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XGB-SEGA coupled energy saving method for wastewater treatment plants

APPLIED WATER SCIENCE 2024年第2期14卷 29页

作者： Wang, Zijian Zhou, xuwen Wang, Hao Huang, Zehan Ji, Jiantao Peng, Zhaoxu jiang, Kun Beijing Univ Technol Fac Architecture Civil & Transportat Engn Beijing 100124 Peoples R China Zhengzhou Univ Sch Water Conservancy & Transportat Zhengzhou 450001 Peoples R China Harbin Inst Technol Sch Civil & Environm Engn Shenzhen 518055 Peoples R China Cent Plains Environm Protect Co Ltd Zhengzhou 450001 Peoples R China Zhengzhou Univ Sch Ecol & Environm Zhengzhou 450001 Peoples R China CSD Water Serv CO Ltd Beijing 100124 Peoples R China

To reduce the amount of energy consumed in wastewater treatment plants, nine methods were used to select the key operation parameters that affected energy consumption according to daily operation records, and an intelligent operation management system based on a genetic algorithm was constructed by mapping the relationships between energy consumption and the key operation parameters. The results showed that the prediction and management of energy consumption could be achieved by incorporating the strengthened elastic genetic algorithm into the extreme gradient boosting model. The main parameters affecting energy consumption were the influent flow rate, effluent total nitrogen, NH4+-N loading rate, etc., and the energy consumption could be reduced by 13-27% (with an average of 22%). The parameters were all selected from the daily operation records of the wastewater treatment plant, and no additional complex data acquisition system was needed to collect specific parameters. This study provided a cost-effective strategy to reduce energy consumption in wastewater treatment plants.

关键词： Energy saving Extreme gradient boosting (XGB) Genetic algorithm optimization Carbon neutrality Wastewater treatment

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CircFBLN2 regulates duck myoblast proliferation and differentiation through miR-22-5p and MEF2C interaction

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POULTRY SCIENCE 2025年第5期104卷 105063页

作者： Liu, Shuibing Wu, Jintao jiang, Hongxia Zhou, Ya'nan Huang, xuwen Wang, Yuxiang Xie, Zhanbin Liao, Zurong Ding, Zhenxvan Liu, Jing Hu, Xiaolong Mao, Huirong Liu, Sanfeng Chen, Biao Jiangxi Agr Univ Coll Anim Sci & Technol Nanchang 330045 Jiangxi Peoples R China South China Agr Univ Coll Anim Sci Guangzhou 510642 Guangdong Peoples R China Jiangxi Agr Univ Poultry Inst Nanchang 330045 Peoples R China

The growth and development of duck skeletal muscle significantly affect duck meat production, making it essential to understand the molecular mechanisms underlying these processes. Circular RNAs (circRNAs) and microRNAs (miRNAs) are identified in many species and play essential roles in the regulation of myogenic processes;however, research on circRNAs and miRNAs involved in the duck skeletal muscle development is limited. In prior whole-transcriptome RNA sequencing study, we identified differential expression of miR-22-5p and the novel circular RNA circFBLN2, which arises from the second exon of the FBLN2 gene, in duck primary myoblasts (DPMs). In this study, we confirmed the circular structure of circFBLN2 and explored its expression patterns and functional implications in myogenesis. To elucidate the function of circFBLN2 in the myogenic processes of duck, we conducted experiments involving both the silencing and overexpression of circFBLN2 in DPMs. Our findings indicated that circFBLN2 inhibits DPM proliferation while promoting their differentiation. Conversely, when miR-22-5p was silenced and overexpressed, it exhibited opposing effects by promoting the proliferation of DPMs and inhibiting their differentiation. These results suggest a complex dynamic interplay between circFBLN2 and miR-22-5p in the regulation of DPMs proliferation and differentiation. Additionally, our results revealed that both circFBLN2 and myocyte enhancer factor 2 C (MEF2C) act as sponges for miR-22-5p, as demonstrated by binding predictions and dual-luciferase reporter assays. These results offer novel perspectives on the regulatory pathways underlying the duck embryonic skeletal muscle development, underscoring the pivotal function of circFBLN2 in the regulation of miR-22-5p expression. This research deepens our comprehension of the molecular underpinnings of avian myogenesis, potentially paving the way for more effective approaches to bolster growth and development of livestock.

关键词： Duck skeletal muscle circFBLN2 miR-22-5p MEF2C

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Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

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CANCER NANOTECHNOLOGY 2022年第1期13卷 1-18页

作者： Yao, Hua Mu, Xupeng Wei, Zhenhong Li, Xiuying Wu, Liya Jin, Yongri Li, xuwen Li, Jing jiang, Jinlan Jilin Univ Sci Res Ctr China Japan Union Hosp Changchun 130033 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China

Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh-2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh-2 as both reducing and stabilizing agents. Results The synthesized Au@ginsenoside Rh-2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh-2. Investigations in vitro indicated that Au@ginsenoside Rh-2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well. Conclusions Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh-2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh-2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.

关键词： Ginsenoside Rh-2 Au nanoparticles Drug-modified nanocomposite Facile synthesis Anticancer activity

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Parameters Optimization Method for ADRC of Permanent Magnet Synchronous Motor Based on CMA-ES

Parameters Optimization Method for ADRC of Permanent Magnet ...

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第43届中国控制会议

作者： Tianjian jiang Yang Yang Zhiyuan Li Tianqi Yang xuwen Chen College of Automation and College of Aritifical Intelligence Nanjing University of Posts and Telecommunications College of Internet of Things Nanjing University of Posts and Telecommunications

ISBN: (数字)9789887581581

ISBN: (纸本)9798350366907

Active disturbance rejection control(ADRC) is widely used to control permanent magnet synchronous motors(PMSM). However, the settings of gain parameters in ADRC is often dependent on engineers' experience. Also, it is difficult to design the parameters accurately by hand to achieve satisfactory results. A method based on evolution strategy with covariance matrix adaptation(CMA-ES) for optimizing the gain parameters of ADRC is proposed. By setting up some optimization tasks and using the CMA-ES algorithm, reinforcement learning is performed on the parameters of ADRC. In view of the high population size and complexity of CMA-ES, we adopt a parallel computation method to speed up the optimization *** method can effectively optimize the ADRC gain parameters to adapt to the specified application environment, and at the same time reduce the dependence of setting ADRC parameters on human experience as well as time consumption. Finally, we verify that this CMA-ES-based parameter optimization method can effectively improve the control performance of the motor by running simulations and comparing the motor speed changes before and after optimization.

关键词： Permanent-magnet Synchronous Motor Active Disturbance Rejection Control Field-oriented Control Swarm Optimization High Throughput Computing Modern Control

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang jiang Kejun Yin Mintao Chen Jian Huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment

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MATERIALS RESEARCH EXPRESS 2023年第11期10卷 115404-115404页

作者： Li, Zhuoran Yang, Huikang Xu, Fan Zeng, xuwen Huang, Haowei jiang, Xinqing Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China South China Univ Technol Guangzhou Peoples Hosp 1 Sch Med Dept Radiol Guangzhou Guangdong Peoples R China Jinan Univ Dept Radiotherapy Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China Jinan Univ Guangzhou Peoples Hosp 1 Dept Radiol Guangzhou Guangdong Peoples R China

Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were utilized as theranostic agents for tumor-targeted magnetic resonance imaging (MRI) and chemotherapy. By loading doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) particles into TPGS nanoparticles, FA-SS-TPGS@DOX/SPIO nanoparticles are obtained. In vitro drug release studies revealed that under a reducing environment in the presence of glutathione (GSH), approximately 100% of the doxorubicin (DOX) was released from the disulfide bond-linked theranostic nanoparticles within 24 h. DOX and SPIO were efficiently delivered into HepG2-ADM cells due to the folate receptor-mediated endocytosis process of the nanoparticles. Additionally, the presence of glutathione (GSH) triggered the cleaving of the disulfide bonds, further facilitating the delivery of DOX and SPIO into the cells. Furthermore, the FA-SS-TPGS @DOX-SPIO nanoparticles exhibited strong MRI contrast enhancement properties. In conclusion, FA-SS-TPGS@DOX/SPIO are potential nanoparticles for tumor-targeted MRI and chemotherapy, which can also overcome multidrug resistance.

关键词： multidrug resistance TPGS tumor-targeted disulfide bond theranostic nanoparticles

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NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STRAIN DISTRIBUTION OF VERTICALLY PLACED METAL HYDRIDE BASED HYDROGEN STORAGE CONTAINER 23

NUMERICAL SIMULATION AND PARAMETRIC ANALYSIS OF THE WALL STR...

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23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022

作者： Cao, Shuaijie Yin, xuwen Yang, Fusheng jiang, Lijun Wu, Yuanfang Wu, Zhen Zhang, Zaoxiao Xi'an Jiaotong University School of Chemical Engineering and Technology Shaanxi Xi'an China Xinjiang University School of Mechanical Engineering Xinjiang Uygur Autonomous Regions Urumqi China Co. LTD Beijing China

ISBN: (纸本)9786250008430

Pulverization, settling and agglomeration, and the consequent densification may occur for metal hydride particles during the charge-discharge cycles, which will affect the wall strain of their container for hydrogen storage. In order to study the effects of different factors on the wall strain of metal hydride hydrogen storage vessel, a reaction-thermal-mechanical coupling model for LaNi5 alloy was modified with regard to some relevant parameters, by which sensitivity analysis was conducted. Finally, the strain distribution along the height of reactor filling Mg2Ni was predicted by the model and compared with experimental results reported in literature. © 2022 Proceedings of WHEC 2022 - 23rd World Hydrogen Energy Conference: Bridging Continents by H2. All rights reserved.

关键词： Hydrogen storage

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Research and Optimization of Process Parameters for Internal Thread Forming Based on Numerical Simulation and Experimental Analysis

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MATERIALS 2022年第9期15卷 3160-3160页

作者： He, Qiang jiang, Yuxiang Jing, xuwen jiang, Yonggang Zhou, Honggen Fu, Bofeng Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Jiangsu Peoples R China CSSC Huangpu Wenchong Shipbldg Co Ltd Guangzhou 510715 Peoples R China Shanxi Diesel Engine Heavy Ind Co Ltd Xian 713100 Peoples R China

In order to improve the forming quality of extruded thread, finite element analysis and experimental research are combined to reduce the two keys that affect thread quality in the machining process-extrusion torque and extrusion temperature. The effects of different processing parameters on the extrusion torque and temperature are obtained by numerical simulation, including the bottom hole diameter of the workpiece, the machine tool speed, and the lubrication medium. For the purpose of reducing extrusion torque and temperature, the process parameters for internal thread forming are further optimized by orthogonal design. It is determined that when machining the M22 x 2 internal thread on the connecting rod of the marine diesel engine made of 42CrMo4 steel, the bottom hole diameter of the workpiece should be null 21.20 mm, the speed of the machine tool should be 40 RPM, and the lubricating medium should be PDMS polydimethylsiloxane coolant. Compared to before optimization, the maximum extrusion torque and the maximum extrusion temperature are reduced by 19.27% and 15.07%, respectively. On the premise of ensuring the thread connection strength, the height of the thread tooth is reduced by 0.052 mm, and the surface condition of the thread is improved. The surface microhardness at the root, top, and side of the thread increases by about 5 HV0.2, and the depth of the hardened layer increases by 0.05 mm. The results show that the quality of the optimized thread is higher.

关键词： internal thread thread forming numerical simulation physical test parameter optimization

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DNA mismatch repair in HIV-Associated Lymphoma: Lost in Translation?

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JOURNAL OF INFECTION 2024年第3期88卷 106112-106112页

作者： jiang, Yuanhui Chen, Suling Xia, Muye Xu, xuwen Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China

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Modifiable factors affects cancer-specific survival: findings from a large population-based prospective cohort study

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-12页

作者： Chen, Xiong Zhu, Dongxi Li, Chenchen Lin, Yi Lv, Lin Ai, Feiling Chen, Zhijian Shen, Runnan Shen, xuwen You, Guochang jiang, Zhige Zhong, Wenlong Lin, Tianxin Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Urol Guangzhou Peoples R China Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangdong Hong Kong Joint Lab RNA Med Guangzhou Guangdong Peoples R China Guangdong Prov Clin Res Ctr Urol Dis Guangzhou Peoples R China Sun Yat Sen Univ Affiliated Hosp 6 Dept Med Oncol Guangzhou Peoples R China Sun Yat Sen Univ Sch Med Guangzhou Peoples R China Ludwig Maximilian Univ Munich Fac Med Munich Germany

BackgroundModifiable factors affect cancer's survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different *** this prospective cohort study, we analyzed national data from the UK Biobank, including 121,399 participants, to assess the association of modifiable factors with cancer-specific survival (CSS) in two independent cohorts: a pre-cancer cohort (n = 78,027) and a post-cancer cohort (n = 43,372). Additionally, a weighted standardized score was derived to evaluate the joint effects across different domains. Interactions between the six domains and age at diagnosis, sex, and cancer site were evaluated using likelihood ratio tests. Subgroup analyses were then performed for factors showing significant effect modification. Population-attributable fractions (PAF) of different domains on 5-year cancer-specific death were *** study comprehensively presented the differential patterns of modifiable factors' impact on CSS among pre-cancer and post-cancer cohorts, sexes and different cancer sites. In the pre-cancer cohort, CSS were predominantly attributable to smoking/alcohol consumption (PAF 92%) and daily activity (PAF 106%). Men exhibited a higher risk than women for dietary habits (HR:125 versus 118), daily activity (HR:150 versus 129) and living environment (HR:113 versus 103). The impact of modifiable factors, including daily activity, smoking/alcohol consumption, and physical measures, on CSS varied across different cancer sites. In the post-cancer cohort, 186% of 5-year cancer-specific deaths were attributable to unfavourable mental health. In subgroup analysis, the risk of CSS in the domain of smoking/alcohol consumption was higher in men than that in women (HR: 158 versus 134). The impact of modi

关键词： Cancer-specific survival Modifiable factor Population-attributable fractions

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