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Incidence and Temporal Trend of Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

JOURNAL OF TROPICAL MEDICINE 2022年第0期2022卷 8266878页

作者： Wang, Nannan Chen, Xinyu Hao, Zhuolu Guo, Jia Wang, xuwen Zhu, Xijing Yi, Honggang Wang, Qingliang tang, Shaowen Nanjing Med Univ Sch Publ Hlth Dept Epidemiol & Biostat Nanjing Peoples R China Nanjing Med Univ Sch Pharm Nanjing Peoples R China Nanjing Med Univ Sch Clin Med 1 Nanjing Peoples R China Shandong Univ Qilu Hosp Dept Med Affairs Jinan Peoples R China

Background and Aim. Antituberculosis (anti-TB) drug-induced liver injury (ATLI) is a common and serious adverse drug reaction of tuberculosis treatment, and the incidence of ATLI has been reported to vary from 2.0% to 28.0%. This study aims to estimate the incidence of ATLI in patients who receive anti-TB treatment and describe its temporal trend in the world. Methods. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards were followed, and the protocol was registered in PROSPERO (CRD42020200077). Five electronic databases were searched to identify eligible studies published between 1990 and 2022. Search terms included anti-TB treatment and drug-induced liver injury. Studies that reported the incidence of ATLI or provided sufficient data to calculate the incidence of ATLI were included, and duplicate studies were excluded. Meta-analysis was conducted on the basis of logit-transformed metrics for the incidence of ATLI with 95% confidence intervals (CIs), followed by a predefined subgroup meta-analysis. Temporal trend analyses were performed to describe the change in pooled incidence over time. A random effects metaregression was conducted to explore the source of heterogeneity. All statistical analyses were carried out using R 4.0.1. Results. A total of 160 studies from 156 records with 116147 patients were included in the meta-analysis. Based on the random effects model, the pooled incidence of ATLI was 11.50% (95% CI: 10.10%-12.97%) and showed an upward trend over time (P < 0.001). Patients who received first-line anti-TB drugs, patients in South America, and patients with hepatitis B and C virus coinfection had a higher incidence of ATLI (13.66%, 18.16%, and 39.19%, respectively). Sensitivity analyses also confirmed this robust incidence after the exclusion of some studies. The metaregression showed that different anti-TB regimens and geographical regions were important explanatory factors of the heterogeneity between studies. Conclusion

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Highly sensitive detection of rabbit IgG by electron spin resonance using CuS nanoparticles as probe

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SENSORS AND ACTUATORS B-CHEMICAL 2021年 338卷 129835-129835页

作者： Tian, Sizhu Li, xuwen Jiang, Jia tang, Li Zhang, Hanqi Yu, Yong Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Peoples R China

Water soluble copper sulfide (CuS) nanoparticles were synthesized using L-cysteine as the ligand. Multiple biotins were conjugated to the antibody of rabbit IgG, and the streptavidin was attached to the CuS nanoparticles. The Cu2+ ions enclosed in the nanoparticles were used as the electron spin resonance (ESR) probes and detected with ESR spectrometer. The immunoassay reaction was resulted in the formation of the coating antibody attached to the microplate well, the detecting antibody labeled with the biotins, and the streptavidin attached to the CuS nanoparticles. After the immunoassay reaction was performed, large amount of Cu2+/Cu+ ions inside the nanoparticles were released with the help of diethyldithiocarbamate (DDC) and the Cu2+-DDC complex formed. The Cu2+-DDC complex was extracted into n-butanol, which was used as the analytical sample. Both ESR and UV?vis signals were collected for the analytical sample. The double logarithm standard curve was well simulated with a linear regression equation. The limits of detection of the rabbit IgG were 1.76 pg/mL and 2.36 pg/mL by ESR and UV?vis method, respectively. The detection range using ESR as the detector was from 8.8 pg/mL to 500 ng/mL, covering almost 5 magnitude orders of the rabbit IgG concentrations. The rabbit serum was analyzed and the rabbit IgG concentration was found to be 7.76 mg/mL. The reproducibility of the present method was good enough with the intra-assay error within 3.4 % and the inter-assay error within 11.2 %. The spiked serum samples were analyzed and the experimental results indicated that the recoveries were from 108.2 to 113.7%.

关键词： CuS nanoparticles Electron spin resonance Immunoassay Cu2+-DDC complex Rabbit IgG

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吐酸病患者中医情志辨证疗效的单中心回顾性研究

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中国中西医结合消化杂志 2023年第7期31卷 523-526页

作者：弓艳霞唐艳萍郝旭雯刘茜刘莹康丽丽天津市南开医院消化科天津300100

目的回顾性研究21010例吐酸病患者的基本资料,包括病因、心理评估、中医辨证分型,重点分析中医情志辨证施治的功效,为临床加强心身治疗提供依据。方法收集2016年1月-2018年12月就诊于消化科的吐酸病患者的病历资料,按照病因分为反流性... 详细信息

目的回顾性研究21010例吐酸病患者的基本资料,包括病因、心理评估、中医辨证分型,重点分析中医情志辨证施治的功效,为临床加强心身治疗提供依据。方法收集2016年1月-2018年12月就诊于消化科的吐酸病患者的病历资料,按照病因分为反流性食管炎(reflux esophagitis,RE)、非糜烂性反流病(non-erosive reflux disease,NERD)、反流高敏感(reflux hypersensitivity,RH)、功能性烧心(functional heartburn,FH)4个组,统计各组患者的一般资料、情志因素、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)和汉密尔顿抑郁量表(Hamilton depression Scale,HAMD)评分,重点分析中医情志辨证治疗对于吐酸病患者症状缓解的有效率。结果筛选吐酸病患者21010例,男8864例,女12146例,发病年龄40~60岁。病因:RE患者6284例(29.9%),NERD患者10426例(49.6%),RH患者2430例(11.6%),FH患者1870例(8.9%)。该类症状患者中合并情志障碍者约占38%(7901/21010),主要表现为焦虑、抑郁及睡眠障碍。其中RE患者1131例(18%),NERD患者3649例(35%),RH患者1531例(63%),FH患者1590例(85%),结果FH>RH>NERD>RE,差异有统计学意义(P<0.05),8周质子泵抑制剂治疗后有效率分别为89%、72%、54%、0;部分予以中医情志辨证施治2周,各组有效率均有提升,总有效率为76%,其中FH组有效率提升52%,差异有统计学意义(P<0.05)。结论吐酸病主要病因包括NERD、RE、RH及FH。患者多合并焦虑、抑郁情绪,该类患者加强心身治疗至关重要,中医情志调节可提高质子泵抑制剂治疗的疗效。

关键词：吐酸病反流性食管炎非糜烂性食管炎反流高敏感功能性烧心情志中医辨证

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HKUST-1负载磷钨酸选择性合成乙二醇单叔丁基醚

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精细化工 2022年第7期39卷 1411-1418页

作者：马德亮蒙旭雯汤吉海张竹修崔咪芬乔旭南京工业大学化工学院江苏南京211800 南京工业大学材料化学工程国家重点实验室江苏南京211800

采用一锅法制备了HKUST-1负载磷钨酸(HPW)(HPW@HKUST-1),采用XRD、SEM、EDS、BET、ICP、吡啶红外(Py-IR)、酸碱滴定对其进行了表征。评价了HPW@HKUST-1作为催化剂用于异丁烯(IB)与乙二醇(EG)选择性醚化合成乙二醇单叔丁基醚(EGME)的催... 详细信息

采用一锅法制备了HKUST-1负载磷钨酸(HPW)(HPW@HKUST-1),采用XRD、SEM、EDS、BET、ICP、吡啶红外(Py-IR)、酸碱滴定对其进行了表征。评价了HPW@HKUST-1作为催化剂用于异丁烯(IB)与乙二醇(EG)选择性醚化合成乙二醇单叔丁基醚(EGME)的催化性能。结果表明,HPW负载量的提高增加了催化剂Bronsted酸活性位点,有利于提高反应物转化率,同时HPW负载量与催化剂平均孔径呈负相关性,平均孔径减小有利于提高EGME选择性。HPW负载量为10%(以HKUST-1物质的量为基准,下同)的HPW@HKUST-1催化剂活性较优,其催化IB和EG合成EGME最优的反应条件为:反应温度100℃,n(IB)/n(EG)=6,催化剂用量为EG质量(11.13 g)的10%,反应时间4 h。在该反应条件下,EG转化率为97%,EGME选择性为85%。此外,该催化剂具有良好的循环稳定性,使用5次后,EG转化率为91%,EGME选择性为78%。

关键词： HKUST-1 负载磷钨酸选择性醚化乙二醇单叔丁基醚催化技术

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Design, Synthesis and Biological Evaluation of Quinazoline Derivatives as TXNIP Inhibitors for the Treatment of Type 2 Diabetes Mellitus

SSRN

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SSRN 2022年

作者： Li, Aiyun Guan, Li Su, Wanzhen Zhao, Ning Song, xuwen Wang, Jin tang, Xiaoxiao Li, Weize Jiao, Xiangying Key Laboratory of Cellular Physiology Ministry of Education Department of Physiology Shanxi Medical University Taiyuan030001 China College of Pharmacy Xi’an Medical University Xi’an710021 China

Thioredoxin interacting protein (TXNIP) is a potential target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesized and evaluated as TXNIP inhibitor to protect palmitate (PA)-induced β cells injury and for T2DM treatment. Most of compounds displayed potent pancreatic β cells protective activities especially for the compounds D-2 and C-1. In cell viability assay, compounds D-2 and C-1 could effectively promote β cells survival and protect β cells from PA-induced β cells apoptosis. Further cellular mechanism of action studies demonstrated that their potent β cells protective activities against PA-induced β cells apoptosis were achieved by reducing intracellular reactive oxygen species (ROS) production and modulating TXNIP-NLRP3 inflammasome signaling, and thus alleviating oxidative stress injury and inflammatory response. Besides, compounds D-2 and C-1 could inhibit TXNIP protein expression both in physiological condition and in PA-treated Min6 pancreatic β cells. Subsequent experiment showed that compounds D-2 and C-1 decrease TXNIP protein expression via accelerating its protein degradation. The present study evidently showed that compounds D-2 and C-1 were two potent pancreatic β cells protective agents as TXNIP inhibitors and might serve as promising lead candidates for the treatment of T2DM. © 2022, The Authors. All rights reserved.

关键词： Proteins

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数字化视角下应急测绘管理服务平台的研究与设计

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测绘与空间地理信息 2025年第3期48卷 41-43页

作者：马旭文万术海唐伟王沛冯思园浙江省测绘科学技术研究院浙江杭州311100

为了高效应对重大突发事件和维护人民生命财产安全情景下的数字化管理的深度应用,通过相关文献资料的研究,并结合浙江省应急测绘管理工作的实际需求,提出一种面向突发事件全闭环管理的应急测绘管理服务平台的设计方案。系统阐述了平台... 详细信息

为了高效应对重大突发事件和维护人民生命财产安全情景下的数字化管理的深度应用,通过相关文献资料的研究,并结合浙江省应急测绘管理工作的实际需求,提出一种面向突发事件全闭环管理的应急测绘管理服务平台的设计方案。系统阐述了平台的业务流程、总体框架、功能模块和关键技术。该平台有效提升了应急测绘灾前、灾中、灾后的管理水平和工作效率,实现了事前防范准备、事发监测预警、事中处置救援、事后应急复盘的全流程管理。

关键词：数字化应急测绘管理闭环平台

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基于高分辨率卫星遥感技术的风化层厚度制图方法

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地质科技通报 2020年第3期39卷 220-226页

作者：秦绪文唐壮陈伟涛广州海洋地质调查局广州510075 中国地质大学(武汉) 武汉430074

区域尺度风化层厚度是制约民用和军事地质工程施工、陆域军事交通能力重要因素之一。传统方法通常都需要大量的野外踏勘和实地采样,效率较低,在人迹罕至、人不能至的地区无法完成。因此,利用高分辨率遥感技术开展区域尺度风化层厚度制... 详细信息

区域尺度风化层厚度是制约民用和军事地质工程施工、陆域军事交通能力重要因素之一。传统方法通常都需要大量的野外踏勘和实地采样,效率较低,在人迹罕至、人不能至的地区无法完成。因此,利用高分辨率遥感技术开展区域尺度风化层厚度制图研究具有非常重要的意义。在野外调查的基础上,利用国产高分二号卫星数据,采用人机交互目视解译方法获取研究区岩性、土地覆盖类型分布图,并基于ASTER GDEM数据获取地形地貌图像;然后,以坡度、岩性、土地覆盖类型为影响因子,基于云模型理论和方法综合评估获取研究区的风化层厚度图,制图结果与野外验证数据吻合度较好,精度可达81.69%。

关键词：风化层厚度云模型军事地质遥感高分辨率遥感

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JOINTS RELATION INFERENCE NETWORK FOR SKELETON-BASED ACTION RECOGNITION 26

JOINTS RELATION INFERENCE NETWORK FOR SKELETON-BASED ACTION ...

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26th IEEE International Conference on Image Processing (ICIP)

作者： Ye, Fanfan tang, Huiming Wang, xuwen Liang, Xiao Zhejiang Univ Coll Informat Sci & Elect Engn Hangzhou Peoples R China

ISBN: (纸本)9781538662496

Recently, the graph convolutional networks based methods have achieved remarkable performance in skeleton-based action recognition. However, current methods do not make full use of the topology of the skeleton graph, because they set and fixed the relation of skeleton joints or adjacency matrix for all input samples manually. In order to solve the problem, we design an end-to-end architecture consisting of joints relation inference network (JRIN) and skeleton graph convolutional network (SGCN). JRIN can aggregate spatial-temporal feature of every two joints globally, then infer the optimal relation between every two joints automatically. These relations of joints is quantified as the optimal adjacency matrices. Then SGCN will take the optimal matrices to do the final action recognition. During training, special initialization and alternate training strategies are proposed to optimize the model. Our method achieves very competitive performance on widely used NTU-RGB+D and Kinetics datasets.

关键词： Action Recognition Relation Inference Graph Convolutional Network Skeleton

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老年股骨颈骨折内固定术后股骨头坏死发生率及影响因素研究

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中国继续医学教育 2017年第34期9卷 61-63页

作者：唐绪文潜江市中医院骨科湖北潜江433100

目的探讨老年股骨颈骨折经闭合复位内固定术后股骨头坏死的发生率及影响因素。方法选取2016年5月—2017年5月我院收治的股骨颈骨折患者120例作为研究对象,将其随机分为两组,研究组行闭合复位内固定术进行治疗,对照组采取一般方法进行治... 详细信息

目的探讨老年股骨颈骨折经闭合复位内固定术后股骨头坏死的发生率及影响因素。方法选取2016年5月—2017年5月我院收治的股骨颈骨折患者120例作为研究对象,将其随机分为两组,研究组行闭合复位内固定术进行治疗,对照组采取一般方法进行治疗。对随访记录完整的120例进行统计学分析,并运用logistic回归进行因素分析。结果患者在不同时期股骨头坏死的发生率不同,研究组术后1个月及2个月发生率低于对照组,差异具有统计学意义(P<0.05);单因素分析结果显示,患者在复位时间、完全负重时间、手术方式方面均存在差异(P<0.05);多因素分析结果显示,患者在复位时间、完全负重时间、手术方式方面均存在差异(P<0.05)。结论老年股骨颈骨折患者经闭合复位内固定术后股骨头坏死率并未高于平均水平,取得较为满意的效果。患者的骨折类型、受伤至手术时间、骨折复位质量与股骨头坏死的发生明显相关。

关键词：老年股骨颈骨折闭合复位内固定术股骨头坏死发生率影响因素研究

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经皮穴位电刺激对腰椎间盘突出症患者免疫平衡及临床预后的影响

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温州医科大学学报 2024年第6期54卷 446-451页

作者：钱旭雯李国艳刘国凯汤雯倩李春黇北京中医药大学东方医院麻醉科北京100078 北京中医药大学东直门医院麻醉科北京100700 北京中医药大学东直门医院针灸科北京100700

目的:探讨经皮穴位电刺激(TEAS)对行脊柱开放性手术的腰椎间盘突出患者的免疫平衡、术后感染以及临床预后的影响。方法:选取2021年3月—2022年12月北京中医药大学东直门医院因腰椎间盘突出症于全麻下行脊柱开放性手术的患者112例,采用... 详细信息

目的:探讨经皮穴位电刺激(TEAS)对行脊柱开放性手术的腰椎间盘突出患者的免疫平衡、术后感染以及临床预后的影响。方法:选取2021年3月—2022年12月北京中医药大学东直门医院因腰椎间盘突出症于全麻下行脊柱开放性手术的患者112例,采用随机数字表法分为单纯全身麻醉组(对照组)和穴位电刺激复合全身麻醉组(试验组),每组各56例。观察入室后麻醉前(T0)、气管插管时(T1)、切皮时(T2)、置入第一个椎弓根钉时(T3)、术毕(T4)、术后第1天(T5)、术后第2天(T6)患者的血清指标[IL-2、TNF-α、干扰素-γ(IFN-γ)、IL-4、IL-6、IL-10、转化生长因子-β(TGF-β)、IL-17]水平、脑电双频谱指数(BIS)值的变化、术后并发症(切口感染、恶心呕吐),以探讨TEAS对患者的免疫平衡以及临床预后的影响。结果:与T0时比,对照组IL-17水平在T4时明显升高(P<0.05);两组患者的TGF-β水平在T2、T4、T5、T6时均明显降低(P<0.01,P<0.05)。与对照组相比,试验组的IL-2水平在T4及T6时明显降低(P<0.01);试验组IL-4水平在T3及T4时间点明显升高(P<0.05);试验组IFN-γ水平在T1及T5时明显降低(P<0.05);试验组IL-17水平在T4时有所下降(P<0.05);试验组的TGF-β水平在T3时明显升高(P<0.01)。两组患者切口感染率试验组(1例,1.7%)低于对照组(5例,8.9%),差异有统计学意义(P<0.05);两组患者术后恶心呕吐率试验组(8例,14%)低于对照组(24例,43%),差异有统计学意义(P<0.05)。在BIS值的比较中,术毕时试验组BIS值高于对照组(P<0.05)。结论:围手术期在双侧内关、合谷、足三里、三阴交穴位应用TEAS可以改善患者的免疫平衡、降低炎症反应,升高抗炎反应,从而减少术后感染的发生,同时能够缩短患者苏醒时间,有效减少恶心、呕吐等术后并发症的发生。

关键词：经皮穴位电刺激免疫平衡并发症预后脊柱开放性手术

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