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Evaluation of DNA Damage, Biomarkers of Oxidative Stress, and Status of Antioxidant Enzymes in Freshwater Fish (Labeo rohita) Exposed to Pyriproxyfen

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022年第0期2022卷 5859266页

作者： li, xuwen Naseem, Sumaira Hussain, Riaz Ghaffar, Abdul li, Kun Khan, Ahrar Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Peoples R China Nanjing Agr Univ Coll Vet Med MOE Joint Int Res Lab Anim Hlth & Food Safety Nanjing 210095 Peoples R China Islamia Univ Bahawalpur Dept Zool Bahawalpur 63100 Pakistan Islamia Univ Bahawalpur Fac Vet & Anim Sci Dept Pathol Bahawalpur 63100 Pakistan Univ Agr Faisalabad Fac Vet Sci Faisalabad 38040 Pakistan Shandong Vocat Anim Sci & Vet Coll Weifang 261061 Peoples R China

Pyriproxyfen (PPF) mimics a natural hormone in insects and disrupts their growth. It is a well-known synthetic insecticide and aromatic juvenile hormone analog frequently used in agriculture and vegetable crops to control various insect species. At present, scanty information is available about the possible potential threats of PPF in aquatic organisms. Therefore, in this study, different toxico-pathologic endpoints of PPF like DNA damage, biomarkers of oxidative stress, and status of antioxidant enzymes were determined in Labeo rohita (freshwater fish). In our study, 60 active, free from any external obvious ailments, same size, age, and body mass were randomly allocated to four glass aquaria (T0-T3) separately containing 100 L water. The fish present in groups T1, T2, and T3 were administered PPF dissolved in water 300, 600, and 900 mu g/L for 30 days. Different tissues including the blood and visceral organs were obtained from each fish on days 10, 20, and 30 of the experiment. Results on various morphological and nuclear changes in red blood cells of PPF-exposed Labeo rohita fish including pear-shaped erythrocytes, spherocytes, red blood cells with a blebbed nucleus, micronucleus, and nuclear remnants were significantly increased. Our results on genotoxicity (comet assay) recorded significantly (P <= 0.05) increased DNA damage in various tissues of insecticide-exposed fish. The results on oxidative stress profile (reactive oxygen species and thiobarbituric acid reactive substances) and antioxidant enzymes (reduced glutathione superoxide dismutase, peroxidase, and catalase) in multiple tissues of Labeo rohita fish concluded significantly (P <= 0.05) higher quantity of biomarkers of oxidative stress and lower concentrations of different antioxidant enzymes in treated fish. Hence, the findings of our experimental research determine that PPF could induce adverse toxic impacts on multiple tissues of Labeo rohita fish.

关键词： Oxidative stress

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Risk prevention of different forms of gestational diabetes mellitus based on energy metabolism prior to diagnosis

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TECHNOLOGY AND HEALTH CARE 2022年第1_suppl期30卷 S285-S292页

作者： Lu, Jiayu Jiang, Hongqing Zhang, Song Yang, Yimin Hao, Dongmei li, xuwen Chen, Aiqing Shao, Jing liu, Xiaohong Yang, lin Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing Peoples R China Haidian Maternal & Children Hlth Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively. OBJECTIVE: GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively. METHODS: By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences. RESULTS: For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy. CONCLUSION: The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

关键词： Diabetes mellitus in the second trimester diagnosis of diabetes mellitus in the third trimester energy metabolism

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Amanita peptide toxin analysis: An innovative UPLC-MS/MS method utilizing Fe3O4-based magnetic adsorbent

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JOURNAL OF FOOD COMPOSITION AND ANALYSIS 2024年 131卷

作者： Jiang, Yifu Lang, Le Zhang, Jingwen Ji, Yining Zhang, Chenglong Yang, Ruiqin li, xuwen Peoples Publ Secur Univ China Sch Criminal Invest Beijing 100038 Peoples R China Jilin Univ Coll Chem Changchun 130021 Peoples R China Jilin Prov Prod Qual Supervis & Inspect Inst Changchun 130000 Peoples R China Jilin Univ Coll New Energy & Environm Changchun 130000 Peoples R China

This study combined the structural characteristics of amanita peptide toxins to prepare a Fe3O4/P4VPBA/PPy/ GO composite material as a magnetic solid-phase extraction adsorbent. The experimental results indicated that this adsorbent showed excellent selectivity for the extraction of amatoxins and phallotoxins from mushroom samples. Compared with traditional dispersive solid-phase extraction, this adsorbent enables rapid separation in the enrichment and elution recovery stages through the application of a magnetic field. Simultaneously, the study optimized the conditions for ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS), ensuring both separation efficiency and accuracy while reducing the analysis time. The researchers established the MSPE-UPLC-MS/MS method for the determination of amanita peptide toxins in wild mushrooms. This method not only simplified and expedited the sample pretreatment process but also achieved qualitative and quantitative analyses in a short period, thus demonstrating high detection sensitivity and outstanding recovery rates. Furthermore, the developed method was successfully applied to analyze toxic mushrooms discovered in Nanjing, China. The potential for extensive utilization of this method is highlighted in the field of food analysis and detection.

关键词： Mushroom poisoning Amanita peptide toxins Magnetic solid -phase extraction UPLC-MS/MS Food analysis

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The exploration of N6-deoxyadenosine methylation in mammalian genomes

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Protein & Cell 2021年第10期12卷 756-768页

作者： xuwen li Zijian Zhang Xinlong Luo Jacob Schrier Andrew D.Yang Tao P.Wu Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Medical Scientist Training Program Baylor College of MedicineHoustonTX 77030USA Huffington Center on Aging Baylor College of MedicineHoustonTX 77030USA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTX 77030USA

N^(6)-methyladenine(N^(6)-mA,m^(6)dA,or 6mA),a prevalent DNA modification in prokaryotes,has recently been identified in higher eukaryotes,including *** 6mA has been well-studied in prokaryotes,the function and regulatory mechanism of 6mA in eukaryotes are still poorly *** studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes,from transposable-element suppression to environmental stress ***,we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical DNA methylation in eukaryotes,predominantly mammals.

关键词： DNA N^(6)-methyladenine(6mA) mammalian DNA modification norvcanonical mammalian DNA methylation

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Gradient tumor microenvironment-promoted penetrating micelles for hypoxia relief and immunosuppression reversion in pancreatic cancer treatment

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ACTA BIOMATERIAliA 2023年第1期167卷 387-400页

作者： Luo, Yifan li, Chao Zhang, Yiwen liu, Peixin Chen, Hongyi Zhao, Zhenhao Wang, Yu Zhou, Zheng Song, Haolin Su, Boyu li, Chufeng li, xuwen Zhang, Tongyu You, Haoyu Wu, Yuxing Tian, Zonghua Zhang, Shilin Guo, Yun Fan, Hongrui Chen, Qinjun Jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is the main block for the penetration of chemotherapy. In the tumor microenvironment, a dense matrix composed of fibrin is formed on the exterior, while the interior is featured by high reduction, hypoxia and low pH. How to match the special microenvironment to on-demand drug release is the key to improve chemotherapeutic efficacy. Herein, a microenvironment-responsive micellar system is developed to deepen tumoral penetration. Briefly, the conjugation of a fibrin-targeting peptide to PEG-poly amino acid has been utilized to achieve accumulation of micelles in the tumor stroma. By modification of micelles with hypoxia-reducible nitroimidazole which becomes protonated under acidic conditions, their surface charge is more positive, facilitating deeper penetration into tumors. Paclitaxel was loaded onto the micelles via a disulfide bond to enable glutathione (GSH)-responsive release. Therefore, the immunosuppressive microenvironment is relived through the alleviation of hypoxia and depletion of GSH. Hopefully, this work could establish paradigms by designing sophisticated drug-delivery systems to tactfully employ and retroact the tamed tumoral microenvironment to improve the therapeutic efficacy based on understanding the multiple hallmarks and learning the mutual regulation.

关键词： Pancreatic cancer Penetration Nitroimidazole Tumor hypoxia Gemcitabine

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

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NANO LETTERS 2025年第7期25卷 2949-2959页

作者： Zhang, Shilin You, Haoyu Fan, Hongrui Chen, Yun Song, Haolin Zhao, Zhenhao Chen, Qinjun Wang, Yu Tian, Zonghua Wu, Yuxing Zhou, Zheng Guo, Yun Su, Boyu li, xuwen Jia, Ru Fang, Mingzhu Jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Key Lab Smart Drug Delivery State Key Lab Med NeurobiolMinist Educ Shanghai 201203 Peoples R China Fudan Univ Frontiers Ctr Brain Sci Sch Pharm MOE Shanghai 201203 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China Fujian Med Univ Binhai Campus Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Fuzhou 350212 Peoples R China

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8+ T cells inward. Additionally, the overactivated TGF-beta/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy. In this work, a type of enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) and pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral enamine N-oxides can trigger transcytosis and then respond to hypoxia and acidic microenvironments, turning the surface charge of the nanoparticles to a positive charge and enhancing penetration. The released galunisertib inhibits the TGF-beta/SMAD signaling pathway, reshapes the matrix, activates antitumor immunity, and combines with gemcitabine (Gem) to kill tumor cells.

关键词： Drug delivery system transcytosis tumor penetration enamine N-oxide TGF-beta/SMAD signalingpathway

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A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex and Xilinx Ultrascale+ MPSoC DUAL VOLTAGE MECHANISM 2021

A POWER MANAGEMENT CIRCUIT COMPATIBLE with Ti SmartReflex an...

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2021 10th International Conference on Computing and Pattern Recognition

作者： Chenyun li xuwen li Changjiang Tang Qiang Wu Beijing University of Technology China

ISBN: (纸本)9781450390439

Since the semiconductor technology has entered the age of 90 nm, the static power consumption of the chip has increased rapidly. For edge computing devices, the waste of power can not be ignored. This paper uses the relationship between power consumption and power supply voltage of FPGA and DSP, analyzes the characteristics of the traditional scheme, and designs a hardware circuit according to the different mechanisms of reducing static power consumption of FPGA and DSP According to the design of FPGA and DSP core power supply voltage compatibility, the system realizes the requirement of FPGA and DSP for power supply voltage amplitude and realizes dynamic control of power supply voltage. After verification and comparison, FPGA and DSP can realize the adjustment of performance power consumption and stable operation under the power system.

关键词： FPGA DSP POWER CONSUMPTION

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The simultaneous control over the alternating sequence and the inner- core position of the mesogenic segments in side-chain liquid crystal polymers

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JOURNAL OF MOLECULAR liQUIDS 2022年 363卷

作者： Zhang, Ruixue Ma, Hongwei li, xuwen Wang, Bo li, Chao liao, Wen li, Yang Han, li Dalian Univ Technol Sch Chem Engn Dept Polymer Sci & Engn State Key Lab Fine ChemLiaoning Key Lab Polymer S Dalian 116024 Peoples R China

Hydrosilylated 1,1-diphenylethylene (DPE-SiH/2SiH) are herein quantitatively and alternatingly incorpo-rated during the living anionic copolymerization of isoprene with DPE-SiH/2SiH, which can efficiently control the Si-H densities and positions. The diversified mesogenic moieties containing azobenzene (Azo) or trifluoromethyl (F3C) groups, respectively, with the tuned inner-core position of the mesogenic segments are rationally designed and then fabricated into multiple alternatingly-arranged side-chain liq-uid crystal polymers (SCLCPs) along the alternating backbones. This study presents the novel SCLCPs with the simultaneous control over the sequence and the inner-core position of the mesogenic segment, pro-viding the promising route and study model to develop the mechanistic investigations. The temperature range of mesomorphic phase formation (delta T) and polarized optical morphologies are proved to be syner-gistically dependent on the diversified mesogenic moieties and the exactly controlled densities of the mesogenic segment. (C) 2022 Elsevier B.V. All rights reserved.

关键词： living anionic copolymerization Side -chain liquid crystal polymers Alternating sequence Azobenzene (Azo) Trifluoromethyl (CF3 ) groups

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南疆地区图木舒克市主城区园林树木调查及评价

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绿色科技 2024年第9期26卷 1-6页

作者：宁阳阳李许文广州园林建筑规划设计研究总院有限公司广东广州510440 广州市名卉景观科技发展有限公司广东广州510420 新疆前昆工程建设集团有限责任公司新疆图木舒克843900 广州市建筑集团有限责任公司广东广州510030

为摸清南疆地区图木舒克市主城区园林树木应用情况,在分析以往资料的基础上,选择图木舒克市主城区3类绿地类型进行调查。结果表明:图木舒克主城区现有木本园林植物112种,隶属于31科58属,其中乔木65种,灌木47种;在观赏特性上,有观花植物... 详细信息

为摸清南疆地区图木舒克市主城区园林树木应用情况,在分析以往资料的基础上,选择图木舒克市主城区3类绿地类型进行调查。结果表明:图木舒克主城区现有木本园林植物112种,隶属于31科58属,其中乔木65种,灌木47种;在观赏特性上,有观花植物、观形植物、观色植物、观果植物;应用频率高的植物种类较少;绝大部分乔灌木生长状况良好。针对树种种植间距密集、植物景观单一、植物材料缺乏本土特性、植物养护不当等问题提出针对性建议。

关键词：园林树木调查与评价图木舒克市

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Study of Pulse Wave Changes in Patients with End-stage Renal Disease Receiving Hemodialysis Treatment 23

Study of Pulse Wave Changes in Patients with End-stage Renal...

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Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science

作者： Ziwei li Chong Wang lin Yang Jie Yang Ying li Cuiting lian Dongmei Hao Guangfei li Yimin Yang xuwen li Faculty of Chemistry and Life Sciences Beijing University of Technology China Beijing Jishuitan Hospital Capital Medical University China

ISBN: (纸本)9798400708138

This study presents a novel experimental approach to investigate the changes in pulse wave patterns and pulse wave characteristic parameters in patients before, during, and after hemodialysis by analyzing radial artery pulse waves collected at time intervals from end-stage renal disease patients receiving hemodialysis. The results show that the morphology of the pulse wave is characterized by diversity between patients due to different vascular elasticity, but five categories can be classified according to the shape. When individuals of the same waveform Type-Are studied, we found that there were significant differences in some of the characteristic parameters of the pulse wave at different times of the day as the hemodialysis process progressed, a finding that also verifies the existence of hemodynamic changes during hemodialysis.

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