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Hierarchical flower-like manganese oxide/polystyrene with enhanced oxidase-mimicking performance for sensitive colorimetric detection of glutathione

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MICROCHIMICA ACTA 2022年第2期189卷 63-63页

作者： liu, Ying Yan, Jianghong Sun, Zhiheng Huang, Yu Li, xuwen Jin, Yongri Jilin Univ Coll Chem 2699 Qianjin Rd Changchun 130012 Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In this paper, 3D hierarchical flower-like nanozyme named MnO2/PS (polystyrene) was successfully prepared by template method for the first time. After the systematical studies, MnO2/PS nanozyme was evaluated to possess favorable oxidase activity and direct 3,3',5,5'-tetramethylbenzidine (TMB) catalytic ability in the near-neutral environment at room temperature. With the addition of different concentrations of GSH, oxidized TMB can be reduced to TMB with the whole process from blue to nearly colorless be observed by naked eyes. In addition, there is a good linear relationship in the range 1-50 mu M and a detection limit of 0.08 mu M. The method proposed can be successfully applied to the detection of reduced GSH in tablets and injections with good selectivity and high sensitivity. The analysis results exhibited good consistency with the results obtained by HPLC.

关键词： Oxidase-like activity Manganese oxide Flower-like nanozyme GSH detection Colorimetric sensor

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Selective and Coverage Multi-head Attention for Abstractive Summarization 2

Selective and Coverage Multi-head Attention for Abstractive ...

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2019 2nd International Conference on Computer Information Science and Artificial Intelligence, CISAI 2019

作者： Zhang, xuwen liu, Gongshen School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai200240 China

Although the Transformer model has outperformed traditional sequence-To-sequence model in a variety of natural language processing (NLP) tasks, it still suffers from semantic irrelevance and repetition for abstractive text summarization. The main reason is that the long text to be summarized is usually composed of multi-sentences and has much redundant information. To tackle this problem, we propose a selective and coverage multi-head attention framework based on the original Transformer. It contains a Convolutional Neural Network (CNN) selective gate, which combines n-gram features with whole semantic representation to obtain core information from the long input sentence. Besides, we use a coverage mechanism in the multi-head attention to keep track of the words which have been summarized. The evaluations on Chinese and English text summarization datasets both demonstrate that the proposed selective and coverage multi-head attention model outperforms the baseline models by 4.6 and 0.3 ROUGE-2 points respectively. And the analysis shows that the proposed model generates the summary with higher quality and less repetition. © Published under licence by IOP Publishing Ltd.

关键词： Semantics

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Nitrogen-rich and core-sheath polyamide/polyethyleneimine@Zr-MOF for iodine adsorption and nerve agent simulant degradation

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JOURNAL OF HAZARDOUS MATERIALS 2024年 480卷 135713页

作者： Zheng, Yu-Xuan Wu, xuwen Yang, Wei-Guang Li, Bai-Xue Gao, Kejing Zhou, Jingsheng liu, Yunfang Yang, Dongzhi Beijing Univ Chem Technol Coll Mat Sci & Engn Beijing Key Lab Adv Funct Polymer Composites Beijing 100029 Peoples R China Petrochina Petrochem Res Inst Beijing 102206 Peoples R China

Radioactive nuclides and highly toxic organophosphates are typical deadly threats. Materials with the function of radioactive substances adsorption and organophosphates degradation provide double protection. Herein, dual-functional polyamide (PA)/polyethyleneimine (PEI)@Zr-MOF fiber composite membranes, fabricated by in-situ solvothermal growth of Zr-MOF on PA/PEI electrospun fiber membranes, are designed for protection against two typical model compounds of iodine and dimethyl 4-nitrophenyl phosphate (DMNP). Benefiting from the unique core-sheath structure composed of inner nitrogen-rich fibers and outer porous Zr-MOF, the composite membranes rapidly enrich iodine through abundant active sites of the outer sheath and form complexes with the amine of inner PEI, exhibiting a highly competitive adsorption capacity of 609 mg g(-1). Moreover, it can adsorb and degrade DMNP with the synergy of PEI component and Zr-MOF, achieving an 80 % removal of DMNP within 7 min without any additional co-catalyst. This work provides a feasible strategy to fabricate dual-functional materials that protect against radioactive and organophosphorus contaminants.

关键词： Electrospun fibers Zr-MOF Iodine adsorption Catalytic hydrolysis Nerve agent and simulant

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Comparison of health-related quality of life measures in asthma-COPD overlap

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CHRONIC RESPIRATORY DISEASE 2023年 20卷

作者： liu, Meishan Yang, xuwen Wang, Ying Lu, Yong Liang, Lirong Zhang, Hong Huang, Kewu Capital Med Univ Beijing Inst Resp Med Dept Resp & Crit Care Med Beijing Peoples R China Capital Med Univ Beijing Chao Yang Hosp Beijing Peoples R China Capital Med Univ Beijing Inst Resp Med Dept Clin Epidemiol Beijing Peoples R China Capital Med Univ Beijing Inst Resp Med Dept Resp & Crit Care Med 8 Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp 8 Gongti South Rd Beijing 100020 Peoples R China

Objective: The Asthma Quality of Life Questionnaire (AQLQ) and COPD assessment test (CAT) are used to assess the health status of asthma and chronic obstructive pulmonary disease (COPD), respectively. However, whether these questionnaires are appropriate in patients with asthma-COPD overlap (ACO) has not been reported. This study aimed to evaluate the performance of the AQLQ and CAT in subjects with ***: Subjects were enrolled from two previously described observational studies in Beijing, China. ACO was defined by a consensus definition from a roundtable discussion. All subjects completed the AQLQ, CAT, St George's Respiratory Questionnaire (SGRQ), pulmonary function tests, and the Asthma Control Questionnaire (ACQ)-5. Cross-sectional construct validity was evaluated by correlating the AQLQ and CAT with SGRQ score and other measures of asthma and COPD ***: 147 subjects with ACO were recruited. There were floor effects on non-respiratory components of the CAT, and ceiling effects on emotion domains of the AQLQ. Both questionnaires were significantly correlated with ACQ-5 score but were not correlated with FEV1% predicted or FVC% predicted. The AQLQ and CAT were strongly correlated with SGRQ score (r = -0.657 and r = 0.623, respectively). Multivariable linear regression analysis showed that the AQLQ (standardized beta-coefficient = -0.449, p < .001) had a stronger association with SGRQ score compared with CAT (standardized beta-coefficient = 0.211, p = .023).Discussion: The AQLQ and CAT were both valid for assessing the health-related quality of life in subjects with ACO, but the AQLQ performed better than CAT.

关键词： asthma-chronic obstructive pulmonary disease overlap health-related quality of life chronic obstructive pulmonary disease assessment test asthma quality of life questionnaire validity

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High Level of IL-16 Secreted By Non-GCB DLBCL Facilitates Tumor Growth Though the Tumor-Promoting and Immunosuppressive Tumor Microenvironment

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BLOOD 2023年 142卷 6080-6080页

作者： Guan, xuwen Fang, Teng Wang, Yi liu, Wei Hao, Mu Qiu, Lugui Natl Clin Res Ctr Blood Dis State Key Lab Expt Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Natl Clin Res Ctr Blood Dis State Key Lab Expt Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol & Blood Dis Hosp Haihe Lab Cell Ecosyst State Key Lab Expt HematolNatl Clin Res Ctr Bloo Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol & Blood Dis Hosp State Key Lab Expt Hematol Tianjin Peoples R China

Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a highly heterogeneous non-Hodgkin's lymphoma. Based on cell origin, DLBCL is classified into two main molecular subtypes: the germinal center B-cell-like (GCB) subtype and the activated B-cell-like (ABC) subtype. ABC subtype is more aggressive and associated with a worse prognosis than GCB subtype. Previous studies have shown that cytokines play an important role in the growth of ABC subtypes, and IL-16 was supposed to be highly expressed in ABC-DLBCL, however it has not been explored in depth in DLBCL. In this study, we broadly assessed the expression and role of IL-16 on DLBCL. Method: Serum and tissues samples from patients with DLBCL and whole blood from healthy donors were collected. The characterization of protein expression, mRNA expression, and levels of cytokines in cells and tissues was detected by Western blotting, IHC/IHF, PCR, ELISA, RNA-seq, and Flow cytometry. Cells experiments such as cell proliferation, cell apoptosis, cell cycle, cell migration, and ADPC were detected by CCK-8, Flow cytometry, and Transwells. Gene knockdown or overexpression was conducted by lentiviruses and then verified by Western blotting and ELISA. We established subcutaneous tumors (human DLBCL cells and murine DLBCL cells) in BALB/c mice, BALC/c nude mice, and NOD SCID mice for the tumor size or the therapeutic evaluation. Results: First, we found that IL-16, secreted by the cleavage of active caspase-3 from the lymphoma cells under tumor burden, was highly expressed in ABC-DLBCL compared to GCB-DLBCL. The serum IL-16 levels were positively correlated with unfavorable prognosis in DLBCL patients. The dynamic change of serum IL-16 levels accurately predicted the treatment response in patients with DLBCL who received R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) or anti-CD19 Chimeric Antigen Receptor (CAR) T cells. Interestingly, bioactive IL-16 showed rare effect on DLBCL cells in vitro, b

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Multi-Stage Task Allocation Strategy for Uav Cluster in Multi-Object Tracking

SSRN

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SSRN 2023年

作者： liu, Yunping Niu, Tianyu Zhang, Tingting Sun, xuwen Li, Liansheng Zhou, Li Jiangsu Province Atmospheric Environment and Equipment Technology Collaborative Innovation Center Nanjing University of Information Science and Technology Nanjing210044 China Army Engineering University of PLA Nanjing210001 China Dalian Naval Academy Dalian116018 China Beijing Institute of Control Engineering Beijing100094 China College of Marine Technology and Geomatics Jiangsu Ocean University Lianyungang Jiangsu222005 China

Multi-unarmed aerial vehicle (UAV) collaborative mission planning is a key technology for the intelligent development of UAV clusters at this stage, where mission assignment under multiple constraints is a core part of UAV mission planning technology. The poor planning ability of an UAV swarm often leads to resource waste and revenue reduction during mission execution, while the adoption of task allocation in the multi-target tracking of UAV clusters guarantees the highest profit. Algorithms of traditional pigeon-inspired optimization(PIO) and contract network protocol reflect defects of low timeliness and high time costs, respectively. Compared with these methods, the multilevel PIO algorithm maximizes the efficiency and profitability of the overall tracking task. A staged UAV cluster task allocation architecture was constructed to complete the global optimal initialization before tracking, and then a parallel auction contract network was employed to further perform the local optimal redistribution of each UAV. The simulation results suggest that this scheme not only guides cluster allocation in stages but also decreases the negotiatory time of a UAV cluster to in-crease the integral profitability under multiple constraints, such as prohibited areas. © 2023, The Authors. All rights reserved.

关键词： Profitability

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie Li, Chao Li, xuwen Chu, Yongchao Guo, Qin Zhang, Yiwen Xia, Weiyi liu, Peixin Chen, Hongyi Wang, Yu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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Ultrafast synthesis and densification of ZrO2 doped KNN ceramics by reactive flash sintering

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INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY 2021年第6期18卷 1999-2009页

作者： Su, Xinghua Jiao, Zhihua Fu, Mengying An, Gai Wu, Yajuan Tian, Qiang Xu, Pan Wu, Weiwei Chang, xuwen liu, Jiarui Changan Univ Sch Mat Sci & Engn Xian Peoples R China Southwest Univ Sci & Technol State Key Lab Environm Friendly Energy Mat Mianyang Sichuan Peoples R China Xidian Univ Sch Adv Mat & Nanotechnol Xian Peoples R China

Fabrication of dense KNN-based lead-free piezoelectric ceramics at low temperatures in short time through a cost-effective way remains a challenge. Herein, this challenge could be addressed by using reactive flash sintering. It is demonstrated that the phase transformation of KNbO3-NaNbO3 into (K,Na)NbO3 and densification occur simultaneously during the flash event. Most importantly, ZrO2 doping can greatly decrease the onset flash temperature, which is ascribed to the increased conductivity of sample. In addition, the current limit has a significant effect on the phase transformation and densification. The flash-sintered KNN ceramics exhibit the good ferroelectric and piezoelectric properties. Furthermore, the ZrO2 doped and undoped KNN ceramics show a comparable coercive field E-c, which may be related to the residual point defects after the flash. Besides the Joule heating, the avalanche generation of point defects is suggested to be responsible for the ultrafast solid-state reaction and densification rates.

关键词： densification doping phase transformations reactive flash sintering synthesis

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Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters (vol 56, pg 5665, 2020)

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CHEMICAL COMMUNICATIONS 2020年第48期56卷 6594-6594页

作者： liu, Jianbo Zhao, Rusong Wang, Xia Gao, xuwen Zou, Guizheng Qilu Univ Technol Key Lab Appl Technol Sophisticated Analyt Instrum Shandong Acad Sci Shandong Anal & Test Ctr Jinan 250353 Peoples R China Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

Synergetic effects in Au-Ag bimetallic nanoclusters (BNCs) more favorably enhanced electrochemical redox induced electrochemiluminescence (ECL) over photoexcitation induced photoluminescence (PL); this not only led to Au-Ag BNCs with enhanced bandgap-engineered ECL compared to Au NCs, but it also generated surface-defect related ECL to enhance the total ECL intensity.

关键词： Surface defects

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Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir

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ORGANIC PROCESS RESEARCH & DEVELOPMENT 2021年第4期25卷 838-848页

作者： Xie, Hongming liu, Haiwang Zhang, Yingjun Huang, Enhuo Feng, Yahui Xiang, xuwen Fang, Qinghong Peng, Zhihong Dong, Wanrong An, Delie Hunan Univ Coll Chem & Chem Engn State Key Lab Chemo Biosensing & Chemometr Changsha 410082 Hunan Peoples R China Sunshine Lake Pharma Co Ltd State Key Lab Antiinfect Drug Dev 2015DQ780357 Dongguan 523871 Peoples R China HEC Pharm Grp HEC Res & Dev Ctr Dongguan 523871 Peoples R China

A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization with hydrolases in the synthetical approach can significantly avoid the loss of chiral raw materials in the resolution process. The synthesis route is further optimized and scaled-up to establish a new process that is applied to the preparation of kilogram scales of target active pharmaceutical ingredients (APIs). Compared with our initial process, the overall yield of target API was dramatically improved from 17 to 40%.

关键词： hepatitis C virus inhibitor Emitasvir enantioselective synthesis process development

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