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中国防痨杂志 2023年第5期45卷 499-506页

作者：李翔杞敏姜建杰魏佳璐付旭文李海雯张乐昆明市第三人民医院/云南省传染性疾病临床医学中心医学影像科昆明650041 昆明市第三人民医院/云南省传染性疾病临床医学中心互联网医疗部昆明650041 昆明市第三人民医院/云南省传染性疾病临床医学中心重症医学科昆明650041

目的:分析颅内结核患者的临床特征及合并急性脑梗死的危险因素。方法:采用回顾性研究方法,收集昆明市第三人民医院2019年7月至2021年12月收治的脑脊液结核分枝杆菌培养阳性的84例患者作为研究对象。收集整理研究对象的临床症状、实验室... 详细信息

目的:分析颅内结核患者的临床特征及合并急性脑梗死的危险因素。方法:采用回顾性研究方法,收集昆明市第三人民医院2019年7月至2021年12月收治的脑脊液结核分枝杆菌培养阳性的84例患者作为研究对象。收集整理研究对象的临床症状、实验室检查结果及影像学检查结果等资料;依据颅脑磁共振成像(magnetic resonance imaging,MRI)表现,将研究对象分为脑梗死组32例(38.1%)和非脑梗死组52例(61.9%)。采用单因素和多因素logistic回归分析颅内结核合并急性脑梗死的危险因素。结果:颅内结核临床症状常见的有头痛(95.2%,80/84)、发热(73.8%,62/84)、呕吐(52.4%,44/84)及意识障碍(48.8%,41/84),抽搐(7.1%,6/84)少见。非脑梗死组患者外周血血镁浓度[中位数(四分位数)]为0.80(0.75,0.85)mmol/L(正常值0.73~1.06 mmol/L),明显低于脑梗死组的0.84(0.81,0.89)mmol/L,差异有统计学意义(Z=2.079,P=0.038)。脑梗死组颅脑MRI表现为基底池/环池脑膜增厚者31例(96.9%),外侧裂池脑膜增厚者21例(65.6%),合并动脉血管壁增厚者31例(96.9%);非脑梗死组颅脑MRI表现为基底池/环池脑膜增厚者26例(50.0%),外侧裂池脑膜增厚者18例(34.6%),合并动脉血管壁增厚者28例(53.8%)。脑梗死组基底池/环池脑膜增厚、外侧裂池脑膜增厚及动脉管壁增厚的发生率均明显高于非脑梗死组,差异均有统计学意义(χ^(2)=19.956,P=0.000;χ^(2)=7.659,P=0.006;χ^(2)=17.545,P=0.000)。多因素logisitic回归分析显示,动脉血管壁增厚是颅内结核合并急性脑梗死的独立危险因素[OR(95%CI)=27.128(3.393~216.917)]。结论:颅内结核常见临床症状有头痛、发热、呕吐及意识障碍,MRI提示动脉血管壁增厚是发生急性脑梗死的独立危险因素。

关键词：结核,脑膜脑梗死磁共振成像危险因素

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Predictive models of hypertensive disorders in pregnancy based on support vector machine algorithm

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S181-S186页

作者： Yang, Lin Sun, Ge Wang, Anran jiang, Hongqing Zhang, Song Yang, Yimin Li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Beijing Peoples R China Chinese Acad Med Sci Inst Med Informat Beijing 100020 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The risk factors of hypertensive disorders in pregnancy (HDP) could be summarized into three categories: clinical epidemiological factors, hemodynamic factors and biochemical factors. OBJECTIVE: To establish models for early prediction and intervention of HDP. METHODS: This study used the three types of risk factors and support vector machine (SVM) to establish prediction models of HDP at different gestational weeks. RESULTS: The average accuracy of the model was gradually increased when the pregnancy progressed, especially in the late pregnancy 28-34 weeks and >= 35 weeks, it reached more than 92%. CONCLUSION: Multi-risk factors combined with dynamic gestational weeks' prediction of HDP based on machine learning was superior to static and single-class conventional prediction methods. Multiple continuous tests could be performed from early pregnancy to late pregnancy.

关键词： Support vector machine algorithm machine learning model research

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPLIED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi Li, xuwen Li, Chao Zhang, Yiwen Chen, Hongyi Liu, Peixin Chu, Yongchao Sun, Tao jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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“哨兵-2”卫星影像及C2RCC算法在太湖冬春季水色分析中的应用

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中国环境监测 2024年第3期40卷 271-282页

作者：李旭文张悦姜晟王甜甜崔嘉宇纪轩禹陈冰魏玉强陈栋江苏省环境监测中心江苏省太湖水质监测中心站江苏南京210019 南京信息工程大学遥感与测绘工程学院江苏南京210044

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水... 详细信息

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水色参数反演。结果表明:冬春季太湖各湖区叶绿素a浓度处于较低水平,但4月中旬起有明显抬升;太湖西部沿岸区、南部沿岸区和湖心区总悬浮物浓度较高,表明这些湖区易受风浪影响,造成沉积物再悬浮;太湖东部沿岸区、北部湖湾及东太湖遥感反演的水体清澈度较高,可能与这些湖区冬春季沉水植物菹草的分布有关,菹草生长对水质有较好的净化效果。总体来看,基于C2X-nets模式的C2RCC反演算法从较高分辨率卫星遥感影像中提取的水色信息,能有效反映太湖冬春季水色指标的空间分布特征,可为湖体生态状况及动态变化的长期监测评估提供有价值的参考。

关键词：哨兵-2 遥感 C2RCC算法水色反演太湖

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中国玉米种子质量:十年变迁和未来展望

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中国种业 2023年第12期 6-10页

作者：鲁苗苗辛婷婷贾濡张佳欣李贺勤赵延明张海艳李朝霞裴玉贺赵美爱韩登旭袁志鹏张巧巧李莉陈全全杜雪梅薛艳芳夏海勇刘铁山汪黎明何军光马云国王宝卿陈景堂宋希云岳海旺顾日良王建华江绪文青岛农业大学青岛266109 山东省聊城市茌平区农业农村局聊城252100 中国农业大学北京100193 新疆农业科学院粮食作物研究所乌鲁木齐860000 山东省农业科学院玉米研究所济南250100 山东省农业科学院作物研究所济南250100 山东鑫丰种业股份有限公司聊城252400 河北省农林科学院旱作农业研究所衡水053000

种子是农业科技的载体,种子质量代表着国家农业科技水平,决定了品种推广范围、播种方式及种子市场竞争力。质量调研作为种子质量保障的一项基础性工作,对推动现代种业高质量发展发挥着重要作用。从包衣包装、4项基本指标测定、种子活力... 详细信息

种子是农业科技的载体,种子质量代表着国家农业科技水平,决定了品种推广范围、播种方式及种子市场竞争力。质量调研作为种子质量保障的一项基础性工作,对推动现代种业高质量发展发挥着重要作用。从包衣包装、4项基本指标测定、种子活力测定、合格率、交流问卷等方面回顾了中国玉米主产区市售品种样品种子质量十年变迁概况,并从种子质量标准认证建设、种企高质量种子生产能力提升、种子质量科普培训及市场监管等方面对玉米种子质量有效控制、保障用种安全提出了一些建设性意见,为推进新时代中国现代玉米产业高质量发展提供参考。

关键词：玉米种子质量种子活力

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Comparison and development of a metagenomic next-generation sequencing protocol for combined detection of DNA and RNA pathogens in cerebrospinal fluid

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BMC INFECTIOUS DISEASES 2022年第1期22卷 326-326页

作者： jiang, Hanfang Xing, Zhihao Liu, Xiaorong Chai, Qiang Xin, Zefeng Zhu, Chunqing Lin, Ruihong Deng, xuwen Cui, Dong Gao, HongDan Ma, Dongli Shenzhen Childrens Hosp Inst Pediat Clin Lab Shenzhen Guangdong Peoples R China Shenzhen Childrens Hosp Inst Pediat Shenzhen Guangdong Peoples R China Bengbu Med Coll Med Technol Bengbu Anhui Peoples R China

Background: The purpose of this study was to evaluate different pretreatment, extraction, amplification, and library generation methods for metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) and to develop an efficient procedure for the simultaneous detection of DNA and RNA pathogens. Methods: We generated thirteen mock CSF samples with four representative pathogens of encephalitis. Each sample was subjected to ten different methods by varying sample pretreatment/nucleic acid extraction (microbial DNA, total DNA, total NA, total RNA, Whole Transcriptome Amplification (WTA)) and library generation (Illumina or NEB). Negative extraction controls (NECs) were used for each method variation. Results: We found that the quality of mNGS sequencing reads was higher from the NEB kit for library generation. Microbial DNA and total RNA increased microbial deposition by depleting the host DNA. Methods total NA and total RNA can detect gram-positive, gram-negative, RNA and DNA pathogens. We applied mNGS, including total NA and NEB library generation, to CSF samples from five patients diagnosed with infectious encephalitis and correctly determined all pathogens identified in clinical etiological tests. Conclusions: Our findings suggested that total nucleic acid extraction combined with NEB library generation is the most effective mNGS procedure in CSF pathogen detection. The optimization of positive criteria and databases can improve the specificity and sensitivity of mNGS diagnosis.

关键词： Encephalitis Next-generation sequencing Metagenomic diagnosis

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海洋技术国际标准化工作的现状及其发展趋势

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中国造船 2021年第3期62卷 258-266页

作者：马乐天王瑶姜磊冯旭文叶聪李家彪自然资源部第二海洋研究所杭州310012 自然资源部海底科学重点实验室杭州310012 中国船舶科学研究中心无锡214082 深海载人装备国家重点实验室无锡214082

海洋技术的发展需要实现跨领域的学科交叉,而基于共识的国际标准将为这一新兴技术的全球推广提供必要支撑。论文从海洋技术的背景入手,概述了当今海洋技术领域国际标准化组织的工作现状,对现行的和制订中的相关国际标准进行了梳理,重点... 详细信息

海洋技术的发展需要实现跨领域的学科交叉,而基于共识的国际标准将为这一新兴技术的全球推广提供必要支撑。论文从海洋技术的背景入手,概述了当今海洋技术领域国际标准化组织的工作现状,对现行的和制订中的相关国际标准进行了梳理,重点阐述了潜水器国际标准的起步与实践。对我国在海洋技术国际标准化工作中所做的贡献予以初步总结,分析了工作前景和发展趋势,并提出了未来工作重点。

关键词：海洋技术潜水器 ISO国际标准

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Effect of a closed-loop medication order executive system on safe medication administration at a tertiary hospital: a quasi-experimental study

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THERAPEUTIC ADVANCES IN DRUG SAFETY 2024年 15卷

作者： Yin, xuwen Song, Haiyan Lu, Jieyu Yang, Jing Wang, Rong Lin, Zheng jiang, Shudi Yuan, Hui Wang, Xumei Xu, Dongmei Gao, Chunhong Zhou, Yuan Xu, Jiayi Chen, Chen Gu, Chenyu Diao, Qingqing Li, Fang Gu, Zejuan Nanjing Univ Chinese Med Sch Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Nursing Nanjing 210029 Peoples R China Nanjing Med Univ Sch Nursing Nanjing Peoples R China

Background: Closed-loop electronic medication management systems are effective measures for preventing medication errors (MEs). However, there is limited evidence supporting this, and few studies have evaluated the long-term effects of these systems on safe medication. Objective: To evaluate the long-term effects of implementing a closed-loop medication order executive system on the safe clinical use of medications. Design: A quasi-experimental design. Method: Data from 2017 to 2023 were extracted and retrospectively analyzed. The primary outcome indicator was the ME rate. Secondary outcome indicators were the accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing. The autoregressive integrated moving average (ARIMA) model in time-series analysis was used to evaluate the level and trend changes in ME rates using SPSS 25.0 before and after system implementation. Root cause analysis and descriptive statistics were used to assess changes in types, stages, and causes of ME rates. The independent samples t-test was used to analyze secondary outcomes. Results: Overall, 295 MEs were reported with a mean of 0.26 +/- 0.26 ME rates per month during 2017-2023. The ARIMA model showed a decrease in the average level of ME rates after system implementation, with no statistically significant decrease in the long term, and a significant drop in the ME rate in the short and medium term (p < 0.01). Nurses' administration accounted for more than 60% of errors post-implementation, and lack of communication was a prominent factor. The accuracy of order verification and patient identification and the implementation rate of fresh medicine dispensing all increased after implementation. Conclusion: Adopting a closed-loop executive system is beneficial for ensuring patient medication safety, but a single integrated system does not completely eliminate MEs. Optimizing system functionalities and applying structured handoff tools are r

关键词： closed-loop electronic medication management system medication error patient safety

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Application of Cu²⁺-based electron spin resonance spectroscopy in measurement of antioxidant capacity of fruits

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ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2019年第25期411卷 6677-6686页

作者： Tian, Sizhu Li, xuwen jiang, Jia Wang, Kun Zhang, Hanqi Yu, Aimin Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Jilin Peoples R China

The antioxidant capacity of 22 kinds of fruits was measured by the developed electron spin resonance (ESR) method based on Cu2+ sensor. Cu2+ is reduced to Cu+ by the antioxidants in the fruits, and the remaining Cu2+ was determined by ESR and UV-Vis spectroscopy. Cu2+ can give an ESR signal whereas Cu+ cannot, and the loss of the ESR signal was used to quantify the antioxidant capacity of various fruits. The results were shown as vitamin C equivalent antioxidant capacity (VCEAC). The VCEAC values obtained by ESR and UV-Vis methods ranged from 24.23 to 688.61 mg/100 g and from 24.12 to 677.79 mg/100 g, respectively. Cupric ion reducing antioxidant capacity (CUPRAC) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) methods were employed for comparison. Based on Pearson's correlation test, the results obtained by CUPRAC and DPPH methods were both significantly correlated with these obtained by the present method, which indicated that the novel method was reliable. Total phenolic content for all kinds of fruits was measured with the Folin-Ciocalteu reagent, and VCEAC values obtained by the ESR method were significantly correlated with total phenolic contents.

关键词： Electron spin resonance Cu2+ reduction Fruits Antioxidant capacity VCEAC Total phenolic content

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太湖流域水生生物群落结构与水生态质量状况分析

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生态毒理学报 2023年第1期18卷 271-279页

作者：李娣李旭文吕学研姜晟蔡琨高占啟王甜甜蔡永久江苏省环境监测中心南京210019 中国科学院南京地理与湖泊研究所南京210008

研究水生态环境功能的整体性是树立一个生命共同体的基础。本研究于2020年,对江苏省太湖流域49个水生态环境功能区水生态监控点位进行水质、底栖动物和浮游植物调查;评价了太湖流域水生态环境功能区底栖动物和浮游植物群落结构和其质量... 详细信息

研究水生态环境功能的整体性是树立一个生命共同体的基础。本研究于2020年,对江苏省太湖流域49个水生态环境功能区水生态监控点位进行水质、底栖动物和浮游植物调查;评价了太湖流域水生态环境功能区底栖动物和浮游植物群落结构和其质量状况,分析了水质目标和水生态质量目标达标情况。研究结果表明,太湖流域57个点位共获得底栖动物物种94种,底栖动物群落前二位优势种为霍甫水丝蚓和河蚬,17个湖库点位共获得浮游植物物种247种,隶属7个门113属,硅藻门57种、蓝藻门51种、绿藻门107种、隐藻门7种、甲藻门9种、裸藻门15种和金藻门1种,优势种属于微囊藻属,太湖流域底栖动物、浮游植物群落结构呈向好发展趋势;太湖流域4个水生态功能分区中底栖动物、浮游藻类质量指数评价等级均为“一般”,均低于水质指数评价等级(“中”~“良”);对照2020年管理目标,太湖流域49个水生态环境功能分区水质目标达标率为81.6%,远高于水生态质量达标率(40.8%)。综上所述,本研究结果表明,水环境管理应尽快从水质目标管理向水质、水生态双重管理转变。

关键词：太湖流域底栖动物浮游植物水生态管理

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