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Decreased intestinal abundance of Akkermansia muciniphila is associated with metabolic disorders among people living with HIV

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ANNALS OF MEDICINE 2025年第1期57卷 2474730页

作者： Qian, Zhe Chen, Suling Liao, Xiaoyang Xie, Jingfang Xu, Yuyuan zhong, Huiqun Ou, Lang Zuo, Xiang Xu, xuwen Peng, Jie Wu, Jian Cai, Shaohang Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Elderly Resp 2 Guangzhou 510030 Peoples R China Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Geriatr Guangzhou Peoples R China Univ South China Affiliated Nanhua Hosp Dept Hepatobiliary Surg Hengyang Peoples R China Southern Med Univ Nanfang Hosp Dept Gen Surg Div Hepatobiliopancreat Surg Guangzhou Peoples R China South China Univ Technol Sch Med Guangzhou Peoples R China

BackgroundPrevious studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic *** total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. Akkermansia abundance in stool samples was measured using RT-qPCR, and Pearson correlation and logistic regression were applied for *** sequencing revealed a significant decline in gut Akkermansia abundance in PLWHIV with NAFLD. STAMP analysis of public datasets confirmed this decline after HIV infection, while KEGG pathway analysis identified enrichment of metabolism-related genes. A prospective cohort study with 103 PLWHIV followed for 48 weeks validated these findings. Akkermansia abundance was significantly lower in participants with NAFLD, overweight, and hyperlipidemia at baseline, and it emerged as an independent predictor of NAFLD and overweight. Negative correlations were observed between Akkermansia abundance and both CAP values and body mass index (BMI) at baseline and at week 48. At the 48-week follow-up, Akkermansia remained a predictive marker for *** abundance was reduced in PLWHIV with metabolic disorders and served as a predictive biomarker for NAFLD progression over 48 weeks of ART.

关键词： HIV gut microbiota metabolic diseases NAFLD overweight Akkermansia muciniphila

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Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-12页

作者： Chen, Xiong Zhu, Dongxi Li, Chenchen Lin, Yi Lv, Lin Ai, Feiling Chen, Zhijian Shen, Runnan Shen, xuwen You, Guochang Jiang, Zhige zhong, Wenlong Lin, Tianxin Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Urol Guangzhou Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangdong Hong Kong Joint Lab RNA Med Guangzhou Guangdong Peoples R China Guangdong Prov Clin Res Ctr Urol Dis Guangzhou Peoples R China Sun Yat Sen Univ Affiliated Hosp 6 Dept Med Oncol Guangzhou Peoples R China Sun Yat Sen Univ Sch Med Guangzhou Peoples R China Ludwig Maximilian Univ Munich Fac Med Munich Germany

BackgroundModifiable factors affect cancer's survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different *** this prospective cohort study, we analyzed national data from the UK Biobank, including 121,399 participants, to assess the association of modifiable factors with cancer-specific survival (CSS) in two independent cohorts: a pre-cancer cohort (n = 78,027) and a post-cancer cohort (n = 43,372). Additionally, a weighted standardized score was derived to evaluate the joint effects across different domains. Interactions between the six domains and age at diagnosis, sex, and cancer site were evaluated using likelihood ratio tests. Subgroup analyses were then performed for factors showing significant effect modification. Population-attributable fractions (PAF) of different domains on 5-year cancer-specific death were *** study comprehensively presented the differential patterns of modifiable factors' impact on CSS among pre-cancer and post-cancer cohorts, sexes and different cancer sites. In the pre-cancer cohort, CSS were predominantly attributable to smoking/alcohol consumption (PAF 92%) and daily activity (PAF 106%). Men exhibited a higher risk than women for dietary habits (HR:125 versus 118), daily activity (HR:150 versus 129) and living environment (HR:113 versus 103). The impact of modifiable factors, including daily activity, smoking/alcohol consumption, and physical measures, on CSS varied across different cancer sites. In the post-cancer cohort, 186% of 5-year cancer-specific deaths were attributable to unfavourable mental health. In subgroup analysis, the risk of CSS in the domain of smoking/alcohol consumption was higher in men than that in women (HR: 158 versus 134). The impact of modi

关键词： Cancer-specific survival Modifiable factor Population-attributable fractions

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Design of a new scintillator-based fast ion loss detector on the HL-2A tokamak

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JOURNAL OF INSTRUMENTATION 2024年第10期19卷 P10013-P10013页

作者： Han, Yuxiao Xie, Jinlin Zhang, Jie He, Xiaofei Wang, Yongqing Liu, Linzi Xu, Hongbing Zhan, xuwen Liu, Kuancheng Zhang, Yipo Shi, zhongbing Chen, Wei zhong, Wulv Xu, Min Zhuang, Gea Univ Sci & Technol China Dept Plasma Phys & Fus Engn Hefei Anhui Peoples R China Southwestern Inst Phys Chengdu Sichuan Peoples R China

A new scintillator-based fast ion loss detector (FILD) has been devised for the HL-2A tokamak, with the objective of discerning the temporal evolution of energy and pitch angle among lost fast ions. A code named FILD Simulation (FSC) has been developed to assist in the design of the detector head and the interpretation of experimental data. By optimising the geometric design, the resolutions of energy and pitch angle are optimised to 5 keV and 3 degrees, respectively. A branched imaging fiber bundle is used to relay the fluorescence image on the scintillator to two distinct instruments. One of these is a high-speed camera, while the other is a silicon photomultiplier tube (SiPM) array with a sampling rate of up to 1 MSamples/s. This configuration enables the attainment of superior temporal and spatial resolution, as well as high photon sensitivity.

关键词： Nuclear instruments and methods for hot plasma diagnostics Plasma diagnostics- high speed photography Plasma diagnostics- probes Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators)

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Analog Beamforming Enabled Multicasting: Finite-Alphabet Inputs and Statistical CSI

arXiv

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arXiv 2024年

作者： Wu, Yanjun Xie, zhong Xie, Zhuochen Ouyang, Chongjun Liang, xuwen The Innovation Academy for Microsatellites Chinese Academy of Science Shanghai201304 China The Key Lab for Satellite Digitalization Technology Chinese Academy of Science Shanghai201210 China University of Chinese Academy of Sciences Beijing100049 China The Shanghai Engineering Center for Microsatellites Shanghai201210 China ShanghaiTech University Shanghai201210 China The National Space Science Center Chinese Academy of Sciences Beijing100190 China The School of Electrical and Electronic Engineering College of Engineering and Architecture University College Dublin DublinD04 V1W8 Ireland

The average multicast rate (AMR) is analyzed in a multicast channel utilizing analog beamforming with finite-alphabet inputs, considering statistical channel state information (CSI). New expressions for the AMR are derived for non-cooperative and cooperative multicasting scenarios. Asymptotic analyses are conducted in the high signal-to-noise ratio regime to derive the array gain and diversity order. It is proved that the analog beamformer influences the AMR through its array gain, leading to the proposal of efficient beamforming algorithms aimed at maximizing the array gain to enhance the AMR. © 2024, CC BY.

关键词： Multicasting

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Discovery of 5-Nitro-N-(3-(trifluoromethyl)phenyl) Pyridin-2-amine as a Novel Pure Androgen Receptor Antagonist against Antiandrogen Resistance

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JOURNAL OF MEDICINAL CHEMISTRY 2024年第22期67卷 20514-20530页

作者： Wang, Huating Wang, xuwen zhong, Haiyang Cai, Lvtao Fu, Weitao Chai, Xin Liao, Jianing Sheng, Rong Shan, Luhu Xu, Xiaohong Xu, Lei Pan, Peichen Hou, Tingjun Li, Dan Zhejiang Univ Coll Pharmaceut Sci State Key Lab Adv Drug Delivery & Release Syst Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ Jinhua Inst Jinhua 321000 Zhejiang Peoples R China Xuzhou Med Univ Jiangsu Key Lab New Drug Res & Clin Pharm Xuzhou 221004 Jiangsu Peoples R China Hefei Comprehens Natl Sci Ctr Inst Hlth & Med Hefei 230601 Anhui Peoples R China Univ Chinese Acad Sci Chinese Acad Sci Zhejiang Canc Hosp Inst Canc Res & Basic Med SciCanc Hosp Hangzhou 310022 Zhejiang Peoples R China Jiangsu Univ Technol Inst Bioinformat & Med Engn Sch Elect & Informat Engn Changzhou 213001 Jiangsu Peoples R China

The transformation of clinical androgen receptor (AR) antagonists into agonists driven by AR mutations poses a significant challenge in treating prostate cancer (PCa). Novel anti-AR therapeutics combating mutation-induced resistance are required. Herein, by combining structure-based virtual screening and biological evaluation, a high-affinity agonist E10 was first discovered. Then guided by the representative conformation of State 1 at the free energy landscape, the structural optimization of E10 was performed, and pure AR antagonists EL15 (IC50 = 0.94 mu M) and EF2 (IC50 = 0.30 mu M) were successfully identified. Both can antagonize wild-type and variant drug-resistant ARs. Therein, EF2 demonstrated potent inhibition of the AR pathway and effectively suppressed tumor growth in a C4-2B xenograft mouse model following oral administration. Further molecular dynamics simulation and mutagenesis studies revealed atomic insights into the mode of action of EF2 which may serve as a novel lead compound for developing therapeutics against AR-driven PCa.

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao Chen Jian Huang Xincheng zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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Damage imaging in composite plate by using double-turn coil omnidirectional shear-horizontal wave magnetostrictive patch transducer array

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ADVANCED COMPOSITE MATERIALS 2017年第Sup1期26卷 67-78页

作者： Liu, Zenghua zhong, xuwen Xie, Muwen Liu, Xiucheng He, Cunfu Wu, Bin Beijing Univ Technol Coll Mech Engn & Appl Elect Technol Beijing 100124 Peoples R China

A double-turn coil omnidirectional shear-horizontal wave magnetostrictive patch transducer (DC-OSH-MPT) array for imaging detection in composite plates is presented. DC-OSH-MPT parameters are optimized in order to make the transducer more suitable for imaging detection. Besides, the characteristic of the lowest shear-horizontal mode (SH0), which can be generated and received in all directions by DC-OSH-MPT bonded on composite plate, is beneficial for imaging. Due to anisotropic property of composite plates, the group velocity of SH0 mode in different azimuthal directions was experimentally measured in damage imaging. The location of simulated damage, which was a bonded circular cylinder, was estimated by DC-OSH-MPT array and ellipse imaging algorithm. The imaging results have demonstrated that DC-OSH-MPT can be considered as a spatially distributed array suitable for imaging detection in composite plates.

关键词： composite plate omnidirectional shear-horizontal wave ellipse imaging magnetostrictive patch transducer array

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基于全向性SH0模态磁致伸缩贴片型传感器阵列的铝板缺陷成像研究

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机械工程学报 2018年第14期54卷 8-15页

作者：刘增华钟栩文李欣何存富吴斌北京工业大学机械工程与应用电子技术学院北京工业大学北京市精密测控与仪器工程技术研究中心

板材在生产、运输或使用过程中易产生缺陷,影响板材的使用并造成安全隐患。采用传感器阵列成像技术能够直观、清晰地显示出缺陷的相关信息。SH0模态在铝板中传播时无频散现象,波速恒定,在对信号进行处理时,不需要考虑频散特性带来的影响... 详细信息

板材在生产、运输或使用过程中易产生缺陷,影响板材的使用并造成安全隐患。采用传感器阵列成像技术能够直观、清晰地显示出缺陷的相关信息。SH0模态在铝板中传播时无频散现象,波速恒定,在对信号进行处理时,不需要考虑频散特性带来的影响,有利于缺陷定位和成像。基于磁致伸缩换能机理,研制出一种能在板中激励接收SH波最低阶模态即SH0模态的磁致伸缩贴片型传感器,并测试其全向性。以工程中应用广泛的铝板作为研究对象,运用研制的全向性SH0模态磁致伸缩贴片型传感器布置成分布式传感器阵列。利用椭圆成像算法,实现了铝板中不同直径的模拟缺陷成像检测,探究了全向性SH0模态磁致伸缩贴片型传感器阵列的检测能力,并基于ROC曲线设定成像通用阈值,提高了缺陷成像质量。

关键词：铝板磁致伸缩贴片型传感器 SH0模态缺陷成像阈值

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Zeolite biofilm aeration filter plays a pre-nitritation role in autotrophic nitrogen removal from iron oxide red wastewater

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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2020年第12期95卷 3261-3269页

作者： Feng, Xinghui Wang, Xiaojun Wang, Ruixin Zheng, xuwen zhong, zhong Chen, Xiaozhen South China Univ Technol Sch Environm & Energy Guangzhou Peoples R China Minist Educ Key Lab Pollut Control & Ecosyst Restorat Ind Clu Guangzhou Peoples R China Hua An Biotech Co Ltd Foshan Peoples R China

BACKGROUND The completely autotrophic nitrogen removal over nitrite (CANON) system has excellent performance in treating ammonium-rich wastewater and it depends on ammonia oxidizing bacteria (AOB) working together with anammox bacteria in a reactor. Higher ammonium nitrogen loading requires higher aeration to provide sufficient dissolved oxygen (DO) for nitritation, whereas high-strength aeration in theCANON will destroy the sludge structure and inhibit the activity of anammox bacteria. The present study uses a stable pre-nitritation system to reduce a part of nitritation and also decrease aeration intensity in the CANON. RESULTS Continuous aeration to maintain the DO concentration between 1.5 and 4.3 mg L(-1)in the CANON achieved a stable nitrogen removal rate (1.22 kg N m(-3)d(-1)) from iron oxide red wastewater with 400-1016 mg N L(-1)after 183 days of operation. Using a mixed alkalinity donor [sodium carbonate (Na2CO3) and bicarbonate (NaHCO3)] in the combined system can save approximate to 14.1-28.2% of the alkalinity cost compared with using NaHCO(3)only. CONCLUSIONS A zeolite biofilm aeration filter (ZBAF) used in a pre-nitritation process can tolerate high DO concentration of <= 6.5 mg L(-1)for nitritation and avoid all of the nitritation taking place in the CANON system. This can protect the sludge structure and anammox bacteria from high-strength aeration erosion. (c) 2020 Society of Chemical Industry

关键词： pre-nitritation zeolite dissolved oxygen control Anammox granular sludge

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Interfacial modification of recombinant protein for immunoglobulin G adsorption with spindle-shaped MOF as nano molecular containers

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TALANTA 2024年 280卷 126535页

作者： Wang, Kai Zhang, Hongjin Jin, Nishan Zhou, Yutian Guo, Xinli zhong, Wenbin Li, Xin Li, xuwen Zhang, Yang Shenyang Med Coll Sch Pharm Shenyang Key Lab Med Mol Theranost Probes 146 Huanghe North Ave Shenyang 110034 Peoples R China Shenyang Med Coll Dept Sci & Technol 146 Huanghe North Ave Shenyang 110034 Peoples R China Shenyang Med Coll Sch Basic Med 146 Huanghe North Ave Shenyang 110034 Peoples R China Jilin Univ Coll Chem Dept Analyt Chem Changchun 130012 Peoples R China

Development of fresh solid phase extractant is critical for selective separation and purification of special proteins. Herein, we demonstrated a recombinant Staphylococcal Protein G (rSPG) with a His-tag modified the novel single-metal organic framework (rSPG@Ni-MOF-74). The proposed solid-phase extraction material possessed a uniform spindle-shaped structure, large surface area (709.60 m2 g-1) and pore volume (0.08 m3 g- 1), high metal content (22.57 wt%), which facilitated the interaction between host and guest. As results, the composite displayed outstanding selective recognition and adsorption of IgG, due to synergistic effect of the binding ability of rSPG with the Fc region of IgG, maintained through hydrogen bonding and electrostatic attraction, as well as hydrophobic interaction. The adsorption performance and mechanism of rSPG@Ni-MOF-74 have been fully investigated. Additionally, the rSPG@Ni-MOF-74 composite could effectively separate IgG from serum obtained from healthy humans, with the purity of the separated IgG verified through SDS-PAGE analysis. Furthermore, LCMS/MS analysis identified a high content of IgG (55.3 %) in the eluate from rSPG@Ni-MOF-74, suggesting the great potential of rSPG@Ni-MOF-74 in IgG separation and enrichment from complex matrix.

关键词： Metal-organic framework Immunoglobulin G Protein separation Purification

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