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Dynamic design method of digital twin process model driven by knowledge-evolution machining features

INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH 2022年第7期60卷 2312-2330页

作者： Liu, Jinfeng Zhao, Peng Jing, xuwen cao, Xuwu Sheng, Sushan Zhou, Honggen Liu, Xiaojun Feng, Feng Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Southeast Univ Sch Mech Engn Nanjing Peoples R China Shaanxi Diesel Engine Heavy Ind Co Ltd Xingping Peoples R China

Machining plan is the core of guiding manufacturing production and is regarded as one of the keys to ensure the quality of product processing. Existing process design methods are inefficient to quickly handle the machining plan changed induced by the unpredictable events in real-time production. It inevitably causes time and economic losses for the enterprise. In order to express the evolutionary characteristics of product processing, the construction method of digital twin process model (DTPM) is proposed based on the knowledge-evolution machining features. Three key technologies include correlation structure of process knowledge, expression method of the evolution geometric features and the association mechanism between two are solved. On this basis, the construction framework of DTPM is illustrated. Then, the organisation and management mechanism of multi-source heterogeneous data is discussed in detail. At last, a case study of the complex machined part is researched, the results show that the processing time reduced by about 7% and the processing stability improved by 40%. Meanwhile, the implementation scheme, application process and effect of this case are described in detail to provide reference for enterprises.

关键词： Digital twin process knowledge machining features dynamic evolution

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A Study on Genotype-by-Environment Interaction Analysis for Agronomic Traits of Maize Genotypes Across Huang-Huai-Hai Region in China

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 57-81页

作者： Haiwang Yue Jianwei Wei Junliang Xie Shuping Chen Haicheng Peng Hongmei cao Junzhou Bu xuwen Jiang Dryland Farming Institute Hebei Academy of Agriculture and Forestry SciencesHebei Provincial Key Laboratory of Crops Drought Resistance ResearchHengshui053000China Soil and Fertilizer Workstation of Hengshui Agriculture and Rural Bureau Hengshui053000China Maize Research Institute/College of Agronomy Qingdao Agricultural UniversityQingdao266109China

Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food *** this study,28 nationally approved maize hybrids were evaluated across 24 different climatic conditions for two consecutive years(2018-2019).The purpose of this study was to select high-yield with stable genotypes and identify important agronomic traits for maize breeding program *** results of this study showed that the genotypeenvironment interaction effects of the 12 evaluated agronomic traits was highly significant(P<0.001).We introduced a novel multi-trait genotype-ideotype distance index(MGIDI)to select genotypes based on multiple agronomic *** selection process exhibited by this method is unique and easy to understand,so the MGIDI index will have more and more important applications in future multi-environment trials(METs)*** genotypes selected by the MGIDI index were G22,G10,G12 and G1 as the high yielding and stable *** parents of these selected genotypes have the ability to play a greater role as the basic germplasm in the breeding process.A new form of genotype(G)main effects and genotype(G)-by-environment(E)interaction(GGE)technician,genotypeyieldtrait(GYT)biplot,based on multiple traits for genotypes selection was also applied in this *** GYT biplot ranked genotypes by combining grain yield with other evaluated agronomic traits,and displayed the distribution of their traits,namely strengths and weaknesses.

关键词： GEI MGIDI GYT biplot AMMI model GGE

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CRISPR/Cas9基因编辑技术在线虫中的应用进展和展望

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中国科学：生命科学 2018年第5期48卷 513-520页

作者：曹绪文张留所中国科学院海洋研究所实验海洋生物学重点实验室青岛266071 青岛海洋科学与技术国家实验室海洋生物学与生物技术功能实验室青岛266237 中国科学院大学北京100049

线虫属于线虫动物门,从陆地到海洋,从浅海到深海,线虫可以生存于几乎所有可栖息环境,是地球上数量最多的多细胞动物.线虫中不仅有生物医学研究领域的明星模式生物秀丽线虫(Caenorhabditis elegans),还包括对海洋生态环境具有重要意义的... 详细信息

线虫属于线虫动物门,从陆地到海洋,从浅海到深海,线虫可以生存于几乎所有可栖息环境,是地球上数量最多的多细胞动物.线虫中不仅有生物医学研究领域的明星模式生物秀丽线虫(Caenorhabditis elegans),还包括对海洋生态环境具有重要意义的自由生活海洋线虫,以及引起人类、牲畜和农作物寄生虫病的寄生线虫等.近几年来,CRISPR/Cas9基因编辑技术的快速发展和广泛应用,带动了生命科学研究技术的革命.CRISPR/Cas9技术具有易构建、成本低、靶点广、效率高的优点,很快就成为了研究者不可缺少的实验工具.利用CRISPR/Cas9基因编辑技术研究线虫领域的重要科学问题,将加速人们对基因功能和重要生命过程规律的深入解析,并大大促进与线虫紧密关联的人类健康、产业经济和生态环境等领域的发展.本文总结了近期CRISPR/Cas9基因编辑技术在秀丽线虫以及其他线虫中应用的一些重要进展,并对其应用前景和未来的热点研究领域进行展望.

关键词：线虫 CRISPR/Cas9 基因编辑基因敲除基因敲入

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Mechanisms of the homolog of human deafness gene tmc-1 in regulating the development of ***

Mechanisms of the homolog of human deafness gene tmc-1 in re...

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第五届中国秀丽线虫大会

作者： Beining Xue xuwen cao Liusuo Zhang CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of Sciences Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Center for Ocean Mega-Science Chinese Academy of Sciences University of Chinese Academy of Sciences

Organisms dynamically react to changes of environment while the mechanism of the reaction and adaptation to changes of nutritional environment remains *** study of organisms' reaction to changes of nutritional environment contributes notably to human's health since diet plays an irreplaceable role in daily *** we studied the mechanism of action of Caenorhabditis elegans' tmc-1,a homolog of human deafness gene TMC1,in ***' reaction to novel nutrients.

关键词： Mechanisms of the homolog of human deafness gene tmc-1 in regulating the development of C.elegans

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Impact of Oligo(Ethylene Glycol) Side Chains on the Thermoelectric Properties of Naphthalenediimide-Dialkoxybithiazole Polymers

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ACS MATERIALS LETTERS 2024年第4期6卷 1207-1215页

作者： Yang, xuwen Ye, Gang Tran, Karolina Liu, Yuru cao, Jiamin Dong, Jingjin Portale, Giuseppe Liu, Jian Zhang, Ping Loi, Maria Antonietta Chiechi, Ryan C. Koster, L. Jan Anton Univ Groningen Zernike Inst Adv Mat Nijenborgh 4 NL-9747 AG Groningen Netherlands Univ Groningen Stratingh Inst Chem Nijenborgh 4 NL-9747 AG Groningen Netherlands Hunan Univ Sci & Technol Sch Chem & Chem Engn Key Lab Theoret Organ Chem & Funct Mol Minist Educ Xiangtan 411201 Peoples R China Nanjing Tech Univ Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM Key Lab Flexible Elect KLOFE Nanjing 211816 Jiangsu Peoples R China Nanjing Tech Univ Inst Adv Mat IAM Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM Nanjing 211816 Jiangsu Peoples R China Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Jilin Peoples R China Jiangxi Univ Sci & Technol Sch Elect Engn & Automat Ganzhou 341000 Jiangxi Peoples R China Hubei Univ Sch Mat Sci & Engn Key Lab Green Preparat & Applicat Funct Mat Hubei Key Lab Polymer Mat Wuhan 430062 Peoples R China North Carolina State Univ Dept Chem Raleigh NC 27695 USA

Organic thermoelectric materials have garnered significant interest as promising candidates for energy harvesting applications. In recent years, ethylene-glycol side-chain engineering in organic semiconductors has gradually become an efficient approach to boost the performance of organic thermoelectrics. Although this strategy is widely utilized, the impact of their volume and branching structure remains unknown. This contribution describes a trade-off phenomenon between the oligo(ethylene glycol) (OEG) side chains and thermoelectric properties based on the n-type doped low-bandgap conjugated polymers, achieved through the modification of the volume and structure of side chains. Three conjugated polymers comprising a naphthalenediimide-dialkoxybithiazole backbone and different linear length or branched OEG side chains exhibit good host/dopant miscibility after doping. We find that, in the linear OEG side-chain-based polymers, the increased volume of side chains slightly influences the planarity of backbones, thereby leading to similar and satisfactory thermoelectric performances. The high fraction of side chains does not consistently yield enhanced performance, as the branched OEG side-chain introduces steric hindrance. Consequently, the accordingly conjugated backbones become less planar and rigid, resulting in critical molecular packing changes and low charge carrier mobility and doping efficiency and thus low thermoelectric performance. Our work provides a unique insight into the fundamental understanding of the relationship between molecular packing and thermoelectric properties and guides the future rational design of efficient n-type organic semiconductors.

关键词： Carrier dynamics Conjugated polymers Doping Polymers Thin films

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Transcriptome analysis of blood for the discovery of sex-related genes in ricefield eelMonopterus albus

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FISH PHYSIOLOGY AND BIOCHEMISTRY 2020年第4期46卷 1507-1518页

作者： Ding, Weidong cao, Liping cao, Zheming Bing, xuwen Chinese Acad Fishery Sci Key Lab Freshwater Fisheries & Germplasm Resource Minist Agr Freshwater Fisheries Res Ctr Wuxi 214081 Jiangsu Peoples R China

The blood acts as a transfer channel for a variety of factors in the whole body. The ricefield eel(Monopterus albus) is a protogynous hermaphrodite vertebrate. Until now, no research has reported an analysis of the blood transcriptome during the process of sexual development in the ricefield eel. In this study, the transcriptome sequencing of blood samples from male and female ricefield eels was completed with a total of 34.70 Gb clean data. The clean data of each sample all reached 5.23 GB, and the percent of the Q30 basic group was 88.62% and above. A total of 106,369 unigenes were obtained after assembly, including 13,296 unigenes with a length of more than 1 kb. Further functional annotation analysis showed that there are 28,522 unigenes that can be annotated. The annotations of genes with differential expression revealed that there were 563 genes with significant differential expression in the blood of male and female ricefield eels, including 91 upregulated genes and 472 downregulated genes. Among which, 14 genes may be closely related to sex differentiation, the qPCR was used to confirmed the expression pattern of those genes and result shown that 11 genes were downregulated and 3 genes were upregulated, consistent with the results of our RNA-Seq analysis. This blood transcript dataset will open future research avenues on ricefield eel sex development and differentiation.

关键词： Blood Transcriptome Sex development genes Ricefield eel

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Latex microspheres lateral flow immunoassay with smartphone-based device for rapid detection of Cryptococcus

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TALANTA 2025年 284卷 127254页

作者： Zang, Xuelei Zhou, Yangyu Li, Shuming Shi, Gang Deng, Hengyu Zang, Xuefeng cao, Jingrong Yang, Ruonan Lin, xuwen Deng, Hui Huang, Yemei Yang, Chen Wu, Ningxin Song, Chao Wu, Lidong Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China Shandong Second Med Univ Weifang 261053 Peoples R China Datang Telecom Convergence Commun Technol Co Ltd Beijing 100094 Peoples R China Chinese Acad Fishery Sci Beijing 100141 Peoples R China Capital Med Univ Xuanwu Hosp Dept Clin Lab Beijing 100053 Peoples R China Nanjing Normal Univ Sch Food Sci & Pharmaceut Engn Nanjing 210023 Peoples R China Chinese Peoples Liberat Army Gen Hosp Med Lab Ctr Med Ctr 1 Beijing 1000853 Peoples R China 971 Hosp Chinese Peoples Liberat Army Navy Dept Cadres Qingdao 266000 Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Wuxi 214081 Peoples R China

Cryptococcus is a pathogenic fungus that poses a threat to human health. Conventional detection methods have limited the rapid and accurate qualitative and quantitative analysis of Cryptococcus, affecting early diagnosis and treatment. In this study, we developed a Point-of-Care Testing (POCT) platform that integrates lateral flow immunoassay (LFIA) with smartphones, enabling both rapid qualitative and quantitative detection of Cryptococcus. The LFIA strip utilizes latex microspheres (LMs) as labeling probes, achieving a detection limit of 3000 CFU/mL and presenting higher sensitivity than the Colloidal Gold Nanoparticles Lateral Flow Immunoassay (AuNPs-LFIA) strip, and approximately eight times that of the AuNPs-LFIA strip. Additionally, it exhibiting no cross-reactivity with over 24 common pathogens and validated in clinical samples. For quantitative analysis, artificial intelligence algorithms were employed to convert smartphone-captured images into grayscale values. Eleven feature values were utilized as a dataset for machine learning to construct a linear regression model, with Mean Squared Error (MSE) and R2 reaching 0.45 and 0.91, respectively. Moreover, the recovery rates in the serum samples ranged from 90.0 % to 108 %, indicating a good practicability. This research presents a rapid diagnostic technology for Cryptococcus and lays the theoretical and technical groundwork for detecting other pathogens.

关键词： Gold nanoparticles

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Mechanisms of acetylcholine receptor gene eat-2 in regulating the development of ***

Mechanisms of acetylcholine receptor gene eat-2 in regulatin...

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第五届中国秀丽线虫大会

作者： xuwen cao Yusu Xie Pengchi Zhang Liusuo Zhang CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of Sciences Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Center for Ocean Mega-Science Chinese Academy of Sciences University of Chinese Academy of Sciences

＜正＞How the amount and nutritional composition of diets influence organismal development,fecundity and health are largely *** axenic chemically defined food *** maintenance medium（CeMM） is a powerful experiment material to study the impact of diet and nutrition on life-history traits such as growth and *** studies have shown that the eat-2 gene,

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NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STRAIN DISTRIBUTION OF VERTICALLY PLACED METAL HYDRIDE BASED HYDROGEN STORAGE CONTAINER 23

NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STR...

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23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022

作者： cao, Shuaijie Yin, xuwen Yang, Fusheng Jiang, Lijun Wu, Yuanfang Wu, Zhen Zhang, Zaoxiao Xi'an Jiaotong University School of Chemical Engineering and Technology Shaanxi Xi'an China Xinjiang University School of Mechanical Engineering Xinjiang Uygur Autonomous Regions Urumqi China Co. LTD Beijing China

ISBN: (纸本)9786250008430

Pulverization, settling and agglomeration, and the consequent densification may occur for metal hydride particles during the charge-discharge cycles, which will affect the wall strain of their container for hydrogen storage. In order to study the effects of different factors on the wall strain of metal hydride hydrogen storage vessel, a reaction-thermal-mechanical coupling model for LaNi5 alloy was modified with regard to some relevant parameters, by which sensitivity analysis was conducted. Finally, the strain distribution along the height of reactor filling Mg2Ni was predicted by the model and compared with experimental results reported in literature. © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.

关键词： Hydrogen storage

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Controlled Anodic Decomposition Pathway of Supramolecular Lithium Borate for Rationally Tuned Interphase Chemistry

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025年第19期64卷 e202500425页

作者： Zhou, Haiyu Hou, Wenhui Zhu, Da Zhou, Pan Peng, xuwen Liu, Zhi Yan, Shuaishuai Lu, Yang Ou, Yu Liu, Fengxiang Xia, Yingchun Liu, Hao cao, Qingbin Song, Xuan Guo, Decai Xu, Hong Liu, Kai Tsinghua Univ Dept Chem Engn State Key Lab Chem Engn Beijing 100084 Peoples R China Tsinghua Univ Inst Nucl & New Energy Technol Beijing 100084 Peoples R China SINOPEC Dalian Res Inst Petr & Petrochem 96 Nankai RdTieshan St Dalian 116045 Liaoning Peoples R China

The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium metal batteries. However, developing well-tailored electrolyte additives with rationally controlled interfacial chemistry remains highly challenging. Here, two lithium borates: lithium (2-methoxy-15-crown-5)trifluoroborate (C-LiMCFB) and lithium (15-methoxy-2,5,8,11,14-pentaoxahexadecan)trifluoroborate (L-LiMCFB), incorporating cyclic 15-crown-5 (15C5) and linear pentaethylene glycol monomethyl ether (PEGME) as respective host groups tethered to the boron center are designed and synthesized. In C-LiMCFB, the supramolecular polydentate chelation/de-chelation of the 15C5 with Li+ can sequentially deactivate/activate the anodic decomposition of the C & horbar;O bonds, therefore leading to the controlled cleavage pathway of B & horbar;O and C & horbar;O bonds. The controlled interfacial chemistry leads to the formation of a uniform CEI layer, rich in lithium boron-oxygen clusters interwoven with LiF, on the NCM811 surface. This novel CEI configuration demonstrates an exceptional balance of mechanical robustness, adhesiveness, and toughness, providing highly desirable protection for the NCM811 cathode. The discovery of these novel supramolecular boron-based lithium salts not only unlocks supramolecular chemistry for rational electrolyte tuning but also provides a deeper understanding of the CEI formation mechanism in high-energy lithium metal batteries.

关键词： Battery electrolytes Energy storage Lithium metal batteries Supramolecular chemistry

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