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α-Amylase and tyrosinase inhibitory activities, phenolic contents, and antioxidant capacities of wild and cultivated blueberries

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JOURNAL OF FOOD PROCESSING AND PRESERVATION 2021年第1期45卷 e15087-e15087页

作者： Tian, Sizhu li, xuwen Zang, Shuang Jin, Yongri Zhang, Ziwei Yu, Yong Jilin Univ Coll Chem Changchun Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Peoples R China

The phenolic compound contents, antioxidant capacities, and alpha-amylase and tyrosinase inhibitory activities of 10 wild and 19 cultivated blueberries grown in northeast China were evaluated. The results showed that the alpha-amylase inhibitory activities of the blueberries represented, by 1/IC50, correlated with their total phenolic contents (TPCs). Moreover, the tyrosinase inhibitory activities correlated with the total anthocyanin contents (TACs). High-performance liquid chromatography and electrospray mass spectrometry were conducted to determine and identify seven phenolic acids. The average caffeic acid contents of the cultivated and wild blueberries were 277.37 and 17.71 mu g/g, respectively. The total phenolic, anthocyanin, and flavonoid contents were determined. Wild blueberries have higher TPCs, alpha-amylase inhibitory activities, and antioxidant capacities. Cultivated blueberries have higher TACs and exhibit tyrosinase inhibitory activities similar to those of the wild ones. Practical applications This study revealed that wild blueberries have high alpha-amylase inhibitory activities and are effective as natural alpha-amylase inhibitors for the treatment of diabetes. In addition, wild blueberries were found to be rich in phenolics and have high antioxidant capacities. Thus, because of these properties, wild blueberry products with antidiabetic and antioxidant potential can be developed for use in biomedical and pharmaceutical industries.

关键词： Amylases

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Fetal growth prediction: Establishing fetal growth prediction curves in the second trimester

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S345-S350页

作者： Wang, Yan Bao, Xinyu Zhang, Song Yang, lin liu, Guoli Yang, Yimin li, xuwen Hao, Dongmei Chen, Aiqing liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Monitoring fetal weight during pregnancy has a guiding role in prenatal care. OBJECTIVE: To establish a personalized fetal growth curve for effectively monitoring fetal growth during pregnancy. METHODS: (1) This study retrospectively analyzed the birth weight database of 2,474 singleton newborns delivered normally at term. The personalized fetal growth curve model was formed by combining the estimating birth weight of newborns with the proportional weight formula. (2) Multiple linear stepwise regression method was used to estimate the birth weight of newborns. RESULTS: (1) Delivery gestational age, weight at first visit, maternal height, pre-pregnancy body mass index, fetal sex, parity had significant effects on birth weight. Based on these parameters, the formula for calculating term optimal weight was obtained (R-2 = 22.8%, P < 0.001). (2) The personalized fetal growth curve was obtained according to the epidemiological factors input model of each pregnant woman. CONCLUSIONS: A model of personalized fetal growth curve can be established, and be used to evaluate fetal growth and development through estimated fetal weight monitoring.

关键词： Fetal weight growth charts personal health services

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Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga

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JOURNAL OF BIOLOGICAL CHEMISTRY 2023年第8期299卷 105017页

作者： Zhou, Jujun Horton, John R. Kaur, Gundeep Chen, Qin li, xuwen Mendoza, Fabian Wu, Tao Blumenthal, Robert M. Zhang, Xing Cheng, Xiaodong Univ Texas MD Anderson Canc Ctr Dept Epigenet & Mol Carcinogenesis Houston TX 77030 USA Baylor Coll Med Dept Mol & Human Genet Houston TX USA Univ Toledo Coll Med & Life Sci Dept Med Microbiol & Immunol Program Bioinformat Toledo OH 43614 USA

Much is known about the generation, removal, and roles of 5-methylcytosine (5mC) in eukaryote DNA, and there is a growing body of evidence regarding N6-methyladenine, but very little is known about N4-methylcytosine (4mC) in the DNA of eukaryotes. The gene for the first metazoan DNA methyltransferase generating 4mC (N4CMT) was reported and characterized recently by others, in tiny freshwater invertebrates called bdelloid rotifers. Bdelloid rotifers are ancient, apparently asexual animals, and lack canonical 5mC DNA methyltransferases. Here, we characterize the kinetic properties and structural features of the catalytic domain of the N4CMT protein from the bdelloid rotifer Adineta vaga. We find that N4CMT generates high-level methylation at preferred sites, (A/C)CG(T/C/A), and low-level methylation at disfavored sites, exemplified by ACGG. like the mammalian de novo 5mC DNA methyltransferase 3A/3B (DNMT3A/3B), N4CMT methylates CpG dinucleotides on both DNA strands, generating hemimethylated intermediates and eventually fully methylated CpG sites, particularly in the context of favored symmetric sites. In addition, like DNMT3A/3B, N4CMT methylates non-CpG sites, mainly CpA/TpG, though at a lower rate. Both N4CMT and DNMT3A/3B even prefer similar CpGflanking sequences. Structurally, the catalytic domain of N4CMT closely resembles the Caulobacter crescentus cell cycle-regulated DNA methyltransferase. The symmetric methylation of CpG, and similarity to a cell cycle-regulated DNA methyltransferase, together suggest that N4CMT might also carry out DNA synthesis-dependent methylation following DNA replication.

关键词： DNA methylation N4-methylcytosine metazoan cytosine-N4 DNA methyltransferase bdelloid rotifer Adineta vaga

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The impact of radiotherapy on the prognosis of metastatic clear cell renal cell carcinoma after surgery

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Scientific Reports 2025年第1期15卷 1-11页

作者： li, xuwen Tan, Zhongyu Zhu, Yihao Zhai, Yabo Chen, Can Wang, Dong Wang, Mingshuai Xing, Nianzeng Yang, Feiya Ye, Xiongjun Department of Urology National Cancer Center National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China First Clinical Medical College Nanchang University Nanchang China Zunyi Medical University Zunyi China

Clear cell renal cell carcinoma, one of the most common types of renal cell carcinoma, has been increasing in incidence year by year. This study aims to investigate the impact of radiotherapy on the prognosis of patients with metastatic clear cell renal cell carcinoma (mccRCC) undergoing cytoreductive surgery. Clinical data of patients with mccRCC who underwent cytoreductive surgery were collected from the SEER database (2000–2021). This study employed propensity score matching (PSM) and R software to evaluate the overall survival (OS) of radiotherapy. Univariate and multivariate COX regression analyses were conducted to explore the impact of different variables on prognosis. Finally, a nomogram was developed to predict patient survival rates. A total of 2076 patients with mccRCC who underwent cytoreductive surgery were included in this study, with 538 (25.92%) in the radiotherapy group and 1539 (74.08%) in the non-radiotherapy group. After propensity score matching (PSM), there were 300 cases in each group. Kaplan-Meier values and the Cox proportional hazards model were used to plot the overall survival (OS) curves, which showed that the median survival time in the radiotherapy group was significantly lower than that in the non-radiotherapy group. Additionally, multivariate Cox regression analysis revealed that tumor grade, N stage, radiotherapy, lung metastasis, and liver metastasis were independent factors affecting the prognosis of patients with mccRCC undergoing cytoreductive surgery. Lastly, a nomogram was developed to estimate the survival rates of patients with mccRCC after cytoreductive surgery. Radiotherapy after cytoreductive surgery may have an adverse impact on the prognosis of patients with mccRCC. © The Author(s) 2025.

关键词： Metastatic clear cell renal cell carcinoma Overall survival Propensity score matching Radiotherapy Surgery

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Sequentially Triggered Bacterial Outer Membrane Vesicles for Macrophage Metabolism Modulation and Tumor Metastasis Suppression

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ACS NANO 2021年第8期15卷 13826-13838页

作者： Guo, Qin li, xuwen Zhou, Wenxi Chu, Yongchao Chen, Qinjun Zhang, Yiwen li, Chao Chen, Hongyi liu, Peixin Zhao, Zhenhao Wang, Yu Zhou, Zheng Luo, Yifan li, Chufeng You, Haoyu Song, Haolin Su, Boyu Zhang, Tongyu Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China

Metabolic interactions between different cell types in the tumor microenvironment (TME) often result in reprogramming of the metabolism to be totally different from their normal physiological processes in order to support tumor growth. Many studies have attempted to inhibit tumor growth and activate tumor immunity by regulating the metabolism of tumors and other cells in TME. However, metabolic inhibitors often suffer from the heterogeneity of tumors, since the favorable metabolic regulation of malignant cells and other cells in TME is often inconsistent with each other. Therefore, we reported the design of a pH-sensitive drug delivery system that targets different cells in TME successively. Outer membrane vesicles (OMVs) derived from Gram-negative bacteria were applied to coload paclitaxel (PTX) and regulated in development and DNA damage response 1 (Redd1)-siRNA and regulate tumor metabolism microenvironment and suppress tumor growth. Our siRNA@M-/PTX-CA-OMVs could first release PTX triggered by the tumor pH (pH 6.8). Then the rest of it would be taken in by M2 macrophages to increase their level of glycolysis. Great potential was observed in TAM repolarization, tumor suppression, tumor immune activation, and TME remolding in the triple-negative breast cancer model. The application of the OMV provided an insight for establishing a codelivery platform for chemical drugs and genetic medicines.

关键词： bacterial OMVs pH sensitive TAM polarization immune therapy cancer treatment

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Modelling the Public Perception of Urban Public Space lighting Based on SDGSAT-1 Glimmer Imagery: A Case Study in Beijing, China

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SUSTAINABLE CITIES AND SOCIETY 2023年 88卷

作者： lin, Zirong Jiao, Weili liu, Huichan Long, Tengfei liu, Yongkun Wei, Shengrong He, Guojin Trop, Tamar Portnov, Boris A. liu, Ming li, xuwen Wen, Chunhui Chinese Acad Sci Aerosp Informat Res Inst Beijing 100094 Peoples R China Int Res Ctr Big Data Sustainable Dev Goals CBAS Beijing 100094 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chinese Acad Forestry CAF Inst Forest Resource Informat Tech Beijing 100091 Peoples R China Natl Forestry & Grassland Adm Key Lab Forestry Remote Sensing & Informat Syst Beijing 100091 Peoples R China Univ Haifa Dept Nat Resources & Environm Management IL-3498838 Haifa Israel Dalian Univ Technol Sch Architecture & Fine Art Dalian 116024 Peoples R China McGill Univ Dept Mech Engn Montreal PQ H3A 0G4 Canada

Public space lighting is important for public perception, human health and urban planning. Previous studies used nighttime light remote sensing data to evaluate light pollution and its impacts on human health, few investigated the impact on public perception. This study combines Beijing's SDGSAT-1 imagery with ground-measured and public perception data to evaluate the feasibility of SDGSAT-1 images simulating public perception. First, ground measurements were performed to collect light attributes and questionnaires were distributed to assess public safety and comfort. Next, the relationship between SDGSAT-1 image and measured illuminance was established. Lastly, public perception in Beijing was estimated. The results show that, (1) public perception is affected by panoramic illuminance, uniformity, and blue light;(2) although illuminance is positively related to public perception, it shows diminishing marginal returns;(3) a strong correlation is found between panoramic illu-minance and SDGSAT-1 image;(4) the perception map shows that most areas in Beijing can provide safe and comfortable lighting, while there are also insufficient or overlit in some places. This study explores methods for assessing public perceptions by satellite data, indicates remote sensing can provide a larger-scale and quanti-tative evaluation of public perception, which can contribute to urban lighting design and sustainable development.

关键词： Public space lighting Public perception Nighttime light remote sensing SDGSAT-1 imagery Sustainable development

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Prediction of hypertensive disorders in pregnancy based on placental growth factor

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S165-S170页

作者： Xu, Qi Sun, Ge Zhang, Song liu, Guoli Yang, lin Meng, Yu Chen, Aiqing Yang, Yimin li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

关键词： Model accuracy placental growth factor logistic regression

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A study of a fetal heart rate calculation system based on R-R interval

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S187-S195页

作者： Zhang, Yisong Zhang, Song Yang, lin Yang, Yimin li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal electrocardiogram (FECG) can be obtained in a non-invasive manner to monitor fetal growth status. OBJECTIVE: In this study, a fetal heart rate (FHR) calculation system was proposed, which consists of the FECG recorder (MF-HOLTER) and the FECG monitoring software (FECG-MS). The abdomen electrocardiogram (AECG) of pregnant woman is acquired through the MF-HOLTER. The FECG-MS packs the AECG data and calls the FECG separation algorithm to obtain the separated FECG and the fetal QRS (FQRS) position. The FHR is further obtained by calculating the R-R interval value. At the same time, this study proposed a FQRS position correction algorithm to calculate the correct FHR values. METHOD: In order to verify the accuracy of the FHR calculation, the ECG signal of FLUKE's PS320 FETAL SIMULATOR and clinical data were simultaneously tested. RESULTS: The accuracy rate is over 98% in processing the simulator's data. In processing clinical data, the FHR values obtained by both the system proposed in this study and Monica AN24 are very close, and the difference is less than 1 bpm. CONCLUSION: The results show that the FHR calculation system is accurate and stable, and has a positive application value and prospect.

关键词： Fetal ECG fetal heart rate R-R interval fetal QRS position correction

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPliED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi li, xuwen li, Chao Zhang, Yiwen Chen, Hongyi liu, Peixin Chu, Yongchao Sun, Tao Jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, Song Yang, lin liu, Guoli Meng, Yu Chen, Aiqing Yang, Yimin li, xuwen Hao, Dongmei liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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