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INDIVIDUALIZED SPORTS MANAGEMENT SCHEME FOR PREGNANT WOMEN IN CHINA

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2019年第8期19卷

作者： Yang, lin Luo, Qi Lu, Yang Zhang, Song Yang, Yimin Li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Beijing 100124 Peoples R China Beijing Elect Power Hosp Beijing 100073 Peoples R China Beijing Aerosp Chang Feng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

In recent years, pregnant women in China generally face problems such as unbalanced and excessive nutrition, lack of proper exercise during pregnancy, which shows a significant increase in weight during pregnancy, leading to an increasing trend of perinatal complications. At present, there is less sports health management system for pregnant women throughout pregnancy. In view of this, based on the existing research in related fields, this study deeply explores the appropriate monitoring methods of pregnant women's sports in China. In this study, effective and convenient testing methods and evaluation criteria were proposed for pregnant women's sports and psychology. The research idea was a method based on the pulse wave to detect pregnant women's cardiac reserve capacity, and grading the Diastolic/Systolic value of pregnant women as a reference for grading individualized target heart rate range of moderate intensity exercise. The effective time and energy expenditure of pregnant women were assessed by monitoring the exercise process. The purpose is to help and guide pregnant women in the whole process of pregnancy self-movement management, and thus improve the quality of maternal health care services in China.

关键词： Pregnancy health sports management pulse wave, exercise assessment

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Association of rs1059004 polymorphism in the OLIG2 locus with functional brain network in first-episode negative schizophrenia

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PSYCHIATRY RESEARCH-NEUROIMAGING 2020年 303卷 111130-111130页

作者： Lv, Yahui Wu, Sijia lin, Yanyan Wang, xuwen Wang, Jijun Cai, Suping Huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Shanghai 200030 Peoples R China

Schizophrenia has often been viewed as a disorder of connectivity. The single nucleotide polymorphism rs1059004 in the oligodendrocyte lineage transcription factor 2 gene locus has been reported to be associated with schizophrenia. We measured the functional connectivity and functional brain network topology properties in 49 schizophrenic patients and 47 healthy controls. We compared the strength and diversity of the functional connectivity and topological properties of functional networks between different genotypes. The correlations among functional connectivity, topological properties and behavioral performances were also investigated in this study. We found that the connectivity strength of schizophrenic patients carrying the risk A allele was generally decreased whereas connectivity diversity was increased. Regarding topological properties, all groups showed small-world properties, the nodal efficiency showed significant differences in the right precuneus and left middle temporal pole between different genotypes in schizophrenic patients. Moreover, the nodal efficiency in the left middle temporal pole was positively correlated with the neuropsychological assessment battery results of the schizophrenic patients who were homozygous for the C allele. Our results elucidate the contribution of rs1059004 to the functional brain network, and may help enhance the present understanding of the role of risk gene in the functional dysconnectivity of schizophrenia.

关键词： Schizophrenia Oligodendrocyte lineage transcription factor 2 Functional connectivity Functional network Graph theoretical analysis

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血清I-FABP和CBG对新生儿坏死性小肠结肠炎需要选择手术治疗的预测价值

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江苏医药 2024年第6期50卷 577-581页

作者：杨福江胡博戴春娟马林赵绪稳王金虎杜晓斌天津市儿童医院(天津大学儿童医院)新生儿外科天津300074

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿... 详细信息

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿一般资料及确诊NEC时血清I-FABP、CBG水平。采用多因素logistic回归分析NEC患儿选择手术治疗的独立影响因素。分析血清I-FABP和CBG单独及联合检测对NEC患儿行手术治疗的预测价值。结果手术组血清I-FABP及CBG水平高于非手术组(P<0.05)。多因素logistic回归分析结果显示,确诊NEC时血清I-FABP及CBG水平升高是NEC患儿行手术治疗的独立危险因素(P<0.05)。血清I-FABP联合CBG检测预测NEC患儿行手术治疗的AUC为0.941[95%CI(0.888~0.993),P<0.01],相应的预测灵敏度和特异度分别为85.0%和94.0%。结论确诊NEC时的血清I-FABP和CBG水平有助于早期预测需行手术治疗的NEC患儿。

关键词：新生儿坏死性小肠结肠炎肠型脂肪酸结合蛋白 β葡萄糖苷酶

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Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2019年 160卷 87-94页

作者： Tao, Hui Tian, Hao Jiang, Shan Xiang, xuwen lin, Yinuo Ahmed, Wasim Tang, Riyuan Cui, Zi-Ning South China Agr Univ Guangdong Prov Key Lab Microbial Signals & Dis Co Integrat Microbiol Res Ctr State Key Lab Conservat & Utilizat Subtrop Agrobi Guangzhou 510642 Guangdong Peoples R China South China Agr Univ Coll Mat & Energy Dept Appl Chem Guangzhou 510642 Guangdong Peoples R China

Xanthomonas oryzae pv. oryzae (Xoo) infection directly leads to a severe disease known as leaf blight, which is a major cause of yield loss of rice. Use of traditional bactericides has resulted in severe resistance in pathogenic bacteria. A new approach screening compounds that target the virulence factors rather than killing bacterial pathogens is imperative. In gram-negative bacteria, the type III secretion system (T3SS) is a conserved and significant virulence factor considered as a target for drug development. Therefore, we designed and synthesized a new series of 5-phenyl-2-furan carboxylic acid derivatives stitched with 2-mercapto-1,3,4-thiadiazole. Bioassays revealed that the title candidates attenuated the hypersensitive response through suppressing the promoter activity of a harpin gene hpa1 without affecting bacterial growth. Quantitative real time polymerase chain reaction (qRT-PCR) analysis demonstrated reduced the expression of several genes associated with T3SS, when title compounds were applied. Additionally, hrp gene cluster members, including hrpG and hrpX, had reduced mRNA levels. In vivo greenhouse tests showed that candidate compounds could alleviate the effects of Xoo infection in rice (Oryza sativa) and possess better protective activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. All tested compounds were safe to rice. This work suggests there are new safe options for Xoo control in rice from these 1,3,4-thiadiazole derivatives.

关键词： 2-mercapto-1,3,4-thiadiazole Inhibitors Type III secretion system (T3SS) Anti-virulence factors Xanthomonas oryzae pv. oryzae (Xoo)

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生物医学工程国际化人才培养的需求与探索——以北京工业大学为例

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北京生物医学工程 2022年第2期41卷 190-193页

作者：郝冬梅杨琳李旭雯杨益民张松北京工业大学环境与生命学部北京100124 智能化生理测量与临床转化北京市国际科技合作基地北京100124

生物医学工程国际化人才培养对于我国医疗健康产业的发展具有重要意义。论文通过系统分析国际化教育的国内外研究现状,针对生物医学工程领域的科研和产业的需求,从办学方式、培养目标、课程设置和国际化举措方面探索了生物医学工程国际... 详细信息

生物医学工程国际化人才培养对于我国医疗健康产业的发展具有重要意义。论文通过系统分析国际化教育的国内外研究现状,针对生物医学工程领域的科研和产业的需求,从办学方式、培养目标、课程设置和国际化举措方面探索了生物医学工程国际化人才培养模式,并得到一些有益的结果。激励学生具有国际化视野、全球思维,能够与世界各国专业人士合作,解决人类共同面临的健康问题。

关键词：生物医学工程国际化人才培养医疗器械

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Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

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BIOORGANIC & MEDICINAL CHEMISTRY 2020年第11期28卷 115480-115480页

作者： Liu, xuwen Wilson, Michael W. Liu, Kun Lee, Pil Yeomans, Larisa Hagen, Susan E. lin, Cheng-Mao Wen, Bo Sun, Duxin White, Andrew D. Showalter, Hollis D. Antonetti, David A. Univ Michigan Dept Ophthalmol & Visual Sci Ann Arbor MI 48105 USA Univ Michigan Dept Med Chem Ann Arbor MI 48105 USA Univ Michigan Vahlteich Med Chem Core Ann Arbor MI 48109 USA Univ Michigan Dept Pharmaceut Sci Ann Arbor MI 48109 USA Univ Michigan Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA

Studies demonstrate that small molecule targeting of atypical protein kinase C (aPKC) may provide an effective means to control vascular permeability, prevent edema, and reduce inflammation providing novel and important alternatives to anti-VEGF therapies for certain blinding eye diseases. Based on a literature tricyclic thieno[2,3-d] pyrimidine lead (1), an ATP-competitive inhibitor of the aPKC iota (iota) and aPKC zeta (zeta) isoforms, we have synthesized a small series of compounds in 1-2 steps from a readily available chloro intermediate. A single pyridine congener was also made using 2D NMR to assign regiochemistry. Within the parent pyrimidine series, a range of potencies was observed against aPKC zeta whereas the pyridine congener was inactive. Selected compounds were also tested for their effect toward VEGF-induced permeability in BREC cells. The most potent of these (7l) was further assayed against the aPKC iota isoform and showed a favorable selectivity profile against a panel of 31 kinases, including kinases from the AGC superfamily, with a focus on PKC isoforms and kinases previously shown to affect permeability. Further testing of 7l in a luciferase assay in HEK293 cells showed an ability to prevent TNF-alpha induced NF kappa B activation while not having any effect on cell survival. Intravitreal administration of 7l to the eye yielded a complete reduction in permeability in a test to determine whether the compound could block VEGF- and TNF alpha-induced permeability across the retinal vasculature in a rat model. The compound in mice displayed good microsomal stability and in plasma moderate exposure (AUC and C-max), low clearance, a long half-life and high oral bioavailability. With IV dosing, higher levels were observed in the brain and eye relative to plasma, with highest levels in the eye by either IV or PO dosing. With a slow oral absorption profile, 7l accumulates in the eye to maintain a high concentration after dosing with higher levels than in

关键词： Blinding eye diseases atypical protein kinaseC (aPKC) Vascular permeability Vascular endothelial growth factor (VEGF) Tumor necrosis factor-alpha (TNF alpha) Homology model Thieno[2,3-d]pyrimidine inhibitors SAR

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桂东大瑶山成矿带鸡笼顶金矿地质特征及找矿前景

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矿产与地质 2020年第3期34卷 432-438页

作者：梁徐文林冰霞广西壮族自治区二七二地质队广西南宁530031 中国-东盟地学合作中心(南宁) 广西南宁530023

鸡笼顶金矿地处广西重要的大瑶山金、银、铜多金属成矿带,为构造破碎带—蚀变岩型金矿。矿区金矿体主要赋存于寒武系黄洞口组第一段(∈h^1)与第二段(∈h^2),近SN向的F1、F3断裂构造控制了矿区两个主要金矿化带,断裂构造既是本区控矿构... 详细信息

鸡笼顶金矿地处广西重要的大瑶山金、银、铜多金属成矿带,为构造破碎带—蚀变岩型金矿。矿区金矿体主要赋存于寒武系黄洞口组第一段(∈h^1)与第二段(∈h^2),近SN向的F1、F3断裂构造控制了矿区两个主要金矿化带,断裂构造既是本区控矿构造又是容矿构造。矿石物质组分简单,金矿物主要以自然金单体形态赋存于氧化矿石、原生矿石中。通过分析其成矿地质条件,对矿床地质特征进行了总结,认为该矿具有较大的找矿潜力,为今后矿区扩大资源量提供了依据。

关键词：鸡笼顶金矿床大瑶山成矿带成矿地质条件找矿前景

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基于5G网络的工业产品识别系统设计

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江西科学 2022年第2期40卷 341-345页

作者：林若波姚亮谢扬陈旭文吴容冰许泽波揭阳职业技术学院广东揭阳522000 广东伟兴电子科技有限公司广东揭阳522000

针对工业产品识别准确度的不足,提出一种基于5G网络的工业产品识别系统框架。在传统卷积神经网络CNN基础上,提出DNN深度神经网络算法,并引入控制参数k_(p)实现采集数据的变换特征映射;基于5G网络传输和加密,实现实时数据传输和保密通信... 详细信息

针对工业产品识别准确度的不足,提出一种基于5G网络的工业产品识别系统框架。在传统卷积神经网络CNN基础上,提出DNN深度神经网络算法,并引入控制参数k_(p)实现采集数据的变换特征映射;基于5G网络传输和加密,实现实时数据传输和保密通信;基于云平台,使用Pytorch进行物体识别的匹配运算;最后开发了一套基于5G网络的工业产品识别与溯源平台,验证本设计的实用性。结果表明,本系统对于工业产品识别具有很高的准确率和识别效果。

关键词： 5G网络 DNN 控制参数工业产品识别

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The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability

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JOURNAL OF BIOLOGICAL CHEMISTRY 2018年第2期293卷 717-730页

作者： Ramos, Carla J. lin, Chengmao Liu, xuwen Antonetti, David A. Univ Michigan Kellogg Eye Ctr Dept Ophthalmol & Visual Sci Ann Arbor MI 48105 USA

Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascular permeability are driven by growth factors such as VEGF and pro-inflammatory cytokines such as TNF-. Identifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies. The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-protein directly activated by cAMP promotes exchange of GTP in the small GTPase Rap1. Rap1 enhances barrier properties in human umbilical endothelial cells by promoting adherens junction assembly. We hypothesized that the EPAC-Rap1 signaling pathway may regulate the tight junction complex of the BRB and may restore barrier properties after cytokine-induced permeability. Here, we show that stimulating EPAC or Rap1 activation can prevent or reverse VEGF- or TNF--induced permeability in cell culture and in vivo. Moreover, EPAC activation inhibited VEGF receptor (VEGFR) signaling through the Ras/MEK/ERK pathway. We also found that Rap1B knockdown or an EPAC antagonist increases endothelial permeability and that VEGF has no additive effect, suggesting a common pathway. Furthermore, GTP-bound Rap1 promoted tight junction assembly, and loss of Rap1B led to loss of junctional border organization. Collectively, our results indicate that the EPAC-Rap1 pathway helps maintain basal barrier properties in the retinal vascular endothelium and activation of the EPAC-Rap1 pathway may therefore represent a potential therapeutic strategy to restore the BRB.

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A Micro-Environment Regulator for Filling the Clinical Treatment Gap after a Glioblastoma Operation

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ADVANCED HEALTHCARE MATERIALS 2022年第3期11卷 2101578-2101578页

作者： Zhang, Yiwen You, Haoyu Wang, Yaoben Chen, Qinjun Guo, Qin Chu, Yongchao Li, Chao Zhou, Wenxi Chen, Hongyi Liu, Peixin Wang, Yu Zhao, Zhenhao Zhou, Zheng Luo, Yifan Li, xuwen Zhang, Tongyu Song, Haolin Li, Chufeng Su, Boyu Sun, Tao Bi, Yunke Yu, lin Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol & MOE Inst Brain SciMinist EducKey Lab Smart Drug Del Shanghai 201203 Peoples R China Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Neurosurg Shanghai 201203 Peoples R China

The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. Herein, an immediate and mild postoperative local treatment strategy is developed that regulates the postoperative microenvironment and delays GBM recurrence. Briefly, an injectable hydrogel system (imGEL) loaded with Zn(II)(2)-AMD3100 (AMD-Zn) and CpG oligonucleotide nanoparticles (CpG NPs) is injected into the operation cavity, with long-term function to block the recruitment of microglia/ macrophages and activate cytotoxic T cells. The finding indicated that the imGEL can regulate the immune microenvironment, inhibit GBM recurrence, and gain valuable time for subsequent adjuvant clinical chemotherapy.

关键词： drug delivery glioblastoma injectable hydrogels microenvironments post-operative therapy

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