Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth and metabolism. Its activity is controlled by various types of signals, including growth factors, nutrients, and stresses. In this stu...
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Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth and metabolism. Its activity is controlled by various types of signals, including growth factors, nutrients, and stresses. In this study, we show that changes in expression levels of two antiapoptotic proteins, Bcl-2 and Bcl-X-L, also affect mTORC1 signaling activity. In cells overexpressing Bcl-X-L, mTORC1 activity is increased and becomes less sensitive to growth factor or nutrient conditions. In contrast, reduction in expression levels of the two antiapoptotic proteins inhibits mTORC1 signaling activity. Our results suggest that the effect of Bcl-2 and Bcl-X-L on mTORC1 is mediated by FKBP38, an inhibitor of mTORC1. The two proteins compete with mTORC1 for FKBP38 binding and hence alter mTORC1 activity. This study reveals a novel cross-talk between Bcl-2/X-L and mTORC1 signaling, which is likely to contribute to cancer development.
Nano-catalyst was prepared in the lab. Non-thermal plasma was generated by dielectric barrier discharge (DBD). Through nano-catalyst coupled with non-thermal plasma, a series of experiments for toluene decomposition w...
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ISBN:
(纸本)9783037851920
Nano-catalyst was prepared in the lab. Non-thermal plasma was generated by dielectric barrier discharge (DBD). Through nano-catalyst coupled with non-thermal plasma, a series of experiments for toluene decomposition were carried out. Based on reactor input energy density and removal efficiency and energy efficiency and inhibition for O-3 formation, the load amount MnOx catalyst on the surface of gamma-Al2O3 pellets were compared in the experiment. The results show the catalysis performance of 10 wt% MnOx/gamma-Al2O3 coupled with non-thermal plasma resulted in higher removal efficiency of toluene and better energy efficiency. At the same time, 10 wt% MnOx/gamma-Al2O3 operated on a better inhibition for O-3 formation in the gas exhaust.
Non-thermal plasma (NTP) technology generated by dielectric barrier discharge with adsorption-enhanced γ-Al2O3was used to decompose volatile organic compounds (VOCs). The experimental results show the adsorption-enha...
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This paper presents an OWL ontology model of the multi-disciplinary collaborative development (RDMCD) system of the radar product including an ontology-based resource-sharing mechanism. Furthermore, the ontology-based...
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