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Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials

BMC CARDIOVASCULAR DISORDERS 2024年第1期24卷 592页

作者： Xu, Jiayi Xiang, Luwei yin, xuwen Song, Haiyan Chen, Chen Yang, Bei Ye, Hongfang Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing 138 Xianlin Rd Nanjing 210023 Jiangsu Peoples R China Nanjing Med Univ Sch Nursing 101 Longmian Rd Nanjing 211166 Jiangsu Peoples R China Nanjing Drum Tower Hosp Dept Nursing 123 Zhongshan Rd Nanjing 210008 Jiangsu Peoples R China Nanjing Med Univ Affiliated Hosp 1 Jiangsu Prov Hosp Dept Nursing 300 Guangzhou Rd Nanjing 210029 Jiangsu Peoples R China Soochow Univ Suzhou Med Coll 199 Renai Rd Suzhou 215123 Jiangsu Peoples R China

Background The effectiveness and adverse effects of coenzyme Q10 for heart failure remain unclear owing to small sample sizes and variations in the quality of existing studies in literature. Methods The databases of EMBASE, PubMed, Web of Science, CINAHL databases, Scopus, Cochrane Central Register of Controlled Trials, VIP, Wanfang, and CNKI were searched for randomized controlled trials on the coenzyme Q10-assisted treatment of heart failure. Relevant literature was retrieved, data were extracted, and the risk of bias of the included studies was evaluated by two investigators independently using the Review Manager 5.4 software and the STATA 15 software. Results In total, 33 studies were included in this meta-analysis, which showed that all-cause mortality [RR = 0.64, 95% CI (0.48, 0.85), P = 0.002;GRADE: moderate quality], hospitalization for heart failure [RR = 0.50, 95% CI (0.37, 0.67), P < 0.00001;GRADE: moderate quality], New York Heart Association classification [MD = - 0.29, 95% CI (- 0.39, - 0.19), P < 0.00001;GRADE: low quality], and brain natriuretic peptide level [MD = - 91.97, 95% CI (- 103.11, - 80.83), P < 0.00001;GRADE: low quality] were lower in the coenzyme Q10 group than in the control group. Meanwhile, left ventricular ejection fraction [MD = 0.51, 95% CI (0.31, 0.71), P < 0.00001;GRADE: low quality] and 6-min walk test result [MD = 31.70, 95% CI (19.96, 43.43), P < 0.00001;GRADE: moderate quality] were better than those in the control group. Conclusions According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and brain natriuretic peptide level and improves left ventricular ejection fraction and 6-min walk test result in those with heart failure without major adverse effects. Trial registration This study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, http://***/prospero), with the

关键词： Heart failure Safety outcomes Coenzyme Q10 Meta analysis Randomized controlled trial

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Study of Wall Strain during LaNi5Alloy's Hydrogen Absorption/Desorption Process

Study of Wall Strain during LaNi5Alloy's Hydrogen Absorption...

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2022 International Conference on Energy and Power Engineering, EPE 2022

作者： yin, xuwen Cao, Shuaijie Yang, Fusheng Imin, Rahmatjan School of Mechanical Engineering Xinjiang University Xinjiang Urumqi830017 China School of Chemical Engineering and Technology Xi'an Jiaotong University Shanxi Xi'an710049 China School of Mathematics and Systems Science Xinjiang University Xinjiang Urumqi830017 China

An experimental LaNi5 alloy's hydrogen absorption/desorption system was established to explore the strain generation process mechanism on the reactor wall during the cyclic hydrogen absorption/desorption process of LaNi5 alloy powders at room temperature after different cycles and periods. On this basis, the influence of the hydrogen pressure on the wall strain of the reactor was verified. Results showed that with the increase in cycles, the reactor wall was subjected to an expansion strain, and the closer to the reactor bottom, the greater the strain value. As the hydrogen pressure grew from 3.0 to 4.0 MPa, the strain value at the reactor bottom increased obviously. Still, it did not grow during cycling experiments with hydrogen, indicating that the agglomeration phenomenon was mainly attributed to the pulverization effect after hydrogen absorption by the alloy instead of the gas pressure itself. After 24 cyclic reactions, the wall strain at the 1/5 position from the bottom experienced changes in growth laws since the thermal strain was not enough to influence the expansion strain triggered by agglomeration, and the closer to the reactor top, the more greatly the wall strain was influenced by reaction heat. © Published under licence by IOP Publishing Ltd.

关键词： Binary alloys

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Tunable band gaps and high carrier mobilities in germanene by Si doping in the presence of an external electric field: Field effect transistors

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PHYSICA B-CONDENSED MATTER 2024年 682卷

作者： Xiao, Meixia yin, xuwen Song, Haiyang Lv, ying Xiao, Beibei Xian Shiyou Univ Coll New Energy Xian 710065 Peoples R China Xian Shiyou Univ Sch Mat Sci & Engn Xian 710065 Peoples R China Jiangsu Univ Sci & Technol Sch Energy & Power Engn Zhenjiang 212003 Peoples R China

We have systematically investigated the electronic properties of Si doping germanene under external electric fields by the first-principle calculations. The results show that a wide range of linearly tunable and sizable direct band gaps for the Ge31Si1 and Ge28Si4 systems (3-1048 meV and 6-716 meV) are merely determined by the strength of the electric field. More importantly, the high carrier mobilities of the stable Ge31Si1 and Ge28Si4 systems are largely retained under external electric field. The mechanism of charge transfer confirms the p-type semiconductor properties in the Si doping germanene systems. These results indicate that the electronic properties of Si doping germanene can be effectively modulated under the external electric field, providing a potential application in novel electronic devices, such as Field effect transistors.

关键词： Germanene Doping External electric field Band gaps High carrier mobilities

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A Cross-Sectional Study of the Practice of Orthopedic Specialty Nursing in Hospitals in Jiangsu Province

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JOURNAL OF MULTIDISCIPLINARY HEALTHCARE 2025年 18卷 2481-2495页

作者： Song, Haiyan yin, xuwen Xu, Jiayi Yang, Jing Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing Nanjing Peoples R China Soochow Univ Suzhou Med Coll Suzhou Peoples R China Nanjing Med Univ Affiliated Hosp 1 Jiangsu Prov Hosp Dept Nursing 300 Guangzhou Rd Nanjing 210029 Jiangsu Peoples R China

Purpose: To evaluate the development status of orthopedic specialty nursing in hospitals in Jiangsu Province in China. Patients and Methods: This cross-sectional study was conducted from August to September 2024 in the orthopedics departments of secondary and tertiary hospitals in Jiangsu Province, China. Data were collected using a self-designed questionnaire administered through the online platform Wenjuan Xing. Moreover, data on specialty nursing techniques and specialty quality indicators were collected. The Pearson's chi-square test and Mann-Whitney U-test were used to identify the differences between the different types and sizes of hospitals. Results: Data analysis involved 229 hospitals. Nurse-led clinics (8.30%) were the least used format of orthopedic specialty nursing, and there were significant differences in different sizes of hospitals (P<0.001). The most commonly implemented specialty nursing technique was coordination and nursing of bone traction (79.23%). Concerning the measures to guarantee the quality of specialty nursing, the nursing ward round was the most common, and there were significant differences in different sizes of hospitals about "specialty nursing goals or evaluation indicators to be developed" (P<0.001). 88.21% of the hospitals regularly provided specialized nursing training to nurses, and only 29.26% of hospitals set up specialist nurse positions. Only 90.83% of hospitals regularly monitored, analyzed, and there were significant differences in the improvement of quality through "clinical research" in hospitals of different sizes (P<0.001). Specialty nursing activities conducted by nurses were mainly related to performance assessment (73.80%). The standardized prevention rate of venous thromboembolism (62.31%) was the most frequently used indicator. Concerning obstacles to implementing orthopedic specialty nursing, 82.53% of the orthopedic departments expressed dissatisfaction over a lack of nurses. Conclusion: Hospital managers and

关键词： orthopedic current situation specialty nursing hospitals

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NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STRAIN DISTRIBUTION OF VERTICALLY PLACED METAL HYDRIDE BASED HYDROGEN STORAGE CONTAINER 23

NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STR...

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23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022

作者： Cao, Shuaijie yin, xuwen Yang, Fusheng Jiang, Lijun Wu, Yuanfang Wu, Zhen Zhang, Zaoxiao Xi'an Jiaotong University School of Chemical Engineering and Technology Shaanxi Xi'an China Xinjiang University School of Mechanical Engineering Xinjiang Uygur Autonomous Regions Urumqi China Co. LTD Beijing China

ISBN: (纸本)9786250008430

Pulverization, settling and agglomeration, and the consequent densification may occur for metal hydride particles during the charge-discharge cycles, which will affect the wall strain of their container for hydrogen storage. In order to study the effects of different factors on the wall strain of metal hydride hydrogen storage vessel, a reaction-thermal-mechanical coupling model for LaNi5 alloy was modified with regard to some relevant parameters, by which sensitivity analysis was conducted. Finally, the strain distribution along the height of reactor filling Mg2Ni was predicted by the model and compared with experimental results reported in literature. © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.

关键词： Hydrogen storage

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Tunable Band Gaps and High Carrier Mobilities in Germanene by Si Doping in the Presence of an External Electric Field: Field Effect Transistors

SSRN

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SSRN 2023年

作者： Xiao, Meixia yin, xuwen Song, Haiyang Lv, ying Xiao, Beibei College of New Energy Xi′an Shiyou University Xi′an710065 China School of Materials Science and Engineering Xi′an Shiyou University Xi′an710065 China School of Energy and Power Engineering Jiangsu University of Science and Technology Zhenjiang212003 China

We have systematically investigated the electronic properties of Si doping germanene under external electric fields by the first-principle calculations. The results show that a wide range of linearly tunable and sizable direct band gaps for the Ge31Si1 and Ge28Si4 systems (3~1048 meV and 6~716 meV) are merely determined by the strength of the electric field. More importantly, the high carrier mobilities of the stable Ge31Si1 and Ge28Si4 systems are largely retained under external electric field. The mechanism of charge transfer confirms the p-type semiconductor properties in the Si doping germanene systems. These results indicate that the electronic properties of Si doping germanene can be effectively modulated under the external electric field, providing a potential application in novel electronic devices, such as Field effect transistors. © 2023, The Authors. All rights reserved.

关键词： Energy gap

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Enantioselective Reductive (Hetero)Arylation of Cyclic N-Sulfonyl Imines by Cobalt Catalysis

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023年第19期62卷 e202300743-e202300743页

作者： Xiao, Jieshuai Wang, Minyan yin, xuwen Yang, Shuo Gu, Pei Lv, Xueli Zhao, Yue Shi, Zhuangzhi Nanjing Univ Chem & Biomed Innovat Ctr ChemBIC Sch Chem & Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Peoples R China Yangzhou Univ Coll Chem & Chem Engn Yangzhou 225002 Peoples R China Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

Transition-metal-catalyzed enantioselective addition of aryl organometallic reagents to imines has emerged as one of the most powerful tools for the formation of optically active diarylmethylamines. Here, we report the first asymmetric reductive (hetero)arylations of imines using aryl and heteroaryl halides enabled by a chiral cobalt-bisphosphine catalyst. This approach shows good functional group compatibility and complements the reported strategy without use of organometallic reagents. Mechanistic investigations supported that aryl-cobalt, instead of an arylzinc reagent, was formed in situ in this reductive aryl-addition event.

关键词： Addition Arylation Cobalt Enantioselectivity Imines

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国家通用语言文字教育教学与铸牢中华民族共同体意识协同共进研究

语言与文化研究

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语言与文化研究 2024年第6期32卷 107-110页

作者：宋娇娇尹绪文席楷轩新疆理工学院阿克苏843000

国家通用语言文字承载着中华文化的语言符号系统,推广与普及国家通用语言文字是铸牢中华民族共同体意识的必然要求。高校作为师生双向沟通交流的共同场域,要充分发挥课堂教学“主渠道”的作用,从宏观到微观深入构建国家通用语言文字教... 详细信息

国家通用语言文字承载着中华文化的语言符号系统,推广与普及国家通用语言文字是铸牢中华民族共同体意识的必然要求。高校作为师生双向沟通交流的共同场域,要充分发挥课堂教学“主渠道”的作用,从宏观到微观深入构建国家通用语言文字教育教学模式,促进学生自觉规范地运用国家通用语言文字,培育各族学生厚植中华民族情感。鉴于此,本文以新疆理工学院为例,将在铸牢中华民族共同体意识融入国家通用语言文字教育教学的实践做法基础上,探讨分析其面临的困境并提出对策建议,从而实现国家通用语言文字教育教学与铸牢中华民族共同体意识之间的有效协同与融合发展。

关键词：新建高校国家通用语言文字共同体意识协同共进

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慢性心力衰竭患者居家液体摄入管理影响因素的质性研究

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护理学杂志 2025年第5期40卷 94-98页

作者：鲁欢欢徐苏梦杨静徐冬梅周媛宋海燕殷徐雯顾则娟南京医科大学护理学院江苏南京211166 南京中医药大学护理学院南京医科大学第一附属医院

目的探讨居家慢性心力衰竭患者居家液体摄入管理影响因素,为制订居家干预方案提供参考。方法采用描述性质性研究,基于Pender健康促进模式,对20例慢性心力衰竭出院患者进行半结构式访谈,采用内容分析法进行资料分析、主题提练。结果提炼... 详细信息

目的探讨居家慢性心力衰竭患者居家液体摄入管理影响因素,为制订居家干预方案提供参考。方法采用描述性质性研究,基于Pender健康促进模式,对20例慢性心力衰竭出院患者进行半结构式访谈,采用内容分析法进行资料分析、主题提练。结果提炼2个主题及8个亚主题,促进因素为感知液体管理益处,参与主动健康行为,积极发挥自我效能,自护时间投入增加;障碍因素为居家应对行为不佳,记忆力减退,消极认知与延迟就医,内外部支持削弱。结论引导慢性心力衰竭患者树立正确液体摄入管理认知,激励居家患者发挥自我效能,落实居家液体摄入管理,同时加强“医院-社区-家庭”联动,持续追踪患者疾病轨迹。

关键词：慢性心力衰竭居家液体摄入管理决定因素 Pender健康促进模式质性研究

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Effect of a closed-loop medication order executive system on safe medication administration at a tertiary hospital: a quasi-experimental study

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THERAPEUTIC ADVANCES IN DRUG SAFETY 2024年 15卷

作者： yin, xuwen Song, Haiyan Lu, Jieyu Yang, Jing Wang, Rong Lin, Zheng Jiang, Shudi Yuan, Hui Wang, Xumei Xu, Dongmei Gao, Chunhong Zhou, Yuan Xu, Jiayi Chen, Chen Gu, Chenyu Diao, Qingqing Li, Fang Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Sch Nursing Nanjing Peoples R China

Background: Closed-loop electronic medication management systems are effective measures for preventing medication errors (MEs). However, there is limited evidence supporting this, and few studies have evaluated the long-term effects of these systems on safe medication. Objective: To evaluate the long-term effects of implementing a closed-loop medication order executive system on the safe clinical use of medications. Design: A quasi-experimental design. Method: Data from 2017 to 2023 were extracted and retrospectively analyzed. The primary outcome indicator was the ME rate. Secondary outcome indicators were the accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing. The autoregressive integrated moving average (ARIMA) model in time-series analysis was used to evaluate the level and trend changes in ME rates using SPSS 25.0 before and after system implementation. Root cause analysis and descriptive statistics were used to assess changes in types, stages, and causes of ME rates. The independent samples t-test was used to analyze secondary outcomes. Results: Overall, 295 MEs were reported with a mean of 0.26 +/- 0.26 ME rates per month during 2017-2023. The ARIMA model showed a decrease in the average level of ME rates after system implementation, with no statistically significant decrease in the long term, and a significant drop in the ME rate in the short and medium term (p < 0.01). Nurses' administration accounted for more than 60% of errors post-implementation, and lack of communication was a prominent factor. The accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing all increased after implementation. Conclusion: Adopting a closed-loop executive system is beneficial for ensuring patient medication safety, but a single integrated system does not completely eliminate MEs. Optimizing system functionalities and applying structured handoff tools are r

关键词： closed-loop electronic medication management system medication error patient safety

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