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Research on the dynamic evolution of residual stress in thermal processing of diesel engine blocks based on FEM

JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY 2021年第6期35卷 2419-2430页

作者： Tian, Guizhong Ma, Zhengyu zhao, Donghao Zhou, Honggen Jing, xuwen Xie, Zhancheng Li, Guochao Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Jiangsu Univ Sci & Technol Jiangsu Prov Key Lab Adv Mfg Marine Mech Equipmen Zhenjiang 212003 Jiangsu Peoples R China Shaanxi Diesel Engine Heavy Ind Co Ltd Xingping 713105 Shaanxi Peoples R China

The residual stresses (RS) generated during the thermal processing processes such as casting and heat treatment is one of the fundamental causes of irreversible deformation of diesel engine bodies (DEBs). However, previous studies only focused on the RS generated from casting or the effect of annealing heat treatment on the RS in castings unilaterally, and the analytical results were far from the actual conditions. Therefore, this paper proposes a comprehensive research method to consider the whole dynamic evolution of the casting from the RS generated by casting to the stress relief by heat treatment. Numerical simulation of DEBs casting process is carried out by PROCAST, and the results of casting RS obtained from the simulation are imported into ABAQUS, and then numerical simulation of annealing heat treatment is carried out for the DEB casting model with casting RS, so as to realize the analysis of dynamic evolution of RS from casting to heat treatment.

关键词： DEB RS Numerical simulation Thermal processing parameters Response surface method

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Altered levels of circulating CD8⁺CXCR5⁺PD-1⁺T follicular cytotoxic cells in primary Sjogren's syndrome

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CLINICAL RHEUMATOLOGY 2022年第6期41卷 1697-1708页

作者： Zhai, xuwen Wang, Yanlin Guo, Hui Liang, zhaojun Feng, Min Wu, Yanyao Qin, Yan zhao, Xiangcong Gao, Chong Luo, Jing Shanxi Med Univ Simulat Hosp Clin Skills Teaching Jinzhong 030600 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Rheumatol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Nephrol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shenzhen Baoan Shiyan Peoples Hosp Dept Med Div Nephrol Shenzhen 518005 Guangdong Peoples R China Harvard Med Sch Brigham & Womens Hosp Dept Pathol Boston MA 02115 USA

Background Circulating CD8(+)T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) (CD8(+)CXCR5(+)T), a recently identified follicular cytotoxic T cell subset, are involved in antiviral immunity and autoimmunity, but their abundance and role in the pathogenesis of primary Sjogren syndrome (pSS) are unknown. Methods Circulating CD8(+)CXCR5(+)T cell and CD8(+) regulatory T cells (CD8(+)Treg) were evaluated in 49 pSS patients (19 patients with pulmonary involvement) and 24 age- and sex-matched healthy controls (HCs) by flow cytometry. Orthogonal partial least squares discriminant analysis (OPLS-DA) was performed, and receiver operating characteristic curves (ROC) were generated to identify characteristic cell subsets. Spearman's correlation analysis was conducted to examine the relationships between CD8(+)T cell subsets and clinical features. Results The proportions and numbers of CD8(+)CXCR5(+) , CD8(+)CXCR5(+) programmed death 1-positive (PD-1(+)), and CD8(+)CXCR5 PD-1(+)T cells were significantly higher, whereas those of CD8 +/- Treg were markedly lower, in pSS patients than HCs. The CD8(+)CXCR5(+)PD-1(+)T cell to CD8(+)Treg ratio had the greatest discriminatory power for pSS and HCs according to OPLS-DA and ROC analyses. The increased numbers of CD8(+)CXCR5(+)T cells and CD8(+)CXCR5(+)PD-1(+)T cells were strongly associated with those of CD4(+)CXCR5(+)T and B cells. The proportions and numbers of CD8(+)CXCR5(+)PD-1(+)T cells were increased in pSS patients with lung involvement. Conclusions We identified a new CD8(+)CXCR5(+)PD-1(+)T subset, which was increased in abundance in pSS patients, particularly those with lung involvement, compared with HCs. Also, the CD8(+)CXCR5(+)PD-1(+)T to CD8(+)Treg ratio may be useful for identifying pSS. Our findings suggest that targeting follicular CD8(+)T cell subsets has therapeutic potential for pSS.

关键词： CD8(+)CXCR5(+) follicular cytotoxic T subsets CD8(+) regulatory T cells Lung involvement OPLS-DA Primary Sjogren's syndrome

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Distribution of bound-PAH residues and their correlations with the bacterial community at different depths of soil from an abandoned chemical plant site

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JOURNAL OF HAZARDOUS MATERIALS 2023年第1期453卷 131328页

作者： Tang, Lei zhao, Xuqiang Chen, xuwen Jiang, Yi Gudda, Fredrick Wang, Yunhao Ling, Wanting Nanjing Agr Univ Coll Resources & Environm Sci Inst Organ Contaminant Control & Soil Remediat Nanjing 210095 Peoples R China Huazhong Agr Univ Coll Resources & Environm State Key Lab Agr Microbiol Wuhan 430070 Peoples R China

The situ pollutant residue and microbial characteristics in contaminated environments are crucial for ecological restoration and soil utilization. This work reported the variation of polycyclic aromatic hydrocarbon (PAH) residues and the bacterial community at different depths in an aged-abandoned site. These results unveiled that over 90% of low molecular weight (LMW) and medium molecular weight (MMW), 52.84-76.88% of high mo-lecular weight (HMW) bound-PAH (BP) residues were sequestrated in humin (HM). The stresses of PAH and soil depth enhanced the frequency of bacteria associations, especially positive associations. We enriched and cultured PAH degradation bacteria (PDB) from the sampling site mainly consisting of Pseudomonas and Acinetobacter, which were originally 0.39-0.52% abundant in the sampling site. The abundances of PDB and PAH-degradation genes (PDGs) were higher at shallower depths and increased with high PAH concentration. Simultaneously, Pearson correlation analysis and experimental verification found that the process of PAH binding with SOM limited the further increase of PDB and PDGs in PAH-contaminated sites. These findings may illustrate possible ecological risks of contaminated soils and provide guidance for the isolation and application of PDB.

关键词： Vertical distribution PAH residues Bacterial communication Degradation gene Ecosystem risks

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Leather Defect Detection Algorithm Based on an Improved YOLOv5s

Leather Defect Detection Algorithm Based on an Improved YOLO...

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Pattern Recognition and Artificial Intelligence (PRAI), International Conference on

作者： xuwen He Hao Li Yifan Liu Rui Song Yuchen zhao Xiao Ou School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

ISBN: (数字)9798350350890

ISBN: (纸本)9798350350906

In the field of intelligent manufacturing, the realization of efficient and accurate automated surface defect detection is particularly critical for enhancing product quality, especially in the leather industry, which holds a significant position in global trade. Traditional defect detection methods encounter challenges in handling complex scenes and identifying minute defects. However, the advent of deep learning technologies has provided a new pathway to address these issues. This paper is dedicated to innovative research on the precise localization and detailed classification of leather surface defects through the enhancement of deep learning models, aiming to overcome the limitations of existing technologies and improve the accuracy and efficiency of detection. By extending the YOLOv5s model, this study has developed the CMR-YOLO algorithm. This algorithm integrates the Channel Attention mechanism (CA), an improved Multi-Dimensional Precision Intersection over Union (MPDIoU), and the Cross Stage Partial Residual feature enhancement module (C3R). These enhancements not only improve the classification accuracy but also bolster the model's stability and robustness in complex scenes. Through the comprehensive application of these techniques, the CMR-YOLO algorithm demonstrates improved performance in categorizing different types of leather defects, particularly effective in handling diverse defect characteristics and accurately classifying various defects. Compared to the traditional YOLOv5s, the CMR-YOLO algorithm also exhibits improved accuracy in defect classification, with the mAP50 increasing from 62.5% to 79.5%, effectively enhancing the overall performance of leather defect detection. These research outcomes not only achieve technological breakthroughs but also provide significant technical support for quality control and intelligent manufacturing in the leather goods industry.

关键词： YOLO Industries Deep learning Accuracy Attention mechanisms Prediction algorithms Robustness Classification algorithms Manufacturing Defect detection

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

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NANO LETTERS 2025年第7期25卷 2949-2959页

作者： Zhang, Shilin You, Haoyu Fan, Hongrui Chen, Yun Song, Haolin zhao, Zhenhao Chen, Qinjun Wang, Yu Tian, Zonghua Wu, Yuxing Zhou, Zheng Guo, Yun Su, Boyu Li, xuwen Jia, Ru Fang, Mingzhu Jiang, Chen Sun, Tao Fudan Univ Minhang Hosp Key Lab Smart Drug Delivery State Key Lab Med NeurobiolMinist Educ Shanghai 201203 Peoples R China Fudan Univ Frontiers Ctr Brain Sci Sch Pharm MOE Shanghai 201203 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China Fujian Med Univ Binhai Campus Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Fuzhou 350212 Peoples R China

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8+ T cells inward. Additionally, the overactivated TGF-beta/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy. In this work, a type of enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) and pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral enamine N-oxides can trigger transcytosis and then respond to hypoxia and acidic microenvironments, turning the surface charge of the nanoparticles to a positive charge and enhancing penetration. The released galunisertib inhibits the TGF-beta/SMAD signaling pathway, reshapes the matrix, activates antitumor immunity, and combines with gemcitabine (Gem) to kill tumor cells.

关键词： Drug delivery system transcytosis tumor penetration enamine N-oxide TGF-beta/SMAD signalingpathway

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Ultraflexible Reedlike Carbon Nanofiber Membranes Decorated with Ni-Co-S Nanosheets and Fe2O3-C Core-Shell Nanoneedle Arrays as Electrodes of Flexible Quasi-Solid-State Asymmetric Supercapacitors

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ACS APPLIED ENERGY MATERIALS 2021年第2期4卷 1505-1516页

作者： Zhang, Ming Wu, xuwen Yang, Dongzhi Qin, Liyuan Zhang, Shiyi Xu, Ting zhao, Tianyu Yu, Zhong-Zhen Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Coll Mat Sci & Engn Beijing 100029 Peoples R China Beijing Univ Chem Technol Beijing Key Lab Adv Funct Polymer Composites Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Coll Mat Sci & Engn Beijing Key Lab Adv Funct Polymer Composites Beijing 100029 Peoples R China Beijing Univ Chem Technol Beijing Adv Innovat Ctr Soft Matter Sci & Engn Beijing 100029 Peoples R China

Flexible and lightweight supercapacitors with satisfactory energy density and long-term stability are urgently required to provide power for flexible, foldable, and wearable electronic devices. Herein, reedlike carbon nanofibers (RCNFs) with hierarchical macropores in the core and micropores and honeycomb mesopores in the shell are designed by electrospinning, carbonization, and etching, leading to high electronic conductivity and satisfactory mechanical flexibility and foldability. Subsequently, flowerlike Ni-Co-S nanoarrays are grown in situ on RCNFs by electrodeposition, and fern leaf-like Fe2O3-C core-shell nanoneedles, in which porous Fe2O3 are coated with ultrathin carbon layers, are decorated on RCNFs via hydrothermal synthesis, polydopamine modification, and thermal annealing. Because of unique core-shell structures and synergistic effects of these active components, the RCNF@ Ni-Co-S cathode and the RCNF@Fe2O3-C anode exhibit high specific capacitances of 1728 and 221.5 F g(-1) at 1 A g(-1), respectively. With a poly(vinyl alcohol) (PVA)/potassium hydroxide (KOH) solid gel as both an electrolyte and a separator, the assembled flexible quasi-solid-state asymmetric supercapacitor achieves a high energy density of 44.9 W h kg(-1) at 1549.7 W kg(-1), and the capacitance remains at 94% after bending the asymmetric supercapacitor to 180 degrees. The flexible electrodes with excellent electrochemical performances are highly promising for high-performance wearable energy storage devices.

关键词： electrospinning asymmetric supercapacitors carbon nanofibers Ni-Co-S nanosheets Fe2O3-C nanoneedles

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活瓣式小肠造瘘术在新生儿腹部外科疾病中的应用分析

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临床小儿外科杂志 2020年第1期19卷 36-39页

作者：王金虎赵绪稳杜晓斌戴春娟胡博包国强天津市儿童医院新生儿外科

目的探讨活瓣式小肠造瘘术在降低新生儿及婴儿小肠造瘘术后并发症中的临床应用价值。方法根据治疗方案的不同将入选的患儿分为活瓣式肠造瘘术组(13例)以及常规肠造瘘术组(10例),其中活瓣式肠造瘘术组采用袢式造瘘的方法,先将肠管浆肌层... 详细信息

目的探讨活瓣式小肠造瘘术在降低新生儿及婴儿小肠造瘘术后并发症中的临床应用价值。方法根据治疗方案的不同将入选的患儿分为活瓣式肠造瘘术组(13例)以及常规肠造瘘术组(10例),其中活瓣式肠造瘘术组采用袢式造瘘的方法,先将肠管浆肌层与腹膜及腹壁肌层缝合固定,在与该缝合层面约一个肠管直径距离处将肠管浆肌层与皮肤、皮下、腹壁肌肉一并缝合固定,使处于腹壁内的肠段形成类似回盲部的“瓣样”皱襞结构。对比活瓣式小肠造瘘术组与常规肠造瘘组术后水电失衡情况,皮肤糜烂、肠管脱出的发生率及排便情况。结果与常规造瘘术组相比,活瓣式造瘘术组患儿每日每百毫升进奶量对应的排便质量显著降低[(25.95±3.39)g vs.(22.23±2.49)g,P<0.05],每日每千克体质量对应的排便质量显著降低[(27.05±3.31)g vs.(23.23±2.64)g,P<0.05],每周体质量增长量显著提高[(136.42±20.23)g vs.(154.27±16.74)g,P<0.05];同时可以有效预防肠管脱出,并减轻瘘口周围皮肤糜烂程度。结论活瓣式小肠造瘘术可以减少肠造瘘口排便内容物中的水分含量,降低新生儿及婴儿小肠造瘘术后并发症的发生率,减轻护理负担,显著改善预后。

关键词：肠造口术婴儿,新生治疗结果

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Enantioselective Reductive (Hetero)Arylation of Cyclic N-Sulfonyl Imines by Cobalt Catalysis

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023年第19期62卷 e202300743-e202300743页

作者： Xiao, Jieshuai Wang, Minyan Yin, xuwen Yang, Shuo Gu, Pei Lv, Xueli zhao, Yue Shi, Zhuangzhi Nanjing Univ Chem & Biomed Innovat Ctr ChemBIC Sch Chem & Chem Engn State Key Lab Coordinat Chem Nanjing 210093 Peoples R China Yangzhou Univ Coll Chem & Chem Engn Yangzhou 225002 Peoples R China Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

Transition-metal-catalyzed enantioselective addition of aryl organometallic reagents to imines has emerged as one of the most powerful tools for the formation of optically active diarylmethylamines. Here, we report the first asymmetric reductive (hetero)arylations of imines using aryl and heteroaryl halides enabled by a chiral cobalt-bisphosphine catalyst. This approach shows good functional group compatibility and complements the reported strategy without use of organometallic reagents. Mechanistic investigations supported that aryl-cobalt, instead of an arylzinc reagent, was formed in situ in this reductive aryl-addition event.

关键词： Addition Arylation Cobalt Enantioselectivity Imines

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma

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ADVANCED MATERIALS 2025年第15期37卷 e2418053页

作者： You, Haoyu Zhang, Shilin Zhang, Yiwen Chen, Qinjun Wu, Yuxing Zhou, Zheng zhao, Zhenhao Su, Boyu Li, xuwen Guo, Yun Chen, Yun Tang, Weiyi Liu, Bing Fan, Hongrui Geng, Shuo Fang, Mingzhu Li, Fangxin Liu, Guangna Jiang, Chen Sun, Tao Fudan Univ Sch Pharm State Key Lab Med Neurobiol Minhang HospInnovat Ctr New Drug Dev Immune Infla Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Orthoped Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB. Therefore, to enhance the in vivo safety and targeting capability of OMVs, we introduced engineered OMVs to reduce toxicity and further constructed a modularly assembled nanoplatform by performing simple peptide modifications. This nanoplatform demonstrates satisfactory biosafety and is able to continuously cross the BBB and target GBM with the assistance of Angiopep-2. Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenicity of GBM, ultimately overcoming GBM immune resistance to enhance the efficacy of immunotherapy. This OMVs-based nanoplatform provides a new paradigm and insights into the development of immunotherapy for GBM.

关键词： engineering technology glioblastoma immune resistance immunotherapy outer membrane vesicles

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同构型知识基础合作研发伙伴的优势

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科技管理研究 2018年第2期38卷 131-138页

作者：曾德明赵旭雯冯科湖南大学工商管理学院湖南长沙410082

在专利竞赛的压力下,企业普遍选择知识基础多元化、网络化路线。基于汽车产业1999—2010年专利数据和负二项混合回归模型的实证研究表明,企业自身知识基础多元化与创新产出正相关,而自身知识基础网络密度与创新产出负相关;合作研发伙伴... 详细信息

在专利竞赛的压力下,企业普遍选择知识基础多元化、网络化路线。基于汽车产业1999—2010年专利数据和负二项混合回归模型的实证研究表明,企业自身知识基础多元化与创新产出正相关,而自身知识基础网络密度与创新产出负相关;合作研发伙伴知识基础多元化正向调节自身知识基础多元化,合作研发伙伴知识基础网络密度正向调节自身知识基础网络密度。同构型合作研发伙伴有利于企业自身吸收能力的释放,对于提升其创新产出更有优势。

关键词：合作研发知识基础多元化知识基础网络创新产出

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