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Mesoporous Palladium-Boron-Sulfur Alloy Nanospheres for Efficient Hydrogen Evolution

INORGANIC CHEMISTRY 2021年第7期60卷 4380-4384页

作者： Guo, xuwen Chen, Zhichao Huang, Yanping Lv, Hao Wang, Yaru sun, Lizhi Song, Kai Liu, Ben Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab New Power Batteries Nanjing 210023 Peoples R China Shenzhen RELX Technol Co Ltd Shenzhen 518108 Peoples R China Sichuan Univ Coll Chem Chengdu 610064 Peoples R China Changchun Normal Univ Sch Life Sci Changchun 130032 Peoples R China Sichuan Univ Sch Chem Engn Ctr Engn Expt Teaching Chengdu 610065 Peoples R China

Ternary noble metal-metalloid-nonmetal PdBS alloy mesoporous nanospheres (MSs) with three-dimensional central-radial pore channels were prepared for an electrocatalytic hydrogen evolution reaction. The synthesis was performed via precise control in the reduction and nucleation growth of ternary PdBS alloy MSs along confined cylinder mesophases assembled by amphiphilic dioctadecyldimethylammonium chloride. The resultant PdBS alloy MSs disclosed a remarkably improved electrocatalytic performance due to their structural and compositional synergies. This finding extended our knowledge on the rational design and targeted synthesis of novel noble metal-metalloid-nonmetal alloys with desired structures and morphologies for catalysis and other applications.

关键词： Palladium Alloys Genetics Evolution reactions Transmission electron microscopy

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The impact of mineral compositions on hydrate morphology evolution and phase transition hysteresis in natural clayey silts

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ENERGY 2023年 274卷

作者： Bian, Hang Qin, xuwen sun, Jinsheng Luo, Wanjing Lu, Cheng Zhu, Jian Ma, Chao Zhou, Yingfang China Univ Geosci Sch Energy Resources Beijing 100083 Peoples R China China Geol Survey Ctr Oil & Nat Gas Resource Explorat Beijing 100083 Peoples R China China Geol Survey Beijing 100083 Peoples R China China Geol Survey Guangzhou Marine Geol Survey Guangzhou 510075 Peoples R China Natl Engn Res Ctr Gas Hydrate Explorat & Dev Guangzhou 511458 Peoples R China China Univ Petr East China Qingdao 266580 Peoples R China CNPC Engn Technol R&D Co Ltd Beijing 102206 Peoples R China iRock Technol Beijing 100094 Peoples R China Univ Aberdeen Sch Engn Aberdeen Scotland

Natural gas hydrate is a clean and high-efficient energy resource, and more than 90% of its reserves are con-tained in fine-grained (typically clayey silts) sediment. In this work, for the first time, the micro-scale imaging is performed to explore hydrate phase transition, morphology evolution and fundamental characteristics (mineral compositions, pore structures and seepage capacity) in clayey silt sediments. The results indicate that clayey silts formation properties strongly depend on dominant minerals component in the sediments. The clay-rich clayey silt possesses more microcapillary interstice with smaller permeability than that in quartz-rich sediment. Hy-drates generally occur as microfracture-filling (veins) and grain-displacing (nodulus) in sand-rich clayey silt. While they occur in the form of fracture-filling (vein) and foraminifera-filling in clay-rich clayey silt sediments. Biological fossils (especially foraminifera) provides potential space for hydrate aggregates. But hydrate formed inside it depends on the structures of fossils, the mineral components and pore structure of surrounding matrix. The hysteresis between hydrate formation and decomposition found to be more significant in clay-rich clayey silt sediment than quartz-rich sediment. And this hysteresis inside foraminifera is much more serious compared with that in matrix. In addition, dispersed pore-filling hydrates forms during decomposition, which has adverse effect on continuous gas production.

关键词： Clayey silt Hydrate phase transition Micro -scale properties Micro -scale imaging

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ImageSem group at ImageCLEFmed caption 2021 task: Exploring the clinical significance of the textual descriptions derived from medical images

ImageSem group at ImageCLEFmed caption 2021 task: Exploring ...

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2021 Working Notes of CLEF - Conference and Labs of the Evaluation Forum, CLEF-WN 2021

作者： Wang, xuwen Guo, Zhen Xu, Chunyuan sun, Lianglong Li, Jiao Institute of Medical Information and Library Chinese Academy of Medical Sciences Peking Union Medical College Beijing100020 China School of Life Science Beijing Institute of Technology Beijing100081 China

This paper presents the work of ImageSem group in the ImageCLEFmed Caption 2021 task. In the concept detection subtask, we employed the transfer learning-based multi-label classification model as our baseline. We also trained multiple fine-grained MLC models based on manually annotated semantic categories, such as Imaging Type, Anatomic Structure, and Findings, which may reveal clinical insights of radiology images. We submitted 9 runs to the concept detection subtask, and achieved the F1 Score of 0.419, which ranked 3rd in the leader board. In the caption prediction subtask, our first method simply combines detected concepts according to the sentence patterns. The second method used a dual path CNN model for matching images and captions. We submitted 4 runs to the caption prediction subtask, and achieved the BLEU score of 0.257, which ranked 6th among the participating teams. © 2021 Copyright for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).

关键词： Forecasting

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Hierarchical flower-like manganese oxide/polystyrene with enhanced oxidase-mimicking performance for sensitive colorimetric detection of glutathione

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MICROCHIMICA ACTA 2022年第2期189卷 63-63页

作者： Liu, Ying Yan, Jianghong sun, Zhiheng Huang, Yu Li, xuwen Jin, Yongri Jilin Univ Coll Chem 2699 Qianjin Rd Changchun 130012 Peoples R China Jilin Prov Acad Tradit Chinese Med Clin Hosp 1 Changchun 130021 Peoples R China

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In this paper, 3D hierarchical flower-like nanozyme named MnO2/PS (polystyrene) was successfully prepared by template method for the first time. After the systematical studies, MnO2/PS nanozyme was evaluated to possess favorable oxidase activity and direct 3,3',5,5'-tetramethylbenzidine (TMB) catalytic ability in the near-neutral environment at room temperature. With the addition of different concentrations of GSH, oxidized TMB can be reduced to TMB with the whole process from blue to nearly colorless be observed by naked eyes. In addition, there is a good linear relationship in the range 1-50 mu M and a detection limit of 0.08 mu M. The method proposed can be successfully applied to the detection of reduced GSH in tablets and injections with good selectivity and high sensitivity. The analysis results exhibited good consistency with the results obtained by HPLC.

关键词： Oxidase-like activity Manganese oxide Flower-like nanozyme GSH detection Colorimetric sensor

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma

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ADVANCED MATERIALS 2025年第15期37卷 e2418053页

作者： You, Haoyu Zhang, Shilin Zhang, Yiwen Chen, Qinjun Wu, Yuxing Zhou, Zheng Zhao, Zhenhao Su, Boyu Li, xuwen Guo, Yun Chen, Yun Tang, Weiyi Liu, Bing Fan, Hongrui Geng, Shuo Fang, Mingzhu Li, Fangxin Liu, Guangna Jiang, Chen sun, Tao Fudan Univ Sch Pharm State Key Lab Med Neurobiol Minhang HospInnovat Ctr New Drug Dev Immune Infla Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Orthoped Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB. Therefore, to enhance the in vivo safety and targeting capability of OMVs, we introduced engineered OMVs to reduce toxicity and further constructed a modularly assembled nanoplatform by performing simple peptide modifications. This nanoplatform demonstrates satisfactory biosafety and is able to continuously cross the BBB and target GBM with the assistance of Angiopep-2. Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenicity of GBM, ultimately overcoming GBM immune resistance to enhance the efficacy of immunotherapy. This OMVs-based nanoplatform provides a new paradigm and insights into the development of immunotherapy for GBM.

关键词： engineering technology glioblastoma immune resistance immunotherapy outer membrane vesicles

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Chemical Constituents of the Marine Traditional Chinese Medicine of Pegasus laternarius Cuvier (Hai-E Yu)

Pharmaceutical Fronts

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Pharmaceutical Fronts 2024年第2期6卷 E149-E154页

作者： sun, Shuqian Gao, Zhen Wang, Mengxue Chen, Sha Guo, Wenjuan Li, xuwen School of Chemistry and Chemical Engineering University of Jinan Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery State Key Laboratory of Chemical Biology Shanghai Institute of Materia Medica Chinese Academy of Sciences

Pegasus laternarius Cuvier (Hai-E Yu) is a marine traditional Chinese medicine that has been used to treat cancers and reduce inflammation. Previous chemical investigations have only revealed the occurrence of high levels of protein, fatty acids, and a large number of steroids, thusmore active compounds in P. laternarius still need to be further discovered. The present study aims to search for new bioactive constituents of P. laternarius with cytotoxic effects and nitric oxide (NO) inhibitory activities. In this work, 16 pure compounds from the ethyl acetate fraction of Pegasus laternarius Cuvier were successively obtained by various chromatographic techniques, and the structure of the isolates was elucidated by spectroscopic analyses. The isolated and identified compounds included one 2H-1,2,3-triazole-4-carboxylate derivative (1), two oxadiazines (2, 3), two amino acids (4, 5), three nucleosides (6-8), three steroids (9-11), and five others (12-16). All the obtained compounds were evaluated for their antitumor activity on A549 and HCT-116 cell lines along with their inhibitory effects on lipopolysaccharide-induced NO production in RAW264.7 cells. The triazole compound 1 was found to exhibit moderate cytotoxicity against two human cell lines (A549 and HCT-116) with IC₅₀ values of 44.5 and 32.9 μmol/L, respectively. The steroid compound 10 inhibited NO production with IC₅₀ values lower than 50 μmol/L. Consequently, this study provides insight into the cytotoxic and NO inhibitory activities of the marine traditional Chinese medicines in Hai-E-Yu. © 2024. The Author(s).

关键词： anti-inflammatory cytotoxicity marine traditional Chinese medicine Pegasus laternarius Cuvier

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Experimental Study on the Evolution of Hydrate Formation and Blockage in a Water-Dominated Bubbly Flow System

SSRN

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SSRN 2023年

作者： Kong, Qingwen Qin, xuwen Wang, Zhiyuan Zhang, Jianbo Tong, Shikun sun, Baojiang Qingdao266580 China Department of Basic Investigation China Geological Survey Beijing100083 China National Engineering Research Center of Oil & Gas Drilling and Completion Technology Qingdao266580 China

During deepwater oil and gas drilling and hydrate production testing, water-dominated bubbly flow patterns may appear in the wellbore and drainage pipeline. Hydrate formation in bubbly flow may cause hydrate blockage and threaten the flow safety. In this study, a newly built high-pressure flow loop and a focused beam reflectance measurement device were used to investigate the evolution of hydrate formation and blockage in bubbly flow. The concentration and rate of hydrate rapid formation were mainly influenced by the initial flow velocity and maximum subcooling of the system. Considering the bubble breakage, coalescence and deformation, a kinetic model of hydrate rapid formation in bubbly flow was established based on the correction of the reaction rate factor K, and the model error was experimentally verified to be less than 15%. Hydrate aggregates in the range of 150–500 μm caused severe flow barriers, and three significant events were proposed to characterize the evolution degree of hydrate aggregation and blockage in bubbly flow. The critical initial flow velocity of 0.65±0.05 m/s determines whether hydrate aggregates with particle sizes larger than 150 μm will appear immediately when the hydrate is formed. And two main mechanisms of hydrate blockage in water-dominated bubbly flow were revealed. This study is expected to lay the foundation for hydrate flow assurance in wellbores and pipelines. © 2023, The Authors. All rights reserved.

关键词： Flow velocity

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie Li, Chao Li, xuwen Chu, Yongchao Guo, Qin Zhang, Yiwen Xia, Weiyi Liu, Peixin Chen, Hongyi Wang, Yu Li, Chufeng sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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Synergistic effects of asphaltenes, kaolinite, and water chemistry on oil-water emulsion stability

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Separation and Purification Technology 2025年 372卷

作者： Zhou, Qi sun, Yongxiang Ma, Hongtao Song, Xuguang Huang, Pan Mao, Xiaohui Peng, xuwen Zeng, Hongbo Department of Chemical and Materials Engineering University of Alberta EdmontonABT6G 1H9 Canada College of Materials Science and Engineering Donghua University 2999 North Renmin Road Shanghai201620 China Department of Chemical Engineering Tsinghua University Beijing100084 China

Effective treatment of emulsions formed during the bitumen extraction process is crucial for oil–water separation and subsequent processing. However, it remains a challenge in the oil sands industry due to the complex mixture of solids, water, and bitumen. Asphaltenes in bitumen and fine clay minerals in solids can significantly adsorb at interfaces and contribute to emulsion stability, which makes oil–water separation difficult. Very limited attention has been paid to the synergistic effects of asphaltenes, solids, and complex water chemistry involved in the bitumen extraction process. This study characterized asphaltenes and kaolinite, with kaolinite acting as a representative clay mineral in the experiments. The synergistic effects of asphaltenes and kaolinite fine particles on emulsion stability and interfacial properties were systematically investigated through demulsification bottle tests, zeta potential measurements, dynamic interfacial tension, and dilatational rheology analyses. The results suggest that kaolinite fine particles substantially enhance the stability of asphaltene-stabilized emulsions. Meanwhile, metal salts, especially divalent salts such as MgCl2 and CaCl2 in water, can further contribute to the stability of both asphaltene-stabilized emulsions and emulsions co-stabilized by asphaltenes and kaolinite. Computational insights from density functional theory and ab initio molecular dynamics elucidate the molecular-level interactions between asphaltenes, kaolinite, and metal cations. This work has improved the understanding of emulsion stability mechanisms posed by asphaltenes, clay minerals, and complex water chemistries in bitumen extraction and crude oil production. The results contribute to advancing separation and purification technologies critical to the oil sands industry. © 2025 The Authors

关键词： Asphalt mixtures

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A Curved Four-Conductor Assembly with Larger Uniform Region

A Curved Four-Conductor Assembly with Larger Uniform Region

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IEEE International Frequency Control Symposium

作者： Chao Li xuwen Hu Fuyu sun Jie Liu Xiaofeng Li Shougang Zhang Chinese Academy of Sciences National Time Service Center Xi’an China University of Chinese Academy of Sciences Beijing China

Most atomic physics setups require a uniform static magnetic field to define a quantization axis. The straight four-conductor assembly has been proven to be a useful structure for producing such a uniform static magnetic field. Here, we present an improved four-conductor assembly, where each conductor consists of one straight section and two curved sections. This hybrid structure arrangement offers more degrees of freedom than the conventional straight four-conductor assembly, enabling a larger uniform field region and better field spatial uniformity. The modified magnetic field generation structure can be used in many fields of atomic precision spectroscopy.

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