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Improving the non-radical/radical transformation efficiency of halogenated polycyclic aromatic hydrocarbons by using metal ion-exchanged cryptomelane-type OMS-2 under moisture-unsaturated conditions

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JOURNAL OF CLEANER PRODUCTION 2023年第1期405卷

作者： Cheng, Pengfei zhao, Xuqiang Chen, xuwen Czech, Bozena Oleszczuk, Patryk Ma, Junchao Zhou, Xian Gao, Yanzheng Nanjing Agr Univ Inst Organ Contaminant Control & Soil Remediat Coll Resources & Environm Sci Nanjing 210095 Peoples R China Jiangsu Univ Inst Environm Hlth & Ecol Secur Sch Environm & Safety Engn Zhenjiang 212013 Jiangsu Peoples R China Marie Curie Sklodowska Univ Inst Chem Sci Dept Radiochem & Environm Chem Fac Chem Pl M Curie Sklodowskiej 3 541 PL-20031 Lublin Poland

Halogenated polycyclic aromatic hydrocarbons (HPAHs) have recently remerged as major soil contaminants. However, limited studies have focused on the transformation and removal of HPAHs in soils. The transformation behaviors of HPAHs on cryptomelane-type manganese oxide (K(I)-OMS-2) and its metal ion-exchanged M-OMS-2 (M = Fe(III), Cu(II), and Zn(II)) under moisture-unsaturated conditions were systematically investigated. The transformation kinetics results showed that the transformation rate constants (k) of HPAHs were 0.077-0.829, 0.071-0.629, 0.068-0.530, and 0.064-0.259 d(-1) for Fe(III)-OMS-2, Cu(II)-OMS-2, Zn(II)-OMS-2, and K(I)-OMS-2. The metal ion exchange treatment of K(I)-OMS-2 enhanced the transformation efficiency of HPAHs. The characterization (H-2-TPR, CV, ESI, XPS, and EPR) and theoretical calculation (density of states and formation energy of oxygen vacancies) results indicated that the non-radical/radical transformation efficiency of HPAHs on M-OMS-2 was higher than that on K(I)-OMS-2. The transformation rate of HPAHs was positively correlated with the redox potential of metal ions and superoxide radical yield of M-OMS-2. Additionally, this study revealed that HPAHs with lower redox potential and more strongly bound to M-OMS-2 were more preferentially transformed. Finally, the experimental results of the addition of M-OMS-2 to the natural soil revealed that M-OMS-2 aids the transformation of HPAHs in soils. This study reveals the chemical transformation behavior of HPAHs in soils and suggests that M-OMS-2 can a promising agent for soil remediation.

关键词： Halogenated polycyclic aromatic hydrocarbons OMS-2 Moisture-unsaturated conditions Metal ion exchange Transformation

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Direct Arylation Polycondensation toward Water/Alcohol-Soluble Conjugated Polymers: Influence of Side Chain Functional Groups

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ACS MACRO LETTERS 2021年第4期10卷 419-425页

作者： zhao, Bowen Liang, Ziqi Zhang, Ying Sui, Ying Shi, Yibo Zhang, xuwen Li, Miaomiao Deng, Yunfeng Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Fuzhou 350207 Peoples R China

Direct arylation of 2,7-dibromofluorene with n-octyl, 6-diethoxylphosphorylhexyl, 6-(N,N-diethylamino)hexyl or 6-bromohexyl side chains and 1,2,4,5-tetrafluorobenzene (TFB) were conducted to investigate the effect of side chain functional groups on the coupling, and the resulting TFB-substituted fluorene derivatives were used as C-H monomers for the synthesis of water/alcohol soluble conjugated polymers (WSCPs) by direct arylation polycondensation (DArP). The direct arylation and DArP of the monomers carrying phosphonate and amino groups went on smoothly in typical DArP conditions, that is, Pd(OAc)(2)/(PBu2Me)-Bu-t-HBF4/base/DMAc and Pd-2(dba)(3)center dot CHCl3/P(o-MeOPh)(3)/pivalic acid/base/THF, and high molecular weight polymers with these groups were successfully synthesized. However, for fluorenemonomers with bromohexyl side chains, the target products could not be obtained from the above conditions but could be prepared in the absence of carboxylic acid additives in low polar solvents. With the above DArP-made polymers as cathode interfacial layers, high performance organic solar cells (OSCs) were successfully fabricated.

关键词： Monomers Organic reactions Organophosphorus compounds Condensation Polymers

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： zhao, Zhenhao Zhang, Yujie Li, Chao Li, xuwen Chu, Yongchao Guo, Qin Zhang, Yiwen Xia, Weiyi Liu, Peixin Chen, Hongyi Wang, Yu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters (vol 56, pg 5665, 2020)

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CHEMICAL COMMUNICATIONS 2020年第48期56卷 6594-6594页

作者： Liu, Jianbo zhao, Rusong Wang, Xia Gao, xuwen Zou, Guizheng Qilu Univ Technol Key Lab Appl Technol Sophisticated Analyt Instrum Shandong Acad Sci Shandong Anal & Test Ctr Jinan 250353 Peoples R China Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

Synergetic effects in Au-Ag bimetallic nanoclusters (BNCs) more favorably enhanced electrochemical redox induced electrochemiluminescence (ECL) over photoexcitation induced photoluminescence (PL); this not only led to Au-Ag BNCs with enhanced bandgap-engineered ECL compared to Au NCs, but it also generated surface-defect related ECL to enhance the total ECL intensity.

关键词： Surface defects

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EXCEPTIONAL DATA TRANSMISSION METHOD, APPARATUS AND SYSTEM

EXCEPTIONAL DATA TRANSMISSION METHOD, APPARATUS AND SYSTEM

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作者： SHU, Lin zhao, xuwen

标准号: WO2018196761(A1)

Disclosed is an exceptional data transmission method, relating to the field of communications, and used for achieving that APN rate control is not executed on exceptional data sent by a UE to a core network. The exceptional data transmission method comprises: in the case where APN rate control is executed, a UE determining that there is exceptional data to be sent to a network side, then the UE sending a NAS message to a first core network device;after receiving the NAS message, the first core network device learning, according to exceptional data indicator information in the NAS message, that exceptional data is comprised in the NAS message;the first core network device sending a first message to a third core network via the second core network device;the third core network device receiving the first message when executing APN rate control, and when the APN rate control reaches a maximum rate limit, the third core network device sending the exceptional data to a data network according to the received exceptional data indicator information. The embodiments of the present application are applied to transmission of exceptional data in an emergency situation.

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TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples

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BRIEFINGS IN BIOINFORMATICS 2024年第3期25卷 bbae159-bbae159页

作者： Wang, Shenjie Zhu, Xiaoyan Wang, xuwen Liu, Yuqian zhao, Minchao Chang, Zhili Wang, Xiaonan Shao, Yang Wang, Jiayin Xi An Jiao Tong Univ Sch Comp Sci & Technol Xian Peoples R China Nanjing Geneseeq Technol Inc Nanjing Jiangsu Peoples R China

In cancer genomics, variant calling has advanced, but traditional mean accuracy evaluations are inadequate for biomarkers like tumor mutation burden, which vary significantly across samples, affecting immunotherapy patient selection and threshold settings. In this study, we introduce TMBstable, an innovative method that dynamically selects optimal variant calling strategies for specific genomic regions using a meta-learning framework, distinguishing it from traditional callers with uniform sample-wide strategies. The process begins with segmenting the sample into windows and extracting meta-features for clustering, followed by using a pre-trained meta-model to select suitable algorithms for each cluster, thereby addressing strategy-sample mismatches, reducing performance fluctuations and ensuring consistent performance across various samples. We evaluated TMBstable using both simulated and real non-small cell lung cancer and nasopharyngeal carcinoma samples, comparing it with advanced callers. The assessment, focusing on stability measures, such as the variance and coefficient of variation in false positive rate, false negative rate, precision and recall, involved 300 simulated and 106 real tumor samples. Benchmark results showed TMBstable's superior stability with the lowest variance and coefficient of variation across performance metrics, highlighting its effectiveness in analyzing the counting-based biomarker. The TMBstable algorithm can be accessed at https://***/hello-json/TMBstable for academic usage only.

关键词： sequencing data analysis variant calling counting-based biomarker tumor mutation burden immunotherapy meta-learning approach

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基于CNN与LightGBM的入侵检测研究

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郑州大学学报（理学版） 2023年第6期55卷 35-40页

作者：魏明军闫旭文纪占林陈钊华北理工大学人工智能学院河北唐山063210 华北理工大学河北省工业智能感知重点实验室河北唐山063210

网络入侵检测少数类样本不仅自身准确率和召回率低,而且还影响整体准确率和召回率。针对此问题,提出一种基于生成式对抗网络(GAN)、卷积神经网络与LightGBM相结合的算法。首先,使用降噪变分自动编码器改进GAN,以实现对不平衡数据集的处... 详细信息

网络入侵检测少数类样本不仅自身准确率和召回率低,而且还影响整体准确率和召回率。针对此问题,提出一种基于生成式对抗网络(GAN)、卷积神经网络与LightGBM相结合的算法。首先,使用降噪变分自动编码器改进GAN,以实现对不平衡数据集的处理。其次,使用卷积注意力机制改进残差卷积神经网络,更好地提取数据的关键特征。最后,利用LightGBM集成学习算法对处理后的数据集进行分类。实验结果表明,在NSL-KDD测试集上,改进后算法的准确率、召回率、精确率和F1值均有提高。该模型缓解了少数类样本对模型分类带来的负面影响,具有良好的分类性能。

关键词：入侵检测生成式对抗网络卷积神经网络 LightGBM

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Parental category B vaccine hesitancy and associated factors in China: an online cross-sectional survey

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EXPERT REVIEW OF VACCINES 2022年第1期21卷 145-153页

作者： Han, Ying Wang, Qiang zhao, Shuangyu Wang, Jianli Dong, Shuheng Cui, Tingting Liu, Minqi Shi, Naiyang Yang, Liuqing Han, Yue Xiu, Shixin Wang, xuwen Jin, Hui Southeast Univ Sch Publ Hlth Dept Epidemiol & Hlth Stat Nanjing Peoples R China Southeast Univ Sch Publ Hlth Key Lab Environm Med Engn Minist Educ Nanjing Peoples R China Wuxi Ctr Dis Control & Prevent Wuxi Jiangsu Peoples R China

Background Vaccine hesitancy is one of the top ten health threats. We aimed to (1) assess parental Category B vaccines hesitancy and associated sociodemographic factors in China, and (2) explore the association between attitude toward vaccines and self-reported hesitant behavior. Methods A cross-sectional study was performed through a web-based anonymous online questionnaire survey between 9 February and 7 April 2021. Chinese parents aged >= 18 years with one child aged < 6 years were included to assess vaccine hesitancy using the vaccine-hesitancy scale (VHS). Structural equation model was used to determine relationships between variables. Results Of 2952 Chinese parents included in the analysis, 17.5% were highly hesitant in Category B vaccines. Parents who were younger, less educated, engaged in health-related occupations, and had been vaccinated against influenza in the past year were more hesitant when vaccinating their children (P < 0.001). VHS score accuracy to identify vaccine-hesitant behavior was acceptable, and the optimal cutoff was 37.50 (with 61.96% parental vaccine hesitancy). Parents who lack confidence or believe vaccines were risk were more likely to show vaccine hesitant behavior (P < 0.001). Conclusions In China, effective interventions need to be implemented to eliminate parental Category B vaccines hesitancy.

关键词： Vaccine hesitancy Parents Structural equation model Online survey China

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Theoretical Analysis and Numerical Simulation of the Motion of RDX Deflagration-Driven Flyer Plate Based on Laser-Initiated Micro-Pyrotechnic Devices

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MICROMACHINES 2023年第5期14卷 917-917页

作者： Xian, Mingchun zhao, Kang Liu, xuwen Meng, Yangang Xie, Junyao Li, Jingwei Tong, Lele Huang, Meng Wu, Lizhi Nanjing Univ Sci & Technol Sch Chem & Chem Engn Nanjing 210094 Peoples R China Sichuan Aerosp Chuannan Pyrotech Co Ltd Luzhou 646000 Peoples R China Jianghan Univ State Key Lab Precis Blasting Wuhan 430056 Peoples R China

Miniaturized laser-initiated pyrotechnic devices have great application prospects in aerospace and modern weapon systems due to their excellent energy output performance and reliability. In order to develop a low-energy insensitive laser detonation technology based on a two-stage charge structure, it is important to deeply analyze the motion law of a titanium flyer plate driven by the deflagration of the first-stage charge (RDX). The effects of the charge mass of RDX, flyer plate mass, and barrel length on the motion law of flyer plates were studied through a numerical simulation method based on the Powder Burn deflagration model. The consistency between the numerical simulation and the experimental results was analyzed using the paired t confidence interval estimation method. The results show that the Powder Burn deflagration model can effectively describe the motion process of the RDX deflagration-driven flyer plate with a 90% confidence level, and its velocity error is =6.7%. The speed of the flyer plate is proportional to the mass of the RDX charge, inversely proportional to the mass of the flyer plate, and exponentially related to its moving distance. As the moving distance of the flyer plate increases, the RDX deflagration products and air in front of the flyer plate are compressed, which inhibits the motion of the flyer plate. In the optimum state (the mass of the RDX charge is 60 mg, the mass of the flyer is 85 mg, and the length of the barrel is 3 mm), the speed of the titanium flyer reaches 583 m/s, and the peak pressure of the RDX deflagration reaches 2182 MPa. This work will provide a theoretical basis for the refined design of a new generation of miniaturized high-performance laser-initiated pyrotechnic devices.

关键词： laser-initiated deflagration-driven flyer plate powder burn

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Influence of coded mask rotation speed and central detector to imaging performance for time-encoded imager

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RADIATION PHYSICS AND CHEMISTRY 2023年第1期209卷

作者： zhao, Dong Jia, Wenbao Hei, Daqian Liang, xuwen Cheng, Wei Cai, Pingkun Zhang, Ronghua Shan, Qing Ling, Yongsheng Nanjing Univ Aeronaut & Astronaut Dept Nucl Sci & Technol Nanjing 211106 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Jiangsu Higher Educ Inst Collaborat Innovat Ctr Radiat Med Suzhou 215000 Peoples R China

Time-encoded imaging could be useful for searching potential radioactive sources for preventing illicit trans-portation and trafficking of nuclear materials. A 2-D, dual-particle, time-encoded imager was developed for gamma-ray and neutron source imaging. The influence of central detector and coded mask rotation speed to imaging performance, such as angular resolution, signal-to-noise ratio and detection time, was investigated by Am-Be neutron source imaging experiments. The EJ276 plastic scintillator (Size: phi 5.08 cm x 5.08 cm) and CLYC scintillator (Size: phi 2.54 cm x 2.54 cm) couple to photomultiplier tubes was set as the central detector, respectively. Under the experiment conditions (Am-Be neutron source;300 mCi;1.8 m), for the neutron and gamma-ray images with EJ276 detector, the best horizontal and vertical angular resolution was (3.7 degrees, 4.8 degrees) and (5.9 degrees, 6.6 degrees), minimum detection time was 100 s and 600 s, respectively;for the neutron and gamma-ray images with CLYC detector, the best horizontal, vertical angular resolution was (3.1 degrees, 3.1 degrees) and (3.5 degrees, 3.3 degrees), minimum detection time was 2200 s and 1600 s, respectively. For different central detector, the results showed that the smaller volume of detector, the better angular resolution;the lower detection efficiency, the longer detection time. For different rotation speed, too fast rotation speed can lead to failure to locate the source.

关键词： Time-encoded imager Dual-particle imaging Imaging performance

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