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Parameter identification for mixed fractional Brownian motions with the drift parameter

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 2019年 536卷 120942-000页

作者： Cai, Chunhao Cheng, xuwen Xiao, Weilin Wu, xiang Shanghai Univ Econ & Finance Sch Math Shanghai Peoples R China Zhejiang Univ Sch Management Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Finance & Econ Sch Finance Hangzhou 300018 Zhejiang Peoples R China

This paper deals with the problem of estimating the unknown parameters in the drift mixed fractional Brownian motion based on discrete-sampled observations. We construct two different estimators for the drift parameter based on the approximation by random walks of the driving noise and prove the consistency of these two estimators. Some numerical simulations are also presented to illustrate the performance of these maximum likelihood estimators. Empirical examples are given to illustrate the potential applications of these proposed estimators. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Maximum likelihood estimation Mixed fractional Brownian motions Euler-Murayama scheme Donsker type approximation

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Positioning accuracy improvement method of industrial robot based on laser tracking measurement

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Measurement: Sensors 2021年 18卷

作者： Hongfei Zu xuwen Chen Zhangwei Chen Zhirong Wang xiang Zhang School of Mechanical Engineering & Automation Zhejiang Sci-Tech University China Zhejiang Premax Technology Co. Ltd Ningbo 315048 China State Key Laboratory of Fluid Power and Mechatronics Systems Zhejiang University China Hangzhou ECON Technology Co. Ltd Hangzhou 310015 China School of Computer Science Hangzhou Dianzi University Hangzhou 310000 China

Positioning accuracy is of great significance for industrial robots in high-end industries. In addition to kinematic parameter errors, there are also some dynamic parameter errors, which are nonlinear. This paper proposes a novel method to improve the positioning accuracy of industrial robot, which takes both kinematics and dynamics parameter errors into account. Firstly, the method uses improved Denavit-Hartenberg (DH) model to establish kinematics model and identifies the geometric errors. Then, the deformation of the joint is analysed, and the angle deviation of each joint due to the end load is compensated. Finally, the accuracy improvement experiment is carried out on 6R robot. The experimental results show that the method is very effective.

关键词： DH model Joint deformation Positioning accuracy Laser tracking measurement

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DFT Study of Oxygenated Organic Pollutants Catalyzed by Molybdenum Oxides: Comparison of Reaction Mechanisms of MoO_x + HCHO(x = 1, 2, 3)

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Chinese Journal of Structural Chemistry 2019年第8期38卷 1229-1240页

作者： GAO Xiao-Zhen LIANG Yan YANG Jing MENG xiang-Jun YANG Xiao-Chun JIA Jing-Xian xuwen-Guo Yangquan Municipal Key Laboratory of Quantum Manipulation Shanxi Institute of TechnologyYangquan045000China Department of Chemistry Tangshan Normal CollegeTangshan063000China Institute for Physical Chemistry Beijing Institute of TechnologyBeijing100081China

The reaction mechanisms between formaldehyde and MoOx(x = 1, 2, 3) have been studied thoroughly in this paper. Five reaction pathways were found in three reactions(reactions Ⅰ to Ⅲ) through studying the mechanisms of MoOx(x = 1, 2, 3) catalyzing formaldehyde. Different products were obtained from three reactions. Of all three reactions, the barrier energy of Route ⅡA is the lowest(4.70 kcal/mol), which means in MoOx(x = 1, 2, 3), MoO2 has the best catalytic effect. Compared with other similar non-toxic treatments of formaldehyde, our barrier energy is the lowest. In this research, there was no good leaving group of the compound, so the mechanisms are addition reaction. We speculate that there must be an addition reaction to the more complex reactions to molybdenum oxides and aldehydes. As a chemical reagent for removing formaldehyde, it only absorbs formaldehyde and does not emit other toxic substances outward. Molybdenum oxides retain its original structures of the final products, which means it has excellent stability in the reaction of MoOx(x = 1, 2, 3) + HCHO. The mechanisms of all three reactions are addition reactions, but they are entirely different. As the number of oxygen atoms increases, the reaction mechanisms become simpler.

关键词： reaction mechanism formaldehyde elimination molybdenum oxides addition reaction barrier energy

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Adhesive Coacervates: Adhesive Coacervates Driven by Hydrogen-Bonding Interaction (Small 43/2020)

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Small 2020年第43期16卷

作者： Qiongyao Peng Jingsi Chen Zicheng Zeng Tao Wang Li xiang xuwen Peng Jifang Liu Hongbo Zeng Department of Chemical and Materials Engineering University of Alberta Edmonton Alberta T6G 1H9 Canada The Fifth Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong 510700 China

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乌鲁木齐市典型水体夏季温室气体排放初探

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环境保护科学 2020年第6期46卷 122-128页

作者：李典鹏蒋靖佰伦向殷马雯琪肖旭文贾宏涛新疆农业大学草业与环境科学学院新疆乌鲁木齐830052 乌鲁木齐市第五十九中学新疆乌鲁木齐830000

文章以乌鲁木齐南湖(观赏性湖泊)和幸福一号水库(灌溉水库)为例,对其夏季表层水体CH4和CO2分压[p(CH4)和p(CO2)]进行了监测,并分析了影响湖泊温室气体排放的水质参数。结果表明,乌鲁木齐典型水体对大气温室气体排放主要以CO2为主,CO2通... 详细信息

文章以乌鲁木齐南湖(观赏性湖泊)和幸福一号水库(灌溉水库)为例,对其夏季表层水体CH4和CO2分压[p(CH4)和p(CO2)]进行了监测,并分析了影响湖泊温室气体排放的水质参数。结果表明,乌鲁木齐典型水体对大气温室气体排放主要以CO2为主,CO2通量是CH4的2.29倍。pH、电导率、氧化还原电位与CH4、CO2通量显著相关(P<0.05),溶解氧、温度与温室气体排放通量不存在显著相关性。

关键词：城市湖泊南湖幸福一号水库 p(CH4) p(CO2)

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巨噬细胞抑制因子-1对老年膝骨关节炎软骨细胞增殖代谢影响的实验研究

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中华风湿病学杂志 2019年第12期23卷 839-844,I0004页

作者：王东明翟旭雯耿翔李鹏翠卫小春李璐山西医科大学第二医院骨科山西医科大学第二医院骨与软组织损伤修复山西省重点实验室太原030001 山西医科大学模拟医院晋中030619 山西卫生健康职业学院药学系晋中030619

目的观察不同浓度巨噬细胞抑制因子-1(MIC-1)对老年膝OA患者软骨细胞增殖代谢的影响。方法收集健康年轻人和老年膝OA患者的血清、膝关节软骨标本各10例,检测标本中MIC-1的含量变化。常规培养人软骨细胞,对照组单纯加培养液,实验组培养... 详细信息

目的观察不同浓度巨噬细胞抑制因子-1(MIC-1)对老年膝OA患者软骨细胞增殖代谢的影响。方法收集健康年轻人和老年膝OA患者的血清、膝关节软骨标本各10例,检测标本中MIC-1的含量变化。常规培养人软骨细胞,对照组单纯加培养液,实验组培养液中含不同浓度重组人MIC-1蛋白,其中,实验组1浓度为10 ng/ml,实验组2浓度为100 ng/ml和实验组3浓度为200 ng/ml,培养48 h后,5-乙炔基-2-脱氧尿苷(EdU)检测软骨细胞增殖情况,蛋白质印迹法和实时荧光定量(qRT)-PCR检测软骨细胞pSmad2、Smad2和Col2等指标的表达情况。统计学分析采用t检验,单因素方差分析(ANOVA),Tukey法。结果年轻人血清中MIC-1蛋白相对表达量(0.89±0.11)高于老年人(0.48±0.12),差异有统计学意义(t=2.58,P<0.05)。对照组EdU阳性细胞百分比为(26.8±1.5)%,实验组1为(26.2±1.6)%,实验组2为(35.2±1.8)%,实验组3为(45.6±2.7)%,多组间比较差异有统计学意义(F=21.45,P<0.01)。pSmad2蛋白相对表达量在多组之间比较差异有统计学意义(F=18.32,P<0.01),其中,实验组2(1.25±0.11)和实验组3(0.93±0.22)分别高于对照组(0.54±0.10);多组比较Col2蛋白相对表达量差异有统计学意义(F=17.90,P<0.01),其中,实验组2(1.28±0.14)和实验组3(1.74±0.14)分别高于对照组(0.80±0.04)。Col2的mRNA相对表达量在多组间比较差异有统计学意义(F=17.90,P<0.01),其中,实验组2(1.13±0.16)和实验组3(1.65±0.15)分别高于对照组(0.49±0.10)。结论老年膝OA患者血清和软骨组织MIC-1含量低于年轻人,MIC-1可以促进老年膝关节软骨细胞增殖。

关键词：老年人软骨细胞骨关节炎巨噬细胞

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CEPC Technical Design Report - Accelerator (v2)

arXiv

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arXiv 2023年

作者： Abdallah, Waleed De Freitas, Tiago Carlos Adorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ayse Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Biekötter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D'Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, S Agh University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Anhui University Anhui Hefei China Applied Physics Department Federal Urdu University of Arts Science and Technology Islamabad Pakistan Banaras Hindu University Institute of Science Varanasi India Bandirma Onyedi Eylul University Bandirma Turkey Beihang University Beijing China Beijing Computational Science Research Center Beijing China Beijing Conveyi Ltd Beijing China Beijing Glass Research Institute Co. Ltd Beijing China Beijing Institute of Technology Beijing China Beijing Normal University Beijing China Brown University ProvidenceRI United States Budker Institute of Nuclear Physics Novosibirsk Russia Cadi Ayyad University Laboratory of Fundamental and Applied Physics Polydisciplinary Faculty Marrakech Morocco Cairo University Giza Egypt Center for Theory and Computation National Tsing Hua University Hsinchu Taiwan Central China Normal University Hubei Wuhan China Central South University Hunan Changsha China Centro de Fisica Teorica de Particulas Universidade Tecnica de Lisboa Lisboa Portugal Chengdu KaitengSifang Digital Radio & Tv Equipment Co. Ltd Sichuan Chengdu China China Academy of Engineering Physics Sichuan Mianyang China China Building Materials Academy Beijing China China Center of Advanced Science and Technology Beijing China China Institute of Atomic Energy Beijing China China Jiliang University Zhejiang Hangzhou China China Nuclear Instrument CO. Ltd Beijing China China University of Geosciences Beijing China China University of Geosciences Hubei Wuhan China China University of Mining and Technology Jiangsu Xuzhou China China West Normal University Sichuan Nanchong China Chongqing University Department of Physics Chongqing China Chulalongkorn University Bangkok Thailand City University of Hong Kong Department of Physics Hong Kong Cockcroft Institute Daresbury United Kingdom Cornell University IthacaNY

The Circular Electron Positron Collider (CEPC) is a large scientific projectinitiated and hosted by China, fostered through extensive collaboration withinternational partners. The complex comprises four accelerators: a 30 GeVLinac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar).The Linac and Damping Ring are situated on the surface, while the Booster andCollider are housed in a 100 km circumference underground tunnel, strategicallyaccommodating future expansion with provisions for a Super Proton ProtonCollider (SPPC). The CEPC primarily serves as a Higgs factory. In its baselinedesign with synchrotron radiation (SR) power of 30 MW per beam, it can achievea luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /abfor two interaction points over a decade, producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC\'s capability togenerate 4.3 million Higgs bosons, facilitating precise measurements of Higgscoupling at sub-percent levels, exceeding the precision expected from theHL-LHC by an order of magnitude. This Technical Design Report (TDR) follows thePreliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual DesignReport (CDR, 2018), comprehensively detailing the machine\'s layout andperformance, physical design and analysis, technical systems design, R&D andprototyping efforts, and associated civil engineering aspects. Additionally, itincludes a cost estimate and a preliminary construction timeline, establishinga framework for forthcoming engineering design phase and site selectionprocedures. Construction is anticipated to begin around 2027-2028, pendinggovernment approval, with an estimated duration of 8 years. The commencement ofexperiments could potentially initiate in the mid-2030s. © 2023, CC BY-NC-SA.

关键词： Synchrotron radiation

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Correction: CEPC Technical Design Report: Accelerator

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Radiation Detection Technology and Methods 2024年第1期9卷 184-192页

作者： Abdallah, Waleed de Freitas, Tiago CarlosAdorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ays¸e Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Bieko¨tter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D’Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, Cairo University Giza Egypt Xi’an Jiaotong-Liverpool University Suzhou China Institute of Power Engineering of National Academy of Sciences of Belarus Minsk Belarus Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad Pakistan Applied Physics Department Science and Technology Federal Urdu University of Arts Islamabad Pakistan Zhengzhou University Zhengzhou China Institute of High Energy Physics Chinese Academy of Sciences Beijing China University of California Santa Cruz Santa Cruz USA Nanjing University Nanjing China Beijing Normal University Beijing China Harvard University Cambridge USA South China Normal University Guangzhou China University of Basel Basel Switzerland High Energy Accelerator Research Organization (KEK) Tsukuba Japan Joint Institute for Nuclear Research Dubna Russia Faculty of Sciences and Techniques Université Abdelmalek Essaadi Tangier Morocco Southeast University Nanjing China Department of Physics University of Wisconsin–Madison Madison USA Instituto de Alta Investigación Universidad de Tarapacá Arica Chile Monash University Melbourne Australia Laboratoire de Physique des 2 infinis Irène Joliot-Curie – IJCLab Orsay France Peking University Beijing China Department of Physics and Nanotechnology SRM Institute of Science and Technology Kattankulathur India Shandong University Jinan China University of New Mexico Albuquerque USA Bandirma Onyedi Eylul University Bandırma Turkey National Centre for Nuclear Research Warsaw Poland Indian Institute of Technology Madras (IN) Chennai India University of Southampton Southampton UK INFN Milano - LASA Segrate Italy Sun Yat-Sen University Guangzhou China China Institute of Atomic Energy Beijing China INFN-University of Torino Turin Italy Karlsruhe Institute of Technology Institute for Theoretical Physics Karlsruhe Germany INFN-Sezione di Roma Tre Rome Italy Kutaisi International University Kutaisi Georgia Soochow University Suzhou China Budker Institute

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The wide utility of rabbits as models of human diseases

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EXPERIMENTAL AND MOLECULAR MEDICINE 2018年第5期50卷 66-66页

作者： Esteves, Pedro J. Abrantes, Joana Baldauf, Hanna-Mari BenMohamed, Lbachir Chen, Yuxing Christensen, Neil Gonzalez-Gallego, Javier Giacani, Lorenzo Hu, Jiafen Kaplan, Gilla Keppler, Oliver T. Knight, Katherine L. Kong, xiang-Peng Lanning, Dennis K. Le Pendu, Jacques de Matos, Ana Lemos Liu, Jia Liu, Shuying Lopes, Ana M. Lu, Shan Lukehart, Sheila Manabe, Yukari C. Neves, Fabiana McFadden, Grant Pan, Ruimin Peng, xuwen de Sousa-Pereira, Patricia Pinheiro, Ana Rahman, Masmudur Ruvoen-Clouet, Natalie Subbian, Selvakumar Tunon, Maria Jesus van der Loo, Wessel Vaine, Michael Via, Laura E. Wang, Shixia Mage, Rose Univ Porto CIBIO InBIO Res Network Biodivers & Evolutionary Biol Campus VairaoRua Padre Armando Quintas P-4485661 Vairao Portugal Univ Porto Dept Biol Fac Ciencias Rua Campo Alegre S-N P-4169007 Porto Portugal Inst Invest & Formacao Avancada Ciencias & Tecnol Gandra Portugal LMU Munchen Max von Pettenkofer Inst Fac Med Natl Reference Ctr Retroviruses D-81377 Munich Germany LMU Munchen Gene Ctr Fac Med VirolNatl Reference Ctr Retroviruses D-81377 Munich Germany Univ Calif Irvine Gavin Herbert Eye Inst Lab Cellular & Mol Immunol Sch Med Irvine CA 92697 USA Univ Calif Irvine Sch Med Dept Mol Biol & Biochem Irvine CA 92697 USA Univ Calif Irvine Inst Immunol Sch Med Sch Irvine Irvine CA 92697 USA Univ Massachusetts Med Sch Dept Med Worcester MA 01605 USA Penn State Univ Dept Pathol Hershey PA USA Penn State Univ Dept Microbiol & Immunol Hershey PA USA Penn State Univ Dept Comparat Med Hershey PA USA Univ Leon Inst Biomed IBIOMED Leon 24071 Spain Univ Leon CIBERehd Leon 24071 Spain Univ Washington Dept Med Seattle WA USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Bill & Melinda Gates Fdn Seattle WA USA Loyola Univ Chicago Dept Microbiol & Immunol Maywood IL 60153 USA NYU Sch Med Dept Biochem & Mol Pharmacol New York NY 10016 USA Univ Nantes Univ Angers CRCINA INSERM Nantes France Arizona State Univ Biodesign Inst Ctr Immunotherapy Vaccines & Virotherapy Tempe AZ 85287 USA Univ Arkansas Med Sci Dept Microbiol & Immunol Little Rock AR 72205 USA Univ Porto Inst Biomed Sci Abel Salazar ICBAS Dept Anat Porto Portugal Univ Porto Inst Biomed Sci Abel Salazar ICBAS Unit Multidisciplinary Res Biomed UMIB Porto Portugal Johns Hopkins Univ Sch Med Dept Med Div Infect Dis Baltimore MD 21205 USA Rutgers State Univ PHRI New Jersey Med Sch RBHS Newark NJ USA NIAID Tubercolosis Res Sect Lab Clin Infect Dis Div Intramural ResNIH 9000 Rockville Pike Bethesda MD 20892 USA Univ Cape Town Dept Clin Lab Sci Inst Infect

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.

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