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Anti-allergic activity of 3, 5, 6, 7, 8, 3, 4-heptamethoxyflavone extracted from Citri Reticulatae Pericarpium

SPECTROSCOPY LETTERS 2018年第5期51卷 236-243页

作者： Shi Xiaolei Wang Bo Zhang Lu Wang Ying Yang Jie li xuwen Jin Yongri Jilin Univ Coll Food Sci & Engn Changchun Jilin Peoples R China Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

The inhibitory activity of 3, 5, 6, 7, 8, 3, 4-heptamethoxyflavone extracted from Citri Reticulatae Pericarpium on RBL-2H3 cells degranulation was done by two different methods. At low concentration, the values of inhibition obtained by modified method were much larger than that of the classical method. Spectroscopic measurements and molecular docking calculation were applied to study the mechanism. It was induced by interaction between flavonoid and immunoglobulin E. Compared with the interaction between antibody and receptor, the force was weak, the inhibitory effect on -hexosaminidase release was strong, with some structural changes to the antibody.

关键词： Anti-allergic activity IgE inhibition RBL-2H3 spectroscopic method Flavonoid 3 5 6 7 8 3 4-heptamethoxyflavone 3D fluorescence spectra three-dimensional fluorescence spectra

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Maize kernel damage dynamic prediction in threshing through PSO-LSTM and discrete element modelling

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BIOSYSTEMS ENGINEERING 2024年 242卷 179-195页

作者： Fang, xuwen Zhang, Jinsong Zhao, Xuelin Zhang, Qiang Zhang, li Zhou, Deyi Yu, Chunsheng Hu, Wei Wang, Hao Jilin Univ Coll Biol & Agr Engn Changchun 130022 Peoples R China

This study presents the development of a maize ear model and a predictive approach for kernel damage in maize threshing, integrating physical simulation and predictive analytics to understand better and forecast threshingrelated damage. First, a maize ear model was developed to analyse kernel damage during threshing. Through the angle of repose experiments, the optimal number of spheres for the kernel model was established as 65. Tensile tests were conducted to evaluate the kernel-cob bond strength, revealing an average relative error in the bonding force of 8.71%. Vogel impact energy modelling was applied to the kernel threshing process to determine kernel damage. The correlation between the speed of seed grain movement and the occurrence of damage was analysed by post-processing to identify locations with frequent kernel damage in the drum. In-depth data analysis of kernel damage in the threshing drum further elucidates the inherent relationship between kernel velocity and damage extent. The study then focused on applying neural networks to predict damage rates. The comparative evaluation shows that the PSO-LSTM model has better prediction accuracy than LSTM and RNN models, with the PSO-LSTM network achieving an RMSE of 0.096, a R2 of 99.96%, and a final damage rate of 2.41% in validation tests. Threshing experiments were conducted to verify the model, showing a 1.4% discrepancy between predicted and actual damage rates. This study proposes a kernel damage prediction model and provides new insights and directions for the structural design of threshing drums.

关键词： Maize threshing Kernel damage prediction Machine learning in agriculture Agricultural automation LSTM network

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IVDETR: A Multi-Source Image Pig Detection Method Based on Cross-Domain Feature Fusion 7

IVDETR: A Multi-Source Image Pig Detection Method Based on C...

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7th International Conference on Pattern Recognition and Artificial Intelligence, PRAI 2024

作者： Song, Rui li, Hao Huang, Mengzhen Huang, Zihan li, Peng He, xuwen Wuhan Polytechnic University School of Mathematics and Computer Science Wuhan China

ISBN: (纸本)9798350350890

In large-scale centralised pig farming, object detection algorithms can accurately track and monitor each pig. However, a significant proportion of current detection methods are based on visible images, and the colour differences between different pig breeds limit the applicability of the models. Furthermore, complex background interference, low illumination conditions, or high illumination intensity noise in visible scenes can likewise lead to reduced accuracy during detection. Therefore, we propose a cross-domain encoder based on the self-attention and design the IVDETR model, which integrates features from infrared and visible light images for pig object detection. In order to facilitate the training and evaluation of the model, we constructed a comprehensive, standardised infrared-visible light dataset for the first time. The experimental outcomes demonstrated that the detection accuracy was increased from 0.939 to 0.998 in a real pig breeding environment. © 2024 IEEE.

关键词： Mammals

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A Novel and High-Efficiency Approach to Improve the Sustainability of Agitation Leaching Technology to Refractory Copper Oxide Ore Using the Self-Pressurizing Technology

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JOURNAL OF SUSTAINABLE METALLURGY 2025年第2期11卷 1-17页

作者： Wang, Jian Zeng, Xin liu, xuwen Xu, Wenlong Pan, Yue li, Jinhui Wang, Ruixiang Xiao, Yanfei Xu, Zhifeng Jiangxi Prov Key Lab Green & Low Carbon Met Strate Ganzhou 341000 Peoples R China Jiangxi Univ Sci & Technol Sch Met Engn 86 Hongqi Ave Ganzhou 341000 Peoples R China Ganzhou Engn Technol Res Ctr Green Met & Proc Inte Ganzhou 341000 Peoples R China Nanchang Univ Sch Phys & Mat Sci Nanchang 330031 Peoples R China Tibet Yulong Copper Co Ltd 22 West City Rd Chengdu 854000 Peoples R China Jiangxi Coll Appl Technol 9 Wenfeng Rd Ganzhou 341000 Peoples R China Minist Nat Resources Key Lab Ion Rare Earth Resources & Environm Ganzhou 341000 Peoples R China

Considering economics and environmental protection, the agitation leaching technology using sulfuric acid is considered a preferred alternative to recover copper oxide ores in the copper industry. However, this process is still extremely difficult to extract copper from some complex polymetallic and refractory oxide ores, such as copper oxide ores with high alkalinity gangues (HAG) and high binding rates (HBR), respectively. In this paper, a novel and high-efficiency extraction process involving agitation leaching with self-pressurizing technology at low temperatures is proposed to improve copper extraction of the refractory HAG and HBR copper oxide ores from Tibet. Under the self-pressurizing agitation leaching process, the effects of leaching parameters are investigated on copper extraction and other elements dissolution including aluminum, arsenic, and iron, respectively. The results show that the self-pressurizing leaching technology of complex copper oxide ores has some advantages, including relatively simple to apply, environmentally friendly, energy-saving, and high efficiency, especially the higher copper extraction (more than 98.0%) over the conventional agitation leaching process in the sulfuric acid media. Under optimum experimental conditions of mass ratio of copper oxide ores of 5:5, agitation speed of 400 rpm, initial sulfuric acid concentration of 4.0 mol/L, and leaching time of 60 min at 80 degrees C, the copper extraction reached 98.9%, while the maximum average pressure reached 1.31 MPa in the closed reaction vessel. The self-pressurizing leaching technology can significantly improve the adaptability of the conventional agitation leaching technology to the refractory copper oxide ore without adding the other reagent.

关键词： Self-driven pressurization Agitation leaching Copper oxide ores Low temperature

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A Compact Optically Pumped Cesium Beam Clock with a Differential Detection Scheme 37

A Compact Optically Pumped Cesium Beam Clock with a Differen...

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37th European Frequency and Time Forum, EFTF 2024

作者： li, Chao Sun, Fuyu Hu, xuwen liu, Jie li, Xiaofeng Zhang, Shougang National Time Service Center Chinese Academy of Sciences Xi'an China Chinese Academy of Sciences Key Laboratory of Time Reference and Applications Xi'an China

ISBN: (纸本)9798350354270

Compact optically pumped cesium beam clocks have become a focus in cesium clock research due to their high atomic utilization and excellent short-term frequency stability. However, stray light noise, one of the main noise sources, limits the stability improvement. In this paper, we present a compact optically pumped cesium clock that uses differential detection to reduce the impact of stray light on clock performance. It incorporates an additional fluorescence collector to capture stray light during detection and subtract it from the clock transition signal, effectively reducing stray light level. Consequently, this scheme significantly enhances the signal-to-noise ratio, improving the short-term frequency stability of the compact optically pumped cesium clock. © 2024 IEEE.

关键词： Frequency stability

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Determination of common ginsenosides in Kang'ai injection by aqueous two-phase extraction with deep eutectic solvents and HPLC-UV/DAD

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MICROCHEMICAL JOURNAL 2018年 137卷 302-308页

作者： li, Peng Zhao, Pengyun liu, Weijie Jiang, Yifu Wang, Wenjiao Bao, Longyue Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

In this work, four kinds of deep eutectic solvents (DESs), composed of choline chloride (ChCl) and several alcohols, were synthesized and characterized by H-1 NMR and FT-IR spectra. Based on DES ( ChCl and 1,4-butanediol) and inorganic salt solution (dipotassium phosphate, K2HPO4), aqueous two-phase system (ATPS) coupled with high-performance liquid chromatography has been developed and applied. This method was used for the efficient extraction and determination of eight common ginsenosides (including ginsenoside Rg(1), Re, Rf, Rg(2), Rc, Rb-2 and Rd) in the traditional Chinese medicine injection named Kang'ai injection. To achieve optimum extraction performance, the experimental conditions were optimized, including type and amount of DES and salt, ultrasound time, temperature and pH value. In the dynamic linearity range, experimental results showed satisfactory recoveries of analytes ranging from 92.7-110.8% with the relative standard deviations (RSDs) ranging from 1.2-3.9%. It has been proved that DES-ATPS has great potential for determination of active ingredients in traditional Chinese medicine injection as well as samples in other analytical science field. (C) 2017 Elsevier B.V. All rights reserved.

关键词： Aqueous two-phase system Ginsenosides High-performance liquid chromatography Kang'ai injection

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Fatty Infiltration of Multifidus Muscles: An Easily Overlooked Risk Factor for the Severity of Osteoporotic Vertebral Fractures

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ORTHOPAEDIC SURGERY 2024年第3期16卷 585-593页

作者： Xu, Wuyan liu, Xiaowen Wu, li liang, Shaohua Zhang, Ye Huang, Junbing Zeng, xuwen li, Siming Xu, Fan Xiong, Yuchao Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Dept Orthoped Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Clin Med Coll 2 Shenzhen Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou 510220 Peoples R China

ObjectivesOsteoporotic vertebral fractures (OVFs) are a critical public health concern requiring urgent attention, and severe OVFs impose substantial health and economic burdens on patients and society. Analysis of the risk factors for severe OVF is imperative to actively prevent the occurrence of this degenerative disorder. This study aimed to investigate the risk factors associated with the severity of OVF, with a specific focus on changes in the paraspinal *** total of 281 patients with a first-time single-level acute OVF between January 2016 and January 2023 were enrolled in the study. Clinical and radiological data were collected and analyzed. The cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles, including the multifidus muscles (MFMs), erector spinae muscles (ESMs), and psoas major muscles (PSMs), were measured by magnetic resonance imaging (MRI) of the L4/5 intervertebral discs. According to the classification system of osteoporotic fractures (OF classification) and recommended treatment plan, OVFs were divided into a low-grade OF group and a high-grade OF group. Univariate and multivariate logistic regression analyse s were performed to identify risk factors associated with the severity of ***-eight patients were included in the low-grade OF group, and 183 patients were included in the high-grade OF group. Univariate analysis revealed a significantly higher incidence of a high degree of FI of MFMs (OR = 1.71, p = 0.002) and ESMs (OR = 1.56, p = 0.021) in the high-grade OF group. Further multivariate logistic regression analysis demonstrated that a high degree of FI of the MFMs (OR = 1.71, p = 0.002) is an independent risk factor for the severity of *** high degree of FI of the MFMs was identified as an independent risk factor for the severity of OVF. Decreasing the degree of FI in the MFMs might lower the incidence of the severity of OVF, potentially reducing the necessity for s

关键词： Fatty Infiltration Osteoporosis Multifidus Muscles Osteoporotic Vertebral Fracture

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Exploring bifunctional molecules for anti-SARS-CoV-2 and anti-inflammatory activity through structure-based virtual screening, SAR investigation, and biological evaluation

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025年 287卷 138529页

作者： Lu, Jiani He, Yingying li, Yaqi Chen, Xixiang li, Hongtao Chen, xuwen Xu, Jianrong Chen, Hongzhuan Wang, Ying He, Xiao liu, Shunying Chen, lili Shanghai Univ Tradit Chinese Med Longhua Hosp Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr TCM Chem Biol Shanghai 201203 Peoples R China East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Hunan Normal Univ Coll Life Sci Natl & Local Joint Engn Lab Anim Peptide Drug Dev Changsha 410081 Peoples R China Hunan Normal Univ Inst Interdisciplinary Studies Changsha 410081 Peoples R China Hunan Normal Univ Furong Lab Peptide& Small Mol Drug R&D Plateform Changsha 410081 Hunan Peoples R China DP Technol Beijing 100080 Peoples R China Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Acad Integrat Med Shanghai Frontiers Sci Ctr TCM Chem Biol Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Shanghai Inst Infect Dis & Biosecur Inst Interdisciplinary Integrat Med Res Res Ctr Tradit Chinese MedShanghai Frontiers Sci Shanghai 201203 Peoples R China East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Shanghai Frontiers Sci Ctr Mol Intelligent Synth Sch Chem & Mol Engn Shanghai 200062 Peoples R China NYU Shanghai NYU East China Normal Univ Ctr Computat Chem Shanghai 200062 Peoples R China

As new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, they raise increasing concerns about the efficacy of neutralizing antibodies and vaccines. This situation underscores the urgent need for specific drugs against the coronavirus disease 2019 (COVID-19). Given that COVID-19 is particularly associated with substantial inflammation, the development of novel, effective antiviral and antiinflammatory agents represents a promising research direction. In this study, we virtually screened a library consisting of 2900 anti-inflammatory small molecules for their inhibitory effects on the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 and selected 23 promising candidates for further testing using a fluorescence resonance energy transfer (FRET) assay. The results indicated that Gnetol had the most potent inhibitory effect against SARS-CoV-2 3CLpro. Further structural modifications led to the identification of compounds 38 and 39, which displayed superior inhibitory activity. Compound 39 showed good selectivity for host proteases. Subsequently, Gnetol and its structural analogs, which demonstrated SARS-CoV-2 3CLpro inhibitory activity, were tested for their anti-inflammatory effects. Among these, Piceatannol and compound 39 exhibited enhanced antiinflammatory effects, with compound 39 alone showing the most potent antiviral and anti-inflammatory activity. Thus, our study has explored a new research strategy for discovering antiviral and anti-inflammatory bifunctional molecules. The discovery of Gnetol and its structural analogs has provided new lead candidates for the development of COVID-19 therapeutics.

关键词： COVID-19 Virtual screening Anti-inflammation Bifunctional molecule

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Multisite synergistic interaction induced selective adsorption of CB5-Ti3C2T2 complex for strontium ion: A combined theoretical and experimental study

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JOURNAL OF HAZARDOUS MATERIALS 2025年 487卷 137288页

作者： li, Sifan Zhang, Pengcheng Zhang, Yujuan Qiu, Kaikai Wang, lin Lan, Jianhui Zhang, Yu Zhao, xuwen Miao, Chengzhen Shi, Weiqun Univ Sci & Technol Beijing Sch Mat Sci & Engn Beijing 100083 Peoples R China Chinese Acad Sci Inst High Energy Phys Lab Nucl Energy Chem Beijing 100049 Peoples R China Shanghai Jiao Tong Univ Sch Nucl Sci & Engn Minist Educ Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Key Lab Nucl Power Syst & Equipment Minist Educ Shanghai 200240 Peoples R China

In this work, we use a well-defined water-soluble macrocyclic molecule cucurbit[5]uril (CB5) to modify 2D Ti3C2T2 MXene and assemble a novel high-performance adsorbent CB5-Ti3C2T2 for Sr ion by density functional theory and experimental methods. The structural stabilities of two distinct types of CB5-Ti3C2T2 (T = F, O and OH) complexes, i.e., CB5-Ti3C2T2(V) and CB5-Ti3C2T2(P) configurations are proved by binding energy and ab initio molecular dynamics (AIMD) simulations. Calculations of adsorption properties reveal that all the considered CB5-Ti3C2T2 complexes can act as efficient adsorbents for Sr ion, among which CB5-Ti3C2O2 complex possesses the best performance. The high affinity (the calculated adsorption energies < -7.6 eV) and selectivity of CB5-Ti3C2T2 complex for Sr ion are attributed to the synergistic effect between CB5 molecule and Ti3C2T2 MXene in the adsorption process, which arises from the multisite interactions of portal carbonyl groups of CB5 and surface functional groups of Ti3C2T2 towards Sr. Finally, CB5-Ti3C2T2 complex was successfully synthesized, and experimental results confirm its synergistic effect, good selectivity and high removal efficiency for Sr ions. In the treatment of strontium-containing wastewater with low concentrations, the distribution coefficient and decontamination factor of CB5-Ti3C2T2 for Sr were determined to be as high as 2.88 x 10(5) mL/g and 144.9, respectively, and the separation factor (SFSr/Ca) achieved a notable value of 67. 5. This work is expected to present a new strategy for the construction of high-performance MXene-based adsorbent for radionuclide elimination.

关键词： MXene Cucurbit[5]uril Adsorption Strontium First-principles simulation

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赞比亚医疗器械现状及挑战

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中国医疗设备 2022年第5期37卷 146-149,165页

作者： Taizya Kapenda 廉翠婷杨琳郝冬梅杨益民李旭雯张松北京工业大学环境与生命学部智能化生理测量与临床转化北京市国际科研合作基地北京100124

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废... 详细信息

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废更新提供参考。赞比亚卫生部通过赞比亚药品监督管理局制定的医疗设备相关政策、计划、资源、规范和指南,明确了在医疗器械部署过程中各环节应遵循的规定制度。本文分析了赞比亚医疗器械管理所面临的挑战:医疗设备缺乏、人力资源缺乏、规划与预算不足,以及设备采购、安装、调试、维护的难题,并提出相应解决办法,如建立医疗设备委员会,采用临床工程人员对医疗设备进行统一管理的方式,以保障临床医护人员以及患者的安全。赞比亚管理和维护医疗设备的能力仍然有限,导致管理和维修能力的增长大大落后于医疗设备的部署,这些既是赞比亚与他国合作的方向,也是自身需要改进的部分。本研究可为提高赞比亚医疗设备服务水平、缓解医疗压力提供参考。

关键词：赞比亚医疗器械政策法规器械管理挑战

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