检索结果-内蒙古大学图书馆

中国医学创新 2021年第35期18卷 123-126页

作者：王锦祥郑俊城洪旭雯刘特彬李晓辉广东省普宁市人民医院广东普宁515300

目的:探讨吲哚菁绿(ICG)荧光影像引导在复杂肝胆道结石手术中胆道识别的临床应用。方法:选取2021年1-9月本科收治的行再次胆道探查取石的复杂肝胆道结石手术患者120例作为研究对象,按随机数字表法分为对照组和观察组,每组60例。对照组... 详细信息

目的:探讨吲哚菁绿(ICG)荧光影像引导在复杂肝胆道结石手术中胆道识别的临床应用。方法:选取2021年1-9月本科收治的行再次胆道探查取石的复杂肝胆道结石手术患者120例作为研究对象,按随机数字表法分为对照组和观察组,每组60例。对照组采取常规腹腔镜肝外胆管探查术,观察组在对照组的基础上术中采取ICG荧光融合影像引导。记录并比较两组术中术后情况。结果:观察组手术时间、寻找胆总管时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05);观察组胆总管损伤率为0,低于对照组的10.00%(P<0.05);观察组其他并发症发生率为3.33%,明显低于对照组的15.00%(P<0.05)。观察组排气时间、住院时间均短于对照组(P<0.05)。结论:吲哚菁绿荧光影像引导可实时显示肝胆道系统,有效缩短手术时间,避免胆道损伤,减少并发症的发生。

关键词：吲哚菁绿荧光影像肝胆道结石胆道探查胆道识别

来源：评论

学校读者我要写书评

暂无评论

医学数据挖掘在线教学平台的设计与实现

引用

中国医学教育技术 2021年第6期35卷 698-702页

作者：徐晓巍杨林郑思孙月萍王序文李姣中国医学科学院医学信息研究所北京100020

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课... 详细信息

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课程短板,能够满足不同学科背景的学生需求。学生课后反馈结果表明,该平台的应用降低了技术类课程的学习门槛,激发了医学生对于数据挖掘类课程的学习积极性,有助于其实践能力的提升。

关键词：医学数据挖掘平台建设医学教育

来源：评论

学校读者我要写书评

暂无评论

High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

arXiv

引用

arXiv 2023年

作者： Zhai, Jiyuan Pan, Weimin He, Feisi Ge, Rui Mi, zhenghui Sha, Peng Jin, Song Han, Ruixiong Wang, Qunyao Lin, Haiying Wang, Guangwei Li, Mei Sang, Minjing Sun, Liangrui Ye, Rui Zhao, Tongxian Li, Shaopeng Zhu, Keyu Liu, Baiqi Wang, Xiaolong Yang, Xiangchen Bian, Xiaojuan Zhang, Xiangzhen Ma, Huizhou Dai, xuwen Zhang, Zhanjun Zhang, Liang Zhao, Hui Guo, Runbin Mu, Zhihui Yang, Conglai zheng, Xiaobing Dong, Chao Huang, Tongming Ma, Qiang zheng, Hongjuan Liu, Ming Wang, Zihan Zhou, Wenzhong Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

World’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and CEPC R&D. The 9-cell cavities in the cryomodule achieved an unprecedented highest average Q0 of 3.8 × 1010 at 16 MV/m and 3.6 × 1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total CW RF voltage greater than 191 MV, with an average cavity CW accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of CEPC, DALS and the other high repetition rate free electron laser facilities (LCLS-II, LCLS-II-HE, SHINE, S3FEL). There is evidence that the mid-T bake cavity may not require fast cool-down or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing. © 2023, CC BY.

关键词： Free electron lasers

来源：评论

学校读者我要写书评

暂无评论

Thallium contamination in farmlands and common vegetables in a pyrite mining city and potential health risks

引用

ENVIRONMENTAL POLLUTION 2019年 248卷 906-915页

作者： Liu, Juan Li, Nuo Zhang, Weilong Wei, Xudong Tsang, Daniel C. W. Sun, Yubing Luo, xuwen Bao, Zhi'an zheng, Wentao Wang, Jin Xu, Guoliang Hou, Liping Chen, Yongheng Feng, Yuexing Guangzhou Univ Key Lab Water Qual & Conservat Pearl River Delta Guangdong Prov Key Lab Radionuclides Pollut Contr Inst Environm Res Greater BaySch Environm Sci & Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Rural Nonpoint Source Pollut Comprehens Managemen Guangzhou 510006 Guangdong Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hung Hom Kowloon Hong Kong Peoples R China North China Elect Power Univ Coll Environm Sci & Engn MOE Key Lab Resources & Environm Syst Optimizat Beijing 102206 Peoples R China Northwest Univ Dept Geol State Key Lab Continental Dynam Xian 710069 Peoples R China Guangzhou Univ Sch Life Sci Guangzhou 510655 Guangdong Peoples R China Univ Queensland Sch Earth & Environm Sci Brisbane Qld 4072 Australia

Thallium (Tl) is a trace metal of severe toxicity. Its health concerns via consumption of contaminated vegetables have often been overlooked or underestimated. This study was designed to gain insight into the actual level and distribution characteristics of Tl and metal (loid)s (Pb, Cd, Cr, Sb, Mn, Cu, Zn, Ni, and Co) in agricultural soils and common vegetables cultivated in different zones (upstream, midstream, and downstream) of a densely populated residential area in a typical mine city, which has been open-pit exploiting Tl-bearing pyrite minerals since 1960s. The results show that most of the agricultural soils exhibit contaminated levels of Tl, with Tl contents (upstream: 1.35-4.31 mg/kg, midstream: 2.43 -5.19 mg/kg, and downstream: 0.65-233 mg/kg) mostly exceeding the maximum permissible level (MPL) for agricultural land use (1 mg/kg). Sequential extraction procedure indicates that even Tl is predominantly retained in the residual fraction, significant levels of Tl are still present in the geochemically mobile fractions. Besides, metals like Cu, Cd, Mn, and Co are mostly distributed in the labile fractions. Almost all metal (loid)s in edible parts of the vegetables exceed their corresponding MPL for consumption. The chronic daily intake (CDI) and hazard quotient (HQ) values calculated for inhabitants at different ages indicate non-negligible Tl risks via consumption of local vegetables, especially for children. Therefore, it is critical to establish effective measures for hazardous waste management and enforceable regulations in Tl-polluted area to mitigate potential severe impacts of Tl on human health through food chain. (C) 2019 Elsevier Ltd. All rights reserved.

关键词： Thallium Agricultural soil Vegetable Metal/metalloid contamination Pyrite mining

来源：评论

学校读者我要写书评

暂无评论

Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

引用

ADVANCED SCIENCE 2021年第20期8卷 e2101526页

作者： Li, Chao Zhao, Zhenhao Luo, Yifan Ning, Tingting Liu, Peixin Chen, Qinjun Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, zheng Wang, Yu Su, Boyu You, Haoyu Zhang, Tongyu Li, xuwen Song, Haolin Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol Key Lab Smart Drug DeliveryMinist EducInst Brai Shanghai 201203 Peoples R China Fudan Univ Sch Pharm Inst Brain Sci MOE Frontiers Ctr Brain SciDept Pharmaceut Shanghai 201203 Peoples R China

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO2) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrophage-membrane protein-mediated recognition with cell adhesion molecules that are overexpressed on the damaged vascular endothelium. MnO2 nanosphere can consume excess hydrogen peroxide (H2O2) and convert it into desiderated oxygen (O-2), and can be decomposed in acidic lysosome for cargo release, so as to reduce oxidative stress and promote the transition of M1 microglia to M2 type, eventually reversing the proinflammatory microenvironment and reinforcing the survival of damaged neuron. This biomimetic nanomedicine raises new strategy for multitargeted combined treatment of ischemic stroke.

关键词： biomimetic nanoparticles inflammatory microenvironment microglia polarization neuroprotection O-2 generation reperfusion injury reactive oxygen species (ROS) consumption

来源：评论

学校读者我要写书评

暂无评论

乡贤参事会建设和运行标准化研究——以浙江省德清县为例

引用

中国质量与标准导报 2020年第5期 38-41页

作者：郑玲安然陈旭文朱明浙江省方大标准信息有限公司浙江省标准化研究院

以浙江省德清县乡贤参事会为例,剖析乡贤参事组织发展现状及问题,探讨乡贤参事会建设和运行标准化模式,为乡贤参事组织日常管理和工作开展提供有益借鉴和参考,推动乡村治理现代化,助力乡村振兴。

关键词：乡贤乡贤参事会乡村治理标准化

来源：评论

学校读者我要写书评

暂无评论

吉富罗非鱼养殖池塘集成调控技术配比研究

引用

中国农学通报 2021年第33期37卷 148-152页

作者：孙旋辉蒋咏燚刘文婷郑尧陈家长邴旭文中国水产科学研究院淡水渔业研究中心南京农业大学无锡渔业学院江苏无锡214081

前期研究表明"5%空心菜+10%填料+泼藻"水质调控集成模式值得推广,为进一步验证效果,以吉富罗非鱼养殖池塘为对象,研究不同空心菜种植配比其对池塘水质氮、磷净化效果。通过设置5%、8%和10%空心菜种植比例,测定TN、NH;-N、TP、... 详细信息

前期研究表明"5%空心菜+10%填料+泼藻"水质调控集成模式值得推广,为进一步验证效果,以吉富罗非鱼养殖池塘为对象,研究不同空心菜种植配比其对池塘水质氮、磷净化效果。通过设置5%、8%和10%空心菜种植比例,测定TN、NH;-N、TP、CODMn、TSS、p H和DO等水质指标,并进行环境、效益评估。结果表明:空心菜种植对罗非鱼池塘水体中TN、NH;-N、TP、CODMn、TSS均有一定程度的降低,空心菜种植对TN去除率在10%~15%之间,对TP去除率在20%~40%之间,5%空心菜种植组还对NH;-N、CODMn有较好的去除效果,且效益较好适合推广。

关键词：池塘水质调控原位修复集成中草药鱼菜配比营养盐去除效果成本核算

来源：评论

学校读者我要写书评

暂无评论

CTA1: Purified and display onto gram-positive enhancer matrix (GEM) particles as mucosal adjuvant

引用

PROTEIN EXPRESSION AND PURIFICATION 2018年 141卷 19-24页

作者： Zhang, Yuanpeng Yu, Xiaoming Hou, Liting Chen, Jin Li, Pengcheng Qiao, xuwen zheng, Qisheng Hou, Jibo Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing 210014 Jiangsu Peoples R China Jiangsu Acad Agr Sci Natl Res Ctr Engn & Technol Vet Biol 50 Zhongling St Nanjing 210014 Jiangsu Peoples R China Jiangsu Coinnovat Ctr Prevent & Control Important Yangzhou 225009 Jiangsu Peoples R China

The A1 subunit of cholera toxin (CTA1) retains the adjuvant function of CT, without its toxic side effects, making the molecule a promising mucosal adjuvant. However, the methods required to obtain a pure product are both complicated and expensive, constricting its potential commercial applicability. Here, we fused the peptidoglycan binding domain (PA) to the C-terminus of CTA1, which enabled the fusion protein to be expressed by Bacillus subtilis, and secreted into the culture medium. CTA1 was then purified and displayed on GEM particles using a one step process, which resulted in the formation of CTA1-GEM complexes. Next, the CTA1-GEM complexes were used as an adjuvant to enhance the immune responses of mice to the influenza subunit vaccine. It was observed that the CTA1-GEM complexes enhanced specific systemic (IgG) and mucosal (IgA) immune responses against antigen, and induced cellular immune responses as well. The data presented here suggests that CTA1-GEM complexes can serve as a viable mucosal adjuvant. (C) 2017 Elsevier Inc. All rights reserved.

关键词： Cholera toxin A1 subunit Surface display Adjuvant GEM particles Lactococcus lactis

来源：评论

学校读者我要写书评

暂无评论

The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs

引用

VACCINE 2018年第52期36卷 7929-7935页

作者： Chen, Jin Yu, Xiaoming zheng, Qisheng Hou, Liting Du, Luping Zhang, Yuanpeng Qiao, xuwen Hou, Jibo Huang, Kehe Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China Nanjing Agr Univ China Inst Nutr & Metab Disorders Domest Anim & F Nanjing 210095 Jiangsu Peoples R China Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing 210014 Jiangsu Peoples R China Jiangsu Coinnovat Ctr Prevent & Control Important Yangzhou 225009 Jiangsu Peoples R China

The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 group), and the serum liquid phase blocking ELISA (LPB-ELISA) antibody titers, IgG1 and IgG2 levels, and the levels of four cytokines secreted by peripheral blood lymphocytes were measured at 28 days post vaccination (dpv). In the FMD-CVC1302 group, the LPB-ELISA antibody titers, IgG1, and IgG2 titers, and IL-2, IL-4, IL-6, and IFN-gamma levels at 28 dpv were significantly higher than those in the FMD-vaccine group. The FMD-CVC1302 group had long-lasting antibody titers (>7.8 log(2)), lasting for at least 6 months. In addition, piglets were vaccinated with or without addition of CVC1302 to the FMD vaccine at three different doses (1, 1/3, and 1/9 of the standard vaccine dose) and the serum LPBELISA antibody and serum neutralizing (SN) antibody titers were detected at 28 dpv. Then all pigs were challenged with virulent FMDV for PD50 value, and the levels of FMDV-specific RNA copies for the two full-dose groups at 3 and 10 days post challenge (dpc) were measured. The LPB-ELISA and SN antibody titers for the three doses in the FMD-CVC1302 groups were significantly higher than those in the FMD-vaccine groups at the same doses (p < 0.05). Post-virus challenge, the FMDV-specific RNA copy number in the FMD-CVC1302 group was lower than that in the FMD-vaccine group at 3 and 10 dpc. The PD50 value was 15.85 for the FMD-CVC1302 group, which was obviously higher than that for the FMD-vaccine group (10.96), and in the 1/9-dose of FMD-vaccine group only 3/5 pigs were protected. These results indicate that CVC1302 can enhance the immune efficacy and protective ability of the FMD vaccine in pigs. (C) 2018 Elsevier Ltd. All rights reserved.

关键词： Foot-and-mouth disease virus Inactivated vaccine Immunopotentiator CVC1302 Immune efficacy

来源：评论

学校读者我要写书评

暂无评论

Fabrication of CoNPs-embedded porous carbon composites based on morphochemical imprinting strategy for detection of H2O2 released from living cells

引用

ELECTROCHIMICA ACTA 2019年 321卷 134717-000页

作者： Lu, Nannan zheng, Bo Gu, Yue Yan, Xiaoyi Zhang, Tingting Liu, He Xu, Haixin Xu, Zhiqian Li, xuwen Zhang, Zhiquan Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Weinan Normal Univ Coll Chem & Mat Weinan City 714099 Peoples R China

Rational construction of biosensor to determine reactive oxygen species (ROS) generated from living cells is one of the great challenges in physiological and pathological fields. Herein, for the first time, a novel Co nanoparticles (CoNPs) embedded walnut-like N-doped porous carbon microsphere (Co@NCS) can be synthesized using dual imprinting strategy by pyrolysis and acid leaching. The distinct morphology and chemical characteristic of melamine cyanurate (MC) aggregates can be imprinted in the carbon source derived from glucose during the pyrolysis process. According to our research, with synergistic effect of CoHPs and NCS, the Co@NCS shows an excellent electrochemical activity toward the reduction of hydrogen peroxide (H2O2). The Co@NCS modified electrode exhibits a wider linear detection response with the range from 0.5 mu M to 7500 mu M and a low detection limit of 88 nM (S/N = 3). Moreover, with desirable selectivity, decent reproducibility and satisfied anti-interference performance, the fabricated biosensor can be applied to determine H2O2 in human serum samples and that released from living cell, indicating the potential applications in the fields of pathological and physiological sensing. (C) 2019 Elsevier Ltd. All rights reserved.

关键词： Co nanoparticles Porous carbon microspheres Biosensor Hydrogen peroxide Living cells

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：