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CircFBLN2 regulates duck myoblast proliferation and differentiation through miR-22-5p and MEF2C interaction

POULTRY SCIENCE 2025年第5期104卷 105063页

作者： Liu, Shuibing wu, Jintao Jiang, Hongxia Zhou, Ya'nan Huang, xuwen Wang, Yuxiang Xie, Zhanbin Liao, Zurong Ding, Zhenxvan Liu, Jing Hu, Xiaolong Mao, Huirong Liu, Sanfeng Chen, Biao Jiangxi Agr Univ Coll Anim Sci & Technol Nanchang 330045 Jiangxi Peoples R China South China Agr Univ Coll Anim Sci Guangzhou 510642 Guangdong Peoples R China Jiangxi Agr Univ Poultry Inst Nanchang 330045 Peoples R China

The growth and development of duck skeletal muscle significantly affect duck meat production, making it essential to understand the molecular mechanisms underlying these processes. Circular RNAs (circRNAs) and microRNAs (miRNAs) are identified in many species and play essential roles in the regulation of myogenic processes;however, research on circRNAs and miRNAs involved in the duck skeletal muscle development is limited. In prior whole-transcriptome RNA sequencing study, we identified differential expression of miR-22-5p and the novel circular RNA circFBLN2, which arises from the second exon of the FBLN2 gene, in duck primary myoblasts (DPMs). In this study, we confirmed the circular structure of circFBLN2 and explored its expression patterns and functional implications in myogenesis. To elucidate the function of circFBLN2 in the myogenic processes of duck, we conducted experiments involving both the silencing and overexpression of circFBLN2 in DPMs. Our findings indicated that circFBLN2 inhibits DPM proliferation while promoting their differentiation. Conversely, when miR-22-5p was silenced and overexpressed, it exhibited opposing effects by promoting the proliferation of DPMs and inhibiting their differentiation. These results suggest a complex dynamic interplay between circFBLN2 and miR-22-5p in the regulation of DPMs proliferation and differentiation. Additionally, our results revealed that both circFBLN2 and myocyte enhancer factor 2 C (MEF2C) act as sponges for miR-22-5p, as demonstrated by binding predictions and dual-luciferase reporter assays. These results offer novel perspectives on the regulatory pathways underlying the duck embryonic skeletal muscle development, underscoring the pivotal function of circFBLN2 in the regulation of miR-22-5p expression. This research deepens our comprehension of the molecular underpinnings of avian myogenesis, potentially paving the way for more effective approaches to bolster growth and development of livestock.

关键词： Duck skeletal muscle circFBLN2 miR-22-5p MEF2C

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Growth of Robust Carbon Nitride Films by Double Crystallization with Exceptionally Boosted Electrochemiluminescence for Visual DNA Detection

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ADVANCED OPTICAL MATERIALS 2023年第6期11卷

作者： Hou, Yuhua Fang, Yanfeng Zhou, Zhixin Hong, Qing Li, Wang Yang, Hong wu, Kaiqing Xu, Yuan Cao, xuwen Han, Dan Liu, Songqin Shen, Yanfei Zhang, Yuanjian Southeast Univ Sch Chem & Chem Engn Jiangsu Engn Lab Smart Carbon Rich Mat & Device Jiangsu Prov Hitech Key Lab Biomed ResState Key L Nanjing 211189 Peoples R China Southeast Univ Med Sch Nanjing 210009 Peoples R China

Electrochemically generated chemiluminescence (ECL) has attracted significant interest over the past decades, ranging from fundamental studies on highly efficient electron-to-photon interconversion to practical bioassays. Nonetheless, the ECL efficiency (phi(ECL)) of most emitters is low, which significantly hampers further development. Herein, this work reports a highly robust carbon nitride film with unusually enhanced ECL efficiency (2256 times higher than that of the reference Ru(bpy)(3)Cl-2/K2S2O8). Double crystallization, which provides the primary interaction of carbon nitride with the substrate and subsequent growth, plays a crucial role in the preparation. The improved ECL efficiency is ascribed to little pinholes suppressing futile co-reagent reduction, maintenance of more orbit-delocalized heptazine subunits improving ECL kinetics, and high transparency avoiding self-absorption. As a potential application, an ultrasensitive visual DNA biosensor by the naked eye is further successfully developed with a linear detection range of 100 pm to 1 mu m and limit of detection of 27 pm (S/N = 3).

关键词： biosensors carbon nitrides electrochemiluminescence energy conversion mechanical properties

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Analog Beamforming Enabled Multicasting: Finite-Alphabet Inputs and Statistical CSI

arXiv

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arXiv 2024年

作者： wu, Yanjun Xie, Zhong Xie, Zhuochen Ouyang, Chongjun Liang, xuwen The Innovation Academy for Microsatellites Chinese Academy of Science Shanghai201304 China The Key Lab for Satellite Digitalization Technology Chinese Academy of Science Shanghai201210 China University of Chinese Academy of Sciences Beijing100049 China The Shanghai Engineering Center for Microsatellites Shanghai201210 China ShanghaiTech University Shanghai201210 China The National Space Science Center Chinese Academy of Sciences Beijing100190 China The School of Electrical and Electronic Engineering College of Engineering and Architecture University College Dublin DublinD04 V1W8 Ireland

The average multicast rate (AMR) is analyzed in a multicast channel utilizing analog beamforming with finite-alphabet inputs, considering statistical channel state information (CSI). New expressions for the AMR are derived for non-cooperative and cooperative multicasting scenarios. Asymptotic analyses are conducted in the high signal-to-noise ratio regime to derive the array gain and diversity order. It is proved that the analog beamformer influences the AMR through its array gain, leading to the proposal of efficient beamforming algorithms aimed at maximizing the array gain to enhance the AMR. © 2024, CC BY.

关键词： Multicasting

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Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

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CANCER NANOTECHNOLOGY 2022年第1期13卷 1-18页

作者： Yao, Hua Mu, Xupeng Wei, Zhenhong Li, Xiuying wu, Liya Jin, Yongri Li, xuwen Li, Jing Jiang, Jinlan Jilin Univ Sci Res Ctr China Japan Union Hosp Changchun 130033 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China

Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh-2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh-2 as both reducing and stabilizing agents. Results The synthesized Au@ginsenoside Rh-2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh-2. Investigations in vitro indicated that Au@ginsenoside Rh-2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well. Conclusions Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh-2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh-2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.

关键词： Ginsenoside Rh-2 Au nanoparticles Drug-modified nanocomposite Facile synthesis Anticancer activity

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Potential triggers and development processes of submarine landslides in the Xisha Trough Basin, South China Sea

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GEOMORPHOLOGY 2024年 448卷

作者： Zhang, Yunshan wu, Nan Qin, xuwen wu, Tingting Wei, Jiangong Wang, Pingkang Lv, Wenchao Jia, Yonggang Ocean Univ China Shandong Prov Key Lab Marine Environm & Geol Engn Qingdao Peoples R China China Geol Survey Zhoushan Field Sci Observat & Res Stn Marine Geoha Zhoushan Peoples R China Ocean Univ China Sanya Ocean Res Inst Sanya Hainan Peoples R China Tongji Univ State Key Lab Marine Geol Shanghai Peoples R China China Geol Survey Beijing Peoples R China Guangzhou Marine Geol Survey MLR Key Lab Marine Mineral Resources Guangzhou Peoples R China Guangzhou Marine Geol Survey Sanya Inst South China Sea Geol Sanya Peoples R China China Geol Survey Acad South China Sea Geol Sci Sanya Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Geol Qingdao Shandong Peoples R China

Both submarine landslides and submarine canyons can transfer large amounts of terrigenous quantities from the continental shelf to the deep sea. In some cases, they can have a close relationship to their spatial distribution, formation and evolution. Submarine landslides on the shelf-slope can provide early depressions for submarine canyons, representing the early stage of submarine canyons. The continuous downcutting process during the evolution of submarine canyons can steepen the gradient of the canyon sidewalls, which can lead to the occurrence of submarine landslides. However, the role of submarine canyons in the initiation of slope failure has been overlooked. In this study, high-resolution multibeam bathymetry data, submarine image data and 2-D seismic data were used to investigate two adjacent submarine landslides developed on the northern slope of the Xisha Trough and the spatiotemporal relationship of these landslides to the Central Canyon. We identified a steep downslope between the submarine landslides and the Central Canyon. The Central Canyon formation age was much earlier than those of the submarine landslides. The Central Canyon is filled with modern submarine landslide deposits. The characteristics of the multiple failure scarps indicate retrogressive failure of the submarine landslides. We suggest that the submarine landslides developed on the northern slope of the Xisha Trough Basin have finally been captured by the Central Canyon. We determined that the emptying of sediments at the end of the northern slope of the Xisha Trough Basin caused by the development of the Central Canyon caused the end of the northern slope of the Xisha Trough Basin to lose support, which may have affected the slope stability and could have even played a role in the initiation of submarine landslides. Consequently, the slope area along the Central Canyon may be susceptible to slope instability and slope failure processes.

关键词： Submarine landslides Submarine canyons Retrogressive failure Xisha Trough Basin South China Sea

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Reevaluation and New Species of Kainonereis Chamberlin, 1919 (Annelida: Polychaeta: Nereididae)

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ZOOLOGICAL STUDIES 2018年 57卷 e6-e6页

作者： Manuel Conde-Vela, Victor wu, xuwen Ignacio Salazar-Vallejo, Sergio El Colegio Frontera Sur Dept Ecol Acuat Chetmal 77010 Quintana Roo Mexico Chinese Acad Sci Inst Oceanol Dept Marine Organism Taxon & Phylogeny Qingdao 266071 Peoples R China

Kainonereis Chamberlin, 1919 was proposed to include only one species, K. alata, based on epitokes provided with elytriform structures in chaetigers 5-7. The species was thoroughly described and illustrated, but its unique features were enigmatic and the genus is currently regarded as taxon inquirendum. In order to have a better understanding of its diagnostic features and determine how this genus differs from similar ones, type material of K. alata and two other species bearing elytriform structures-Nicon polaris Hartman, 1967 and Rullierinereis elytrocirra Sun and wu, 1979, including additional material from Gulf of California and Caribbean Sea-were examined. Because the K. alata type material is in good condition and the presence of elytriform structures in chaetigers 5-7 is confirmed, this paper regards it as a valid genus. Given that the elytriform structures, or dorsal discs, together with a set of diagnostic features, are consistent in structure and position in all epitokes examined, they are regarded as homologous structures delineating Kainonereis. Consequently, K. alata is redescribed, the new combinations K. polaris comb. n. and K. elytrocirra comb. n. are proposed and redescribed, and two new species are described: K. chamberlini sp. n. from the Caribbean Sea, and K. peltifera sp. n. from the Gulf of California. Also, the discovery of an atoke on K. polaris comb. n. allowed us to better distinguish Kainonereis from the similar genera Nicon Kinberg, 1865 and Rullierinereis Pettibone, 1971. A key to identifying all known Kainonereis species is also included.

关键词： Epitoky Sexual dimorphism Modified dorsal cirri Dorsal discs Polychaetes

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Ultrafast synthesis and densification of ZrO2 doped KNN ceramics by reactive flash sintering

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INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY 2021年第6期18卷 1999-2009页

作者： Su, Xinghua Jiao, Zhihua Fu, Mengying An, Gai wu, Yajuan Tian, Qiang Xu, Pan wu, Weiwei Chang, xuwen Liu, Jiarui Changan Univ Sch Mat Sci & Engn Xian Peoples R China Southwest Univ Sci & Technol State Key Lab Environm Friendly Energy Mat Mianyang Sichuan Peoples R China Xidian Univ Sch Adv Mat & Nanotechnol Xian Peoples R China

Fabrication of dense KNN-based lead-free piezoelectric ceramics at low temperatures in short time through a cost-effective way remains a challenge. Herein, this challenge could be addressed by using reactive flash sintering. It is demonstrated that the phase transformation of KNbO3-NaNbO3 into (K,Na)NbO3 and densification occur simultaneously during the flash event. Most importantly, ZrO2 doping can greatly decrease the onset flash temperature, which is ascribed to the increased conductivity of sample. In addition, the current limit has a significant effect on the phase transformation and densification. The flash-sintered KNN ceramics exhibit the good ferroelectric and piezoelectric properties. Furthermore, the ZrO2 doped and undoped KNN ceramics show a comparable coercive field E-c, which may be related to the residual point defects after the flash. Besides the Joule heating, the avalanche generation of point defects is suggested to be responsible for the ultrafast solid-state reaction and densification rates.

关键词： densification doping phase transformations reactive flash sintering synthesis

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A pH and Temperature Dual-Responsive Microgel-Embedded, Adhesive, and Tough Hydrogel for Drug Delivery and Wound Healing

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ACS APPLIED MATERIALS & INTERFACES 2023年第15期15卷 19560-19573页

作者： Peng, xuwen Peng, Qian wu, Meng Wang, Wenda Gao, Yongfeng Liu, Xiong Sun, Yongxiang Yang, Diling Peng, Qiongyao Wang, Tao Chen, Xing-Zhen Liu, Jifang Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB 619 Canada Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Fac Med & Dent Dept Physiol Edmonton AB 627 Canada

Stimuli-responsive hydrogels have attracted much attention over the past decade for potential bioengineering applications such as wound dressing and drug delivery. In this work, a pH and temperature dual-responsive microgel-embedded hydrogel has been fabricated by incorporating poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAm-co-AAc) based microgel particles into polyacrylamide (PAAm)/chitosan (CS) semi-interpenetrating polymer network (semi-IPN), denoted as microgel@PAM/ CS. The resultant hydrogel possesses excellent mechanical properties including stretchability, compressibility, and elasticity. In addition, the microgel@PAM/CS hydrogels can tightly adhere to the surfaces of a variety of tissues such as porcine skin, kidney, intestine, liver, and heart. Moreover, it shows controlled dual-drug release profile of both bovine serum albumin (BSA) (as a model protein) and sulfamethoxazole (SMZ), an antibiotic. Excellent antimicrobial properties are obtained for SMZ-loaded microgel@ PAM/CS hydrogels. Compared with traditional drug administration methods such as by mouth, injection, and inhalation, the microgel@PAM/CS hydrogels possess advantages such as higher drug loading efficiency (by more than 80%) and controllable and sustained (over 48 h) release. The microgel@PAM/ CS hydrogels can significantly enhance the wound healing process. This work provides a facile approach for the fabrication of multifunctional stimuli-responsive microparticle-embedded hydrogels with semi-IPN structures, and the as-prepared microgel@ PAM/CS hydrogels have great potential for applications as smart wound dressing materials in biomedical engineering.

关键词： stimuli-responsive hydrogel multifunctional hydrogel interfacial interaction drug delivery wound dressing

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Enhancing gas production and CO2 sequestration from marine hydrate reservoirs through optimized CO2 hydrate cap

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ENERGY 2024年 303卷

作者： Guo, Yang Li, Shuxia Sun, Hao wu, Didi Liu, Lu Zhang, Ningtao Qin, xuwen Lu, Cheng China Univ Petr East China State Key Lab Deep Oil & Gas Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China East China Bur Sinopec Explorat & Dev Res Inst Nanjing 210019 Peoples R China China Geol Survey China Aero Geophys Survey & Remote Sensing Ctr Nat Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China

The invasion of formation water during marine hydrate production gravely affects gas productivity. CO2 hydrate caps effectively inhibit water invasion while sequestering CO2, which is considered an excellent prospective application. However, forming field -scale artificial CO2 hydrate caps remains a global challenge. This study proposed an innovative method for forming an artificial CO2 hydrate cap. The fracture length, injection time, production pressure, and production well distance, which are all factors that affect sealing capacity and production enhancement, were optimized. Results indicated that the sealing capacity exhibited a trend of initially increasing and subsequently decreasing with fracture length. The injection time was positively correlated with the sealing capacity and was sufficient to seal both vertically and horizontally once it reached 4 years. In addition to sequestering CO2, the CO2 hydrate cap enhanced gas production by 146.56 % and reduced water production by 37.47 % compared to direct depressurization. CO2 invasion occurred when the well spacing was too close, while being distant was not favorable for pressure propagation and heat utilization by the CO2 hydrate cap. This method simultaneously achieves multiple goals for energy and environmental, providing essential implications for the future commercial application of marine hydrates.

关键词： Gas hydrate CO2 hydrate cap Enhanced gas production CO2 sequestration Numerical simulation

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Hydrogen-Bonding-Driven Multifunctional Polymer Hydrogel Networks Based on Tannic Acid br

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ACS APPLIED POLYMER MATERIALS 2022年第3期4卷 1836-1845页

作者： Gao, Yongfeng Peng, xuwen wu, Qiuqiu Yang, Diling Wang, Wenda Peng, Qiongyao Wang, Tao Wang, Jianmei Liu, Jifang Zhang, Hao Zeng, Hongbo Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Taiyuan Univ Sci & Technol Heavy Machinery Engn Res Ctr Educ Minist Taiyuan 030024 Shanxi Peoples R China

A hydrogel network based on noncovalent inter-molecular interactions via mixing of poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA), poly(vinyl alcohol) (PVA), andtannic acid (TA) aqueous solutions was developed. Thecoacervation and hydrogel formation process is driven by hydro-gen-bonding interactions between catechol moieties of TA,hydroxide groups of PVA, and carboxylic acid groups of *** formation of the PMVEMA-PVA-TA (PPTA) gel occurs inseconds and can be readily obtained and scaled up in both ionic andnonionic systems. It is noteworthy that this PPTA gel can bestretched more than 135 times its original size and for potentialpreparation of mechanically strongfibers. The gel can be alsoremodeled on diverse substrates and into different shapes. The electrical response sensing behavior promotes the PPTA gel materialas a great candidate for fabricating strain sensors. The as-prepared PPTA gel exhibits excellent adhesion to different substrates andshows antibacterial properties against bothEscherichia coli(Gram-negative) bacteria and methicillin-resistantStaphylococcus aureus(MRSA) bacteria, which provides a promising candidate for the design of biocompatible drug carriers with facile fabrication and flexible modification for various biomedical applications.

关键词： hydrogen bond hydrogel adhesive mechanical properties self-healing antibacterial

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