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IEEE International Frequency Control Symposium

作者： Chao Li xuwen Hu Fuyu Sun Jie Liu Xiaofeng Li Shougang zhang Chinese Academy of Sciences National Time Service Center Xi’an China University of Chinese Academy of Sciences Beijing China

Most atomic physics setups require a uniform static magnetic field to define a quantization axis. The straight four-conductor assembly has been proven to be a useful structure for producing such a uniform static magnetic field. Here, we present an improved four-conductor assembly, where each conductor consists of one straight section and two curved sections. This hybrid structure arrangement offers more degrees of freedom than the conventional straight four-conductor assembly, enabling a larger uniform field region and better field spatial uniformity. The modified magnetic field generation structure can be used in many fields of atomic precision spectroscopy.

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Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir

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ORGANIC PROCESS RESEARCH & DEVELOPMENT 2021年第4期25卷 838-848页

作者： Xie, Hongming Liu, Haiwang zhang, Yingjun Huang, Enhuo Feng, Yahui Xiang, xuwen Fang, Qinghong Peng, Zhihong Dong, Wanrong An, Delie Hunan Univ Coll Chem & Chem Engn State Key Lab Chemo Biosensing & Chemometr Changsha 410082 Hunan Peoples R China Sunshine Lake Pharma Co Ltd State Key Lab Antiinfect Drug Dev 2015DQ780357 Dongguan 523871 Peoples R China HEC Pharm Grp HEC Res & Dev Ctr Dongguan 523871 Peoples R China

A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization with hydrolases in the synthetical approach can significantly avoid the loss of chiral raw materials in the resolution process. The synthesis route is further optimized and scaled-up to establish a new process that is applied to the preparation of kilogram scales of target active pharmaceutical ingredients (APIs). Compared with our initial process, the overall yield of target API was dramatically improved from 17 to 40%.

关键词： hepatitis C virus inhibitor Emitasvir enantioselective synthesis process development

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Progresses in biomarkers for cancer immunotherapy

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MEDCOMM 2023年第5期4卷 e387页

作者： Lin, xuwen Zong, Chenyu zhang, Zhihan Fang, Weiyi Xu, Ping Peking Univ Shenzhen Hosp Dept Pulm & Crit Care Med Shenzhen Guangdong Peoples R China Shantou Univ Med Coll Dept Internal Med Shantou Guangdong Peoples R China Zunyi Med Univ Dept Internal Med Zunyi Guizhou Peoples R China Southern Med Univ Canc Res Inst Sch Basic Med Sci Guangzhou Guangdong Peoples R China Southern Med Univ Integrated Hosp Tradit Chinese Med Canc Ctr Guangzhou Guangdong Peoples R China Peking Univ Shenzhen Hosp Dept Pulm & Crit Care Med Shenzhen 518034 Guangdong Peoples R China Southern Med Univ Canc Res Inst Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China

Currently, checkpoint inhibitor-based immunotherapy has emerged as prevailing treatment modality for diverse cancers. However, immunotherapy as a first-line therapy has not consistently yielded durable responses. Moreover, the risk of immune-related adverse events increases with combination regimens. Thus, the development of predictive biomarkers is needed to optimize individuals benefit, minimize risk of toxicities, and guide combination approaches. The greatest focus has been on tumor programmed cell death-ligand 1 (PD-L1), microsatellite instability (MSI), and tumor mutational burden (TMB). However, there remains a subject of debate due to thresholds variability and significant heterogeneity. Major unmet challenges in immunotherapy are the discovery and validation of predictive biomarkers. Here, we show the status of tumor PD-L1, MSI, TMB, and emerging data on novel biomarker strategies with oncogenic signaling and epigenetic regulation. Considering the exploration of peripheral and intestinal immunity has served as noninvasive alternative in predicting immunotherapy, this review also summarizes current data in systemic immunity, encompassing solute PD-L1 and TMB, circulating tumor DNA and infiltrating lymphocytes, routine emerging inflammatory markers and cytokines, as well as gut microbiota. This review provides up-to-date information on the evolving field of currently available biomarkers in predicting immunotherapy. Future exploration of novel biomarkers is warranted. Although immunotherapy has dramatically changed the clinical therapeutic landscape of various cancer patients, predictive biomarkers should therefore be early identified to discriminate patients who are most likely to benefit from *** review mainly focused on recent clinical trials presenting biomarkers derived from tissue, peripheral blood as well as gut microbiome that encompass tumor cells, immune cells, solute inflammation markers, and commensal *** prospective clini

关键词： biomarker immunity immunotherapy liquid biopsy tumor

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煤直接液化柴油加氢制备轻质白油研究

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石油炼制与化工 2018年第10期49卷 43-47页

作者：单贤根舒歌平章序文曹雪萍中国神华煤制油化工有限公司上海研究院煤直接液化国家重点工程实验室上海201108

为制备轻质白油,采用贵金属加氢催化剂在30mL连续加氢实验装置上对煤直接液化柴油进行了深度加氢实验,考察了不同反应压力(6~12MPa)、反应温度(80~240℃)、体积空速(0.6~1.2h-1)条件下煤直接液化柴油的芳烃饱和行为。研究结果表明,加氢... 详细信息

为制备轻质白油,采用贵金属加氢催化剂在30mL连续加氢实验装置上对煤直接液化柴油进行了深度加氢实验,考察了不同反应压力(6~12MPa)、反应温度(80~240℃)、体积空速(0.6~1.2h-1)条件下煤直接液化柴油的芳烃饱和行为。研究结果表明,加氢后的柴油馏程、黏度、密度等性质无明显变化,但芳烃含量大幅度下降,在合适的加氢条件下产品油中芳烃质量分数可以降低至0.01%以下,满足环保型轻质白油标准要求。通过蒸馏切割发现,煤直接液化柴油所生产的轻质白油牌号主要集中在W2-40~W2-90之间。

关键词：煤直接液化柴油加氢轻质白油

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PDS高频球阀设计优化

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仪器仪表用户 2020年第4期27卷 11-13,80页

作者：崔国彪王一民张绪文周爱辉罗元明李宏伟中国石油四川石化有限责任公司四川彭州611930 重庆川仪调节阀有限公司重庆400707

PDS高频球阀作为聚丙烯生产装置中产品卸料系统的关键设备,要求具有动作频率高、开关时间短、使用寿命长、密封性能好等特点。但由于PDS高频球阀的介质工况较为严苛,介质气固双相、压差高并有自聚性,同时阀门动作开关频繁,导致PDS高频... 详细信息

PDS高频球阀作为聚丙烯生产装置中产品卸料系统的关键设备,要求具有动作频率高、开关时间短、使用寿命长、密封性能好等特点。但由于PDS高频球阀的介质工况较为严苛,介质气固双相、压差高并有自聚性,同时阀门动作开关频繁,导致PDS高频球阀易出现卡、冒、漏等问题。本文通过以往对国外PDS高频球阀的使用和维修情况,从产品结构、材料选择等方面对阀门设计提出几点优化建议。

关键词：聚丙烯高频球阀耐磨性

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Theoretical and experimental study on vibration sensitivity of cubic cavity for space applications

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OPTICS AND LASER TECHNOLOGY 2023年第PartA期158卷

作者： Chen, Long Hu, xuwen Han, Liang Xu, Guanjun Liu, Lei Li, Yang Liu, Tao Dong, Ruifang zhang, Shougang Chinese Acad Sci Natl Time Serv Ctr Xian 710600 Peoples R China Northwestern Polytech Univ Sch Astronaut Xian 710072 Peoples R China Chinese Acad Sci Key Lab Time & Frequency Stand Xian 710600 Peoples R China

The increasing performance of ultra-stable lasers has made them attractive for non-laboratory and space field applications. How to reduce the vibration sensitivity of the optical reference cavity is one of the key points. To develop vibration-insensitive cavity for space applications, we investigate the vibration sensitivity of a cubic cavity with the length of 100 mm theoretically and experimentally. The functional expression of the fractional length change of the cubic cavity versus the cutting depth of the cubic spacer vertices and the compressive forces is presented for the first time. The vibration sensitivity of the 100 mm cubic cavity is measured as low as 2 x 10-11/g. Based on the vibration-insensitive cubic cavity, a 1 Hz-linewidth laser system with an envelope size of 450 mm x 541 mm x 598 mm is developed, which would be the prototype for space applications.

关键词： Vibration sensitivity Cubic cavity Ultra-stable laser

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EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment

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CELLULAR AND MOLECULAR LIFE SCIENCES 2023年第8期80卷 205-205页

作者： Cao, xuwen Xie, Yusu Yang, Hanwen Sun, Peiqi Xue, Beining Garcia, L. Rene zhang, Liusuo Chinese Acad Sci Inst Oceanol CAS & Shandong Prov Key Lab Expt Marine Biol Qingdao 266071 Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Biol & Biotechnol Qingdao 266237 Peoples R China Chinese Acad Sci Ctr Ocean Mega Sci 7 Nanhai Rd Qingdao 266071 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Texas A&M Univ Dept Biol College Stn TX 77843 USA Shandong Univ Inst Marine Sci & Technol 72 Binhai Rd Qingdao 266237 Peoples R China

Dietary intake and nutrient composition regulate animal growth and development;however, the underlying mechanisms remain elusive. Our previous study has shown that either the mammalian deafness homolog gene tmc-1 or its downstream acetylcholine receptor gene eat-2 attenuates Caenorhabditis elegans development in a chemically defined food CeMM (C. elegans maintenance medium) environment, but the underpinning mechanisms are not well-understood. Here, we found that, in CeMM food environment, for both eat-2 and tmc-1 fast-growing mutants, several fatty acid synthesis and elongation genes were highly expressed, while many fatty acid beta-oxidation genes were repressed. Accordingly, dietary supplementation of individual fatty acids, such as monomethyl branch chain fatty acid C17ISO, palmitic acid and stearic acid significantly promoted wild-type animal development on CeMM, and mutations in either C17ISO synthesis gene elo-5 or elo-6 slowed the rapid growth of eat-2 mutant. Tissue-specific rescue experiments showed that elo-6 promoted animal development mainly in the intestine. Furthermore, transcriptome and metabolome analyses revealed that elo-6/C17ISO regulation of C. elegans development may be correlated with up-regulating expression of cuticle synthetic and hedgehog signaling genes, as well as promoting biosynthesis of amino acids, amino acid derivatives and vitamins. Correspondingly, we found that amino acid derivative S-adenosylmethionine and its upstream metabolite methionine sulfoxide significantly promoted C. elegans development on CeMM. This study demonstrated that C17ISO, palmitic acid, stearic acid, S-adenosylmethionine and methionine sulfoxide inhibited or bypassed the TMC-1 and EAT-2-mediated attenuation of development via metabolic remodeling, and allowed the animals to adapt to the new nutritional niche.

关键词： C. elegans maintenance medium CeMM Development Acetylcholine receptor Fatty acid C17ISO S-adenosylmethionine SAM

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体育器材专用尼龙6复合材料的3D打印丝材制备与表征

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塑料助剂 2023年第1期 24-26,60页

作者：张琳李绪稳咸阳师范学院咸阳712000 西藏民族大学咸阳712082

为增强尼龙6在体育器材器件3D打印应用中的适用性,本次研究采用滑石粉对尼龙6实施改性处理,制备出可直接用于3D打印的滑石粉改性PA6复合丝材。通过微观形貌观测的方式来确定滑石粉的合理添加量,并对滑石粉合理添加量下改性PA6复合丝材... 详细信息

为增强尼龙6在体育器材器件3D打印应用中的适用性,本次研究采用滑石粉对尼龙6实施改性处理,制备出可直接用于3D打印的滑石粉改性PA6复合丝材。通过微观形貌观测的方式来确定滑石粉的合理添加量,并对滑石粉合理添加量下改性PA6复合丝材的力学性能进行测试。经实验研究发现,本次研究所制备的尼龙6复合3D打印丝材相比于单纯尼龙6和市售e-PA6丝材来说,整体力学性能得到显著提升,在体育器材设备轻质化方面具有一定的应用价值。

关键词：尼龙6 微观形貌观测 3D打印丝材力学性能

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Coacervate-Based Instant and Repeatable Underwater Adhesive with Anticancer and Antibacterial Properties

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ACS APPLIED MATERIALS & INTERFACES 2021年第40期13卷 48239-48251页

作者： Peng, Qiongyao Wu, Qiuqiu Chen, Jingsi Wang, Tao Wu, Meng Yang, Diling Peng, xuwen Liu, Jifang zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Guangzhou Med Univ Affiliated Hosp 6 Qingyuan Peoples Hosp Qingyuan 511500 Guangdong Peoples R China

Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface hydration layer. The coacervation process of sessile organisms like marine mussels and sandcastle worms has inspired substantial research interest in the fabrication of long-lasting underwater adhesives, but they generally suffer from time-consuming curing triggered by surrounding environmental changes and cannot reserve the adhesiveness once damaged. Herein, an instant and repeatable underwater adhesive was developed based on the coacervation of tannic acid (TA) and poly(ethylene glycol)(77)-b-poly(propylene glycol)(29)-b-poly(ethylene glycol)(77) (PEG-PPG-PEG, F68), which was driven by hydrogen-bonding interaction, and the hydrophobic cores of F68 micelles offered an additional cross-linking to enhance the mechanical properties. The TA-F68 coacervates could be facilely painted on different substrates, exhibiting robust and instant underwater adhesion (with adhesion strength up to 1.1 MPa on porcine skin) and excellent repeatability (at least 1000 cycles), superior to the previously reported coacervates. Due to the biological activities of TA, the underwater adhesive displayed innate anticancer and antibacterial properties against different types of cancer cells and bacteria, showing great potential for diverse biomedical applications, such as injectable drug carriers, tissue glues, and wound dressings.

关键词： instant and repeatable underwater adhesive coacervation hydrogen-bonding interaction hydrophobic interaction anticancer antibacterial

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Carbon Sequestration in Overlying Methane Hydrate Layers Via Hydrate Technology: Feasibility and Synergistic Benefits

SSRN

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SSRN 2024年

作者： zhang, Zhaobin Li, Yuxuan Li, Shouding He, Jianming Xie, Zhuoran Li, Xiao Lu, Cheng Qin, xuwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and Geophysics Chinese Academy of Sciences Beijing100029 China Innovation Academy for Earth Science Chinese Academy of Sciences Beijing100029 China College of Earth and Planetary Sciences University of Chinese Academy of Sciences Beijing100049 China Oil and Gas Resources Survey China Geological Survey Ministry of Natural Resources Beijing100083 China China Geological Survey Ministry of Natural Resources Beijing100037 China

Excessive carbon dioxide emissions pose a global environmental issue, and carbon sequestration technology offers a solution. This study proposes a novel approach for carbon dioxide sequestration in the overlying layers of methane hydrate reservoirs using carbon dioxide hydrate technology. The feasibility and risks of this method are evaluated over a time scale of 100,000 years. The research indicates that after injection into the overlying layers of methane hydrate reservoirs, carbon dioxide migrates upwards driven by buoyancy, gradually forming highly saturated carbon dioxide hydrate shells at the leading edge of migration. Within these carbon dioxide hydrate shells, a portion of the carbon dioxide is sequestered in liquid and dissolved forms;however, over tens of thousands of years, some carbon dioxide escapes via dissolution and diffusion. The study further discusses the synergistic effects between methane hydrate extraction and carbon sequestration in overlying layers, showing that the cold seawater downdraw effect induced by methane hydrate extraction significantly enhances the efficiency and safety of carbon dioxide hydrate sequestration in the overlying layers. Given the widespread distribution of methane hydrate reservoirs globally, this research provides new insights into carbon sequestration technology. © 2024, The Authors. All rights reserved.

关键词： Carbon dioxide

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