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26th IEEE International Conference on Image Processing (ICIP)

作者： ye, Fanfan Tang, Huiming Wang, xuwen Liang, Xiao Zhejiang Univ Coll Informat Sci & Elect Engn Hangzhou Peoples R China

ISBN: (纸本)9781538662496

Recently, the graph convolutional networks based methods have achieved remarkable performance in skeleton-based action recognition. However, current methods do not make full use of the topology of the skeleton graph, because they set and fixed the relation of skeleton joints or adjacency matrix for all input samples manually. In order to solve the problem, we design an end-to-end architecture consisting of joints relation inference network (JRIN) and skeleton graph convolutional network (SGCN). JRIN can aggregate spatial-temporal feature of every two joints globally, then infer the optimal relation between every two joints automatically. These relations of joints is quantified as the optimal adjacency matrices. Then SGCN will take the optimal matrices to do the final action recognition. During training, special initialization and alternate training strategies are proposed to optimize the model. Our method achieves very competitive performance on widely used NTU-RGB+D and Kinetics datasets.

关键词： Action Recognition Relation Inference Graph Convolutional Network Skeleton

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Energetic Films Realized by Encapsulating Copper Azide in Silicon-Based Carbon Nanotube Arrays with Higher Electrostatic Safety

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MICROMACHINES 2020年第6期11卷 575-575页

作者： Liu, xuwen Hu, Yan Wei, Hai Chen, Bingwen ye, Yinghua Shen, Ruiqi Nanjing Univ Sci & Technol Sch Chem Engn Nanjing 210094 Peoples R China Minist Ind & Informat Technol Micronano Energet Devices Key Lab Nanjing 210094 Peoples R China

Since copper azide (Cu(N-3)(2)) has high electrostatic sensitivity and is difficult to be practically applied, silicon-based Cu(N-3)(2)@carbon nanotubes (CNTs) composite energetic films with higher electrostatic safety were fabricated, which can be compatible with micro-electro mechanical systems (MEMS). First, a silicon-based porous alumina film was prepared by a modified two-step anodic oxidation method. Next, CNTs were grown in pores of the silicon-based porous alumina film by chemical vapor deposition. Then, copper nanoparticles were deposited in CNTs by electrochemical deposition and oxidized to Cu(N-3)(2)by gaseous hydrogen azide. The morphology and composition of the prepared silicon-based Cu(N-3)(2)@CNTs energetic films were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD), respectively. The electrostatic sensitivity of the composite energetic film was tested by the Bruceton method. The thermal decomposition kinetics of the composite energetic films were studied by differential scanning calorimetry (DSC). The results show that the exothermic peak of the silicon-based Cu(N-3)(2)@CNTs composite energetic film is at the temperature of 210.95 degrees C, its electrostatic sensitivity is significantly less than that of Cu(N-3)(2)and its 50% ignition energy is about 4.0 mJ. The energetic film shows good electric explosion characteristics and is successfully ignited by laser.

关键词： energetic films composite energetic materials Cu(N-3)(2)@carbon nanotubes (CNTs) electrostatic sensitivity electrochemical deposition

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杨树桑黄菌次生代谢产物及其生物活性研究

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中国抗生素杂志 2025年第4期50卷 445-451页

作者：刘旭雯周洁叶董艳李芊慧尹树仁徐子雯刘丹努尔比亚姆·努尔麦麦提白鹤龙长春师范大学化学学院长春130032

目的研究杨树桑黄菌固体培养物的化学成分和生物活性。方法采用超声提取和半制备液相色谱法进行分离纯化化合物,通过核磁共振波谱数据鉴定其结构,评估了它们对α-淀粉酶和α-葡萄糖苷酶的抑制活性。结果从杨树桑黄菌提取物中分离得到7... 详细信息

目的研究杨树桑黄菌固体培养物的化学成分和生物活性。方法采用超声提取和半制备液相色谱法进行分离纯化化合物,通过核磁共振波谱数据鉴定其结构,评估了它们对α-淀粉酶和α-葡萄糖苷酶的抑制活性。结果从杨树桑黄菌提取物中分离得到7个化合物,分别是牛奶树碱(1),莨菪亭(2),phellifuropyranone A(3),青霉内脂D(4),(3E,6S)-3-庚烯-1,6-二醇(5),ethyl orsellinate(6),3,4-二羟基苯乙醇(7)。α-淀粉酶和α-葡萄糖苷酶的抑制活性实验结果表明,化合物2对α-淀粉酶和α-葡萄糖苷酶有强抑制活性。其中,化合物2对2种酶的抑制率分别为82%和68%,IC_(50)分别是29.28μmol/L和61.28μmol/L,对α-淀粉酶为混合型抑制,对α-葡萄糖苷酶为竞争型抑制。结论本研究丰富了杨树桑黄菌固体培养物的化学成分和生物活性,为其进一步开发应用提供了依据。

关键词：杨树桑黄 α-淀粉酶 α-葡萄糖苷酶抑制类型

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Geochemistry and sources of hydrate-bound gas in the Shenhu area, northern south China sea: Insights from drilling and gas hydrate production tests

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JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING 2022年第PartC期208卷 109459-109459页

作者： Liang, Qianyong Xiao, Xi Zhao, Jing Zhang, Wei Li, Yun Wu, Xuemin ye, Jianliang Qin, xuwen Qiu, Haijun Liang, Jinqiang Lu, Jing'an Dong, Yifei Zhang, Tingting Xiong, Yongqiang Jiang, Wenmin Guo, Binbin China Geol Survey Guangzhou Marine Geol Survey Guangzhou 510075 Peoples R China China Geol Survey Nat Gas Hydrate Engn Technol Ctr Guangzhou 510075 Peoples R China Southern Marine Sci & Engn Guangdong Lab Guangzho Guangzhou 511458 Peoples R China Chinese Acad Sci Guangzhou Inst Geochem State Key Lab Organ Geochem Guangzhou 510640 Peoples R China

Research on the origin and source of hydrate-bound gas and its relationship to deep conventional oil and gas accumulation in a basin is critical to understanding the accumulation mechanism of gas hydrates and to resource evaluation of gas hydrate accumulation. In this study, the hydrate-bound gas obtained via pressure coring and the production gas recovered during a production test on a gas hydrate reservoir in the Shenhu area offshore of Southern China were tested and discussed. The geochemical analysis results indicate that methane is the predominant gas, and heavier hydrocarbons (C2+) are also present but in low concentrations. The molecular compositions of the hydrate gas recovered from two production test sites are similar to those of the hydrate-bound gas acquired via pressure coring. In addition to the isotopic composition of the methane, the carbon and hydrogen isotopes of the C2+ hydrocarbons were obtained for the first time. The delta C-13 isotopes of the methane range from -66.6 parts per thousand to -46.2 parts per thousand, indicating that the hydrate-bound gases have a mixed origin, containing both biogenic and thermogenic gases. The plot of delta C-13(1) versus delta C-13(2) suggests that the biogenic and thermogenic hydrocarbons were derived from marine organic matter and terrestrial organic matter, respectively. The isotopic characterization of the hydrate-bound gas reveals that the thermogenic hydrate gas contains both humic-type gas and sapropel-type gas, but the sapropel-type gas is predominant. The source rocks of the thermogenic hydrate gas are interpreted to be both the gas-prone coal measure strata of the Enping Formation and the oil-prone medium-deep lacustrine strata of the Wenchang Formation, the latter of which contributed more to the hydrocarbon supply of the gas hydrates. In addition, the maturity of the source rocks of the thermogenic hydrate gas may be lower than that of the deeply buried conventional hydrocarbons discovered in the Ba

关键词： Gas hydrates Pressure core Production test Hydrate-bound gas Source rocks Migration Shenhu area Northern South China Sea

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Magnetic dispersive solid-phase extraction for the determination of three different glycosides in the Kang'ai injection

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MICROCHEMICAL JOURNAL 2019年 146卷 575-581页

作者： Li, Peng ye, Junfeng Zhang, Yue Wang, Ziqi Ren, Sujuan Jin, Yongri Li, xuwen Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Jilin Univ Hosp 1 Changchun 130012 Jilin Peoples R China

In this work, the content of flavonoid glycosides and astragalosides in a Chinese medicine injection was determined by using the magnetic dispersive solid phase extraction method coupled with high performance liquid chromatography with an evaporative light-scattering detector (HPLC/ELSD). Multi-walled carbon nanotubes (MWCNTs) modified by Fe3O4 nanoparticles obtained in a one-step synthetic procedure, were used as a sorbent to conveniently remove the analytes from water. Single factor experiments were performed to investigate the factors that affected the extraction efficiency, such as the hydroxyl content of the modified MWCNTs, the amount of sorbent, the type of elution solvent, the volume of elution solvent, sample pH and salting-out effect. Under the appropriate optimal conditions, the limits of detection (LODs) and limits of quantification (LOQs) for the three glycosides ranged from 0.16 mu g/mL to 0.60 mu g/mL and 0.58 mu g/mL to 1.24 mu g/mL, respectively. Moreover, the intra- and interday precision ranged from 1.9% to 2.9% and 2.4% to 4.5%, respectively. Meanwhile, the recoveries of spiked samples were measured, which ranged from 91.1% to 96.2% with relative standard deviations (RSDs) ranging from 2.8% to 3.8%. Accordingly, the application of the proposed method for the analysis of Chinese medicine injection samples offered several advantages: an acceptable precision, low LODs and good recoveries. This work might provide a research basis for the quality control of Chinese medicine injections and the further study of the Kang'ai injection.

关键词： Dispersive solid phase extraction Evaporative light-scattering detector Kang'ai injection

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Comparison and analysis of fecal components in Blaptica dubia and Blatta lateralis

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分子科学学报 2024年第6期40卷 546-551页

作者： ZHOU Jie LIU xuwen ye Dongyan LI Qianhui YIN Shuren ZHANG Suyi ZHOU Zhihan WANG Jing LIU Lijuan BAI Helong College of Chemistry Changchun Normal UniversityChangchun 130032China Technical Innovation Laboratory for Research and Development of Economic Plants and Edible Mushroomsand Medicinal Mushrooms in Cold Regions of Jilin ProvinceChangchun 130032China Changchun Guoxin Modern Agricultural Science and Technology Development Co. Ltd.Changchun 130600China

The fecal components of Blaptica dubia and Blatta lateralis were analyzed and characterized using solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)to explore can-didate compounds mediating their aggregation *** results revealed that hydrocarbons and alde-hydes accounted for the majority of the 85 components detected in the fecula of ***,with hexadecane(6.721%)and tetradecanal(6.555%)as the most *** the fecula of ***,esters and hy-drocarbons accounted for the majority of the 93 identified components,with 3-phenylpropionic acid methyl ester(10.020%)and 2,7-dioxa-tricyclo[4.4.0.0(3,8)]deca-4,9-diene(3.604%)hexadecane(2.504%)*** fecal compositions of the two cockroach species exhibited similarities,with seven common substances identified out of a total of *** relative percentages of these common components in the fecula were 68.516%for *** and 53.541%for ***.

关键词： Blaptica dubia Blatta lateralis fecal component SPME-GC-MS aggregation pheromone

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The response of temperature and pressure of hydrate reservoirs in the first gas hydrate production test in South China Sea

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APPLIED ENERGY 2020年 278卷 115649-115649页

作者： Qin, xuwen Liang, Qianyong ye, Jianliang Yang, Lin Qiu, Haijun Xie, Wenwei Liang, Jinqiang Lu, Jin'an Lu, Cheng Lu, Hailong Ma, Baojin Kuang, Zenggui Wei, Jiangong Lu, Hongfeng Kou, Beibei China Geol Survey Guangzhou Marine Geol Survey Guangzhou 510075 Peoples R China China Geol Survey Gas Hydrate Engn Technol Ctr Guangzhou 510075 Peoples R China China Acad Geol Sci Inst Explorat Tech Langfang 065000 Peoples R China China Geol Survey Ctr Oil & Nat Gas Resource Explorat Beijing 100083 Peoples R China Peking Univ Beijing 100871 Peoples R China CNPC Offshore Engn Co Ltd Beijing 100102 Peoples R China

The first offshore natural gas hydrate production test of China in 2017 has proved the feasibility of hydrate exploitation from clayey-silt reservoirs, which possesses the highest reservoirs than other types of hydrate resources. However, owing to the absence of monitoring wells in this production test, the hydrate dissociation behavior cannot be analyzed through pressure and temperature changes of hydrate reservoirs. This paper focuses on the simulation study on the detailed response of the temperature and pore pressure of hydrate reservoirs of Well SHSC-4 during the gas production by depressurization. Meanwhile, it highlights the analysis of favorable areas for the formation of secondary hydrates and the influence of the secondary hydrates on pressure and temperature field of hydrate reservoirs. The simulation results indicate that in the first 60 days, the hydrate reservoirs feature a dissociation radius of about 5 m, and the gas production from hydrate dissociation accounts for about 85%. After 1 year, 2 years and 5 years of hydrate exploitation, the influence radius of low-pressure area (<10 MPa) is 15 m, 16 m and 17 m, respectively, suggesting that the hydrate reservoirs have higher gas production efficiency in the first year. Furthermore, the temperature and pressure of hydrate reservoirs are not favorable to the formation of secondary hydrates in the first 60 days. In long-term production, secondary hydrates are mainly formed at hydrate dissociation front. This can increase the pore pressure and further decrease the effective stress in the local areas of hydrate reservoirs, thus affecting mechanical stability of the local hydrate reservoirs.

关键词： Marine gas hydrate Temperature response Pore pressure response Depressurization production Secondary hydrate

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^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值:Meta分析

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国际医学放射学杂志 2022年第4期45卷 414-419页

作者：张慈慈段丽霞刘雅慧欧志强叶郭锡曾旭文广州市红十字会医院放射科广州510220

目的系统评价^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值。方法检索PubMed、EMbase、Cochrane Library、中国知网、万方数据、维普数据库从2010年1月—2020年5月公开发表的关于^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的中英... 详细信息

目的系统评价^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值。方法检索PubMed、EMbase、Cochrane Library、中国知网、万方数据、维普数据库从2010年1月—2020年5月公开发表的关于^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的中英文文献,根据纳入、排除标准筛选并提取数据,采用诊断准确性研究质量评价工具-2(QUADAS-2)评价纳入文献质量,应用Meta-Disc 1.4软件进行分析。采用不一致指数(I2)和Cochran-Q检验进行异质性分析,并计算合并敏感度、特异度、阳性似然比、阴性似然比及相应95%CI,绘制汇总受试者操作特征(SROC)曲线并计算曲线下面积(AUC)。采用阈值效应和亚组分析探讨异质性的来源。亚组分析根据研究类型、原发肿瘤类型、是否合并有增强MRI进行分组分析。结果共纳入25篇文献,包括1347例肿瘤病人,^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的合并敏感度、特异度、阳性似然比、阴性似然比、AUC值分别为0.85(95%CI:0.81~0.88)、0.92(95%CI:0.90~0.93)、6.63(95%CI:4.50~9.79)、0.22(95%CI:0.16~0.29)、0.92。亚组分析结果显示,前瞻性研究中的^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断效能高于回顾性研究,AUC值分别为0.92、0.88;无增强MRI的研究诊断效能高于有增强MRI的研究,AUC值分别为0.93、0.91;^(18)F-FDG PET/MRI对胃肠癌淋巴结转移的诊断效能最高,其次为宫颈癌、肺癌、乳腺癌,AUC值分别为0.96、0.95、0.93、0.90。结论^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移具有较高的诊断价值。

关键词：恶性肿瘤淋巴结转移正电子发射计算机体层成像磁共振成像 Meta分析

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The impact of radiotherapy on the prognosis of metastatic clear cell renal cell carcinoma after surgery

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Scientific Reports 2025年第1期15卷 1-11页

作者： Li, xuwen Tan, Zhongyu Zhu, Yihao Zhai, Yabo Chen, Can Wang, Dong Wang, Mingshuai Xing, Nianzeng Yang, Feiya ye, Xiongjun Department of Urology National Cancer Center National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China First Clinical Medical College Nanchang University Nanchang China Zunyi Medical University Zunyi China

Clear cell renal cell carcinoma, one of the most common types of renal cell carcinoma, has been increasing in incidence year by year. This study aims to investigate the impact of radiotherapy on the prognosis of patients with metastatic clear cell renal cell carcinoma (mccRCC) undergoing cytoreductive surgery. Clinical data of patients with mccRCC who underwent cytoreductive surgery were collected from the SEER database (2000–2021). This study employed propensity score matching (PSM) and R software to evaluate the overall survival (OS) of radiotherapy. Univariate and multivariate COX regression analyses were conducted to explore the impact of different variables on prognosis. Finally, a nomogram was developed to predict patient survival rates. A total of 2076 patients with mccRCC who underwent cytoreductive surgery were included in this study, with 538 (25.92%) in the radiotherapy group and 1539 (74.08%) in the non-radiotherapy group. After propensity score matching (PSM), there were 300 cases in each group. Kaplan-Meier values and the Cox proportional hazards model were used to plot the overall survival (OS) curves, which showed that the median survival time in the radiotherapy group was significantly lower than that in the non-radiotherapy group. Additionally, multivariate Cox regression analysis revealed that tumor grade, N stage, radiotherapy, lung metastasis, and liver metastasis were independent factors affecting the prognosis of patients with mccRCC undergoing cytoreductive surgery. Lastly, a nomogram was developed to estimate the survival rates of patients with mccRCC after cytoreductive surgery. Radiotherapy after cytoreductive surgery may have an adverse impact on the prognosis of patients with mccRCC. © The Author(s) 2025.

关键词： Metastatic clear cell renal cell carcinoma Overall survival Propensity score matching Radiotherapy Surgery

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Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations

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JOURNAL OF CHEMICAL INFORMATION AND MODELING 2019年第2期59卷 842-857页

作者： Jin, ye Duan, Mojie Wang, xuwen Kong, Xiaotian Zhou, Wenfang Sun, Huiyong Liu, Hui Li, Dan Yu, Huidong Li, Youyong Hou, Tingjun Soochow Univ Inst Funct Nano & Soft Mat FUNSOM Suzhou 215123 Jiangsu Peoples R China Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Chinese Acad Sci Key Lab Magnet Resonance Biol Syst State Key Lab Magnet Resonance & Atom & Mol Phys Natl Ctr Magnet Resonance WuhanWuhan Inst Phys & Wuhan 430071 Peoples R China Rongene Pharma Co Ltd Shenzhen 518054 Guangdong Peoples R China

Androgen receptor (AR), as a member of the nuclear receptor (NR) superfamily, regulates the gene transcription in response to the sequential binding of diverse agonists and coactivators. Great progress has been made in studies on the pharmacology and structure of AR, but the atomic level mechanism of the bidirectional communications between the ligand-binding pocket (LBP) and the activation function-2 (AF2) region of AR remains poorly understood. Therefore, in this study, molecular dynamics (MD) simulations and free energy calculations were carried out to explore the interactions among water, agonist (DHT) or antagonist (HFT), AR, and coactivator (SRC3). Upon the binding of an agonist (DHT) or antagonist (HFT), the LBP structure would transform to the agonistic or antagonistic state, and the conformational changes of the LBP would regulate the structure of the AF2 surface. As a result, the binding of the androgen DHT could promote the recruitment of the coactivator SRC3 to the AF2, and on the contrary, the binding of the antagonist HFT would induce a perturbation to the shape of the AF2 and then weaken its accommodating capability of the coactivators with the LXXLL motif. The simulation results illustrated that the DHT-AR binding affinity was enhanced by the association of the coactivator SRC3, which would reduce the conformational fluctuation of the AR-LBD and expand the size of the AR LBP. On the other hand, the coactivator-to-HFT allosteric pathway, which involves the SRC3, helix 3 (H3), helix 4 (H4), the loop (L1-3) between helix 1 (H1) and H3, and HFT, was characterized. The HFT's skewness and different interactions between HFT and the LBP were observed in the SRC3-present AR The mutual communications between the AF2 surface and LBP, together with the processes involving the interplay of the ligand binding and coactivator recruitment events, would help in understanding the association of coactivators and rationally develop potent drugs to inhibit the activity o

关键词： Free energy Peptides and proteins Ligands Chemical structure Receptors

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