有很高的准确率和识别效果。

关键词： 5G网络 DNN 控制参数工业产品识别

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基于HX710的车辆称重物联系统设计

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自动化应用 2022年第4期 154-157,162页

作者：陈德富周旭文吴华君邱宝象屈亮亮浙江工业大学信息工程学院浙江杭州310023 万向钱潮股份有限公司浙江杭州311215

目前车辆载荷监测主要采用分离式称重设备进行固定点位称重,这种方式往往存在着精度低、耗时长以及设备铺设困难等问题。针对上述所面临的问题,设计了一种基于HX710的车辆称重物联系统。系统以嵌入式系统、HX710模数转换芯片、NB-IoT模... 详细信息

目前车辆载荷监测主要采用分离式称重设备进行固定点位称重,这种方式往往存在着精度低、耗时长以及设备铺设困难等问题。针对上述所面临的问题,设计了一种基于HX710的车辆称重物联系统。系统以嵌入式系统、HX710模数转换芯片、NB-IoT模块为核心,采集由电阻应变片组成应变电桥的电信号,经过处理后,通过无线通信模块发送至阿里云物联网平台,从而实现远程情况下的车辆载荷实时监测。通过实验验证,该系统实现了预期效果,具有实时性、高精度、装配快捷等特点。

关键词：车载称重 HX710 物联网嵌入式系统 NB-IoT

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Effect of wastewater particles on catalytic ozonation in the advanced treatment of petrochemical secondary effluent

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CHEMICAL ENGINEERING JOURNAL 2018年 345卷 280-289页

作者： Zhang, Siyu wu, Changyong Zhou, Yuexi Wang, Yaning He, xuwen China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China Chinese Res Inst Environm Sci State Key Lab Environm Criteria & Risk Assessment Beijing 100012 Peoples R China Chinese Res Inst Environm Sci Res Ctr Water Pollut Control Technol Beijing 100012 Peoples R China Dalian Ocean Univ Sch Marine Sci & Technol & Environm Dalian 116032 Liaoning Peoples R China

The effect of wastewater particles on catalytic ozonation during the treatment of petrochemical secondary effluent (PSE) was investigated. The dissolved organic carbon (DOC) removal results indicated that wastewater particles could significantly affect the catalytic oxidation reaction and increase ozone (O-3) consumption. When the suspended solids (SS) was filtered by the 0.45 mu m membrane, the O-3 dosage to DOC removal ratio was 1.99 mg(O3) mg(DOC)(-1), while it increased to 2.99 mg(O3) mg(DOC)-1 when the SS concentration was 50 +/- 1.57 mg L-1. Wastewater particles can react with O-3, thus reducing the O-3 and hydroxyl radicals (% OH) available for DOC removal. When the SS concentration was 30 +/- 0.96 mg L-1, O-3 dosages lower than 10 mg L-1 did not induce a change in the size and surface characteristics of the particles. Following the increase in the O-3 dosage to 36 mg L-1, extracellular polymeric substances (EPS) reacted with O-3/(center dot) OH with different characteristics. Dissolved organic matter (DOM) had the highest depletion reaction rate, followed by the loosely bound EPS (LB-EPS) and tightly bound EPS (TB-EPS). The average reaction rates of the three constituents were 1.44, 0.212, and 0.079 mg L-1 min(-1), respectively. In addition, the results showed that eliminating wastewater particles would be beneficial for the removal of organic micro-pollutants (OMPs) by catalytic ozonation.

关键词： Organic micro-pollutants (OMPs) Biological flocs Catalytic ozonation Extracellular polymeric substances (EPS) Excitation-emission matrix (EEM)

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Optimized expression of classical swine fever virus E2 protein via combined strategy in Pichia pastoris

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PROTEIN EXPRESSION AND PURIFICATION 2020年 167卷 105527页

作者： Li, Ding wu, Junchen Chen, Jin Zhang, Dong Zhang, Yuanpeng Qiao, xuwen Yu, Xiaoming Zheng, Qisheng Hou, Jibo Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing Peoples R China Yangzhou Univ Jiangsu Coinnovat Ctr Prevent & Control Important Yangzhou Jiangsu Peoples R China Minist Sci & Technol Jiangsu Key Lab Food Qual & Safety State Key Lab Cultivat Base Beijing Peoples R China Shandong Prov Ctr Anim Dis Control & Prevent Jinan Shandong Peoples R China

Precaution of classical swine fever (CSF) is an important mission for the worldwide swine industry. Glycoprotein E2 is the leading antigen candidate for subunit vaccine of classical swine fever virus (CSFV). In this study, two Spy-tagged E2 genes were synthesized in vitro and subcloned into pMCO-AOX vector for intracellular expression in Pichia pastor-is after methanol induction. Western blot analysis and semi-quantitative analysis showed that the yield of recombinant E2 protein was improved 17.87 folds by using co-translocational signal peptide cSIG. After the construction of the tandem multiple copy expression vectors, further increase of E2 production was observed by repetitive transforming expression vectors into P. pastoris genome. Finally, the yeast transformants harboring 8 or 16 copies of cSIG-E2-Spy increased the E2 expression level by 27.01-fold or 30.72-fold, respectively. These results demonstrate that utilizing co-translocational signal peptide together with multi-copy integration strategy can increase the production of recombinant E2 protein efficiently.

关键词： Classical swine fever virus E2 protein Co-translocational signal peptide Multi-copy integration Combined strategy

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The mobility of thallium in sediments and source apportionment by lead isotopes

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CHEMOSPHERE 2019年 219卷 864-874页

作者： Liu, Juan Yin, Meiling Luo, xuwen Xiao, Tangfu wu, Zhifeng Li, Nuo Wang, Jin Zhang, Weilong Lippold, Holger Belshaw, Nick Stanley Feng, Yuexing Chen, Yongheng Guangzhou Univ Sch Environm Sci & Engn Inst Environm Res Greater Bay Minist EducKey Lab Water Qual & Conservat Pearl Guangzhou 510006 Guangdong Peoples R China Univ Oxford Dept Earth Sci Oxford OX1 3AN England Helmholtz Zentrum Dresden Rossendorf Inst Ressourcenokol D-04318 Leipzig Germany Univ Queensland Sch Earth & Environm Sci Brisbane Qld 4072 Australia

Thallium (TI) is a very toxic heavy metal. As a part of ongoing investigations, the mobility, sources and fate of TI were investigated for sediments from a watershed in the northern part of the Pearl River, South China, whose catchment has been seriously impacted by large-scale Pb Zn smelting activities onshore. A wide dispersion of severe TI contamination was observed throughout the depth profiles. A modified IRMM (Institute for Reference Materials and Measurements, Europe) sequential extraction procedure of a selected depth profile uncovered an exceptionally high enrichment of TI in geochemically-mobile fractions (i.e., weak-acid-exchangeable, reducible and oxidizable fractions), on average 5.94 +/- 2.19 mg/kg (74.6% +/- 5.1% of the total TI content) not only in the surface sediments but also in deep sediments. The proximal quantitative source apportionment using Pb isotopic fingerprinting technique indicated that a majority (80%-90%) of TI contamination along the depth profiles is anthropogenically derived from the Pb Zn smelting wastes. The results highlight the pivotal role of smelting activities in discharging huge amounts of geochemically-mobile TI to the sediments down to approximately 1 m in length, which is quantitatively evidenced by Pb isotopic tracing technique. Lead isotopes combined with distribution of TI and Pb contents identified a potential marker for a point source from the Pb Zn smelter in the river catchment, which also provides a theoretical framework for source apportionment of metal contamination in a larger river/marine system and in other sulfide mining/smelting areas likewise. (C) 2018 Elsevier Ltd. All rights reserved.

关键词： Thallium mobility Lead isotopes Source apportionnient Pb Zn smelting

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