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Enhancing gas production and CO2 sequestration from marine hydrate reservoirs through optimized CO2 hydrate cap

ENERGY 2024年 303卷

作者： Guo, Yang Li, Shuxia Sun, Hao Wu, Didi liu, Lu Zhang, Ningtao Qin, xuwen Lu, Cheng China Univ Petr East China State Key Lab Deep Oil & Gas Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China East China Bur Sinopec Explorat & Dev Res Inst Nanjing 210019 Peoples R China China Geol Survey China Aero Geophys Survey & Remote Sensing Ctr Nat Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China

The invasion of formation water during marine hydrate production gravely affects gas productivity. CO2 hydrate caps effectively inhibit water invasion while sequestering CO2, which is considered an excellent prospective application. However, forming field -scale artificial CO2 hydrate caps remains a global challenge. This study proposed an innovative method for forming an artificial CO2 hydrate cap. The fracture length, injection time, production pressure, and production well distance, which are all factors that affect sealing capacity and production enhancement, were optimized. Results indicated that the sealing capacity exhibited a trend of initially increasing and subsequently decreasing with fracture length. The injection time was positively correlated with the sealing capacity and was sufficient to seal both vertically and horizontally once it reached 4 years. In addition to sequestering CO2, the CO2 hydrate cap enhanced gas production by 146.56 % and reduced water production by 37.47 % compared to direct depressurization. CO2 invasion occurred when the well spacing was too close, while being distant was not favorable for pressure propagation and heat utilization by the CO2 hydrate cap. This method simultaneously achieves multiple goals for energy and environmental, providing essential implications for the future commercial application of marine hydrates.

关键词： Gas hydrate CO2 hydrate cap Enhanced gas production CO2 sequestration Numerical simulation

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Hydrogen-Bonding-Driven Multifunctional Polymer Hydrogel Networks Based on Tannic Acid br

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ACS APPLIED POLYMER MATERIALS 2022年第3期4卷 1836-1845页

作者： Gao, Yongfeng Peng, xuwen Wu, Qiuqiu Yang, Diling Wang, Wenda Peng, Qiongyao Wang, Tao Wang, Jianmei liu, Jifang Zhang, Hao Zeng, Hongbo Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Taiyuan Univ Sci & Technol Heavy Machinery Engn Res Ctr Educ Minist Taiyuan 030024 Shanxi Peoples R China

A hydrogel network based on noncovalent inter-molecular interactions via mixing of poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA), poly(vinyl alcohol) (PVA), andtannic acid (TA) aqueous solutions was developed. Thecoacervation and hydrogel formation process is driven by hydro-gen-bonding interactions between catechol moieties of TA,hydroxide groups of PVA, and carboxylic acid groups of *** formation of the PMVEMA-PVA-TA (PPTA) gel occurs inseconds and can be readily obtained and scaled up in both ionic andnonionic systems. It is noteworthy that this PPTA gel can bestretched more than 135 times its original size and for potentialpreparation of mechanically strongfibers. The gel can be alsoremodeled on diverse substrates and into different shapes. The electrical response sensing behavior promotes the PPTA gel materialas a great candidate for fabricating strain sensors. The as-prepared PPTA gel exhibits excellent adhesion to different substrates andshows antibacterial properties against bothEscherichia coli(Gram-negative) bacteria and methicillin-resistantStaphylococcus aureus(MRSA) bacteria, which provides a promising candidate for the design of biocompatible drug carriers with facile fabrication and flexible modification for various biomedical applications.

关键词： hydrogen bond hydrogel adhesive mechanical properties self-healing antibacterial

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Numerical Simulation and Process Optimization on Hot Twist-Stretch Straightening of Ti-6Al-4V Alloy Profile

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MATERIALS 2022年第13期15卷 4522-4522页

作者： Deng, xuwen Hui, Songxiao Ye, Wenjun liu, Rui Huang, Liang GRINM Grp Co Ltd State Key Lab Nonferrous Met & Proc Beijing 100088 Peoples R China GRIMAT Engn Inst Co Ltd Beijing 101407 Peoples R China Gen Res Inst Nonferrous Met Beijing 100088 Peoples R China Huazhong Univ Sci & Technol Sch Mat Sci & Engn State Key Lab Mat Proc & Die & Mould Technol Wuhan 430074 Peoples R China

Ti-6Al-4V profiles prepared by hot extrusion are usually accompanied by bending and twisting. The hot twist-stretch straightening is an effective strategy such that the bending deflection and twisting angle can be simultaneously decreased by a single straightening process. In addition, utilizing stress relaxation effect, the residual stress and springback can be greatly reduced by holding the straightening temperature and strain constant for a period after twist-stretch straightening. In this study, the hot deformation behaviors of the Ti-6Al-4V profile were revealed by experiments. The tensile model was obtained by uniaxial tensile tests within ranges of temperatures (500-700 degrees C) and strain rates (5 x 10(-5)-1 x 10(-3) s(-1)). The creep constitutive model was acquired with stress relaxation experiments in ranges of temperatures (500-700 degrees C) and pre-strain of 1.5%. Then, the coupled thermo-mechanical model of hot twist-stretch straightening was established. Based on orthogonal experiment strategy, the effects of straightening temperature, stretch strain, and holding time on the bending deflection and torsion angle of profile were investigated systematically and the process was optimized. The straightening accuracy is significantly affected by straightening temperature and holding time. By using optimized process parameters in practical straightening experiments, the deflection/length and angle/length after straightening does not exceed 2 parts per thousand and 2.5 parts per thousand degrees/mm, respectively, which is basically consistent with the numerical simulation result.

关键词： Ti-6Al-4V profile hot twist-stretch straightening orthogonal experiment thermo-mechanical coupling model

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Risk prevention of different forms of gestational diabetes mellitus based on energy metabolism prior to diagnosis

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TECHNOLOGY AND HEALTH CARE 2022年第1_suppl期30卷 S285-S292页

作者： Lu, Jiayu Jiang, Hongqing Zhang, Song Yang, Yimin Hao, Dongmei Li, xuwen Chen, Aiqing Shao, Jing liu, Xiaohong Yang, Lin Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing Peoples R China Haidian Maternal & Children Hlth Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively. OBJECTIVE: GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively. METHODS: By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences. RESULTS: For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy. CONCLUSION: The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

关键词： Diabetes mellitus in the second trimester diagnosis of diabetes mellitus in the third trimester energy metabolism

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A tumor-targeted multifunctional nanosystem with light-triggered NO generation for synergistic photodynamic/gas therapy

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INORGANICA CHIMICA ACTA 2024年 567卷

作者： Peng, Yatong Da, xuwen Zhou, Wanpeng Xu, Yunli Wu, Yao liu, Xiulian Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment. Nevertheless, PDT alone still faces a considerable challenge in efficiently eliminating cancer cells, and combination with other therapeutic strategies can significantly improve anticancer efficacy. Herein, a multifunctional nanosystem (Ru-PArg-HA) composed of biocompatible and tumor-targeted hyaluronic acid (HA), a photosensitizer [Ru(phen)(2)(PIP-OCH3)](2+) (termed Ru, phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1H-imidazo[4,5-f] [1,10] phenanthroline) and a NO donor poly-L-arginine (PArg), was fabricated via electrostatic interactions. Under 470 nm light irradiation, Ru-PArg-HA could not only catalyze 1,4-dihydronicotinamide adenine dinucleotide (NADH) oxidation to produce H2O2, but also could generate a large amount of reactive oxygen species (ROS, including O-1(2) and O-2(center dot-)) for PDT therapy. The light-driven production of O-1(2) and H2O2 could further convert PArg into nitric oxide (NO), enabling synergistic gas therapy. The experimental outcomes demonstrated that Ru-PArg-HA exhibited much enhanced anticancer activity compared to traditional mono-modal PDT. This finding provides new inspiration for the development of multifunctional nanosystems with efficient and targeted anti-cancer activity.

关键词： Photodynamic therapy Gas therapy Ru(II) photosensitizer Nitric oxide Tumor-targeted

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Atomically ordered Rh₂P catalysts anchored within hollow mesoporous carbon for efficient hydrogen production

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CHEMICAL COMMUNICATIONS 2021年第92期57卷 12345-12348页

作者： Guo, xuwen Chen, Xin Huang, Yanping Min, Xiaowen Kong, Chuncai Tang, Yawen liu, Ben Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab New Power Batteries Nanjing 210023 Peoples R China ME Instruments Inc Huahan Sci & Technol Ind Pk Shenzhen 518118 Peoples R China Sichuan Univ Ctr Engn Expt Teaching Sch Chem Engn Chengdu 610065 Peoples R China Sichuan Univ Coll Chem Key Lab Green Chem & Technol Minist Educ Chengdu 610064 Peoples R China Shaanxi Prov Key Lab Adv Funct Mat & Mesoscop Phy Sch Phys Minist EducKey Lab Nonequilibrium Synth & Modula Xian Jiaotong Univ Xian 710049 Peoples R China

Atomically ordered Rh2P nanoclusters encapsulated within a high-surface-area hollow mesoporous carbon nanoreactor are catalytically active for hydrogen production via the electrocatalytic hydrogen evolution reaction a... 详细信息

关键词： Hydrogen production

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A one-pot photocatalytic triazole-based linkerology for PROTACs

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CELL REPORTS PHYSICAL SCIENCE 2024年第8期5卷

作者： liu, Jinhua Deng, Yaqi Yin, Jiabin Ji, Jian Guan, Cong Chen, xuwen Wu, Xiang Zhu, Tong liu, Shunying East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Shanghai Frontiers Sci Ctr Mol Intelligent Synth Sch Chem & Mol Engn Shanghai 200062 Peoples R China

Proteolysis-targeting chimeras (PROTACs) are a powerful approach for targeted protein degradation. One of the current bottlenecks for developing PROTACs is the lack of an operationally simple linkerology to rapidly construct PROTACs with various linkers. The classic convergent synthesis strategy by coupling pre-assembled linkers with two ligands stepwise commonly needs at least four steps to give the final target PROTACs, which results in low total yields with long reaction times (several days) and tedious operations. Here, we develop an efficient photocatalytic one-pot linkerology for the rapid coupling of analogs of PROTACs containing triazole-based linkers without any linker-pre-assembled procedure. The reaction was completed within 4 h with up to 95% yields at room temperature. Easily accessible cyclic ethers are directly used as linker precursors to furnish the one-pot fashion, including alkenyl, polyethylene glycol (PEG), ketone, and cyclohexane chains. The study provides a highly efficient, step-economic, operationally simple, and environmentally friendly one-pot linkerology for PROTAC drug discovery.

关键词： triazole one-pot reaction photocatalysis PROTAC linkerology

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Enhanced gas production from low-permeability hydrate reservoirs based on embedded discrete fracture models: Influence of branch parameters

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ENERGY 2023年第1期282卷

作者： Guo, Yang Li, Shuxia Qin, xuwen Lu, Cheng Wu, Didi liu, Lu Zhang, Ningtao China Univ Petr East China Key Lab Unconvent Oil & Gas Dev Minist Educ Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China Minist Nat Resources China Geol Survey Beijing 100037 Peoples R China Minist Nat Resources China Geol Survey Oil & Gas Resources Survey Beijing 100083 Peoples R China East China Bur Sinopec Explorat & Dev Res Inst Nanjing 210019 Peoples R China

The low permeability of marine hydrate reservoirs makes it difficult for trail results to meet the demand for exploitation. Hydraulic fracturing and multi-branch wells are the primary methods for enhancing productivity. This study proposed a new production enhancement method of multi-branch wells combined with multi-stage fracturing (MWMF) based on the embedded discrete fracture model (EDFM). By simulation of the Shenhu area, the multi-physical field evolution of the MWMF production process was first revealed, followed by the systematic analysis of the MWMF production enhancement effect with branch parameters. Results indicated that the cumulative gas production of MWMF increased by 327% compared with only horizontal wells. The production of four-branch wells exhibited a 7% reduction compared to horizontal wells using the MWMF method, suggesting increased branch numbers inhibit production. Increasing branch length was positively correlated with enhanced production. Notably, the influence of branch length on gas production became more pronounced as the number of branches increased. The interface of the three-phase layer (TPL) and hydrate-bearing layer (HBL) was the most suitable location for branch well placement. This novel study provides valuable insights into new applications of the MWMF method in developing low-permeability hydrate reservoirs.

关键词： Natural gas hydrate Multi-branch well Multi-stage fracture Embedded discrete fracture model Enhanced gas production

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Development of an Interactive Medical Knowledge Graph Based Tool Set

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Procedia Computer Science 2023年 221卷 578-584页

作者： Xiaowei Xu xuwen Wang Meng Wu Hetong Ma liu Shen Jiao Li Institute of Medical Information & Library Chinese Academy of Medical Sciences& Peking Union Medical College Beijing 100020 China Key Laboratory of Medical Information Intelligent Technology Chinese Academy of Medical Sciences Beijing 100020 China

The field of clinical research has reached a turning point in terms of the range and diversity of available data and their potential to improve human health and well-being. However, due to discipline-specific variances in terminology and representation, the data is often compartmentalized, disorganized, and inaccessible to a broad audience. In response to these challenges, we designed and evaluated a pilot knowledge graph-based MedKaaS tool capable of integrating existing clinical datasets and translating those data into insights intended to augment human reasoning and accelerate scientific research. In this paper, we present the architecture and performance of our system, which has been applied to several real-world use cases in collaboration with subject-matter specialists. The MedKaaS Tools are actively developed, with regular updates to performance and features. Our future plans include developing a more user-friendly interface and expanding the visualization capabilities for knowledge exploration.

关键词： knowledge graph visualization application programming interface biomedical data

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Rep-Mca-Former: An Efficient Multi-Scale Convolution Attention Encoder for Text-Independent Speaker Verification

SSRN

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SSRN 2023年

作者： liu, Xiaohu Chen, Defu Wang, Xianbao Xiang, Sheng Zhou, xuwen Zhejiang University of Technology Information Engineer College Zhejiang Hangzhou310023 China

In many speaker verification tasks, the quality of speaker embedding is an important factor affecting speaker verification systems. Current advanced speaker embedding extraction networks aim to aggregate multi-scale features from discourse through a multi-branch network architecture of speaker representations. Networks based on the transformer encoder improve the performance of speaker verification systems to a higher level by using a multi-head self-attention mechanism to model discourse information globally more efficiently (e.g., MFA-Conformer). However, the large model parameters and computational latency are common problems faced by the above approaches, which make them difficult to apply to resource-constrained edge terminals. To address this issue, this paper proposes an effective lightweight transformer model (MCA-former) with multi-scale convolutional attention (MCA), which can perform multi-scale modeling and channel modeling in the temporal direction of the input with low computational cost. In addition, in the inference phase of the model, we further develop a systematic re-parameterization method to convert the multi-branch network structure into a single-path based topology, which effectively improves the inference speed. We investigate the performance of MCA-former for speaker verification under the VoxCeleb1 test set. The results show that the MCA-based transformer model is more advantageous in terms of number of parameters and inference efficiency, while outperforming the state-of-the-art transformer model on short-duration speaker verification. In addition, the inference speed of the model is improved by 20% using re-parameterization. © 2023, The Authors. All rights reserved.

关键词： Convolution

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