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中国医学影像技术 2024年第9期40卷 1449-1450页

作者：李翔付旭文寸新华昆明市第三人民医院云南省传染性疾病医学中心医学影像科云南昆明650041 昆明市第三人民医院云南省传染性疾病医学中心骨科云南昆明650041

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示... 详细信息

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示结核分枝杆菌(+)。

关键词：结核,骨关节体层摄影术,X线计算机磁共振成像

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Surface-Engineering Enhanced Charge Injection and Recombination of Silver Nanoclusters in an Aqueous Medium

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JOURNAL OF PHYSICAL CHEMISTRY C 2021年第40期125卷 22078-22083页

作者： Gao, xuwen Dong, Shuangtian Fu, li Xu, Yuqi Jia, Jingna Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

An effective way to enhance the charge injection and the radiative recombination within atomically precise nanoclusters (NCs) is proposed with Ag-29(BDT)(12) (BDT = 1,3-benzenedithiol) and Ag-29(BDT)(12)(TPP)(4) (TPP = triphenylphosphine) as models. Surface-engineering Ag-29(BDT)(12) with phosphine ligands can passivate the four naked Ag atom sites on the surface of Ag-29(BDT)(12) and circumvent the geometric packing limitation induced by the wide footprint of BDT, which endows Ag-29(BDT)(12)(TPP)(4) with enhanced electrochemical redox for improved charge injection as well as boosted photoluminescence (PL) and electrochemiluminescence (ECL) for enhanced radiative charge recombination. The surface-engineering process demonstrates a negligible effect on the charge-injection potentials as well as the excited state emission for PL and ECL. Ag-29(BDT)(12) and Ag-29(BDT)(12)(TPP)(4) can be injected with holes and electrons via similar electrochemical redox processes;both annihilation ECL and co-reactant ECL of Ag-29(BDT)(12) and Ag-29(BDT)(12)(TPP)(4) match well with their valence (VB) hole/conduction (CB) electron injection-related oxidative/reductive processes and are of similar wavebands with a maximum emission wavelength around 795 nm.

关键词： Elements Redox reactions Quantum mechanics Charge recombination Recombination

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Research on the Development Strategy of Rural Cooperative Economy in the Post‐Epidemic Era ‐‐ Take the Rural Areas in Northern Anhui Province as an Example

Frontiers in Economics and Management

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Frontiers in Economics and Management 2023年第2期4卷 50-54页

作者： xuwen Zhang Han Han Senao li Jing Yan

In recent years, the development of the rural cooperative economy, the government and how to develop. At present, the coordinated development of rural revitalization and urbanization cannot be separated from the revitalization of the rural economy, which means that how to develop the rural cooperative economy has become an important issue of the current rural revitalization. This project is based on discussing how to develop the rural cooperative economy in northern Anhui. Through literature collection, field investigation and research, data analysis and sorting, combined with the advantages of rural areas in northern Anhui, it analyzes the current bottleneck of development and the factors restricting the development of rural cooperative economy in northern Anhui. Based on the basic situation of the rural cooperative economic development, the country and the Anhui province introduced support of rural cooperative economic development policy with the north of rural cooperative economic development actual situation, on the basis of a series of north of rural cooperative economy development quality countermeasures and Suggestions, innovative to develop two village mutual learning evaluation mechanism, promote land adoption agriculture, construction live help farmers base countermeasures, such as policy support, resources as a whole, innovation consciousness gives the specific path of rural cooperative economic development.

关键词： Rural Revitalization Cooperative Economy Urbanization Development Farmers' Income Increase Production Union

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Fe²⁺-Coupled Organic-Substrate-Enhanced Nitrogen Removal in Two-Stage Anammox Biofilm Reactors

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PROCESSES 2025年第5期13卷

作者： Bao, Yingchun Ge, Qilong li, Siyuan Wang, Xiaowei Zheng, xuwen Chen, Zhenguo Southeast Univ Architecture & Engineers Co Ltd Nanjing 210096 Peoples R China Hua An Biotech Co Ltd Foshan 528300 Peoples R China South China Normal Univ Sch Environm Guangzhou 510006 Peoples R China

Anammox is a novel and energy-efficient biological nitrogen removal technology. Enhancing its performance in treating low-strength nitrogen wastewater is essential for expanding its practical applications. In response to challenges such as low nitrogen removal efficiency (NRE), poor operational stability, limited environmental resistance, and the interference of organic compounds commonly found in real wastewater, this study developed a two-stage upflow anammox biofilm reactor system (R1 and R2) enhanced by an Fe2+-coupled organic substrate strategy for deep nitrogen removal under low-nitrogen conditions. Results showed that sodium acetate at a chemical oxygen demand (COD) concentration of 40 mg/L provided the greatest enhancement to anammox activity, achieving an average total nitrogen removal efficiency (NRE) of 90.02%. However, the reactor performance was significantly inhibited under higher COD conditions (e.g., COD = 60 mg/L). Under an influent Fe2+ concentration of 10 mg/L, the reactors' NRE increased and then decreased as the COD concentration rose from 0 to 100 mg/L, resulting in the highest efficiency being achieved at an average NRE of 94.11%, observed under 10 mg/L Fe2+ coupled with 60 mg/L of COD in the two-stage anammox system. Scanning electron microscopy revealed that the co-addition of Fe2+ and organic substrates led to the formation of granular protrusions and pores on the sludge surface, which favored the structural stability of the biomass. At a COD level of 40 mg/L, the contents of extracellular polymeric substances and heme c in anammox biofilm were significantly higher compared to the addition of 10 mg/L Fe2+ alone, whereas excessive COD inhibited both indicators. These findings suggest that moderate levels of Fe2+ coupled with organic matter can promote anammox activity for deep nitrogen removal, while excessive organics have inhibitory effects. This study provides theoretical support for enhancing nitrogen removal from low-strength wastewater

关键词： biological nitrogen removal anammox Fe2+ organic substrates enhancement

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Surface-Defect-Induced and Synergetic-Effect-Enhanced NIR-II Electrochemiluminescence of Au-Ag Bimetallic Nanoclusters and Its Spectral Sensing

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ANALYTICAL CHEMISTRY 2021年第11期93卷 4909-4915页

作者： Fu, li Gao, xuwen Dong, Shuangtian Hsu, Hsien-Yi Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China City Univ Hong Kong Sch Energy & Environm Kowloon Hong Kong 999077 Peoples R China City Univ Hong Kong Dept Mat Sci & Engn Kowloon Hong Kong 999077 Peoples R China

Aqueous electrochemiluminescence (ECL) in the second near-infrared biowindow (NIR-II, 900-1700 nm) was anticipated for ECL evolution and spectral multiplexing. Herein, aqueous and monochromatic ECL with a single emission peak beyond 900 nm was achieved by employing methionine (Met)-capped Au-Ag bimetallic nanoclusters (BNCs) as luminophores and triethanolamine (TEOA) as a coreactant. The Met-capped Au-Ag BNCs with surface-defect-induced PL around 756 nm were water-soluble and synthesized via doping Met-capped Au NCs with Ag in a doping-in-growth way. By extensively exploiting the red-shifting nature of surface-defect-induced ECL to PL and the synergetic-effect-enhanced ECL of BNCs, physically surface-confined Au-Ag BNCs exhibited efficient NIR-II ECL around 906 nm in aqueous medium. A spectrum-based NIR-II ECL immunoassay around 915 nm was also achieved by immobilizing the Au-Ag BNCs onto an electrode surface via forming a sandwich immunocomplex, which could selectively determine CA125 from 5 x 10(-4) to 1 U/mL with a detection limit of 5 x 10(-5) U/mL (S/N = 3). The combined strategy of surface-defect-induced ECL and synergetic-effect-enhanced ECL would enable promising biorelated application of NIR-II ECL.

关键词： Immunology Peptides and proteins Gold Precursors Biopolymers

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Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2024年第PT 2期257卷 128623页

作者： Wang, Ruyu Chen, xuwen li, Hongtao Chen, Xixiang Sun, Donghui Yu, Danmei Lu, Jiani Xie, Yuanyuan Zhang, Qian Xu, Jianrong Zhang, Weidong Chen, Hongzhuan liu, Shunying Chen, lili Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr TCM Chem Biol Shanghai Peoples R China East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Shanghai Univ Tradit Chinese Med Acad Integrat Med 1200 Cailun Rd Shanghai 201203 Peoples R China Fudan Univ Sch Pharm Dept Med Chem Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Shanghai Inst Infect Dis & Biosafety Inst Interdisciplinary Integrat Med Res Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai 201203 Peoples R China

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to human. Since there are still no effective treatment options against the new emerging variants of SARS-CoV-2, it is necessary to devote a continuous endeavor for more targeted drugs and the preparation for the next pandemic. Salvia miltiorrhiza and its active ingredients possess wide antiviral ac-tivities, including against SARS-CoV-2. Danshensu, as one of the most important active ingredients in Salvia miltiorrhiza, has been reported to inhibit the entry of SARS-CoV-2 into ACE2 (angiotensin-converting enzyme 2)-overexpressed HEK-293T cells and Vero-E6 cells. However, there is a paucity of information regarding its detailed target and mechanism against SARS-CoV-2. Here, we present Danshensu as a covalent inhibitor of 3-chymotrypsin-like protease (3CLpro) against SARS-CoV-2 by the time-dependent inhibition assay (TDI) and mass spectrometry analysis. Further molecular docking, site-directed mutagenesis, circular dichroism (CD) and fluorescence spectra revealed that Danshensu covalently binds to C145 of SARS-CoV-2 3CLpro, meanwhile forming the hydrogen bonds with S144, H163 and E166 in the S1 site. Structure-based optimization of Danshensu led to the discovery of the promising compounds with good inhibitory activity and microsomal stability in vitro. Due to Danshensu inhibiting lung inflammation in the mouse model, we found that Danshensu derivatives also showed better anti-inflammatory activity than Danshensu in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Thus, our study provides not only the clue of the efficacy of Salvia miltiorrhiza against SARS-CoV-2, but also a detailed mechanistic insight into the covalent mode of action of Danshensu for design of co-valent inhibitors against SARS-CoV-2 3CLpro, highlighting its potential as a bifunctional molecule with antivirus and anti-inflammation.

关键词： Danshensu SARS-CoV-23CLpro Covalent inhibitor Anti-inflammation Bifunctional molecule

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PCSK9 is upregulated and correlated with more severe disease condition but fails to predict treatment outcomes in psoriasis patients

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JOURNAL OF DERMATOLOGICAL TREATMENT 2025年第1期36卷 2482867页

作者： Yin, xuwen Shi, Lei Zhang, Ni li, Heng Long, Jianwen Yu, Xinjian Hubei Prov Hosp Tradit Chinese Med Dermatol Dept 4 Huayuan Rd Wuhan 430061 Wuchang Peoples R China Huping Municipal Hosp Tradit Chinese Med Dermatol Dept Huping Peoples R China

BackgroundProprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) not only regulates cholesterol metabolism and cardiovascular disorder but also modifies inflammatory response and *** study investigated the relation of PCSK9 to clinical features and treatment outcomes in psoriasis *** hundred and five psoriasis patients who initiated systemic treatment due to moderate-to-severe disease condition were enrolled. Baseline characteristics and treatment response after 12-week treatment were collected. Their serum samples before treatment initiation were collected and sent to PCSK9 detection by enzyme-linked immunosorbent assay. Serum PCSK9 was also detected in 30 healthy ***9 level was 2-fold times in psoriasis patients vs. healthy subjects. PCSK9 could predict psoriasis risk with AUC of 0.777. By optimum cutoff value of 179 ng/ml, PCSK9 had the best predictive potential for psoriasis risk. PCSK9 quartile was positively correlated with BMI, hyperlipemia history, PASI, and sPGA. However, PCSK9 quartile was not correlated with PASI 75 response, PASI 90 response, or sPGA 0/1 response at week ***9 is upregulated and correlated with severe disease condition, but fails to predict treatment outcomes in psoriasis patients.

关键词： PCSK9 psoriasis aberrant level clinical features treatment outcomes

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A Mannich-base imidazoline quaternary ammonium salt for corrosion inhibition of mild steel in HCl solution

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MATERIALS CHEMISTRY AND PHYSICS 2023年 293卷

作者： Wang, Ge li, Wentao Wang, Xuan Yuan, xuwen Yang, Huaiyu Chinese Acad Sci Inst Met Res Shenyang 110016 Peoples R China Univ Sci & Technol China Sch Mat Sci & Engn Hefei 230026 Peoples R China Hubei Univ Automot Technol Dept Mat Sci & Engn Shiyan 442002 Peoples R China

The inhibition performance of a novel Mannich base-type imidazoline quaternary salt, namely [N, N-bis(pro-piophenone), N(-1-polyethyleneployamine-2-stearic-imidazole)] benzyl ammonium chloride (PPLC) for mild steel in 0.5 M HCl was investigated. The experimental results show that PPLC is an excellent corrosion inhibitor, which can retard both the anodic and cathodic reactions through strong chemisorption on the surface. The theoretical results from DFT and MD simulations imply that the active site of PPLC was concentrated on the imidazole ring, carbonyl group and benzene ring, and the PPLC could spontaneously adsorb on the surface of metal in a manner parallel.

关键词： Mild steel Polarization EIS DFT MD

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Geographic differences in pharmacotherapy patterns and outcomes of acute ischemic stroke in China

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BMC NEUROLOGY 2024年第1期24卷 1-10页

作者： li, Ying Ou, Qianhua Lu, Yuxuan Shen, Zhiyuan li, Jieyu Zhang, Zhuangzhuang Tai, liwen li, Guozhong Chen, Huisheng Zhang, Guiru Zhang, Lei Sun, xuwen Qiu, Jinhua Wei, Yan Zhu, Sainan Wang, Zhaoxia Sun, Weiping Huang, Yining Peking Univ First Hosp Dept Neurol 8 Xishiku St Beijing 100034 Peoples R China Beijing Key Lab Neurovasc Dis Discovery Beijing Peoples R China Techpool Biopharm Co Ltd Dept Med Affairs Guangzhou Peoples R China Hebei Med Univ Hosp 2 Dept Neurol Shijiazhuang Peoples R China Harbin Med Univ Affiliated Hosp 1 Dept Neurol Harbin Peoples R China Gen Hosp Shenyang Mil Command Dept Neurol Shenyang Peoples R China Penglai Peoples Hosp Dept Neurol Penglai Peoples R China Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol Zhuhai Peoples R China Qindao Univ Affiliated Yantai Yuhuangding Hosp Med Coll Dept Neurol Yantai Peoples R China Huizhou First Hosp Dept Neurol Huizhou Peoples R China Harrison Int Peace Hosp Dept Neurol Hengshui Peoples R China Peking Univ First Hosp Dept Biostat Beijing Peoples R China

Background: Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for acute ischemic stroke (AIS) and outcomes in China and explore the geographic variation in stroke care. Methods: This study was a multicenter prospective registry study, which collected the data of patients with AIS from 80 hospitals in 46 cities in 2015-2017 across China. Poor functional outcome defined as a modified Rankin Scale score of 3-6 was assessed at 3 and 12 months. Multivariate logistic regression was used. Results: Among 9973 eligible patients, the number of receiving intravenous thrombolysis (IVT), antiplatelet agents, anticoagulants, statin and human urinary kallidinogenase was 429 (4.3%), 9363 (93.9%), 1063 (10.7%), 6828 (74.7%) and 5112 (51.2%), respectively. Multivariable analysis showed IVT use in northeastern was significantly more frequent than in eastern region (OR = 3.17, 95% CI, 2.53-3.99), while the antiplatelets agents use were less frequent (OR = 0.46, 95%CI: 0.38-0.57). The proportions of poor outcomes at 3 and 12 months were 20.7% and 15.8%, respectively. Multivariate analysis showed AIS patients from northeastern and central region had significantly lower risk of poor outcome at month 3 and 12 than those from eastern region (all P < 0.05). Conclusions: There was a low IVT use and a high antiplatelet agent and statin use for AIS in China. The pharmacotherapy and prognosis of AIS had variation by geographic region.

关键词： Acute ischemic stroke Geographic variation Outcome Pharmacotherapy

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Online Monitoring of Ship Block Construction Equipment Based on the Internet of Things and Public Cloud: Take the Intelligent Tire Frame as an Example

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KSII TRANSACTIONS ON INTERNET AND INFORMATION SYSTEMS 2021年第11期15卷 3970-3990页

作者： Cai, Qiuyan Jing, xuwen Chen, Yu liu, Jinfeng Kang, Chao li, Bingqiang Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212100 Jiangsu Peoples R China

In view of the problems of insufficient data collection and processing capability of multi source heterogeneous equipment, and low visibility of equipment status at the ship block construction site. A data collection method for ship block construction equipment based on wireless sensor network (WSN) technology and a data processing method based on edge computing were proposed. Based on the Browser/Server (B/S) architecture and the OneNET platform, an online monitoring system for ship block construction equipment was designed and developed, which realized the visual online monitoring and management of the ship block construction equipment status. Not only that, the feasibility and reliability of the monitoring system were verified by using the intelligent tire frame system as the application object. The research of this project can lay the foundation for the ship block construction equipment management and the ship block intelligent construction, and ultimately improve the quality and efficiency of ship block construction.

关键词： Ship block construction equipment monitoring WSN edge computing Web

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