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生态毒理学报 2017年第1期12卷 163-172页

作者：李娣李旭文牛志春张军毅徐东炯李继影陈明陈志芳曹毅李朝卜伟于红霞南京大学环境学院污染控制与资源化研究国家重点实验室南京210046 江苏省环境监测中心南京210036 无锡市环境监测中心站无锡214000 常州市环境监测中心常州213001 苏州市环境监测中心苏州215004 南京市环境监测中心站南京210013 扬州市环境监测中心站扬州225007 宿迁市环境监测中心站宿迁223800 徐州市环境监测中心站徐州221006 泰州市环境监测中心站泰州225300

为了解江苏省湖泊底栖动物群落结构和多样性并研究其对水环境质量变化的响应,于2012年春秋两季对江苏省16个湖泊51个采样点湖泊底栖动物群落结构与多样性以及湖泊综合营养状态指数进行调查,分析水质指标与底栖动物指数间Pearson相关关... 详细信息

为了解江苏省湖泊底栖动物群落结构和多样性并研究其对水环境质量变化的响应,于2012年春秋两季对江苏省16个湖泊51个采样点湖泊底栖动物群落结构与多样性以及湖泊综合营养状态指数进行调查,分析水质指标与底栖动物指数间Pearson相关关系。结果表明,江苏省16个湖泊营养状态指数范围为35.5~66.4,其中约81.2%的湖泊处于轻度-中度富营养状态,表明水质从好到中度污染;湖泊底栖动物优势种为寡毛类的霍甫水丝蚓(Limnodrilus hoffmeisteri),优势度为13.0%;香浓多样性指数(Shannon-Wiener diversity index)范围为0.00~2.20,级别范围由极贫乏到较丰富状态,表明水质污染程度从重度到轻度污染。从全省尺度看,水质评价结果与生物学(香浓多样性指数、Pielou均匀度指数和Biotic Index(BI)指数)评价结果存在一定差异。与历史数据相比,江苏省湖泊底栖动物清洁敏感物种减少甚至消失,总体群落结构趋于小型化。16个湖泊水体总氮和总磷与底栖动物密度呈显著负相关,而综合营养状态指数与底栖动物指数(香浓多样性指数、Pielou均匀度指数和BI指数)间关系不显著。上述研究结果表明综合营养状态指数无法完全客观反映湖泊水生态健康状况,因此需要综合水质、水文、水生生物、生境状况等因素发展新的评价指标体系。

关键词：江苏省富营养化底栖动物多样性

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Roles of Gibberellin and Auxin in Promoting Seed Germination and Seedling Vigor in Pinus massoniana

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FOREST SCIENCE 2014年第2期60卷 367-373页

作者： zhao Guangwu Jiang xuwen Zhejiang Agr & Forestry Univ Coll Agr & Food Sci Key Lab Qual Improvement Agr Prod Zhejiang Prov Linan Zhejiang Peoples R China Qingdao Agr Univ Coll Agron & Plant Protect Shangdong Prov Key Lab Dryland Technol Qingdao Shandong Peoples R China

Masson pine (Pinus massoniana Lamb.) is an important timber species and is widely planted in southern China. A large quantity of seed is required for sowing each year. However, low germination in the nursery has resulted in low seedling yields with a consequent negative impact on the Masson pine afforestation program. The purpose of our study was to determine whether gibberellin (GA(3)) or indole-3-acetic acid (IAA) would be more effective in propagating the species from seeds for afforestation and to elucidate their effects on seed respiration and endogenous hormone levels. Seeds were soaked in GA(3) and IAA solutions of different concentrations at 25 degrees C in the dark for 24 hours, and a germination test was conducted. Seed respiration was measured indirectly by estimating oxygen consumption in a closed system. Endogenous hormone levels were analyzed by gas chromatography/mass spectrometry (GC/MS). The germination test showed that the most significant promotion of seed germination and seedling vigor occurred at 5 x 10(-5) M GA(3) in both varieties and that the effects of IAA were variety dependent. Oxygen-sensing measurements showed that increased metabolism time, critical oxygen pressure, and relative germination time were decreased and the oxygen metabolism rate was increased in IAA-and GA3-treated seeds. GC/MS analysis showed that the application of 5 x 10(-5) M GA(3) decreased the endogenous abscisic acid (ABA) content, but increased IAA and GA(1), levels. Our experiment suggests that exogenous GA(3) improves seed germination and seedling vigor of Masson pine through promoting seed respiration or lowering the ABA level and stimulating IAA and GA(1), biosynthesis.

关键词： Pinus massoniana seed vigor oxygen-sensing auxin gibberellin

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Regulation of Mammalian Target of Rapamycin Complex 1 by Bcl-2 and Bcl-X_L Proteins

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JOURNAL OF BIOLOGICAL CHEMISTRY 2013年第40期288卷 28824-28830页

作者： Zou, Huafei Lai, Yumei zhao, xuwen Yan, Gonghong Ma, Dongzhu Cardenes, Nayra Shiva, Sruti Liu, Yongjian Bai, Xiaochun Jiang, Yong Jiang, Yu Univ Pittsburgh Sch Med Dept Pharmacol & Chem Biol Pittsburgh PA 15261 USA Univ Pittsburgh Sch Med Vasc Med Inst Pittsburgh PA 15261 USA Southern Med Univ Dept Pathol Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China Southern Med Univ Dept Cell Biol Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China

Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth and metabolism. Its activity is controlled by various types of signals, including growth factors, nutrients, and stresses. In this study, we show that changes in expression levels of two antiapoptotic proteins, Bcl-2 and Bcl-X-L, also affect mTORC1 signaling activity. In cells overexpressing Bcl-X-L, mTORC1 activity is increased and becomes less sensitive to growth factor or nutrient conditions. In contrast, reduction in expression levels of the two antiapoptotic proteins inhibits mTORC1 signaling activity. Our results suggest that the effect of Bcl-2 and Bcl-X-L on mTORC1 is mediated by FKBP38, an inhibitor of mTORC1. The two proteins compete with mTORC1 for FKBP38 binding and hence alter mTORC1 activity. This study reveals a novel cross-talk between Bcl-2/X-L and mTORC1 signaling, which is likely to contribute to cancer development.

关键词： Bcl-2 Mitochondria mTOR Complex (mTORC) S6 Kinase Signaling Bcl-XL FKBP38 mTORC1

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ChemInform Abstract: Simple Broensted Acid Catalyzed C—H Functionalization: Efficient Access to Poly-Substituted Pyridines.

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ChemInform 2016年第43期47卷

作者： Shujun Lai xuwen Ren Jinzhong zhao Zhuo Tang Guangxun Li Coll. Art Sci. Shanxi Agric. Univ. Taigu Shanxi 030800 Peop. Rep. China

An efficient, convenient, and environmentally benign protocol for preparation of various polysubstituted pyridines under mild reaction conditions is described.

关键词： pyridine derivatives C-C bond formation

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嗜中性粒细胞通过分泌IL-22促进结肠上皮细胞的修复研究

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胃肠病学和肝病学杂志 2016年第9期25卷 1044-1046页

作者：赵海晴谢子英魏春华赖续文广州军区广州总医院消化内科广东广州510010

目的探讨嗜中性粒细胞通过分泌白介素-22(Interleukin-22,IL-22)刺激肠道上皮细胞分泌黏液蛋白的作用。方法分离小鼠骨髓来源的嗜中性粒细胞,不同浓度的IL-23刺激中性粒细胞,检测IL-22 mRNA及蛋白合成;收集经IL-23刺激后中性粒细胞上清... 详细信息

目的探讨嗜中性粒细胞通过分泌白介素-22(Interleukin-22,IL-22)刺激肠道上皮细胞分泌黏液蛋白的作用。方法分离小鼠骨髓来源的嗜中性粒细胞,不同浓度的IL-23刺激中性粒细胞,检测IL-22 mRNA及蛋白合成;收集经IL-23刺激后中性粒细胞上清,将其作为条件培养基培养小鼠肠道上皮细胞CMT-93,检测CMT-93合成Reg3及MUC2的变化,并用IL-22中和抗体验证IL-22是否在条件培养基中起主要作用。结果 50 ng/ml IL-23即可显著诱导嗜中性粒细胞合成IL-22 mRNA,ELISA检测培养6 h的嗜中性粒细胞上清,IL-22蛋白量为(92±19)pg/ml。条件培养基培养CMT-93细胞24 h,Reg3和MUC2的mRNA合成倍数与对照组相比分别上升(11±3)和(14±5)倍,与单用IL-22诱导无显著差异,但使用IL-22阻断抗体后,条件培养基诱导CMT-93细胞合成抗菌肽的倍数分别降低至(2.4±0.8)和(2.1±0.5)倍。结论嗜中性粒细胞通过分泌细胞因子IL-22在促进肠道上皮细胞分泌抗菌肽中起重要作用。

关键词：嗜中性粒细胞白介素-22 肠道上皮细胞黏液蛋白

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美迪紫檀素的体外细胞毒性研究

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新疆医科大学学报 2016年第5期39卷 586-590页

作者：赵静毛旭文朱晓雪高晓黎新疆医科大学药学院乌鲁木齐830011 新疆医科大学基础医学院乌鲁木齐830011

目的探究美迪紫檀素对正常大鼠心肌细胞H9C2、人胚肝细胞L-02、人胚肾上皮细胞HEK293、大鼠主动脉血管平滑肌细胞VSMC的细胞毒性作用。方法体外培养H9C2、L-02、HEK293、VSMC细胞,加入不同浓度（0.1、1、5、10、50、100、200、250、300... 详细信息

目的探究美迪紫檀素对正常大鼠心肌细胞H9C2、人胚肝细胞L-02、人胚肾上皮细胞HEK293、大鼠主动脉血管平滑肌细胞VSMC的细胞毒性作用。方法体外培养H9C2、L-02、HEK293、VSMC细胞,加入不同浓度（0.1、1、5、10、50、100、200、250、300μmol/L）的美迪紫檀素溶液,采用MTT法检测美迪紫檀素对细胞增殖的影响;同时给予1、50、300μmol/L的美迪紫檀素溶液,利用Hoechst33342荧光染色观察细胞凋亡情况,并考察细胞培养液中乳酸脱氢酶（LDH）、谷草转氨酶（AST）、谷丙转氨酶（ALT）及肌酸激酶（CK）活性的变化。结果与对照组比较,0.1～300μmol/L浓度下的美迪紫檀素对H9C2细胞增殖和凋亡没有影响,培养液中的LDH、AST、ALT活性无统计学差异（P〉0.05）。0.1～300μmol/L浓度下的美迪紫檀素均可抑制L-02和VSMC细胞增殖,促进细胞的凋亡,并可使培养上清液中的LDH活力增加,L-02细胞培养上清液中AST和ALT活力也增加（P〈0.05）,在250～300μmol/L范围内对HEK293细胞有一定的抑制作用,促进其凋亡,并增加LDH活力。美迪紫檀素对L-02和HEK293细胞的抑制作用呈浓度依赖性。结论美迪紫檀素对H9C2细胞生长没有影响,对L-02、VSMC细胞生长有一定的影响,250～300μmol/L浓度的美迪紫檀素对HEK293细胞生长有影响。

关键词：美迪紫檀素 H9C2 L-02 HEK293 VSMC 细胞毒性

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μ阿片受体在大鼠结肠肠肌丛的神经化学特性

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神经解剖学杂志 2016年第6期32卷 722-726页

作者：李军平李凡焦旭文赵玉琼严青贾桦何仲义宁夏医科大学人体解剖与组织胚胎学系银川750004

目的:探索μ阿片受体(MOR)在大鼠结肠肠肌丛的分布及化学神经解剖学特性。方法:取大鼠结肠右曲和左曲之间肠管行全层铺片,剥离粘膜层、粘膜下层和环形肌层,保留纵行肌层。运用免疫荧光组织化学双重标记技术染色,共聚焦显微镜下观察MOR... 详细信息

目的:探索μ阿片受体(MOR)在大鼠结肠肠肌丛的分布及化学神经解剖学特性。方法:取大鼠结肠右曲和左曲之间肠管行全层铺片,剥离粘膜层、粘膜下层和环形肌层,保留纵行肌层。运用免疫荧光组织化学双重标记技术染色,共聚焦显微镜下观察MOR在大鼠结肠肠肌丛的分布及与一氧化氮合酶(NOS)、肠血管活血肽(VIP)、P物质(SP)或降钙素基因相关蛋白(CGRP)等在肠神经细胞的共存关系。结果:免疫荧光组织化学染色显示:在大鼠结肠肠肌层,MOR阳性细胞聚集形成神经节,其阳性突起穿行于神经节之间形成网格状神经丛。在肠肌丛神经细胞内,可见MOR分别与NOS、VIP、SP、CGRP共存。MOR阳性神经纤维和终末分布于NOS阳性神经细胞周围,也可见部分NOS、VIP阳性神经纤维和终末分布于MOR阳性神经细胞表面。有大量SP和CGRP阳性神经纤维穿行于MOR阳性神经细胞之间并包绕于MOR阳性神经细胞的胞体周围。结论:在结肠的肠肌丛,MOR与抑制性和感觉性神经递质在肠神经细胞有共存,且相互之间有纤维联系,推测MOR可能介导了阿片类调节肠神经细胞内抑制性神经递质的释放,并可能对肠感觉信息的传递有调节作用。

关键词： μ阿片受体肠肌丛肠神经系统结肠大鼠

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Stereo matching algorithm of Color Image Based on Weber's law and Census 10

Stereo matching algorithm of Color Image Based on Weber's la...

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10th International Conference on Intelligent Information Hiding and Multimedia Signal Processing (IIH-MSP)

作者： Wu, Qiang zhao, Xiangnan Li, xuwen Beijing Univ Technol Coll Elect Informat & Control Engn Beijing Peoples R China Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China

ISBN: (纸本)9781479953905

The algorithm presented here is used on unmanned aerial vehicles system. In 2013,*** proposed a matching cost computation model(or function), This matching cost model combined three kinds of constraints, the cost function is formulated by combining three individual costs: a cost computed on an extended census transformation of the images;the absolute difference cost, taking into account information from colour channels;and a cost based on the principal image derivatives. Experiments show that the cost function is excellent performance in similar estimates. Apply it to the stereo matching of ancient buildings, it is favorable for practical. However, this experiment, in color mutated region, leaded to blurred border. Therefore, our proposed method added color space structural information, which based on HVS Weber's law, to the cost function. we use the differential excitation of WLD reflects the structure of color space. This robust cost measures can reduce percent of bad pixels in mutated color region. The proposed method use color image, which is used after epipolar line rectification.

关键词： The stereo matching of color image Census Weber's law

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Study on Mechanical Behavior of Masonry Wall in School Building Reinforced by CFRP

Study on Mechanical Behavior of Masonry Wall in School Build...

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International Conference on Materials Engineering and Mechanical Automation (MEMA 2013)

作者： Lin, Hong Yang, zhao Wang, xuwen Ke, Xiang Wuhan Univ Technol Design & Res Inst Wuhan 430070 Peoples R China Wuhan Univ Sci & Technol Inst Urban Construct Wuhan Peoples R China

ISBN: (纸本)9783037859018

CFRP is a new kind of building materials popularly used in structure strengthening. In order to study the reinforcement technique for masonry walls of school buildings, the walls with window opening strengthened by CFRP were studied in the paper. Based on the experiment result, the finite element simulation and theoretical calculation analysis were done to study the mechanical behavior and shear capacity of the wall with window opening reinforced by CFRP. The CFRP pasted at the corner of window opening were proved to be effectively in improving shear capacity of the walls, and simple calculation formulas of shear capacity were provided in the paper, which proved to be accurate.

关键词： CFRP Masonry structure Mechanical behavior Shear capacity

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Impacts of simulated acid rain on soil organic matter and metal aluminum and iron ions leaching from red soil in central south China

Impacts of simulated acid rain on soil organic matter and me...

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International Conference on Manufacture Engineering and Environment Engineering (MEEE)

作者： Tian, Wenjie zhao, Fangni He, xuwen Li, Fasheng China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing Peoples R China Luoyang Inst Sci & Technol Dept Environm Engn Chem Luoyang Peoples R China Chinese Res Inst Environm Sci Beijing Peoples R China

ISBN: (纸本)9781845648251;9781845648244

Acid rain is a problem of increasing agricultural, environmental, and ecological concerns worldwide. This study investigated impacts of simulated acid rain (SAR) on soil organic matter (SOM) and metal aluminum and iron ions leaching from the red soil in central south China. Laboratory experiments were performed by leaching the soil columns with the SAR at a pH range from 2.5 to 5.6 over a 20-day period. Research results showed subjected to acid rain of different acidities, dissolved organic matter (DOM), Fe and Al ions were leached out from red soil into eluate, huge leaching loss tended to occur in the initial phase of the leaching and the higher the acidity of simulated acid rain was, the bigger the loss of them from red soil. There was a very good linear correlation between DOMs and dissolved Al and Fe in the eluates, squared correlation coefficient (R-2) were respectively 0.93839 and 0.9479. These results contributed to build the theoretical foundation for assessing the potential environmental risks of groundwater.

关键词： simulated acid rain red soil soil organic matters (SOM) inorganic aluminum iron

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