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A Micro-Environment Regulator for Filling the Clinical Treatment Gap after a Glioblastoma Operation

ADVANCED HEALTHCARE MATERIALS 2022年第3期11卷 2101578-2101578页

作者： Zhang, Yiwen You, Haoyu Wang, Yaoben Chen, Qinjun Guo, Qin Chu, Yongchao li, Chao Zhou, Wenxi Chen, Hongyi liu, Peixin Wang, Yu Zhao, Zhenhao Zhou, Zheng Luo, Yifan li, xuwen Zhang, Tongyu Song, Haolin li, Chufeng Su, Boyu Sun, Tao Bi, Yunke Yu, lin Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol & MOE Inst Brain SciMinist EducKey Lab Smart Drug Del Shanghai 201203 Peoples R China Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Neurosurg Shanghai 201203 Peoples R China

The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. Herein, an immediate and mild postoperative local treatment strategy is developed that regulates the postoperative microenvironment and delays GBM recurrence. Briefly, an injectable hydrogel system (imGEL) loaded with Zn(II)(2)-AMD3100 (AMD-Zn) and CpG oligonucleotide nanoparticles (CpG NPs) is injected into the operation cavity, with long-term function to block the recruitment of microglia/ macrophages and activate cytotoxic T cells. The finding indicated that the imGEL can regulate the immune microenvironment, inhibit GBM recurrence, and gain valuable time for subsequent adjuvant clinical chemotherapy.

关键词： drug delivery glioblastoma injectable hydrogels microenvironments post-operative therapy

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基于PBL的微课与多轨教学联合应用于整形外科教学的价值研究

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中国卫生产业 2024年第17期21卷 12-15页

作者：熊竹友李旭文王怀谷霍继武韩志强田丽宋培军蚌埠医科大学第一附属医院整形烧伤科安徽蚌埠233000

目的研究基于以问题为导向的教学方法(problem-based learning,PBL)的微课与多轨教学联合应用于整形外科教学的价值。方法选取2022年1月—2023年12月蚌埠医科大学第一附属医院整形烧伤科的80名规培生为研究对象,按教学方法不同分为对照... 详细信息

目的研究基于以问题为导向的教学方法(problem-based learning,PBL)的微课与多轨教学联合应用于整形外科教学的价值。方法选取2022年1月—2023年12月蚌埠医科大学第一附属医院整形烧伤科的80名规培生为研究对象,按教学方法不同分为对照组与观察组,各40名,对照组接受常规教学,观察组接受PBL微课联合多轨教学。比较两组出科成绩、核心能力、教学满意度。结果观察组出科成绩、核心能力评分均高于对照组,差异有统计学意义(P均<0.05)。观察组教学满意度为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(χ^(2)=4.114,P<0.05)。结论将基于PBL的微课联合多轨教学用于整形外科教学中,可进一步提升规培生出科成绩,强化其核心能力,提高教学满意度。

关键词：以问题为导向的教学方法微课多轨教学整形外科出科成绩核心能力

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Software design of hardware-in-the-loop simulation system based on rapidio 8

Software design of hardware-in-the-loop simulation system ba...

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8th International Conference on Computing and Pattern Recognition, ICCPR 2019

作者： li, xuwen Hu, Jiashun Wu, Xuegang Wu, Qiang Beijing University of Technology College of Life Science and Bioengineering Beijing China

ISBN: (纸本)9781450376570

At present, Rapid IO has been widely used in embedded platforms due to its high transmission efficiency and low transmission delay, making the software of the embedded platform a new speed. Windows system has the advantages of friendly interface, wide user base, easy maintenance and upgrade, etc., which has received extensive attention in the industry, but the real-time performance is poor and it is impossible to directly communicate with the embedded processor directly through Rapid IO, which makes it impossible to become a semi-physical simulation system. Therefore, the TSI721 driver development based on the RTX environment is designed. The internal structure of Rapid IO protocol, RTX real-time subsystem and Tsi721 switch chip is briefly described. Detailed description of the development framework and interface design of the Tsi721Pcie driver, the main process of RTX driver development. Experiments verify that PCIe and RTX drivers are stable, reliable, and capable of completing tasks in real time. © 2019 Association for Computing Machinery.

关键词： Software design

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Employing supercritical n-butanol to remove the EVA film for the delamination of photovoltaic laminated module

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JOURNAL OF SUPERCRITICAL FLUIDS 2025年 219卷

作者： Wang, xuwen liu, Zhifeng Ruan, Haoda li, Xinyu Zhang, Lei Hefei Univ Technol Sch Mech Engn Hefei 230009 Peoples R China Anhui Prov Key Lab Low Carbon Recycling Technol & Hefei 230009 Peoples R China State Key Lab Environm Adaptabil lndustrial Prod Guangzhou 510300 Peoples R China

The rapid advancement of the photovoltaic (PV) industry has elevated the recycling and reuse of decommissioned PV modules to critical challenges, essential for tackling environmental concerns and achieving resource reutilization. To facilitate the efficient layering of PV modules and recovery of valuable materials, this study proposes a PV module degradation and recycling process utilizing supercritical n-butanol. A systematic evaluation was conducted to assess the effects of various factors on the dissolution ratio of PV modules, with an appropriate range of process parameters selected for optimization. A second-order regression model was developed to predict the dissolution ratio of the EVA film. Comparison of actual dissolution ratio with model predictions confirmed the high accuracy of the fitted model. Finally, characterization and elemental analysis of cells recovered from the supercritical process demonstrated the effectiveness of this recycling method, achieving more thorough degradation on the cell surfaces.

关键词： Photovoltaic Supercritical n-butanol Degradation Recycling Characterization

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切削液中微生物对防锈性影响的研究进展

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材料保护 2024年第11期57卷 73-81页

作者：栗旭文申媛媛刘庆坤张俊庄董丽华董耀华上海海事大学海洋科学与工程学院上海201306 中国石化润滑油有限公司上海研究院上海200080

微生物可导致切削液劣化变质,破坏切削液的防锈性能,进而导致工件和机床的腐蚀。首先概述了切削液中微生物不同的入侵途径,对切削液中微生物种类以及对不同阶段的微生物浓度进行分析,总结了微生物菌种变化规律。其次,从切削液的有效成... 详细信息

微生物可导致切削液劣化变质,破坏切削液的防锈性能,进而导致工件和机床的腐蚀。首先概述了切削液中微生物不同的入侵途径,对切削液中微生物种类以及对不同阶段的微生物浓度进行分析,总结了微生物菌种变化规律。其次,从切削液的有效成分失效、环境pH值的降低和微生物生物膜腐蚀3个方面详细总结了微生物对切削液防锈性的影响。最后,比较分析了目前用于控制和抑制切削液中微生物的方法,并提出参考建议。

关键词：切削液微生物防锈性抑制

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树脂整理面料交联程度的表征与评价

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印染助剂 2024年第9期41卷 63-66,75页

作者：王开苗瞿存明赵爱国李旭文耿彩花苏红升山东轻工职业学院山东淄博255300 淄博市生物基纺织新材料重点实验室山东淄博255300 传化智联股份有限公司浙江杭州311200 鲁丰织染有限公司山东淄博255100

用树脂含量法、纤维保水力法、染色K/S值计算法对树脂整理面料交联程度进行表征和评价,并通过实例来验证。结果表明,树脂含量法、纤维保水力法、染色K/S值计算法等均可用数据对树脂整理面料交联程度进行表征和评价;染色K/S值计算法相对... 详细信息

用树脂含量法、纤维保水力法、染色K/S值计算法对树脂整理面料交联程度进行表征和评价,并通过实例来验证。结果表明,树脂含量法、纤维保水力法、染色K/S值计算法等均可用数据对树脂整理面料交联程度进行表征和评价;染色K/S值计算法相对时间短,操作简单,更能客观准确地表征树脂交联程度,并且能测算出理论折皱回复角和洗后外观平整度。

关键词：交联程度树脂含量保水力法染色K/S值计算法

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中小学田径运动竞赛现状与创新探究

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当代体育科技 2020年第32期10卷 59-61,64页

作者：李旭文佛山市南海区狮山中心小学广东佛山528200

该文运用文献资料法、逻辑分析法等研究方法,对中小学田径运动竞赛的现状与创新进行研究,探讨中小学田径运动竞赛可更新发展之处。研究结果表明:中小学生田径运动竞赛存在宣传推广力度不足,项目传统化,竞赛地位边缘化等情况。研究认为,... 详细信息

该文运用文献资料法、逻辑分析法等研究方法,对中小学田径运动竞赛的现状与创新进行研究,探讨中小学田径运动竞赛可更新发展之处。研究结果表明:中小学生田径运动竞赛存在宣传推广力度不足,项目传统化,竞赛地位边缘化等情况。研究认为,创新田径运动竞赛体系,融合人工智能统筹竞赛,借助互联网、媒体塑造“田径运动竞赛文化”等是推动中小学田径运动竞赛发展的重要举措。结合实际情况给出合理的建议,该文以提高田径运动竞赛水平为目的进行了相关阐述。

关键词：中小学体育竞赛田径现状创新

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Case study on the combined use of surface seawater injection and depressurization for sustainable natural gas hydrate extraction

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JOURNAL OF CLEANER PRODUCTION 2025年 494卷

作者： Zhang, Zhaobin li, Yuxuan li, Shouding He, Jianming li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Minist Nat Resources Beijing 100037 Peoples R China

In response to the issue of inefficient extraction of natural gas hydrates due to a lack of heat supplementation during long-term production, a combined extraction method integrating surface seawater injection and depressurization has been proposed. Under the premise that the surface seawater injection pipeline possesses certain thermal insulation properties, this method can sustainably harness solar energy to replenish the thermal energy of gas hydrate reservoirs. Numerical simulations based on a validated three-dimensional heterogeneous model from the 2013 Nankai Trough pilot production in Japan demonstrate that this method significantly enhances hydrate extraction efficiency compared to depressurization alone. The results show that, over a 500-day production scenario, methane recovery efficiency can be enhanced by up to 150%. The study reveals that only an appropriate injection temperature can effectively improve the efficiency of hydrate exploitation. Compared to the depressurization-only method, this extraction approach increases the temperature driving force (TDF) near the injection well improved by up to 12 K. However, higher injection rates suppress depressurization effects, requiring a balance between injection temperature and rate. The proposed approach also facilitates more uniform reservoir deformation, reducing localized subsidence risks. These findings suggest that the combined surface seawater injection and depressurization method provides an effective and environmentally friendly solution for sustainable hydrate exploitation.

关键词： Natural gas hydrate Surface seawater injection Injection temperature and rate Temperature driving force Reservoir deformation

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A novel method for satellite prediction of VDE-TER service traffic information based on multilayers bidirectional LSTM

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INTERNATIONAL JOURNAL OF SATELliTE COMMUNICATIONS AND NETWORKING 2024年第0期

作者： Wu, Ruiwen li, Zongwang Xie, Zhuochen liang, xuwen Univ Chinese Acad Sci Sch Elect Elect & Commun Engn Beijing 100049 Peoples R China Chinese Acad Sci Shanghai Innovat Acad Microsatellites Shanghai Peoples R China Shanghai Engn Ctr Microsatellites Shanghai Peoples R China

Satellite prediction of very high frequency (VHF) Data Exchange (VDE)-Terrestrial (VDE-TER) ship-to-ship Self-Organized Networks (SON) service traffic information is crucial for wireless resource allocation of VHF Data Exchange System (VDES). Due to the VDE-TER, channel load observed by the satellite changes rapidly and the historical information cached on the satellite is limited;the prediction of VDE-TER service traffic is difficult. This paper proposes a multilayer bidirectional long short-term memory (LSTM) neural network model (MLB-LSTM), which controls the amount of forgetting of historical information and the amount of memory of current information through the LSTM unit, so that the model can better learn the nonlinear changes of service traffic. The bidirectional LSTM module combines forward and backward time series data, reducing the amount of data required for prediction and enhancing the prediction accuracy of the model. Numerical results show that the proposed prediction model significantly outperforms traditional methods and is able to adapt to rapidly changing VDE-TER data. This paper proposes a multilayer bidirectional long short-term memory (LSTM) neural network model (MLB-LSTM), which controls the amount of forgetting of historical information and the amount of memory of current information through the LSTM unit, so that the model can better learn the nonlinear changes of service traffic. The bidirectional LSTM module combines forward and backward time series data, reducing the amount of data required for prediction and enhancing the prediction accuracy of the model. image

关键词： bidirectional LSTM LEO satellite multidimensional time series prediction VHF data exchange system

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Biomimetic Dendrimer-Peptide Conjugates for Early Multi-Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation

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ADVANCED MATERIALS 2021年第26期33卷 2100746-2100746页

作者： liu, Peixin Zhang, Tongyu Chen, Qinjun li, Chao Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Zhao, Zhenhao Luo, Yifan li, xuwen Song, Haolin Su, Boyu li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery Minist Educ State Key Lab Med Neurobiol Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Dept Pharmaceut Sch Pharm Shanghai 201203 Peoples R China

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on beta-amyloid (A beta) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting A beta phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease A beta burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

关键词： Alzheimer&apos s disease antioxidant ability glial cell activation inflammatory responses multi‐ target treatments synergistic function

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