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中国医学教育技术 2021年第6期35卷 698-702页

作者：徐晓巍杨林郑思孙月萍王序文李姣中国医学科学院医学信息研究所北京100020

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课... 详细信息

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课程短板,能够满足不同学科背景的学生需求。学生课后反馈结果表明,该平台的应用降低了技术类课程的学习门槛,激发了医学生对于数据挖掘类课程的学习积极性,有助于其实践能力的提升。

关键词：医学数据挖掘平台建设医学教育

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级联金字塔结构的深度图超分辨率重建

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光电工程 2019年第11期46卷 53-65页

作者：付绪文张旭东张骏孙锐合肥工业大学计算机与信息学院

由于成像设备的限制,深度图往往分辨率较低。对低分辨率深度图进行上采样时,通常会造成深度图的边缘模糊。当上采样因子较大时,这种问题尤为明显。本文提出金字塔密集残差网络,实现深度图超分辨率重建。整个网络以残差网络为主框架,采... 详细信息

由于成像设备的限制,深度图往往分辨率较低。对低分辨率深度图进行上采样时,通常会造成深度图的边缘模糊。当上采样因子较大时,这种问题尤为明显。本文提出金字塔密集残差网络,实现深度图超分辨率重建。整个网络以残差网络为主框架,采用级联的金字塔结构对深度图分阶段上采样。在每一阶段,采用简化的密集连接块获取图像的高频残差信息,尤其是底层的边缘信息,同时残差结构中的跳跃连接分支获取图像的低频信息。网络直接以原始低分辨率深度图作为输入,以亚像素卷积层进行上采样操作,减少了运算复杂度。实验结果表明,该方法有效地解决了图像深度边缘的模糊问题,在定性和定量评价上优于现有方法。

关键词：深度图超分辨率金字塔密集残差

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Thallium contamination in farmlands and common vegetables in a pyrite mining city and potential health risks

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ENVIRONMENTAL POLLUTION 2019年 248卷 906-915页

作者： Liu, Juan Li, Nuo Zhang, Weilong Wei, Xudong Tsang, Daniel C. W. sun, Yubing Luo, xuwen Bao, Zhi'an Zheng, Wentao Wang, Jin Xu, Guoliang Hou, Liping Chen, Yongheng Feng, Yuexing Guangzhou Univ Key Lab Water Qual & Conservat Pearl River Delta Guangdong Prov Key Lab Radionuclides Pollut Contr Inst Environm Res Greater BaySch Environm Sci & Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Rural Nonpoint Source Pollut Comprehens Managemen Guangzhou 510006 Guangdong Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hung Hom Kowloon Hong Kong Peoples R China North China Elect Power Univ Coll Environm Sci & Engn MOE Key Lab Resources & Environm Syst Optimizat Beijing 102206 Peoples R China Northwest Univ Dept Geol State Key Lab Continental Dynam Xian 710069 Peoples R China Guangzhou Univ Sch Life Sci Guangzhou 510655 Guangdong Peoples R China Univ Queensland Sch Earth & Environm Sci Brisbane Qld 4072 Australia

Thallium (Tl) is a trace metal of severe toxicity. Its health concerns via consumption of contaminated vegetables have often been overlooked or underestimated. This study was designed to gain insight into the actual level and distribution characteristics of Tl and metal (loid)s (Pb, Cd, Cr, Sb, Mn, Cu, Zn, Ni, and Co) in agricultural soils and common vegetables cultivated in different zones (upstream, midstream, and downstream) of a densely populated residential area in a typical mine city, which has been open-pit exploiting Tl-bearing pyrite minerals since 1960s. The results show that most of the agricultural soils exhibit contaminated levels of Tl, with Tl contents (upstream: 1.35-4.31 mg/kg, midstream: 2.43 -5.19 mg/kg, and downstream: 0.65-233 mg/kg) mostly exceeding the maximum permissible level (MPL) for agricultural land use (1 mg/kg). Sequential extraction procedure indicates that even Tl is predominantly retained in the residual fraction, significant levels of Tl are still present in the geochemically mobile fractions. Besides, metals like Cu, Cd, Mn, and Co are mostly distributed in the labile fractions. Almost all metal (loid)s in edible parts of the vegetables exceed their corresponding MPL for consumption. The chronic daily intake (CDI) and hazard quotient (HQ) values calculated for inhabitants at different ages indicate non-negligible Tl risks via consumption of local vegetables, especially for children. Therefore, it is critical to establish effective measures for hazardous waste management and enforceable regulations in Tl-polluted area to mitigate potential severe impacts of Tl on human health through food chain. (C) 2019 Elsevier Ltd. All rights reserved.

关键词： Thallium Agricultural soil Vegetable Metal/metalloid contamination Pyrite mining

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Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

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ADVANCED SCIENCE 2021年第20期8卷 e2101526页

作者： Li, Chao Zhao, Zhenhao Luo, Yifan Ning, Tingting Liu, Peixin Chen, Qinjun Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Su, Boyu You, Haoyu Zhang, Tongyu Li, xuwen Song, Haolin Li, Chufeng sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol Key Lab Smart Drug DeliveryMinist EducInst Brai Shanghai 201203 Peoples R China Fudan Univ Sch Pharm Inst Brain Sci MOE Frontiers Ctr Brain SciDept Pharmaceut Shanghai 201203 Peoples R China

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO2) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrophage-membrane protein-mediated recognition with cell adhesion molecules that are overexpressed on the damaged vascular endothelium. MnO2 nanosphere can consume excess hydrogen peroxide (H2O2) and convert it into desiderated oxygen (O-2), and can be decomposed in acidic lysosome for cargo release, so as to reduce oxidative stress and promote the transition of M1 microglia to M2 type, eventually reversing the proinflammatory microenvironment and reinforcing the survival of damaged neuron. This biomimetic nanomedicine raises new strategy for multitargeted combined treatment of ischemic stroke.

关键词： biomimetic nanoparticles inflammatory microenvironment microglia polarization neuroprotection O-2 generation reperfusion injury reactive oxygen species (ROS) consumption

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吉富罗非鱼养殖池塘集成调控技术配比研究

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中国农学通报 2021年第33期37卷 148-152页

作者：孙旋辉蒋咏燚刘文婷郑尧陈家长邴旭文中国水产科学研究院淡水渔业研究中心南京农业大学无锡渔业学院江苏无锡214081

前期研究表明"5%空心菜+10%填料+泼藻"水质调控集成模式值得推广,为进一步验证效果,以吉富罗非鱼养殖池塘为对象,研究不同空心菜种植配比其对池塘水质氮、磷净化效果。通过设置5%、8%和10%空心菜种植比例,测定TN、NH;-N、TP、... 详细信息

前期研究表明"5%空心菜+10%填料+泼藻"水质调控集成模式值得推广,为进一步验证效果,以吉富罗非鱼养殖池塘为对象,研究不同空心菜种植配比其对池塘水质氮、磷净化效果。通过设置5%、8%和10%空心菜种植比例,测定TN、NH;-N、TP、CODMn、TSS、p H和DO等水质指标,并进行环境、效益评估。结果表明:空心菜种植对罗非鱼池塘水体中TN、NH;-N、TP、CODMn、TSS均有一定程度的降低,空心菜种植对TN去除率在10%~15%之间,对TP去除率在20%~40%之间,5%空心菜种植组还对NH;-N、CODMn有较好的去除效果,且效益较好适合推广。

关键词：池塘水质调控原位修复集成中草药鱼菜配比营养盐去除效果成本核算

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Misdiagnosis of a Patient with Internal Carotid Artery Fenestration: A Case Report and Literature Review

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ANNALS OF VASCULAR SURGERY 2016年 30卷 309.e1-309.e4页

作者： Liang, Zhigang Xiu, Chunming Liu, Zhuli sun, xuwen Yu, Guoping Tao, Manli Li, Wei Qingdao Univ Coll Med Affiliated Yantai Yuhuangding Hosp Dept Neurol Yantai Shandong Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Neurol Beijing Peoples R China

Background: Internal carotid artery fenestration is a rare congenital cerebrovascular condition and can be misdiagnosed as carotid artery dissection. Case Report: A patient was initially misdiagnosed with carotid artery dissection. This initial diagnosis was made using a carotid vascular computed angiography and magnetic resonance angiography. A digital subtraction angiography examination revealed a fenestration in the terminal C1 segment of the right internal carotid artery. Previous literature related to carotid artery fenestration was reviewed and analyzed. Conclusions: Fenestration of the carotid artery combined with aneurysm at the external segment of the internal carotid artery or from the starting position of the carotid artery remains rare in elderly patients, can be misdiagnosed as artery dissection.

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High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

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Physical Review Accelerators and Beams 2024年第9期27卷 092003页

作者： Weimin Pan Jiyuan Zhai Feisi He Rui Ge Zhenghui Mi Peng Sha Song Jin Ruixiong Han Qunyao Wang Haiying Lin Guangwei Wang xuwen Dai Zhanjun Zhang Mei Li Minjing Sang Liangrui sun Rui Ye Tongxian Zhao Shaopeng Li Keyu Zhu Baiqi Liu Xiaolong Wang Xiangchen Yang Xiaojuan Bian Xiangzhen Zhang Huizhou Ma Jianbing Zhao Liang Zhang Hui Zhao Runbing Guo Zhihui Mu Conglai Yang Xiaobing Zheng Chao Dong Hongjuan Zheng Zhengze Chang Xiaochen Yang Tongming Huang Qiang Ma Zihan Wang Ming Liu Wenzhong Zhou Senyu Chen Chinese Academy of Sciences Beijing 100049 China Beijing 100049 China

The world’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (rf) cavities treated by medium-temperature furnace baking (mid-T bake) was developed at the Institute of High Energy Physics, Chinese Academy of Sciences. The 9-cell cavities in the cryomodule achieved an unprecedented high average intrinsic quality factor (Q0) of 3.8×1010 at 16 MV/m and 3.6×1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total continuous wave rf voltage greater than 193 MV, with an average cavity usable accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of Circular Electron Positron Collider and Dalian advanced light source and the other high repetition rate free electron laser facilities [Linac Coherent Light Source II (LCLS-II), LCLS-II-high energy, Shanghai High Repetition Rate X-ray FEL and Extreme Light Facility, Shenzhen Superconducting Soft X-Ray Free Electron Laser, etc.]. There is evidence that the mid-T bake cavity may not require fast cooldown or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing.

关键词： Radio frequency techniques Superconducting RF

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南海天然气水合物钻采机理与调控研究进展

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中国科学基金 2021年第6期35卷 940-951页

作者：孙金声程远方秦绪文孙友宏金衍王志远李淑霞陆程屈沅治吕开河王成文王金堂王韧中国石油大学(华东) 青岛266580 中国石油集团工程技术研究院有限公司北京102206 中国地质调查局北京100037 广州海洋地质调查局广州510075 中国地质大学(北京) 北京100083 中国石油大学(北京) 北京102249 中国地质调查局油气资源调查中心北京100083

海域天然气水合物试采存在井壁易失稳、井漏、流动安全风险高、储层改造困难、单井日产气量低、稳产时间短等一系列技术难题,水平井、多分支井等有望提高产气量的复杂结构井钻采难度更大。本文基于对国内外水合物钻采研究进展以及已开... 详细信息

海域天然气水合物试采存在井壁易失稳、井漏、流动安全风险高、储层改造困难、单井日产气量低、稳产时间短等一系列技术难题,水平井、多分支井等有望提高产气量的复杂结构井钻采难度更大。本文基于对国内外水合物钻采研究进展以及已开展天然气水合物勘探、试采工程现状的跟踪调研,总结分析了海域天然气水合物试采面临的关键技术难题,进而根据我国南海天然气水合物试采工程特性,对天然气水合物储层力学特性动态演化规律及工程响应机制、井筒工作液与天然气水合物储层作用机理和调控方法、天然气水合物钻采井筒多相流动障碍形成机制与安全控制方法、储层天然气水合物相变和渗流多场时空演化规律、天然气水合物储层结构改造理论与高效开发模式等方面研究进展进行了论述,以期为我国海域天然气水合物钻采理论及技术的发展提供借鉴。

关键词：南海天然气水合物钻采工程力学特性井筒工作液相变及渗流特征

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Amphipathic Side Chain of a Conjugated Polymer Optimizes Dopant Location toward Efficient N-Type Organic Thermoelectrics

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ADVANCED MATERIALS 2021年第4期33卷 2006694-2006694页

作者： Liu, Jian Ye, Gang Potgieser, Hinderikus G. O. Koopmans, Marten Sami, Selim Nugraha, Mohamad Insan Villalva, Diego Rosas sun, Hengda Dong, Jingjin Yang, xuwen Qiu, Xinkai Yao, Chen Portale, Giuseppe Fabiano, Simone Anthopoulos, Thomas D. Baran, Derya Havenith, Remco W. A. Chiechi, Ryan C. Koster, L. Jan Anton Univ Groningen Zernike Inst Adv Mat Nijenborgh 4 NL-9747 AG Groningen Netherlands Univ Groningen Stratingh Inst Chem Nijenborgh 4 NL-9747 AG Groningen Netherlands King Abdullah Univ Sci & Technol KAUST Phys Sci & Engn Div PSE KAUST Solar Ctr KSC Thuwal 239556900 Saudi Arabia Linkoping Univ Dept Sci & Technol Lab Organ Elect SE-60174 Norrkoping Sweden Univ Ghent Dept Inorgan & Phys Chem Krijgslaan 281S3 B-9000 Ghent Belgium

There is no molecular strategy for selectively increasing the Seebeck coefficient without reducing the electrical conductivity for organic thermoelectrics. Here, it is reported that the use of amphipathic side chains in an n-type donor-acceptor copolymer can selectively increase the Seebeck coefficient and thus increase the power factor by a factor of approximate to 5. The amphipathic side chain contains an alkyl chain segment as a spacer between the polymer backbone and an ethylene glycol type chain segment. The use of this alkyl spacer does not only reduce the energetic disorder in the conjugated polymer film but can also properly control the dopant sites away from the backbone, which minimizes the adverse influence of counterions. As confirmed by kinetic Monte Carlo simulations with the host-dopant distance as the only variable, a reduced Coulombic interaction resulting from a larger host-dopant distance contributes to a higher Seebeck coefficient for a given electrical conductivity. Finally, an optimized power factor of 18 mu W m(-1) K-2 is achieved in the doped polymer film. This work provides a facile molecular strategy for selectively improving the Seebeck coefficient and opens up a new route for optimizing the dopant location toward realizing better n-type polymeric thermoelectrics.

关键词： conjugated polymers dopant location N-type doping organic thermoelectrics Seebeck coefficient solution processing

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Parasitic modes suppression in CW cold tests of 1.3 GHz 9-cell high Q cavities at IHEP

arXiv

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arXiv 2021年

作者： Mi, Zhenghui He, Feisi Pan, Weimin Sha, Peng Zhai, Jiyuan Dai, xuwen Jin, Song Zhang, Zhanjun Dong, Chao Liu, Baiqi Zhao, Hui Ge, Rui Zhao, Jianbing Mu, Zhihui Du, Lei sun, Liangrui Zhang, Liang Yang, Conglai Zheng, Xiaobing Lin, Haiying Wang, Guangwei He, Xiangcong Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

The CW RF test of 1.3 GHz 9-cell cavity in liquid helium bath at 2 K is a very important key point in the cavity procurement. Some problems can be found through the test, according which to optimized and improve the process of cavity. Recently, Medium temperature (mid-T) furnace bake of 1.3 GHz 9-cell cavities have been carried out at IHEP. Through the proceed of mid-T bake, the quality factor of cavity has been greatly improved. While the excitation of the parasitic modes in the high Q cavities CW cold test has been encountered, which implies an error source for the cavity gradient and quality factor determination. In order to ensure the testing accuracy of superconducting cavity, we have improved the testing system. Finally, the parasitic mode is completely suppressed and the CW RF cold test of high Q cavity is guaranteed. © 2021, CC BY.

关键词： Superfluid helium

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