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Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials

BMC CARDIOVASCULAR DISORDERS 2024年第1期24卷 592页

作者： Xu, Jiayi xiang, Luwei Yin, xuwen Song, Haiyan Chen, Chen Yang, Bei Ye, Hongfang Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing 138 Xianlin Rd Nanjing 210023 Jiangsu Peoples R China Nanjing Med Univ Sch Nursing 101 Longmian Rd Nanjing 211166 Jiangsu Peoples R China Nanjing Drum Tower Hosp Dept Nursing 123 Zhongshan Rd Nanjing 210008 Jiangsu Peoples R China Nanjing Med Univ Affiliated Hosp 1 Jiangsu Prov Hosp Dept Nursing 300 Guangzhou Rd Nanjing 210029 Jiangsu Peoples R China Soochow Univ Suzhou Med Coll 199 Renai Rd Suzhou 215123 Jiangsu Peoples R China

Background The effectiveness and adverse effects of coenzyme Q10 for heart failure remain unclear owing to small sample sizes and variations in the quality of existing studies in literature. Methods The databases of EMBASE, PubMed, Web of Science, CINAHL databases, Scopus, Cochrane Central Register of Controlled Trials, VIP, Wanfang, and CNKI were searched for randomized controlled trials on the coenzyme Q10-assisted treatment of heart failure. Relevant literature was retrieved, data were extracted, and the risk of bias of the included studies was evaluated by two investigators independently using the Review Manager 5.4 software and the STATA 15 software. Results In total, 33 studies were included in this meta-analysis, which showed that all-cause mortality [RR = 0.64, 95% CI (0.48, 0.85), P = 0.002;GRADE: moderate quality], hospitalization for heart failure [RR = 0.50, 95% CI (0.37, 0.67), P < 0.00001;GRADE: moderate quality], New York Heart Association classification [MD = - 0.29, 95% CI (- 0.39, - 0.19), P < 0.00001;GRADE: low quality], and brain natriuretic peptide level [MD = - 91.97, 95% CI (- 103.11, - 80.83), P < 0.00001;GRADE: low quality] were lower in the coenzyme Q10 group than in the control group. Meanwhile, left ventricular ejection fraction [MD = 0.51, 95% CI (0.31, 0.71), P < 0.00001;GRADE: low quality] and 6-min walk test result [MD = 31.70, 95% CI (19.96, 43.43), P < 0.00001;GRADE: moderate quality] were better than those in the control group. Conclusions According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and brain natriuretic peptide level and improves left ventricular ejection fraction and 6-min walk test result in those with heart failure without major adverse effects. Trial registration This study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, http://***/prospero), with the

关键词： Heart failure Safety outcomes Coenzyme Q10 Meta analysis Randomized controlled trial

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The Imaging Features and Diagnostic Value of Computerised Tomography in Seminal Duct Tuberculosis

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JOURNAL OF MULTIDISCIPLINARY HEALTHCARE 2023年 16卷 1395-1402页

作者： Qi, Min Zhang, Le Gan, Wei Xu, Yanling Wei, Jialu Fu, xuwen Li, xiang Third Peoples Hosp Kunming Yunnan Clin Med Ctr Infect Dis Dept Radiol 319 Wujing St Kunming 650041 Peoples R China Third Peoples Hosp Kunming Yunnan Clin Med Ctr Infect Dis Dept ICU Kunming 650041 Peoples R China

Objective: To analyse the computerised tomography (CT) imaging features and diagnostic value of seminal duct tuberculosis (TB). Methods: The imaging data of male patients with ejaculatory duct TB who underwent surgical treatment in our hospital from 1 January 2019 to 31 December 2019 were retrospectively analysed. Through CT images, seminal duct TB was divided into different types, and the CT image features of different types of TB were analysed. The differences in diagnosis between CT and pathological results were compared. Results: According to the CT manifestations of TB of the intrapelvic segment of seminal duct TB, this disease could be divided into an intra-tubular calcification type, a lumen dilatation and effusion type and a wall thickening type, among which 6 cases (15.8%) were intra-tubular calcification types, 14 cases (36.8%) were lumen dilatation and effusion types and 18 cases (47.4%) were wall thickening types. The diagnostic efficacy of CT in the diagnosis of ejaculatory duct TB: sensitivity = 63.89% (23/36), specificity = 80.01% (44/53), accuracy = 75.28% (67/89), positive predictive value = 51.87% (43/109), negative predictive value = 77.19% (44/57) and kappa = ***: CT has high sensitivity and specificity in the diagnosis of seminal duct TB. The classification of seminal duct TB using CT images is of great significance for the diagnosis and treatment of the disease.

关键词： seminal duct tuberculosis computerised tomography

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Scheduling optimization of AGVs in workshop based on cost-efficiency-emission competition mechanism

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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE 2023年第20期237卷 4828-4839页

作者： Chen, Ye Jing, xuwen Lu, xiang Zhou, Honggen Li, Haipeng Kang, Chao Liu, Jinfeng Li, Jun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China China Merchants Cruise Shipbldg Co Ltd Nantong Peoples R China Jiangsu Univ Sci & Technol Sch Mech Engn Mengxi Rd Zhenjiang 212013 Peoples R China

The untimely material transportation induced by the backward logistics scheduling method in the ship panel block construction workshop is a complex engineering issue with multi-parameter coupling. To overcome the problem, the cost-efficiency-carbon emission competition model is proposed to solve the scheduling optimization for the AGVs in ship panel block construction workshop. Firstly, the logistics path plan of the panel block construction workshop is obtained by establishing the path-planning node map of panel block construction workplace. Secondly, a scheduling model for AGVs is constructed based on the competition mechanism of the lowest transportation cost, maximum transportation efficiency, and lowest carbon emission. Then, the optimized schedule is achieved by a novel hybrid method of the genetic and population migration algorithm considering the competition mechanism. Finally, the case validation indicates that the solving ability of the proposed hybrid method is improved by 52.4% compared with Genetic Algorithm under competitive mechanism. Besides, the results demonstrate material transportation time can be reduced by 17.5%.

关键词： Scheduling optimization automatic guided vehicle competition mechanism similarity ship panel block

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Graded Error Compensation Method for Heavy-Load Manipulators Based on Laser Tracking Measurement 16th

Graded Error Compensation Method for Heavy-Load Manipulators...

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16th International Conference on Intelligent Robotics and Applications, ICIRA 2023

作者： Chen, Zhangwei Zu, Hongfei Zhang, xiang Chen, xuwen Wang, Zhirong State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou310058 China School of Mechanical Engineering Zhejiang Sci-Tech University Hangzhou310018 China Zhejiang Premax Co. Ltd Ningbo315048 China Testing Standardization and Certification Changzhou Institute of Inspection Changzhou21 3000 China

ISBN: (纸本)9789819964888

In order to meet the high positioning accuracy requirements of industrial application scenarios for manipulators, the motion accuracy of industrial manipulators is generally improved through error compensation. However, due to the presence of non-geometric errors such as friction and joint backlash, error compensation is usually a complex nonlinear problem. Therefore, the existing methods of improving the absolute positioning accuracy of manipulators through model parameter calibration are difficult to obtain good performance, especially for heavy-load manipulators. To solve the above problems, this manuscript proposes a graded error compensation method for heavy-load manipulators based on laser tracking measurement, which realizes the compensation of kinematics error and joint stiffness, and improves the positioning accuracy of the manipulator in the entire workspace. Firstly, the geometric parameters were modeled and compensated by combining the distance model and the Denavit-Hartenberg (DH) model. Then, joint stiffness errors were studied and compensated. Finally, experiments were conducted on a heavy-load manipulator to verify the feasibility and effectiveness of this method. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023.

关键词： Error compensation

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基质和生根剂处理对千层金扦插繁育的影响

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森林与环境学报 2020年第6期40卷 648-653页

作者：邱子文林永盛向旭文吴少华李永裕杨超福建农林大学园艺学院福建福州350002 福建农林大学园艺植物天然产物研究所福建福州350002

以多年生千层金植株为材料,采用小拱棚扦插育苗技术,通过L9(33)正交试验研究不同基质(草炭、蛭石、珍珠岩的不同质量配比)、生根剂浓度(100、200、400 mg·L^-1)及处理时间(1、2、3 h)对千层金扦插生根率、平均根长、根系活力和叶... 详细信息

以多年生千层金植株为材料,采用小拱棚扦插育苗技术,通过L9(33)正交试验研究不同基质(草炭、蛭石、珍珠岩的不同质量配比)、生根剂浓度(100、200、400 mg·L^-1)及处理时间(1、2、3 h)对千层金扦插生根率、平均根长、根系活力和叶绿素含量的影响。采用极差分析法和主成分分析法,初步筛选合适千层金扦插的基质配方、生根剂浓度和处理时间。结果表明:处理组合A1B2C3(基质为蛭石,在浓度为200 mg·L^-1生根剂中处理3 h)扦插苗的生根率、根系活力和叶绿素含量均达到最高,分别为78.00%、63.69mg·g^-1·h^-1、13.16mg·g^-1;处理组合A2B1C3(基质为m草炭∶m蛭石=1∶1,在浓度为100 mg·L^-1生根剂中处理3 h)扦插苗的平均根长最长,为10.00 cm。主成分分析表明,生根率是影响千层金扦插效果的主要指标,基质是影响千层金扦插成活及生根率的最关键因素。处理组合A1B2C3的综合得分最高,为1.06,是千层金扦插效果最好的组合。

关键词：千层金扦插基质生根剂处理时间

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Rep-MCA-former: An efficient multi-scale convolution attention encoder for text-independent speaker verification

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COMPUTER SPEECH AND LANGUAGE 2024年 85卷

作者： Liu, Xiaohu Chen, Defu Wang, Xianbao xiang, Sheng Zhou, xuwen Zhejiang Univ Technol Informat Engineer Coll Hangzhou 310023 Zhejiang Peoples R China

In many speaker verification tasks, the quality of speaker embedding is an important factor in affecting speaker verification systems. Advanced speaker embedding extraction networks aim to capture richer speaker features through the multi-branch network architecture. Recently, speaker verification systems based on transformer encoders have received much attention, and many satisfactory results have been achieved because transformer encoders can efficiently extract the global features of the speaker (e.g., MFA-Conformer). However, the large number of model parameters and computational latency are common problems faced by the above approaches, which make them difficult to apply to resource-constrained edge terminals. To address this issue, this paper proposes an effective, lightweight transformer model (MCA-former) with multi-scale convolutional self-attention (MCA), which can perform multi-scale modeling and channel modeling in the temporal direction of the input with low computational cost. In addition, in the inference phase of the model, we further develop a systematic re-parameterization method to convert the multi-branch network structure into the single-path topology, effectively improving the inference speed. We investigate the performance of the MCA-former for speaker verification under the VoxCeleb1 test set. The results show that the MCA-based transformer model is more advantageous in terms of the number of parameters and inference efficiency. By applying the re-parameterization, the inference speed of the model is increased by about 30%, and the memory consumption is significantly improved.

关键词： Speaker verification Transformer encoder Multi-scale convolution Re-parameterization

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One-Pot Construction of β-Selective Quinolines with γ-Quaternary Carbon from Vinylquinolines with Active Ylides via Pd/Sc/Bronsted Acid Co-Catalysis

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ACS CATALYSIS 2023年第10期13卷 6509-6517页

作者： Song, Longlong Xiong, Lulu Ni, Dan Chen, Weixiong Ji, Jian Xue, Jian Chen, xuwen Wu, xiang He, Xiao Liu, Shunying East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China New York Univ Shanghai New York Univ East China Normal Univ Ctr Computat Shanghai 200062 Peoples R China

Vinyl-substituted N-heterocycles, as more challenginginert olefinswith more stable reactivity, have brought about widespread attentionin the reaction of aza-Michael addition or reduction coupling ***, we report a [Pd-(eta(3)-C3H5)-Cl](2)/Sc-(OTf)(3)-catalyzed catalytic processaccelerated by Bronsted acids with a beta-selective aza-Michaeladdition to yield a gamma-quaternary carbon from vinyl-substitutedquinolines, diazos, and anilines/alcohols in one pot. The generationof anhydride analogues from Bronsted acid and the counter anion(OTf-) of Lewis acid promotes the activation ofthe corresponding Lewis acid and the nearly quantitative *** pi-cation and coordination interactions play pivotal rolesin the activation of the vinyl-quinoline substrates by the activatedLewis acid Sc-(OTf)(3). The control mechanistic evidence andDFT calculations presented a Pd/Sc/Bronsted acid co-catalyzedaddition mechanism. The triple co-catalytic system provides a strategyfor the activation of vinyl-quinolines with a linear selectivity containing gamma-quaternary carbon, and the developed method shows a broadsubstrate scope varying from alkyl/aryl alcohols and amines whichprovides a general and rapid strategy for the quinoline-based diverselibrary construction.

关键词： Pd Sc co-catalysis one-pot reaction vinylquinolines active ylide quaternary carbon

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Neutrophil-lymphocyte ratio: a correlation study of its effect on magnetic resonance imaging enhancement patterns in spinal parenchymal tuberculosis

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BMC INFECTIOUS DISEASES 2025年第1期25卷 1-9页

作者： Shan, Qiulan Zhang, Le Fu, xuwen Qi, Min Wei, Jialu Gan, Wei Pu, Ying Shen, Lingjun Li, xiang Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept Radiol 319 Wujing Rd Kunming 650041 Yunnan Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept ICU Kunming 650041 Yunnan Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept Pharm Kunming 650041 Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept TB 319 Wujing Rd Kunming 650041 Yunnan Peoples R China

Objective To explore the impact of the neutrophil-lymphocyte ratio (NLR) on magnetic resonance imaging (MRI) enhancement patterns in patients with spinal parenchymal tuberculosis. Methods In this study, a retrospective analysis was conducted on 42 patients diagnosed for the first time with spinal parenchymal tuberculosis at Kunming Third People's Hospital between 2019 and 2024. They were divided into a homogeneous enhancement group and a ring enhancement group based on MRI characteristics and an analysis of their clinical presentations, imaging features and laboratory test results. Results A total of 42 patients were included in the study, with 30 in the ring enhancement group and 12 in the homogeneous enhancement group. The ring enhancement group exhibited a significantly higher proportion of fever, night sweats and limb sensory/motor dysfunction compared with the homogeneous enhancement group (p < 0.05). For laboratory tests, the ring enhancement group showed remarkably elevated peripheral blood neutrophil counts and NLR, along with markedly reduced lymphocyte counts and proportions (p < 0.05). Additionally, the incidence of perilesional oedema was substantially higher in the ring enhancement group than in the homogeneous enhancement group (p < 0.05). Conclusion The NLR may serve as a potential indicator for assessing MRI enhancement patterns in spinal parenchymal tuberculosis, which is beneficial for identifying patients at different pathological stages of the disease. This study provides novel perspectives for clinical diagnosis and treatment while emphasising the need for further research on the application value of the NLR in tuberculosis.

关键词： Spinal parenchymal tuberculosis Neutrophil-lymphocyte ratio Magnetic resonance imaging enhancement patterns Tuberculosis

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Decreased intestinal abundance of Akkermansia muciniphila is associated with metabolic disorders among people living with HIV

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ANNALS OF MEDICINE 2025年第1期57卷 2474730页

作者： Qian, Zhe Chen, Suling Liao, Xiaoyang Xie, Jingfang Xu, Yuyuan Zhong, Huiqun Ou, Lang Zuo, xiang Xu, xuwen Peng, Jie Wu, Jian Cai, Shaohang Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Elderly Resp 2 Guangzhou 510030 Peoples R China Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Geriatr Guangzhou Peoples R China Univ South China Affiliated Nanhua Hosp Dept Hepatobiliary Surg Hengyang Peoples R China Southern Med Univ Nanfang Hosp Dept Gen Surg Div Hepatobiliopancreat Surg Guangzhou Peoples R China South China Univ Technol Sch Med Guangzhou Peoples R China

BackgroundPrevious studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic *** total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. Akkermansia abundance in stool samples was measured using RT-qPCR, and Pearson correlation and logistic regression were applied for *** sequencing revealed a significant decline in gut Akkermansia abundance in PLWHIV with NAFLD. STAMP analysis of public datasets confirmed this decline after HIV infection, while KEGG pathway analysis identified enrichment of metabolism-related genes. A prospective cohort study with 103 PLWHIV followed for 48 weeks validated these findings. Akkermansia abundance was significantly lower in participants with NAFLD, overweight, and hyperlipidemia at baseline, and it emerged as an independent predictor of NAFLD and overweight. Negative correlations were observed between Akkermansia abundance and both CAP values and body mass index (BMI) at baseline and at week 48. At the 48-week follow-up, Akkermansia remained a predictive marker for *** abundance was reduced in PLWHIV with metabolic disorders and served as a predictive biomarker for NAFLD progression over 48 weeks of ART.

关键词： HIV gut microbiota metabolic diseases NAFLD overweight Akkermansia muciniphila

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右膝关节结核并大量米粒体形成1例

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中国医学影像技术 2024年第9期40卷 1449-1450页

作者：李翔付旭文寸新华昆明市第三人民医院云南省传染性疾病医学中心医学影像科云南昆明650041 昆明市第三人民医院云南省传染性疾病医学中心骨科云南昆明650041

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示... 详细信息

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示结核分枝杆菌(+)。

关键词：结核,骨关节体层摄影术,X线计算机磁共振成像

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