Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
标准号:
EP3246317(A4)
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
Chemical investigation of the fungus Talaromyces stipitatus ATCC 10500, whose genome has been sequenced, led to the isolation of four undescribed talaroenamines B-E along with the known talaroenamine A. Their structur...
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Chemical investigation of the fungus Talaromyces stipitatus ATCC 10500, whose genome has been sequenced, led to the isolation of four undescribed talaroenamines B-E along with the known talaroenamine A. Their structures were elucidated on the basis of spectroscopic studies including mass spectrometry, extensive 2D NMR and electronic circular dichroism (ECD). Interestingly, talaroenamine A had previously been isolated from the strain of T. stipitatus Delta trop C, a strain knocked out for the gene encoding a non-heme Fe(II)-dependent dioxygenase catalyzing the oxidative ring expansion leading to the tropolone, but never from a wild-type strain. All talaroenamines were evaluated for their antiplasmodial activity and Talaroenamine D exhibited the best inhibition against the chloroquine-resistant Plasmodium falciparum (FcB1 strain) without noticeable toxicity on HeLa and preadipose cell lines. In the course of the chemical investigation of T. stipitatus, an undescribed polyester was also isolated and its absolute configuration was determined by hydrolysis and transesterification followed by gas chromatography on chiral column. (C) 2015 Elsevier Ltd. All rights reserved.
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
标准号:
US2017313683(A1)
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
In order to improve University Quality Education, and develop the practical ability of research and innovation of Undergraduates majoring in Biomedical Engineering, this project probes into the development of innovati...
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ISBN:
(纸本)9781479969890
In order to improve University Quality Education, and develop the practical ability of research and innovation of Undergraduates majoring in Biomedical Engineering, this project probes into the development of innovative experiment program for Biomedical Engineering and research on the practical ability cultivation for undergraduates from various aspects, intended to choose interesting experiment topics, encourage independent innovative experiments and efficient innovation team, on the basis of a comparison between Chinese and foreign implementation of innovative experimental program of Biomedical Engineering, combing with the applicants' teaching experiences, as well as the theories and methods in education, engineer and medicine. Moreover, it proposes a set of training hands-on ability processes with its own characteristics for Biomedical Engineering majors, which is "be experimental - participator - leader- thinking after experiment", conducive to promote students to learn by doing, research while learning and innovate in research, as well as of great significance to enhance their innovative ability to research, practical ability and comprehensive quality.
This paper summarizes the diffusion mechanism and relevant research method of oxygen which is diffused from courtyard greenbelt with the action of wind. This paper dynamically simulates the oxygen condition of courtya...
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ISBN:
(纸本)9783037857922
This paper summarizes the diffusion mechanism and relevant research method of oxygen which is diffused from courtyard greenbelt with the action of wind. This paper dynamically simulates the oxygen condition of courtyard space by the method of CFD. According to the simulation results, researchers make triaxial quantitative analysis for greenbelt distribution, oxygen diffusion and concentration distribution of courtyard space. Finally, this paper summarizes the basic law of oxygen diffusion influenced by greenbelt distribution of courtyard and puts forward some design strategies of greenbelt which is in favor of oxygen diffusion and oxygen environment of courtyard.
In order to improve University Quality Education, and develop the practical ability of research and innovation of Undergraduates majoring in Biomedical Engineering, this project probes into the development of innovati...
详细信息
In order to improve University Quality Education, and develop the practical ability of research and innovation of Undergraduates majoring in Biomedical Engineering, this project probes into the development of innovative experiment program for Biomedical Engineering and research on the practical ability cultivation for undergraduates from various aspects, intended to choose interesting experiment topics, encourage independent innovative experiments and efficient innovation team, on the basis of a comparison between Chinese and foreign implementation of innovative experimental program of Biomedical Engineering, combing with the applicants' teaching experiences, as well as the theories and methods in education, engineer and medicine. Moreover, it proposes a set of training hands-on ability processes with its own characteristics for Biomedical Engineering majors, which is “be experimental - participator - leader- thinking after experiment”, conducive to promote students to learn by doing, research while learning and innovate in research, as well as of great significance to enhance their innovative ability to research, practical ability and comprehensive quality.
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