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Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

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IMMUNOLOGY LETTERS 2024年 267卷 106856-106856页

作者： Du, Luping Lu, Haiyan Qiao, xuwen zhang, Yuanpeng Hou, Liting Yu, Xiaoming Cheng, Haiwei Chen, Jin Zheng, Qisheng Hou, Jibo Tong, Guangzhi Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing 210014 Jiangsu Peoples R China Jiangsu Acad Agr Sci Natl Res Ctr Engn & Technol Vet Biol Nanjing 210014 Jiangsu Peoples R China Minist Sci & Technol Nanjing Jiangsu Key Lab Food Qual & Safety State Key Lab Cultivat Base Nanjing 210014 Jiangsu Peoples R China Chinese Acad Agr Sci Shanghai Vet Res Inst Shanghai 200241 Peoples R China Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China Jiangsu Acad Agr Sci 45 Zhongling StRoom A111 Nanjing Jiangsu Peoples R China

Multifunctional CD4+ T helper 1 (Th1) cells, producing IFN-gamma, TNF-alpha and IL-2, define a correlate of vaccinemediated protection against intracellular infection. In our previous study, we found that CVC1302 in oil formulation promoted the differentiation of IFN-gamma+/TNF-alpha+/IL-2+Th1 cells. In order to extend the application of CVC1302 in oil formulation, this study aimed to elucidate the mechanism of action in improving the Th1 immune response. Considering the signals required for the differentiation of CD4+ T cells to Th1 cells, we detected the distribution of innate immune cells and the model antigen OVA-FITC in lymph node (LN), as well as the quantity of cytokines produced by the innate immune cells. The results of these experiments show that, cDC2 and OVAFITC localized to interfollicular region (IFR) of the draining lymph nodes, inflammatory monocytes localized to both IFR and T cell zone, which mainly infiltrate from the blood. In this inflammatory niche within LN, CD4+ T cells were attracted into IFR by CXCL10, secreted by inflammatory monocytes, then activated by cDC2, secreting IL-12. Above all, CVC1302 in oil formulation, on the one hand, targeted antigen and inflammatory monocytes into the LN IFR in order to attract CD4+ T cells, on the other hand, targeted cDC2 to produce IL-12 in order to promote optimal Th1 differentiation. The new finding will provide a blueprint for application of immunopotentiators in optimal formulations.

关键词： CVC1302 Oil formulation Interfollicular region Inflammatory niche Th1 cells

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“心荡”考释

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中医文献杂志 2019年第3期37卷 22-25页

作者：张序文陈晓上海中医药大学

"心荡"在部分吴语地区方言中具有心悸心慌的含义,然而在吴地以外则知之者甚少.事实上,"心荡"一词古术语已有之,并非吴语独有.通过对"心荡"的含义及沿革进行考释,以还原其古今全貌."心荡"一词... 详细信息

"心荡"在部分吴语地区方言中具有心悸心慌的含义,然而在吴地以外则知之者甚少.事实上,"心荡"一词古术语已有之,并非吴语独有.通过对"心荡"的含义及沿革进行考释,以还原其古今全貌."心荡"一词始见于春秋之《左传》,约在六朝至宋代尚可见于医家、道家著作,而其含义有所不同;宋之后医著中少见,时至清代,方才作为症状术语见于多位吴语地区医家医案中."心荡"为方言保留古语的典型现象,可作为中医症状名词术语"心悸"的别称.

关键词：心荡心悸吴语症状

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Tertiary Lymphoid Structure in Tumor Microenvironment and Immunotherapy of Lung Cancer

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ARCHIVOS DE BRONCONEUMOLOGIA 2024年 60卷 S77-S85页

作者： Xie, Mei Lin, xuwen Bao, Xinyu Liang, Yiran Deng, Hui Song, Jialin Ma, Xidong zhang, Xin Yao, Jie Pan, Lei Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Dept Resp & Crit Care Emergency & Crit Care Med Ctr Beijing 100038 Peoples R China Shandong Second Med Univ Sch Clin Med Dept Resp & Crit Care Weifang Shandong Peoples R China

Immune checkpoint inhibitors have opened an era of lung cancer therapy. However, a notable disparity exists in the efficacy of immunotherapy among individual patients. The tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregation that appears under pathological conditions and is the primary site of action for anti-tumor immunity. It is commonly reported that the presence of TLS within the tumor microenvironment (TME) relates to a favorable clinical prognosis and an excellent response to immunotherapy in lung cancer patients. A thorough understanding of TLS and its dynamic changes in TME has become an attractive focus for optimizing immunotherapy strategies for lung cancer. In this review, we comprehensively generalize the composition, formation, mechanism, detection methods of TLS, and summarize the role of TLS in lung cancer immunotherapy. Finally, induction of TLS is also discussed, which may provide more effective therapeutic strategies for lung cancer therapy. (c) 2024 The Authors. Published by Elsevier Espana, S.L.U. on behalf of SEPAR.

关键词： Tertiary lymphoid structures Lung cancer Immunotherapy Prognosis

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GLOBAL DERIVATION OF THE 1D VLASOV-POISSON EQUATION FROM QUANTUM MANY-BODY DYNAMICS WITH SCREENED COULOMB POTENTIAL

arXiv

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arXiv 2024年

作者： Chen, xuwen Shen, Shunlin zhang, Ping zhang, Zhifei Department of Mathematics University of Rochester RochesterNY14627 United States School of Mathematical Sciences University of Science and Technology of China Anhui Province Hefei230026 China Academy of Mathematics & Systems Science Hua Loo-Keng Center for Mathematical Sciences Chinese Academy of Sciences Beijing100190 China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing100049 China School of Mathematical Sciences Peking University Beijing100871 China

We study the 1D quantum many-body dynamics with a screened Coulomb potential in the mean-field setting. Combining the quantum mean-field, semiclassical, and Debye length limits, we prove the global derivation of the 1D Vlasov-Poisson equation. We tackle the difficulties brought by the pure state data, whose Wigner transforms converge to Wigner measures. We find new weighted uniform estimates around which we build the proof. As a result, we obtain, globally, stronger limits, and hence the global existence of solutions to the 1D Vlasov-Poisson equation subject to such Wigner measure data, which satisfy conservation laws of mass, momentum, and energy, despite being measure solutions. This happens to solve the 1D case of an open problem regarding the conservation law of the Vlasov-Poisson equation raised in [18] by Diperna and Lions. Copyright © 2024, The Authors. All rights reserved.

关键词： Poisson equation

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Neutrophil-lymphocyte ratio: a correlation study of its effect on magnetic resonance imaging enhancement patterns in spinal parenchymal tuberculosis

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BMC INFECTIOUS DISEASES 2025年第1期25卷 1-9页

作者： Shan, Qiulan zhang, Le Fu, xuwen Qi, Min Wei, Jialu Gan, Wei Pu, Ying Shen, Lingjun Li, Xiang Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept Radiol 319 Wujing Rd Kunming 650041 Yunnan Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept ICU Kunming 650041 Yunnan Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept Pharm Kunming 650041 Peoples R China Kunming Third Peoples Hosp Yunnan Clin Med Ctr Infect Dis Dept TB 319 Wujing Rd Kunming 650041 Yunnan Peoples R China

Objective To explore the impact of the neutrophil-lymphocyte ratio (NLR) on magnetic resonance imaging (MRI) enhancement patterns in patients with spinal parenchymal tuberculosis. Methods In this study, a retrospective analysis was conducted on 42 patients diagnosed for the first time with spinal parenchymal tuberculosis at Kunming Third People's Hospital between 2019 and 2024. They were divided into a homogeneous enhancement group and a ring enhancement group based on MRI characteristics and an analysis of their clinical presentations, imaging features and laboratory test results. Results A total of 42 patients were included in the study, with 30 in the ring enhancement group and 12 in the homogeneous enhancement group. The ring enhancement group exhibited a significantly higher proportion of fever, night sweats and limb sensory/motor dysfunction compared with the homogeneous enhancement group (p < 0.05). For laboratory tests, the ring enhancement group showed remarkably elevated peripheral blood neutrophil counts and NLR, along with markedly reduced lymphocyte counts and proportions (p < 0.05). Additionally, the incidence of perilesional oedema was substantially higher in the ring enhancement group than in the homogeneous enhancement group (p < 0.05). Conclusion The NLR may serve as a potential indicator for assessing MRI enhancement patterns in spinal parenchymal tuberculosis, which is beneficial for identifying patients at different pathological stages of the disease. This study provides novel perspectives for clinical diagnosis and treatment while emphasising the need for further research on the application value of the NLR in tuberculosis.

关键词： Spinal parenchymal tuberculosis Neutrophil-lymphocyte ratio Magnetic resonance imaging enhancement patterns Tuberculosis

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Influences of Community Coalescence on the Assembly of Bacterial Communities of the Small-Scale Complex Aquatic System from the Perspective of Bacterial Transmission, Core Taxa, and Co-occurrence Patterns

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MICROBIAL ECOLOGY 2024年第1期87卷 145页

作者： Xu, Huimin zhang, Yi Fan, Dingyue Meng, Shunlong Fan, Limin Song, Chao Qiu, Liping Li, Dandan Fang, Longxiang Liu, Zhuping Bing, xuwen Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Wuxi 214081 Peoples R China Minist Agr & Rural Affairs Lab Qual & Safety Risk Assessment Aquat Prod Envir Wuxi 214081 Peoples R China Taihu Basin Author Minist Water Resource Water Conservancy Dev Res Ctr Shanghai 200438 Peoples R China Shanghai Ocean Univ Coll Fisheries & Life Sci Shanghai 201306 Peoples R China

Recirculating aquaculture and aquaponics are considered sustainable aquaculture models playing important roles in animal-derived protein supply. In these aquaculture systems, microorganisms are crucial for the system stability. The community coalescence by mixing substances and microorganisms from various microhabitats under hydraulic forces is important for shaping the bacterial communities in these small-scale complex systems. However, the influences of community coalescence on bacterial communities remain rarely revealed in these systems. In this study, aquaponics (APS) and recirculating aquaculture (RAS) systems were set up to explore the bacterial community coalescence across different microhabitats, including water, fish feces, biofilter biofilms, and plant rhizosphere environment. Our results showed that diversity and compositions varied across different microhabitats in both systems. However, bacterial transmissions across these microhabitats differed between systems. The core microbiome of the RAS and APS were formed under community coalescence with the highest contribution of bacterial taxa derived from the fish feces. Nevertheless, the plant rhizosphere bacterial community also contributed to the core microbiome of the APS. Furthermore, the core taxa showed a higher average degree than the other nodes in the bacterial community networks in all microhabitats except for the plant rhizosphere environment, implying the important roles of core taxa in maintaining these bacterial community networks. Our results provide new insights into the assembly of bacterial communities under community coalescence in the artificial aquatic ecosystems comprising complex microhabitats, which is vital for developing microbial solutions for regulating the microbial communities to improve system performance in the future.

关键词： Aquaponics Microhabitats Community coalescence Bacterial transmission Core taxa Co-occurrence network

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Cascade nanozymatic network mimicking cells with selective and linear perception of H2O2

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CHEMICAL SCIENCE 2023年第24期14卷 6780-6791页

作者： Zhu, Caixia Zhou, Zhixin Gao, Xuejiao J. Tao, Yanhong Cao, xuwen Xu, Yuan Shen, Yanfei Liu, Songqin zhang, Yuanjian Southeast Univ Sch Chem & Chem Engn Med Sch Jiangsu Engn Lab Smart Carbon Rich Mat & DeviceJi Nanjing Peoples R China Jiangxi Normal Univ Coll Chem & Chem Engn Nanchang 330022 Peoples R China

A single stimulus leading to multiple responses is an essential function of many biological networks, which enable complex life activities. However, it is challenging to duplicate a similar chemical reaction network (CRN) using non-living chemicals, aiming at the disclosure of the origin of life. Herein, we report a nanozyme-based CRN with feedback and feedforward functions for the first time. It demonstrates multiple responses at different modes and intensities upon a single H2O2 stimulus. In the two-electron cascade oxidation of 3,3 ',5,5 '-tetramethylbenzidine (TMB), the endogenous product H2O2 competitively inhibited substrates in the first one-electron oxidation reaction on a single-atom nanozyme (Co-N-CNTs) and strikingly accelerated the second one-electron oxidation reaction under a micellar nanozyme. As a proof-of-concept, we further confined the nanozymatic network to a microfluidic chip as a simplified artificial cell. It exhibited remarkable selectivity and linearity in the perception of H2O2 stimulus against more than 20 interferences in a wide range of concentrations (0.01-100 mM) and offered an instructive platform for studying primordial life-like processes.

关键词： Oxidation

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Design of a new scintillator-based fast ion loss detector on the HL-2A tokamak

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JOURNAL OF INSTRUMENTATION 2024年第10期19卷 P10013-P10013页

作者： Han, Yuxiao Xie, Jinlin zhang, Jie He, Xiaofei Wang, Yongqing Liu, Linzi Xu, Hongbing Zhan, xuwen Liu, Kuancheng zhang, Yipo Shi, Zhongbing Chen, Wei Zhong, Wulv Xu, Min Zhuang, Gea Univ Sci & Technol China Dept Plasma Phys & Fus Engn Hefei Anhui Peoples R China Southwestern Inst Phys Chengdu Sichuan Peoples R China

A new scintillator-based fast ion loss detector (FILD) has been devised for the HL-2A tokamak, with the objective of discerning the temporal evolution of energy and pitch angle among lost fast ions. A code named FILD Simulation (FSC) has been developed to assist in the design of the detector head and the interpretation of experimental data. By optimising the geometric design, the resolutions of energy and pitch angle are optimised to 5 keV and 3 degrees, respectively. A branched imaging fiber bundle is used to relay the fluorescence image on the scintillator to two distinct instruments. One of these is a high-speed camera, while the other is a silicon photomultiplier tube (SiPM) array with a sampling rate of up to 1 MSamples/s. This configuration enables the attainment of superior temporal and spatial resolution, as well as high photon sensitivity.

关键词： Nuclear instruments and methods for hot plasma diagnostics Plasma diagnostics- high speed photography Plasma diagnostics- probes Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators)

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Nomogram to screen older adult patients attending the radiology department for sarcopenia

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BMC GERIATRICS 2025年第1期25卷 1-9页

作者： Yuan, Guiying Ye, Guoxi Hu, Jianguang Hu, Huimin Shi, Chanmei zhang, Ye Huang, Junbing Li, Zhiqiong Zeng, xuwen Tan, Rongshao Xiong, Yuchao Jinan Univ Guangzhou Red Cross Hosp Dept Resp Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol 396 Tongfu Rd Guangzhou Guangzhou 510220 Guangdong Provi Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Nephrol Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Inst Dis Oriented Nutr Res Dept Clin Nutr Guangzhou Peoples R China

BackgroundSarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia *** cross-sectional study included 654 patients aged >= 60 years who underwent an examination in the radiology department between October 2023 and June 2024. Patients were diagnosed with sarcopenia according to the method and cutoff value criteria proposed the Asian Working Group on Sarcopenia (AWGS) 2019 criteria. Calf circumference (CC), SARC-F score, mid-upper arm circumference (MUAC), and SARC-CalF score were used as simplified discriminant parameters for sarcopenia. The discriminative ability of these parameters for sarcopenia was assessed using receiver operating characteristic analysis. Additionally, we included each screening parameter and evaluated it's important for screening for the presence of sarcopenia via univariate and multivariate logistic regression analysis to develop a new screening nomogram model. The performance of the nomogram was evaluated using receiver operating characteristic curves, and the performance of the nomogram model was compared to that of CC, SARC-F, MUAC, and the SARC-CalF using the Delong *** the 654 subjects, 120 (18.3%) were diagnosed with sarcopenia, and the areas under the curve (AUCs) of the CC, SARC-F, MUAC, and SARC-CalF were 0.73, 0.61, 0.66, and 0.70, respectively. The multivariate analysis results revealed that older age, male sex, low CC, low MUAC, and low strength were related to sarcopenia. A nomogram model constructed with these five variables had an AUC of 0.84. The DeLong test showed that the diagnostic efficacy of the joint model was significantly higher than that of CC, SARC-F, MUAC, and *** simple nomogram based on simplified discriminant parameters offers personalized

关键词： Sarcopenia Nomogram Calf circumference SARC-F SARC-CalF

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A Curved Four-Conductor Assembly with Larger Uniform Region

A Curved Four-Conductor Assembly with Larger Uniform Region

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2023 Joint Conference of the European Frequency and Time Forum and IEEE International Frequency Control Symposium, EFTF/IFCS 2023

作者： Li, Chao Hu, xuwen Sun, Fuyu Liu, Jie Li, Xiaofeng zhang, Shougang National Time Service Center Chinese Academy of Sciences Xi'an China University of Chinese Academy of Sciences Beijing China

ISBN: (纸本)9798350311426

Most atomic physics setups require a uniform static magnetic field to define a quantization axis. The straight four-conductor assembly has been proven to be a useful structure for producing such a uniform static magnetic field. Here, we present an improved four-conductor assembly, where each conductor consists of one straight section and two curved sections. This hybrid structure arrangement offers more degrees of freedom than the conventional straight four-conductor assembly, enabling a larger uniform field region and better field spatial uniformity. The modified magnetic field generation structure can be used in many fields of atomic precision spectroscopy. © 2023 IEEE.

关键词： curved section four-conductor modified four-conductor static magnetic field uniformity

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