Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breas...
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Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition-cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models. A multimodule nanocomplex dual targeting tumor-associated macrophages (TAMs) and tumor cells is devised to reconcile cooperative-competitive patterns among multiple cells through metabolic-immune regulation. The reversion of metabolic disequilibrium-immunosuppression tumor microenvironment is observed in TNBC models after treatment, contributing to the tumor remission. image
The interplay among topology, crystal symmetry, magnetic order, and strong electron correlation can give rise to a plethora of exotic physical phenomena. The ZrSiS family is known as typical topological Dirac semimeta...
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The interplay among topology, crystal symmetry, magnetic order, and strong electron correlation can give rise to a plethora of exotic physical phenomena. The ZrSiS family is known as typical topological Dirac semimetals, among them LnSbTe (Ln denotes lanthanide) compounds exhibit intriguing characteristics due to the presence of Ln 4f electrons, resulting in quantum states and unique properties. In this paper, the topological electronic structure of PrSbTe is systematically studied by angle-resolved photoemission spectroscopy (ARPES), combined with magnetic, specific heat measurements, and band structure calculations. The detailed three-dimensional electronic structure of PrSbTe has been obtained, and a diamond-shaped Fermi surface and multiple Dirac nodal lines have been observed, which are in remarkable agreement with theoretical calculations. Moreover, the 4f electrons in PrSbTe are rather localized, which can be revealed by on-resonant ARPES data and further confirmed by the rather small Sommerfeld coefficient of γ=2.6231mJ/molK2. Our results provide more detailed information about the LnSbTe family, which gives a deeper understanding of the interaction between Ln 4f electrons and the topological states.
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