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Risk prevention of different forms of gestational diabetes mellitus based on energy metabolism prior to diagnosis

TECHNOLOGY AND HEALTH CARE 2022年第1_suppl期30卷 S285-S292页

作者： Lu, Jiayu jiang, Hongqing Zhang, Song Yang, Yimin Hao, Dongmei Li, xuwen Chen, Aiqing Shao, Jing Liu, Xiaohong Yang, Lin Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing Peoples R China Haidian Maternal & Children Hlth Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively. OBJECTIVE: GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively. METHODS: By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences. RESULTS: For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy. CONCLUSION: The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

关键词： Diabetes mellitus in the second trimester diagnosis of diabetes mellitus in the third trimester energy metabolism

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Amanita peptide toxin analysis: An innovative UPLC-MS/MS method utilizing Fe3O4-based magnetic adsorbent

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JOURNAL OF FOOD COMPOSITION AND ANALYSIS 2024年 131卷

作者： jiang, Yifu Lang, Le Zhang, Jingwen Ji, Yining Zhang, Chenglong Yang, Ruiqin Li, xuwen Peoples Publ Secur Univ China Sch Criminal Invest Beijing 100038 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China Jilin Prov Prod Qual Supervis & Inspect Inst Changchun 130000 Peoples R China Jilin Univ Coll New Energy & Environm Changchun 130000 Peoples R China

This study combined the structural characteristics of amanita peptide toxins to prepare a Fe3O4/P4VPBA/PPy/ GO composite material as a magnetic solid-phase extraction adsorbent. The experimental results indicated that this adsorbent showed excellent selectivity for the extraction of amatoxins and phallotoxins from mushroom samples. Compared with traditional dispersive solid-phase extraction, this adsorbent enables rapid separation in the enrichment and elution recovery stages through the application of a magnetic field. Simultaneously, the study optimized the conditions for ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS), ensuring both separation efficiency and accuracy while reducing the analysis time. The researchers established the MSPE-UPLC-MS/MS method for the determination of amanita peptide toxins in wild mushrooms. This method not only simplified and expedited the sample pretreatment process but also achieved qualitative and quantitative analyses in a short period, thus demonstrating high detection sensitivity and outstanding recovery rates. Furthermore, the developed method was successfully applied to analyze toxic mushrooms discovered in Nanjing, China. The potential for extensive utilization of this method is highlighted in the field of food analysis and detection.

关键词： Mushroom poisoning Amanita peptide toxins Magnetic solid -phase extraction UPLC-MS/MS Food analysis

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Distribution of bound-PAH residues and their correlations with the bacterial community at different depths of soil from an abandoned chemical plant site

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JOURNAL OF HAZARDOUS MATERIALS 2023年第1期453卷 131328页

作者： Tang, Lei Zhao, Xuqiang Chen, xuwen jiang, Yi Gudda, Fredrick Wang, Yunhao Ling, Wanting Nanjing Agr Univ Coll Resources & Environm Sci Inst Organ Contaminant Control & Soil Remediat Nanjing 210095 Peoples R China Huazhong Agr Univ Coll Resources & Environm State Key Lab Agr Microbiol Wuhan 430070 Peoples R China

The situ pollutant residue and microbial characteristics in contaminated environments are crucial for ecological restoration and soil utilization. This work reported the variation of polycyclic aromatic hydrocarbon (PAH) residues and the bacterial community at different depths in an aged-abandoned site. These results unveiled that over 90% of low molecular weight (LMW) and medium molecular weight (MMW), 52.84-76.88% of high mo-lecular weight (HMW) bound-PAH (BP) residues were sequestrated in humin (HM). The stresses of PAH and soil depth enhanced the frequency of bacteria associations, especially positive associations. We enriched and cultured PAH degradation bacteria (PDB) from the sampling site mainly consisting of Pseudomonas and Acinetobacter, which were originally 0.39-0.52% abundant in the sampling site. The abundances of PDB and PAH-degradation genes (PDGs) were higher at shallower depths and increased with high PAH concentration. Simultaneously, Pearson correlation analysis and experimental verification found that the process of PAH binding with SOM limited the further increase of PDB and PDGs in PAH-contaminated sites. These findings may illustrate possible ecological risks of contaminated soils and provide guidance for the isolation and application of PDB.

关键词： Vertical distribution PAH residues Bacterial communication Degradation gene Ecosystem risks

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Improved Eagle Perching Optimizer Based P2P Energy Trading for Smart Homes

Improved Eagle Perching Optimizer Based P2P Energy Trading f...

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Power and Electrical Engineering (ACPEE), 5th Asia Conference on

作者： Yu jiang Yingchun Feng Jie Fan Bo Gao Yang Wang xuwen Liu Jiangsu Electric Power Trading Center State Grid Jiangsu Electric Power Co. LTD Nanjing China

ISBN: (数字)9798350309638

ISBN: (纸本)9798350309645

The purpose of the study is to optimize power price in smart homes that connect to share energy. A Demand Side Management (DSM) system is used to coordinate P2P energy trading between smart homes using the improved eagle perching optimizer (IEPO). The IEPO algorithm produces optimum solutions for 99% of actual datasets, according to the outcomes. It is possible that consumer price distribution in the microgrid (MG) could be unequal as a result of P2P energy trading. The Pareto optimality principle addresses the issue of unequal price distribution, preventing households from being harmed by improving the costs of others. A final evaluation is performed on the effect of renewable energy and the penetration of storage within the MG. As the renewable energy and the penetration of storage increases, savings cannot necessarily be linear. As the saturation point approaches, they slowly begin to decline.

关键词： Electrical engineering Renewable energy sources Demand side management Costs Electricity Asia Optimization methods

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Crushing behavior on the cylindrical tube based on lotus leaf vein branched structure

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MECHANICS OF MATERIALS 2022年 165卷 104205-104205页

作者： He, Qiang Wang, Yonghui Shi, Xiaona Jing, xuwen jiang, Yonggang Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Jiangsu Peoples R China Cssc Huangpu Wenchong Shipbldg Co Ltd Guangzhou 510715 Peoples R China

By imitating the structural characteristics of the lotus leaf, a new excellent energy absorption structure named as the leaf vein branched circular tube (LVBCT) is proposed by referring to lotus leaf vein branched structure. The evolution of its cross-section may be controlled by the number of main veins distributed along the circumference (N) and the ratio of radius of inner circle Rinner to radius of outer circle Router (gamma). To study the crushing behavior of LVBCTs under axial dynamic crushing, the finite element simulation model established by LS-DYNA is first verified by comparing with the experimental results. Following that, a systematic parametric study on geometric parameters N and gamma is carried out with three different wall thicknesses. The mechanical properties of LVBCTs are revealed by analyzing the deformation mechanism and crashworthiness indicators (specific energy absorption per unit mass SEAm and peak crushing force PCF). The numerical results show that the LVBCTs may absorb more impact energy and its energy absorption characteristics are closely related to geometric parameters N, gamma and wall thickness t. The LVBCTs with N = 6 and gamma of 0.5 similar to 0.7 have better crashworthiness. Furthermore, the numerical results show that the thickness matching between main vein and branch vein has influence on the energy absorption ability. The SEAm of LVBCT is improved by 11.3% when the thickness matching between the main vein and the branch vein is 0.92 mm. The results of this study will be helpful to design novel thin-walled structure with better energy absorption ability.

关键词： Leaf vein branched circular tube (LVBCT) Parametric study Crushing behavior Deformation mechanism Energy absorption capability

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Deep Reinforcement Learning Home Energy Management Based Local Energy Trading in a Blockchain Platform

Deep Reinforcement Learning Home Energy Management Based Loc...

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Power and Electrical Engineering (ACPEE), 5th Asia Conference on

作者： Yu jiang Yingchun Feng Jie Fan Bo Gao Yang Wang xuwen Liu Jiangsu Electric Power Trading Center State Grid Jiangsu Electric Power Co. LTD Nanjing China

ISBN: (数字)9798350309638

ISBN: (纸本)9798350309645

Decentralized peer-to-peer Local Energy Markets (LEMs) are gaining popularity as local power production from Renewable Energy Sources (RESs) increases. The study investigates a blockchain-driven LEM in which prosumers and consumers buy and sell energy independently of the involvement of a third party. The suggested scheme involves Home Energy Management (HEM) and demurrage mechanisms that enable both consumers and prosumers to reduce their power prices and improve their power usage. The end-user can likewise move the load to off-peak periods and benefit from lower energy costs from the LEM through the approach. In this solution, HEM and demurrage mechanisms are used to optimize power usage as well as energy costs. As well as providing adequate power for the LEM, it is economically beneficial for end users and the community. The proposed system in the study utilizes the Deep Deterministic Policy Gradient (DDPG) algorithm and demurrage mechanisms to optimize electricity usage and energy costs. Meanwhile, smart contract on the Ethereum blockchain regulate and safeguard the electricity trading process.

关键词： Renewable energy sources Costs Simulation Smart contracts Production Power markets Blockchains

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

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NANO LETTERS 2025年第7期25卷 2949-2959页

作者： Zhang, Shilin You, Haoyu Fan, Hongrui Chen, Yun Song, Haolin Zhao, Zhenhao Chen, Qinjun Wang, Yu Tian, Zonghua Wu, Yuxing Zhou, Zheng Guo, Yun Su, Boyu Li, xuwen Jia, Ru Fang, Mingzhu jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Key Lab Smart Drug Delivery State Key Lab Med NeurobiolMinist Educ Shanghai 201203 Peoples R China Fudan Univ Frontiers Ctr Brain Sci Sch Pharm MOE Shanghai 201203 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China Fujian Med Univ Binhai Campus Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Fuzhou 350212 Peoples R China

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8+ T cells inward. Additionally, the overactivated TGF-beta/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy. In this work, a type of enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) and pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral enamine N-oxides can trigger transcytosis and then respond to hypoxia and acidic microenvironments, turning the surface charge of the nanoparticles to a positive charge and enhancing penetration. The released galunisertib inhibits the TGF-beta/SMAD signaling pathway, reshapes the matrix, activates antitumor immunity, and combines with gemcitabine (Gem) to kill tumor cells.

关键词： Drug delivery system transcytosis tumor penetration enamine N-oxide TGF-beta/SMAD signalingpathway

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Some Explorations Based on the Application of BIM Technology in Housing Construction Project Management

Some Explorations Based on the Application of BIM Technology...

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Computer Science and Engineering Technology (SCSET), International Seminar on

作者： Zhi Xu Xingqu Gao xuwen Tian Hongliang Guan Xiaohan jiang Harbin Far Eastinstitute of Technology Harbin China Northeast Forestry University Engineering Consulting and Design Institute Harbin China

In recent years, the construction industry has gradually become an important industry in the development of national economy, and housing construction projects occupy a large proportion in the construction industry. Building construction projects have high requirements for the application of building information modeling (BIM), and the application of building information modeling technology assists housing construction project management to improve project management and make the model innovation of project management possible. The article analyzes the application of BIM technology in each stage of housing construction project management, discusses the selection and application of BIM technology, and proposes development measures, so as to provide some ideas for the application of BIM technology in housing construction project management.

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Low-level laser activates Wnt/β-catenin signaling pathway-promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1

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SKIN RESEARCH AND TECHNOLOGY 2024年第6期30卷 e13807页

作者： BangHong, jiang YuKun, Wang Ao, Shi Tao, Sun PeiJun, Song xuwen, Li Lin, Li ZhuYou, Xiong Li, Zhang Bengbu Med Coll Affiliated Hosp 1 Dept Plast Surg Bengbu Peoples R China Lanzhou Univ Hosp & Clin Med Sch 2 Lanzhou Peoples R China Bengbu Med Coll Affiliated Hosp 1 Dept Neurosurg Bengbu Peoples R China

BackgroundThe objective of this study is to investigate the mechanism by which low-level laser stimulation promotes the proliferation of intraepithelial hair follicle stem cells (HFSCs) in wounds. This research aims to expand the applications of laser treatment, enhance wound repair methods, and establish a theoretical and experimental foundation for achieving accelerated wound *** experimental approach involved irradiating a cell model with low-level laser to assess the proliferation of HFSCs and examine alterations in the expression of proteins related to the Wnt/beta-catenin signaling pathway. A mouse back wound model was established to investigate the effects of low-level laser irradiation on wound healing rate, wound microenvironment, and the proliferation of HFSCs in relation to the Wnt/beta-catenin signaling *** research findings indicate that low-level laser light effectively activates the Wnt signaling pathway, leading to the increased accumulation of core protein beta-catenin and the upregulation of key downstream gene Lef 1. Consequently, this regulatory mechanism facilitates various downstream biological effects, including the notable promotion of HFSC proliferation and differentiation into skin appendages and epithelial tissues. As a result, the process of wound healing is significantly *** levels of laser activates the Wnt signalling pathway, promotes the regeneration of hair follicle stem cells and accelerates wound healing.

关键词： carcinogenesis low-level laser stem cells Wnt/beta-catenin pathway wound healing

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma

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ADVANCED MATERIALS 2025年第15期37卷 e2418053页

作者： You, Haoyu Zhang, Shilin Zhang, Yiwen Chen, Qinjun Wu, Yuxing Zhou, Zheng Zhao, Zhenhao Su, Boyu Li, xuwen Guo, Yun Chen, Yun Tang, Weiyi Liu, Bing Fan, Hongrui Geng, Shuo Fang, Mingzhu Li, Fangxin Liu, Guangna jiang, Chen Sun, Tao Fudan Univ Sch Pharm State Key Lab Med Neurobiol Minhang HospInnovat Ctr New Drug Dev Immune Infla Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Orthoped Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB. Therefore, to enhance the in vivo safety and targeting capability of OMVs, we introduced engineered OMVs to reduce toxicity and further constructed a modularly assembled nanoplatform by performing simple peptide modifications. This nanoplatform demonstrates satisfactory biosafety and is able to continuously cross the BBB and target GBM with the assistance of Angiopep-2. Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenicity of GBM, ultimately overcoming GBM immune resistance to enhance the efficacy of immunotherapy. This OMVs-based nanoplatform provides a new paradigm and insights into the development of immunotherapy for GBM.

关键词： engineering technology glioblastoma immune resistance immunotherapy outer membrane vesicles

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