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Boosting catalytic performance of N doped porous carbon derived from coal tar pitch: The role of N species and the contribution of 1O2

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JOURNAL OF WATER PROCESS ENGINEERING 2025年 72卷

作者： Huang, Linlin Zhang, xuwen Wang, Lin liu, Tingting Li, Da Sheng, Tao Sun, Caiyu Li, Lixin Heilongjiang Univ Sci & Technol Coll Environm & Chem Engn Harbin 150022 Peoples R China Harbin Inst Technol State Key Lab Urban Water Resource & Environm Harbin 150090 Peoples R China

In this study, nitrogen-doped carbon material (N-PC-d) derived from coal tar pitch using dicyandiamide as N source was successfully synthesized, exhibiting outstanding catalytic performance in the activation of peroxymonosulfate (PMS) for the degradation of Orange G (OG). By optimizing key parameters such as PMS dosage, NPC dosage, nitrogen source, pH, anions, and PS source, the optimal N-PC-d/PMS system achieved a degradation rate 1.45 times higher than that of the PC/PMS system within a broad pH range (2.0-10.0). Through electron paramagnetic resonance (EPR) and quenching experiments, it was found that singlet oxygen (1O2) was the predominant species accountable for OG degradation, while reactive oxygen species (ROS), including superoxide (O2 & sdot;-), hydroxyl radicals (& sdot;OH), and sulfate radicals (SO4 & sdot;-), played auxiliary roles. Moreover, the structure-activity relationship analysis revealed that functional groups such as C--C, C--O, and pyridine N were mainly involved in PMS activation. The degradation mechanism of OG was further elucidated by high-performance liquid chromatography-mass spectrometry (HPLC-MS). This research presented a cost-efficient N-doped porous carbon material for environmental remediation and provides more profound insights into the mechanisms of PMS activation by N doped carbon-based materials.

关键词： N-doped porous carbon Coal tar pitch PMS Singlet oxygen Orange G

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Nitroreductase-responsive photosensitizers for selective imaging and photo-inactivation of intracellular bacteria

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CHEMISTRY-A EUROPEAN JOURNAL 2024年第16期30卷 e202303766-e202303766页

作者： Zhou, Wanpeng Da, xuwen Jian, Yao Peng, Yatong liu, Xiulian Xu, Yunli Wu, Yao Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 1000490 Peoples R China

Intracellular Staphylococcus aureus (S. aureus), especially the methicillin resistant staphylococcus aureus (MRSA), are difficult to detect and eradicate due to the protection by the host cells. Antibacterial photodynamic therapy (aPDT) offers promise in treating intracellular bacteria, provided that selective damage to the bacteria ranther than host cells can be realized. According to the different nitroreductase (NTR) levels in mammalian cells and S. aureus, herein NTR-responsive photosensitizers (PSs) (T)CyI-NO2 were designed and synthesized. The emission and 1O2 generation of (T)CyI-NO2 are quenched by the 4-nitrobenzyl group, but can be specifically switched on by bacterial NTR. Therefore, selective imaging and photo-inactivation of intracellular S. aureus and MRSA were achieved. Our findings may pave the way for the development of more efficient and selective aPDT agents to combat intractable intracellular infections. Two nitroreductase (NTR)-responsive photosensitizers ((T)CyI-NO2) were designed and synthesized. The quenched fluorescence and singlet oxygen production of (T)CyI-NO2 can be switched on by NTR in S. aureus. Detailed studies displayed TCyI-NO2 was able to selectively image and efficiently photo-inactivate intracellular bacteria with little cytotoxicity. image

关键词： Antibacterial photodynamic therapy Intracellular bacteria treatment Nitroreductase responsive Photosensitizer Staphylococcus aureus

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Combining UAV multisensor field phenotyping and genome-wide association studies to reveal the genetic basis of plant height in cotton (Gossypium hirsutum)

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PLANT PHENOMICS 2025年第1期7卷

作者： Fan, Liqiang Yang, Jiajie Wang, xuwen liu, Zhao Xu, Bowei liu, Li Gao, Chenxu Ai, Xiantao Li, Fuguang Gao, Lei Yu, Yu Yang, Zuoren Chinese Acad Agr Sci Inst Cotton Res State Key Lab Cotton Biobreeding & Integrated Util Anyang 455000 Henan Peoples R China CAAS Inst Western Agr Xinjiang Key Lab Crop Gene Editing & Germplasm Inn Changji 831100 Xinjiang Peoples R China Xinjiang Acad Agr & Reclamat Sci Cotton Res Inst Northwest Inland Reg Key Lab Cotton Biol & Genet B Minist Agr Urumqi Peoples R China Zhengzhou Univ Sch Agr Sci State Key Lab Cotton Biobreeding & Integrated Util Zhengzhou Res Base Zhengzhou 450001 Henan Peoples R China Xinjiang Univ Res Inst Coll Smart Agr Urumqi 830046 Xinjiang Peoples R China Xinjiang Agr Univ Coll Agr Engn Res Ctr Cotton Minist Educ 311 Nongda East Rd Urumqi 830052 Peoples R China

Plant height (PH) is a key agronomic trait influencing plant architecture. Suitable PH values for cotton are important for lodging resistance, high planting density, and mechanized harvesting, making it crucial to elucidate the mechanisms of the genetic regulation of PH. However, traditional field PH phenotyping largely relies on manual measurements, limiting its large-scale application. In this study, a high-throughput phenotyping platform based on UAV-mounted RGB and light detection and ranging (LiDAR) was developed to efficiently and accurately obtain time series PHs of 419 cotton accessions in the field. Different strategies were used to extract PH values from two sets of sensor data, and the extracted values were used to train using linear regression and machine learning methods to obtain PH predictions. These predictions were consistent with manual measurements of the PH for the LiDAR (R2 1/4 0.934) and RGB (R2 1/4 0.914) data. The predicted PH values were used for GWAS analysis, and 34 PH-related genes, two of which have been demonstrated to regulate PH in cotton, namely, GhPH1 and GhUBP15, were identified. We further identified significant differences in the expression of a new gene named GhPH_UAV1 in the stems of the G. hirsutum cultivar ZM24 harvested on the 15th, 35th, and 70th days after sowing compared with those from a dwarf mutant (pag1), which presented shortened stem and internode phenotypes. The overexpression of GhPH_UAV1 significantly promoted cotton stem development, whereas its knockout by CRISPR-Cas9 dramatically inhibited stem growth, suggesting that GhPH_UAV1 plays a positive regulatory role in cotton PH. This field-scale high-throughput phenotype monitoring platform significantly improves the ability to obtain high-quality phenotypic data from large populations, which helps overcome the imbalance between massive genotypic data and the shortage of field phenotypic data and facilitates the integration of genotype and phenotype research for cr

关键词： Plant height UAV RGB LiDAR Genome-wide association study

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Adsorption of Orange G on Activated Porous Carbon Derived from Coal Tar Pitch: Experimental and DFT Study

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LANGMUIR 2024年第48期40卷 25471-25482页

作者： Huang, Linlin Zhang, xuwen liu, Tingting Wang, Lin Li, Lixin Li, Da Sheng, Tao Dong, Zilong Zhao, Xinyue Heilongjiang Univ Sci & Technol Coll Environm & Chem Engn Harbin 150022 Peoples R China Harbin Inst Technol State Key Lab Urban Water Resource & Environm Harbin 150000 Peoples R China Northeast Agr Univ Sch Resources & Environm Harbin 150030 Peoples R China

A coal tar pitch-based porous carbon adsorbent (CPA) was synthesized through a straightforward method involving the heating of a mixture of KOH and coal tar pitch (CTP). This CPA exhibited a high surface area of 1811.2 m2 g-1 and a large pore volume of 0.94 cm3 g-1 when prepared with a CTP to KOH mass ratio of 1:4 at 800 degrees C. Parameters such as the heating temperature and activator dose were optimized to enhance the adsorption efficiency. The prepared CPA was extensively characterized by SEM, XRD, FTIR, and BET measurements. Notably, CPA presented a distinct adsorption performance for Orange G (OG), achieving a maximum adsorption capability of 449.7 mg g-1. Kinetic studies indicated that the adsorption process followed the pseudo-second-order model, while the adsorption isotherm data demonstrated that both chemical and physical interactions favored OG adsorption. Thermodynamic analysis revealed that the adsorption of OG on CPA was spontaneous and exothermic and increased the entropy. Density functional theory (DFT) calculations provided insights into the adsorption mechanism, highlighting electrostatic interactions, hydrogen bonds, and pi-pi interactions as the dominant processes governing OG adsorption onto the adsorbent.

关键词： Potassium hydroxide

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Probabilistic chip-collecting games with modulo winning conditions

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DISCRETE APPLIED MATHEMATICS 2023年 324卷 93-98页

作者： Harrington, Joshua Hua, xuwen liu, Xufei Nash, Alex Rios, Rodrigo Wong, Tony W. H. Cedar Crest Muhlenberg Coll Dept Math Allentown PA USA Pomona Coll Dept Math Claremont CA 91711 USA Georgia Inst Technol Dept Ind Engn Atlanta GA 30332 USA Dickinson Coll Dept Math Carlisle PA 17013 USA Florida Atlantic Univ Dept Math Boca Raton FL 33431 USA Kutztown Univ Penn Dept Math Kutztown PA 19530 USA

Let a, b, and n be integers with 0 < a < b < n. In a certain two-player probabilistic chip-collecting game, Alice tosses a coin to determine whether she collects a chips or b chips. If Alice collects a chips, then Bob collects b chips, and vice versa. A player is announced the winner when they have accumulated a number of chips that is a multiple of n. In this paper, we settle two conjectures from the literature related toto this game. (c) 2022 Elsevier B.V. All rights reserved.

关键词： Probabilistic game Random walk

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Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes

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ACS CHEMICAL BIOLOGY 2024年第8期19卷 1803-1812页

作者： Sun, Donghui Kang, Li Chen, xuwen Xue, Jian Wu, Xin Wong, Jiemin Wei, Qinghua liu, Shunying East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China East China Normal Univ Fengxian Dist Cent Hosp Inst Biomed SciECNU Joint Ctr Translat Med Shanghai Key Lab Regulatory Biol Shanghai Peoples R China East China Normal Univ Sch Life Sci Shanghai 200241 Peoples R China

Osteosarcoma (OS) is a rare malignant tumor that has predominantly affected children and adolescents in the past 50 years. The genomes of OS tumors exhibit a high degree of complexity, which leads to the great challenge of target identification for anti-OS. To date, no efficient therapeutic target for the treatment of OS has been validated in clinical practice. In our previous drug hunting for the treatment of OS by phenotypic screening, we found that thiazolone derivate (R)-8i was an effective and selective inhibitor against OS in MNNG/HOS cells and in vivo. However, the mechanism of action and specific molecular targets of (R)-8i remain unclear. In this study, we design and synthesize the photo-cross-linking probes based on the lead compound (R)-8i and identify DDX5 as a potential target protein using an activity-based protein profiling strategy. Further experiments including Western blot, shRNA knockdown experiments, cell colony formation, wound healing assays, and cellular thermal shift assays support that (R)-8i binds to DDX5 and induces its degradation, which affect cell proliferation and migration through the PI3K-AKT-mTOR signaling pathway. The research shows that DDX5 is a potential therapeutic target for the treatment of OS.

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Metabolomic study of natrin-induced apoptosis in SMMC-7721 hepatocellular carcinoma cells by ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2019年第0期124卷 1264-1273页

作者： Lu, Shiyin Lu, Rigang Song, Hui Wu, Jinxia liu, xuwen Zhou, Xiaoling Yang, Jianqing Zhang, Hongye Tang, Chaoling Guo, Hongwei Hu, Jian Mao, Guifu Lin, Hanmei Su, Zhiheng Zheng, Hua Guangxi Med Univ Pharmaceut Coll Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Pharm Liuzhou Peoples R China Guangxi Inst Food & Drug Control Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Gastroenterol Liuzhou Peoples R China Guangxi Tradit Chinese Med Univ Affiliated Hosp 1 Gynaecol Nanning Peoples R China Guangxi Med Univ Med Sci Res Ctr Nanning Peoples R China

Natrin, a new member of the cysteine-rich secretory protein (CRISP) family purified from the snake venom of Naja naja atra, has been demonstrated to have anticancer activity. However, the underlying molecular mechanisms need further elucidation. In this study, MU was used to evaluate cell viability. Apoptotic cells were analyzed by employing a transmission electron microscope (TEM). Metabolomic study of the metabolic perturbations caused by natrin-induced apoptosis in differentiated SMMC-7721 cells was performed for the first time by using integrative ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/IDF MS). To investigate the possible mechanism in the mitochondria] pathway of natrin-induced apoptosis, we measured apoptosis-related mRNA changes using real-time fluorescent quantitative PCR (FQ-PCR). Cell proliferation was significantly inhibited after treatment with natrin in a dose dependent manner. Principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) clearly demonstrated that metabolic profiles were affected by natrin. The results of multivariate statistical analysis showed that a total of 13 metabolites were characterized as potential biomarkers highly implicated in natrin-induced apoptosis, which corresponded to fluctuations of five pathways, including sphingolipid metabolism, fatty acid biosynthesis, fatty acid metabolism, glycerophospholipid metabolism and glycosphingolipid biosynthesis. Furthermore, natrin-induced apoptosis showed an increase in the Bax/Bcl-2 ratio in the mitochondrial pathway compared with controls. This study illustrated that rapid and holistic cell metabolomics combining molecular biological approaches might be a powerful tool for evaluating the underlying mechanisms of natrin-induced apoptosis, which would help to deepen specific insights into the anti-hepatoma mechanisms of natrin and facilitate the clinical application of natrin in the future.

关键词： Metabolomics Natrin Hepatocellular carcinoma (HCC) Apoptosis UPLC-QtrOF MS

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Influence of ballasted material properties in enhancing the separation of high concentration suspended solids in coal mining water

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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION 2022年第0期157卷 458-465页

作者： Zhang, Xiaohang liu, Yanping Wei, Ming Tan, Jinlong Yang, Tingchao He, xuwen China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China Handan Municipal Publ Util Investment Grp Co Ltd Dept Engn & Technol Handan 056000 Hebei Peoples R China Hebei Vocat Coll Polit & Law Party Comm Shijiazhuang 050061 Hebei Peoples R China Hebei Univ Engn Sch Min & Geomat Engn Handan 056038 Hebei Peoples R China Hebei Prov Coal Geol Bureanu Business Dev Sect Hydrol Geol Team Handan 056001 Hebei Peoples R China

With the continuous improvement and economic development of China's coal mining industry, research on the characteristics of wastewater discharge has gained attraction in recent years. Ballasted flocculation technology, has been widely used in recent years. However, its effect on the settling velocity of the flocs in wastewater has not been quantified. This study aimed to screen optimal reaction condition for ballasted flocculation and to derive the settling velocity of the ballasted flocs under these conditions. The results showed that, the size of the ballasted material had no significant effect on the turbidity and suspended solids removal rate;however, the settling time was effectively shortened, and the turbidity removal rate could reach more than 95% within 15 s. Owing to the optimization of the reaction conditions, 90% of the flocs sizes were distributed in the 80-200 mu m range. Moreover, the difference between the theoretical and the measured value of the ballasted flocculation was small, indicating that the derived formula could effectively quantify the settling velocity of the ballasted flocs under optimal conditions. These findings may serve as a critical reference for the treatment of high-suspended solids in coal mining water and have significant potential for engineering application. (c) 2021 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

关键词： Ballasted flocculation Fractal dimension Settlement velocity Stress analysis Coal mining water

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Cascading oxidoreductases-like nanozymes for high selective and sensitive fiuorescent detection of ascorbic acid

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Chinese Chemical Letters 2025年第4期36卷 627-632页

作者： Ying Wang Hong Yang Caixia Zhu Qing Hong xuwen Cao Kaiyuan Wang Yuan Xu Yanfei Shen Songqin liu Yuanjian Zhang Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Devices Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189China

Compared with natural enzymes, nanozymes have the advantages of high stability and low cost;however,selectivity and sensitivity are key issues that prevent their further development. In this study, we report a cascade nanozymatic system with significantly improved selectivity and sensitivity that combines more substrate-specific reactions and sensitive fiuorescence detection. Taking detection of ascorbic acid(AA)as an example, a cascade catalytic reaction system consisting of oxidase-like N-doped carbon nanocages(NC) and peroxidase-like copper oxide(Cu O) improved the reaction selectivity in transforming the substrate into the target product by more than 1200 times against the interference of uric acid. The cascade catalytic reaction system was also applicable for transfer from open reactors into a spatially confined microfiuidic device, increasing the slope of the calibration curves by approximately 1000-fold with a linear detection range of 2.5 nmol/L to 100 nmol/L and a low limit of detection of 0.77 nmol/L. This work offers a new strategy that achieves significant improvements in selectivity and sensitivity.

关键词： Nanozyme Fluorescence Selectivity Sensitivity Ascorbic acid

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Improving identification ability of adulterants in powdered Panax notoginseng using particle swarm optimization and data fusion

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INFRARED PHYSICS & TECHNOLOGY 2019年 103卷 103101-000页

作者： Yang, Xiaodong Song, Jie Peng, Lin Gao, Lutao liu, xuwen Xie, Lin Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China Yunnan Agr Univ Coll Big Data Kunming 650201 Yunnan Peoples R China

Panax notoginseng (P. notoginseng) is frequently targeted for adulteration with lower-grade P. notoginseng because of its high price. This paper presents a novel method to improve the identification ability of adulterants using spectroscopic techniques and chemometrics. P. notoginseng powder of different grades were blended at different percentages (0-100%), in which the minimum blend ratio was 0.5%. NIR (12,497-4000 cm(-1)) and FT-MIR (4000-400 cm(-1)) spectra of samples were acquired. The wavenumbers of 7099-4200 cm(-1), 3600-2750 cm(-1), and 1750-400 cm(-1) were selected manually as characteristic spectra, which included 3706 variables. Then principal component analysis (PCA) was used to further reduce the data dimension of characteristic spectra, and the first nine principal components (PCs) were applied to build classification models of 14 (the ratio of 0.5% excluded) and 15 kinds of blend ratios. Finally, Support vector machine (SVM) was built for classification of adulterants of different blend ratio. The accuracy of prediction set is 92.46% and 91.79%, respectively. On this basis, particle swarm optimization (PSO) was applied to optimize the parameters of SVM, and the accuracy of prediction set increased to 96.65% and 96.97%, respectively. The results demonstrate that the application of data fusion of NIR and FT-MIR spectra combined with SVM optimized by PSO can improve the identification ability of adulterants in powdered P. notoginseng.

关键词： Panax notoginseng Adulteration PCA PSO SVM

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