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化工学报 2008年第3期59卷 659-664页

作者：刘旭文熊金平曹京宜左禹北京化工大学材料科学与工程学院北京100029 海军涂料分析检测中心北京102442

采用电化学阻抗谱(EIS)研究了由水性无机富锌底漆、环氧中间漆和氯化橡胶面漆3种涂料配套而成的3种不同涂层体系在3.5%NaCl溶液中的电化学腐蚀行为,考察了氯化橡胶面漆、水性无机富锌底漆/氯化橡胶面漆、水性无机富锌底漆/环氧中间漆/... 详细信息

采用电化学阻抗谱(EIS)研究了由水性无机富锌底漆、环氧中间漆和氯化橡胶面漆3种涂料配套而成的3种不同涂层体系在3.5%NaCl溶液中的电化学腐蚀行为,考察了氯化橡胶面漆、水性无机富锌底漆/氯化橡胶面漆、水性无机富锌底漆/环氧中间漆/氯化橡胶面漆这3种涂层体系的阻抗谱在浸泡过程中的演化并据此比较了3种涂层体系的防护性能。结果表明,两涂层体系的防护性能比单涂层的还要差,三复合涂层体系的防护性能最好。根据涂层腐蚀电化学阻抗谱特征推测,中间漆在三复合涂层体系中起到了使底漆和面漆结合更加紧密的桥梁作用。

关键词：涂层电化学阻抗谱浸泡

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Comparative transcriptome analysis of gene expression patterns on B16F10 melanoma cells under Photobiomodulation of different light modes

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2021年第0期216卷 112127-112127页

作者： Chen, Zeqing Qin, Haokuan Lin, Shangfei Lu, Zhicheng Fan, Xuewei liu, xuwen liu, Muqing Fudan Univ Acad Engn & Technol Inst Future Lighting 220th Handan Rd Shanghai 200433 Peoples R China Zhongshan Fudan Joint Innovat Ctr 6th Xiangxing Rd Zhongshan City 528403 Peoples R China Fudan Univ Inst Elect Light Sources 220th Handan Rd Shanghai 200433 Peoples R China

Cutaneous melanoma is one of the aggressive cancers. Recent studies have shown that Photobiomodulation (PBM) can inhibit the proliferation of melanoma cells. However, it is not clear that the effect of PBM light mode on the inhibition of melanoma cells. Herein, we investigated the difference of influence between continuous wave (CW) and Pulse PBM on B16F10 melanoma cells. Our results suggested that Pulse mode had a more sig-nificant inhibition on the viability of B16F10 melanoma cells than CW mode under the PBM light parameter of wavelength, dose, and average irradiance at 457 nm, 1.14 J/cm(2), and 0.19 mW/cm(2). Besides, we revealed the differentially expressed genes of B16F10 melanoma cells under the various treatments of PBM light mode (not PBM treatment, CW mode, and Pulse mode) by RNA sequencing. Together, our data suggested that Pulse-PBM can improve the effect of PBM on cells significantly and there may be different molecular mechanisms be-tween Pulse and CW mode including anti-proliferative and cell necrosis. The study shed new light on investi-gating the molecular mechanisms of various PBM light modes on B16F10 melanoma cells.

关键词： Photobiomodulation B16F10 melanoma cells Continuous wave Pulse light mode Transcriptomic study

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Research on alkali corrosion resistance and life prediction of glass fiber recycled concrete based on grey system theory

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STRUCTURES 2025年 75卷

作者： Yang, Wenrui Huang, Yuewen Wu, Weiwei Huang, Weihua Xiong, Xiaolong Li, Chengwei Zhong, xuwen liu, Liai Zhou, Hai Zhang, Xun East China Univ Technol Sch Civil & Architectural Engn Nanchang 330012 Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hung Hom Kowloon Hong Kong Peoples R China Univ British Columbia Sch Engn Kelowna BC V1V 1V7 Canada Jiangxi Ganyue Expressway Co Ltd Nanchang Peoples R China Power China Jiangxi Elect Power Engn Co Ltd Nanchang Peoples R China

In this paper, four kinds of recycled concrete with 0 %, 0.5 %, 1.0 %, and 1.5 % glass fiber volume ratios were prepared to investigate the alkali corrosion resistance life of glass fiber recycled concrete in an alkaline environment. The alkali solution erosion test, uniaxial compression test, and scanning electron microscope (SEM) test were carried out, respectively. The results show that glass fiber can reduce the mass loss of recycled concrete in an alkaline environment, improve its compressive strength, and prolong its alkali resistance life. When the volume ratio of glass fiber was 1.0 %, the mass loss was reduced by 0.65 %, the compressive strength was increased by 11.22 %, and the alkali corrosion life was prolonged by 40 days, up to 183 days. Based on the grey degree theory GM(1,1), the compressive strength and corrosion resistance coefficient prediction models of glass fiber recycled concrete were established. The accuracy grade of the compressive strength prediction model and the corrosion resistance coefficient prediction model were level 1 (good), indicating that the accuracy of the prediction model was good, which provided a certain theoretical basis for the research in related fields of glass fiber recycled concrete in an alkaline environment.

关键词： Recycled concrete Glass fiber Gray prediction model GM(1,1) Alkaline environment Compressive strength

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论新时代全过程人民民主的科学意蕴

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云南行政学院学报 2024年第1期26卷 11-21页

作者：刘旭雯广西大学马克思主义学院

新时代更好推进全过程人民民主建设需要阐释好“因何推进”“推进什么”“谁来推进”“怎样推进”的科学意蕴。在“因何推进”上,全过程人民民主是全面建设社会主义现代化国家的应有之义、是实现人民美好生活的迫切要求,是关系跳出历史... 详细信息

新时代更好推进全过程人民民主建设需要阐释好“因何推进”“推进什么”“谁来推进”“怎样推进”的科学意蕴。在“因何推进”上,全过程人民民主是全面建设社会主义现代化国家的应有之义、是实现人民美好生活的迫切要求,是关系跳出历史周期率的重大问题;在“推进什么”上,全过程人民民主要体现三个“最”、四个“统一”和三个“全”;在“谁来推进”上,要充分发挥中国共产党顶层设计的领导作用、政府治理的积极主导作用以及人民群众创新实践的推动作用;在“怎样推进”上,要通过思想、制度、手段层面上的具体路径形成整体合力。

关键词：全过程人民民主人民当家作主新时代科学意蕴

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Harnessing conversion bridge strategy by organic semiconductor in polymer matrix memristors for high-performance multi-modal neuromorphic signal processing

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INFOMAT 2025年第5期7卷

作者： Dong, Weijia Ji, Xuan An, Chuanbin Xu, Chenhui Zhang, xuwen Zhao, Bin liu, Yuqian Wang, Shiyu Yu, Xi liu, Xinjun Han, Yang Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin Key Lab Mol Optoelect Sci Minist EducCollaborat Innovat Ctr Chem Sci & Engn Tianjin 300350 Peoples R China Tianjin Univ Collaborat Innovat Ctr Chem Sci & Engn Tianjin Key Lab Organ Integrated Circuits Minist Educ Tianjin Peoples R China Tianjin Univ Sch Sci Dept Chem Key Lab Organ Integrated CircuitMinist Educ Tianjin 300072 Peoples R China Tianjin Univ Sch Sci Dept Chem Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Fuzhou Peoples R China Trina Solar State Key Lab Photovolta Sci & Technol Changzhou Peoples R China Tianjin Univ Fac Sci Tianjin Key Lab Low Dimens Mat Phys & Preparat Tec Tianjin 300354 Peoples R China

Organic memristors, integrating chemically designed resistive switching and mechanical flexibility, present promising hardware opportunities for neuromorphic computing, particularly in the development of next-generation wearable artificial intelligence devices. However, challenges persist in achieving high yield, controllable switching, and multi-modal information processing. In this study, we introduce an efficient distribution of conversion bridges (EDCB) strategy by dispersing organic semiconductor (poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene], PBTTT) in elastomer (polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene, SEBS). This innovative approach results in memristors with exceptional yield, high stretchability, and reliable switching performance. By fine-tuning the semiconductor content, we shift the primary charge carriers from ions to electrons, realizing modulable non-volatile, and volatile duo-mode memristors. This advancement enables multi-modal signal processing at distinct operational mechanisms-non-volatile mode for image recognition in convolutional neural networks (CNNs) and volatile mode for dynamic classification and prediction in reservoir computing (RC). A fully analog RC hardware system is further demonstrated by integrating the distinct volatile and non-volatile modes of the EDCB-based memristor into the dynamic neuron network and the linear regression layer of the RC respectively, achieving high accuracy in online arrhythmia detection tasks. Our work paves the way for high-yield organic memristors with mechanical flexibility, advancing efficient multi-mode neuromorphic computing within a unified memristor system integrating volatile and non-volatile ***

关键词： convolutional neural network neuromorphic computing organic memristors reservoir computing stretchable electronics

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Identification of maize seed vigor under different accelerated aging times using hyperspectral imaging and spectral deep features

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COMPUTERS AND ELECTRONICS IN AGRICULTURE 2025年 231卷

作者： Zhu, Hongfei Yang, Ranbing Lu, Miaomiao Shi, Weiming Sun, Wenbin Lv, Danyang liu, Hang Wu, Qiong Jiang, xuwen Han, Zhongzhi Hainan Univ Haikou 570100 Peoples R China Qingdao Agr Univ Qingdao 266109 Peoples R China Minist Agr & Rural Affairs Key Lab Trop Intelligent Agr Equipment Sanya 572025 Peoples R China

Maize seed vigor plays a crucial role in improving crop yield. This study proposes a novel method for detecting maize seed vigor via the MAC-seq2seq model. The model successfully reconstructs the spectral sequence of maize seeds. After optimization and iteration, the model achieved a root mean square error (RMSE) of 2.818 x 10-6 on the test set. Subsequently, deep spectral features were extracted using the pretrained MAC-seq2seq, and an ensemble learning model was applied to detect the seed aging hours, with an accuracy of 93.33 %. Additionally, by labeling the spectral sequences with seed vigor index, the combination of ensemble learning and deep spectral features achieved a detection accuracy of 97.62 % for seed vigor. Ultimately, an online seed vigor detection platform was constructed, which effectively measures seed aging time and vigor, was constructed. This study provides an efficient strategy for the nondestructive detection of maize seed vigor, significantly enhancing detection accuracy.

关键词： Maize Seed Vigor Spectral Reconstruction Deep Features Ensemble Learning

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无机/有机复合涂层体系在3·5%NaCl溶液中的EIS

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化工学报 2007年第9期58卷 2288-2292页

作者：刘旭文熊金平曹京宜左禹北京化工大学材料科学与工程学院北京100029 海军涂料分析检测中心北京102442

采用电化学阻抗谱(EIS)研究了无机富锌底漆/环氧云铁中间漆/氯化橡胶面漆复合涂层体系在3.5%NaCl溶液中的腐蚀电化学行为,考察了紫外辐射对其电化学行为的影响。结果表明:复合涂层体系在3.5%NaCl介质中的腐蚀失效过程可以用4种等效电路... 详细信息

采用电化学阻抗谱(EIS)研究了无机富锌底漆/环氧云铁中间漆/氯化橡胶面漆复合涂层体系在3.5%NaCl溶液中的腐蚀电化学行为,考察了紫外辐射对其电化学行为的影响。结果表明:复合涂层体系在3.5%NaCl介质中的腐蚀失效过程可以用4种等效电路来等效。浸泡失效前120h,电解质溶液电阻Rc从开始的5×109Ω.cm2以大约2.2×107Ω.h-1的速度迅速下降到4×105Ω.cm2,到浸泡120h后Rc则以较小的速度808Ω.h-1下降,涂层电容Cc是按线性增加。紫外辐射不改变复合涂层体系在3.5%NaCl溶液中的电化学行为,仅仅加速复合涂层的失效。

关键词：复合涂层 EIS 老化失效紫外辐射

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Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

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BIOORGANIC & MEDICINAL CHEMISTRY 2020年第11期28卷 115480-115480页

作者： liu, xuwen Wilson, Michael W. liu, Kun Lee, Pil Yeomans, Larisa Hagen, Susan E. Lin, Cheng-Mao Wen, Bo Sun, Duxin White, Andrew D. Showalter, Hollis D. Antonetti, David A. Univ Michigan Dept Ophthalmol & Visual Sci Ann Arbor MI 48105 USA Univ Michigan Dept Med Chem Ann Arbor MI 48105 USA Univ Michigan Vahlteich Med Chem Core Ann Arbor MI 48109 USA Univ Michigan Dept Pharmaceut Sci Ann Arbor MI 48109 USA Univ Michigan Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA

Studies demonstrate that small molecule targeting of atypical protein kinase C (aPKC) may provide an effective means to control vascular permeability, prevent edema, and reduce inflammation providing novel and important alternatives to anti-VEGF therapies for certain blinding eye diseases. Based on a literature tricyclic thieno[2,3-d] pyrimidine lead (1), an ATP-competitive inhibitor of the aPKC iota (iota) and aPKC zeta (zeta) isoforms, we have synthesized a small series of compounds in 1-2 steps from a readily available chloro intermediate. A single pyridine congener was also made using 2D NMR to assign regiochemistry. Within the parent pyrimidine series, a range of potencies was observed against aPKC zeta whereas the pyridine congener was inactive. Selected compounds were also tested for their effect toward VEGF-induced permeability in BREC cells. The most potent of these (7l) was further assayed against the aPKC iota isoform and showed a favorable selectivity profile against a panel of 31 kinases, including kinases from the AGC superfamily, with a focus on PKC isoforms and kinases previously shown to affect permeability. Further testing of 7l in a luciferase assay in HEK293 cells showed an ability to prevent TNF-alpha induced NF kappa B activation while not having any effect on cell survival. Intravitreal administration of 7l to the eye yielded a complete reduction in permeability in a test to determine whether the compound could block VEGF- and TNF alpha-induced permeability across the retinal vasculature in a rat model. The compound in mice displayed good microsomal stability and in plasma moderate exposure (AUC and C-max), low clearance, a long half-life and high oral bioavailability. With IV dosing, higher levels were observed in the brain and eye relative to plasma, with highest levels in the eye by either IV or PO dosing. With a slow oral absorption profile, 7l accumulates in the eye to maintain a high concentration after dosing with higher levels than in

关键词： Blinding eye diseases atypical protein kinaseC (aPKC) Vascular permeability Vascular endothelial growth factor (VEGF) Tumor necrosis factor-alpha (TNF alpha) Homology model Thieno[2,3-d]pyrimidine inhibitors SAR

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人脑胶质瘤中表皮生长因子受体表达的研究

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中华神经外科杂志 1998年第2期14卷 71-74页

作者：刘旭文浦佩玉高之宪天津医科大学总医院神经外科

目的：探讨表皮生长因子受体（ＥＧＦＲ）基因表达与胶质瘤恶性程度的关系。方法：采用Ｎｏｒｔｈｅｒｎ印迹杂交及免疫组织化学技术从ｍＲＮＡ及蛋白水平检测了５０例人脑胶质瘤、４个体外恶性胶质瘤细胞系及８例正常脑组织的ＥＧＦＲ... 详细信息

目的：探讨表皮生长因子受体（ＥＧＦＲ）基因表达与胶质瘤恶性程度的关系。方法：采用Ｎｏｒｔｈｅｒｎ印迹杂交及免疫组织化学技术从ｍＲＮＡ及蛋白水平检测了５０例人脑胶质瘤、４个体外恶性胶质瘤细胞系及８例正常脑组织的ＥＧＦＲ的基因表达。结果：免疫组化检测高恶度胶质瘤（ＷＨＯⅢ－Ⅳ级）ＥＧＦＲ表达６９％（２０／２９），而低恶度胶质瘤（ＷＨＯⅠ－Ⅱ级）表达率为３３％（７／２１），差异显著（Ｐ＜０．０１）；４例细胞系阳性表达１００％；８例正常脑组织无ＥＧＦＲ蛋白表达。ＷＨＯ分级与ＥＧＦＲ蛋白表达呈正相关（ｒ＝０．５５９７，Ｐ＜０．００１）。对５０例胶质瘤进行Ｎｏｒｔｈｅｒｎ印迹杂交，其结果与免疫组化检测结果一致，ＥＧＦＲｍＲＮＡ也随胶质瘤恶性程度的增加而表达增高。结论：ＥＧＦＲ可能在恶性胶质瘤的发生发展中起重要作用，ＥＧＦＲ过表达与胶质瘤分级相关性为从分子水平评估肿瘤的恶性程度及选择基因治疗的靶基因提供了参考。

关键词：脑肿瘤胶质瘤 EGFR 表皮生长因子基因表达

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Deciphering the role of genotype-by-environment interaction in summer maize hybrids based on multiple traits using envirotyping techniques and genotype by yield x trait approaches

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FIELD CROPS RESEARCH 2025年 326卷

作者： Yue, Haiwang Olimpio, das Gracas Dias Kaio Zhu, Jiashuai Bu, Junzhou Wei, Jianwei liu, Pengcheng Yang, Haoxiang Jiang, xuwen Hebei Acad Agr & Forestry Sci Dryland Farming Inst Hebei Prov Key Lab Crops Drought Resistance Res Hengshui 053000 Peoples R China Qingdao Agr Univ Coll Agron Qingdao 266109 Peoples R China Univ Fed Vicosa Dept Gen Biol BR-36571000 Vicosa MG Brazil Univ Melbourne Fac Sci Parkville Vic 3052 Australia

Context: The use of high-yielding, stable, and widely adaptable summer maize hybrids is essential for the sustainable cultivation of maize globally. However, contemporary breeding programs face challenges in identifying genotypes that exhibit consistent performance while maintaining desired agronomic characteristics across diverse environments. Dynamic shifts in global meteorological and edaphic conditions have impacted the evaluation of summer maize performance in China's multi-environment trials (METs). Multi-perspective analysis of genotype-by-environment interactions (GEI) is then essential for characterizing maize yield stability and trait expression across agroecological zones. Objective: This study aims to comprehensively evaluate the performance and stability of maize genotypes in the Huang-Huai-Hai region by integrating environmental techniques (ETs) with multi-trait selection methods. Methods: Twenty-eight maize hybrids and a check hybrid (ZD958) were evaluated across 29 locations in the Huang-Huai-Hai region of China during the 2019-2021 cropping seasons, using a randomized complete block design (RCBD) with three replications. Results: Based on 30 years (1993-2023) of environmental data, which included 19 meteorological and 6 soil physicochemical factors, the ETs classified the 29 locations across eight provinces into six distinct mega-environments (MEs). The additive main effects and multiplicative interaction (AMMI) model analysis revealed that genotype (G), environment (E), and their interaction (GxE) significantly influenced (p < 0.05) for all agronomic parameters from 2019 to 2021. The combined performance of grain yield and other agronomic traits-such as growth period, plant height, ear height, lodging rate, barren stalk rate, grain moisture content at harvest, ear row number, bare tip length, and 100-grain weight-across different MEs was assessed using the genotype by yield x trait (GYT) biplot approach. The integration of GYT biplots with ETs effe

关键词： Multi-environment trials Environmental techniques Genotype by environment interaction Mega-environments Maize (Zea mays L.) GYT biplot

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