Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical ...
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ISBN:
(纸本)9781509040933
Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical explorations, this syndrome can be treated with a group of herbal medicines in TCM. However, their molecular level biological functions are still not clear. In this study, a set of algorithms e.g., hypergeometric distribution, Jaccard index, and recursive programming for hierarchy network were deployed in the context gene/protein functional similarity and enrichment analysis. The analysis was mainly focused on the associated herbal medicines, their chemical compounds, target proteins' similarity, and gene ontology terms' hierarchical network overrepresentation through the enrichment analysis of hypergeometric distribution with P-value set to 0.05. As a result, these associated herbs share low level (<0.5) of therapeutic similarities on target proteins, yet with common biological functions for TCM syndrome wind-cold-dampness e.g., signal transduction, transportation, chemical homeostatic and metabolic process.
The effects of synthetic androgen 17 alpha-methyltestosterone (MT) on endocrine impairment were examined in crucian carp. Immature 7-month old mono-female Pengze crucian carp (Pcc) F2 offspring were exposed to 50 and ...
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The effects of synthetic androgen 17 alpha-methyltestosterone (MT) on endocrine impairment were examined in crucian carp. Immature 7-month old mono-female Pengze crucian carp (Pcc) F2 offspring were exposed to 50 and 100 mu g/L of MT (week 2, 4, and 8). Gonadosomatic index, hepatosomatic index and intestine weight altered considerably and oocyte development was repressed. In the treatment groups, ovarian 11-ketotestosterone decreased, whereas 17 beta-estradiol and testosterone increased, and ovarian aromatase activities increased at week 4. However, in the brain tissue, those values, significantly decreased. Quantitative RT-PCR analysis demonstrated changes in steroid receptor genes and upregulation of steroidogenic genes (Pcc-3bhsd, Pcc-11bhsd2 Pcc-cyp11 alpha 1), while the other three steroidogenic genes (Pcc-cyp17 alpha 1, Pcc-cyp19a1a and Pcc-star) decreased from week 4 to week 8. Ovarian, hepatic Pcc-vtg B and vitellogenin concentration increased in both 50 and 100 a of MT exposure groups. This study adds further information regarding the effects of androgens on the development of previtellogenic oocytes, which suggests that MT could directly target estrogen signaling pathway, or indirectly affect steroidogenesis and vitellogenesis. (C) 2016 Elsevier Inc. All rights reserved.
In this paper the temporary support structures in construction are classified into frame support structures, truss support structures, hybrid support structures and special support structures based on their assembly p...
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