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中国农学通报 2018年第2期34卷 146-152页

作者：孟顺龙胡庚东李丹丹裘丽萍宋超范立民郑尧吴伟陈家长邴旭文中国水产科学研究院淡水渔业研究中心/农业部长江下游渔业资源环境科学观测实验站/中国水产科学研究院内陆渔业生态环境和资源重点开放实验室江苏无锡214081 南京农业大学无锡渔业学院江苏无锡214081

稻渔综合种养可使农业从单一经营转变为复合经营,从平面生产转变为立体生产,是农业转方式、调结构的重要发展方向。为进一步促进稻渔综合种养研究的深入开展和稻渔综合种养模式的推广应用,综述了中国稻渔综合种养技术的发展概况,阐明了... 详细信息

稻渔综合种养可使农业从单一经营转变为复合经营,从平面生产转变为立体生产,是农业转方式、调结构的重要发展方向。为进一步促进稻渔综合种养研究的深入开展和稻渔综合种养模式的推广应用,综述了中国稻渔综合种养技术的发展概况,阐明了稻渔综合种养模式的增产增效作用及与之配套的稻田工程技术、安全植保技术、安全施肥技术、鱼病防治技术、水质管理技术的实施过程,指出了稻渔综合种养模式对产业的支撑作用,展望了稻渔综合种养模式的发展前景,并提出了稻渔综合种养模式的重点研究方向。

关键词：水稻渔业综合种养发展概况

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维生素B_6联用20AA复方氨基酸治疗创伤性凝血病的疗效及机制研究

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中华卫生应急电子杂志 2015年第6期1卷 18-24页

作者：楚鹰岳茂兴包卿郑旭文沈文明刘政周培根李瑛卞晓星黄琴梅尹进南梁华平江苏大学附属武进医院江苏常州213002 第三军医大学创伤烧伤与复合伤国家重点实验室重庆400042

目的探讨维生素B_6联用20AA复方氨基酸治疗创伤性凝血病有关机制。方法 114只雄性SD大鼠,按随机数字表法进行分组。创伤性凝血病大鼠模型建立实验使用60只大鼠,假手术组(10只),模型组(50只),其中模型组分别于造模后4 h,6 h,12 h,24 h和4... 详细信息

目的探讨维生素B_6联用20AA复方氨基酸治疗创伤性凝血病有关机制。方法 114只雄性SD大鼠,按随机数字表法进行分组。创伤性凝血病大鼠模型建立实验使用60只大鼠,假手术组(10只),模型组(50只),其中模型组分别于造模后4 h,6 h,12 h,24 h和48 h时间点采集标本,每个时间点10只;新疗法疗效实验使用24只大鼠,分为假手术组,9%等渗盐水对照组,维生素B_6与20AA复方氨基酸联合治疗组,共3组,每组8只;新疗法作用机制实验使用30只大鼠,正常组3只、假手术组3只、新疗法组与对照组各12只,其中新疗法组与对照组分别在伤后4 h,6 h,12 h及24 h四个时间点采集标本,每个时间点3只。通过造成大鼠重型颅脑损伤、双股骨骨折、开腹及腹主动脉放血20%,制成大鼠多发伤模型,进行干预后,按各时间点采集标本进行相应检测。创伤性凝血病大鼠模型建立实验采用血栓弹力图检测凝血功能变化,新疗法疗效实验分别采用血栓弹力图与凝血4项检测检测凝血功能变化,新疗法作用机制实验采用实时定量PCR检测凝血因子基因表达变化。结果 (1)创伤性凝血病大鼠模型建立实验:R值(反应时间)48h达到高峰,24 h,48 h与正常组比较具有统计学差异(P<0.05),K值(血块生成时间)和Angle值(血块生成率)各组变化不大,与正常组相比较无统计学意义;MA(最大宽度值)4 h开始延长,48 h达到高峰,24 h,48 h与正常组比较具有显著统计学差异(P<0.01)。(2)新疗法疗效实验:新疗法组与对照组比较,血栓弹力图R值为(2.24±0.68)min,显著低于对照组的(3.21±0.30)min(P<0.05);新疗法组血栓弹力图Angle值为(81.98±1.78)°,显著高于对照组的(79.54±2.13)°(P<0.05)。传统凝血试验结果:凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)新疗法治疗组均比对照组低,而纤维蛋白原(FIB)新疗法治疗组高于对照组,但其差异不显著。(3)新疗法作用机制实验:与正常组相比,除FⅪ与FⅩⅢA亚基外,新疗法组和对照组的肝脏凝血因子基因表达明显上调,但随着造模时间延长,其表达水平逐渐下降;新疗法组与对照组相比,肝脏凝血因子基因表达水平更高,其差异具有统计学意义(P<0.05)。结论建立与临床基本相符的大鼠创伤性凝血病模型,利用该模型验证了维生素B_6联用20AA复方氨基酸疗法对创伤性凝血病大鼠凝血功能的改善作用,并发现该新疗法能够通过提高肝脏凝血因子基因mRNA表达水平,从而改善动物模型的凝血功能。

关键词：创伤性凝血病血栓弹力图维生素B620AA复方氨基酸凝血因子基因

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Metabolomics analysis of Danggui Sini decoction on treatment of collagen-induced arthritis in rats

Metabolomics analysis of Danggui Sini decoction on treatment...

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第四届中荷代谢组学论坛

作者： Bang Cheng Hua zheng Fang Wu Jinxia Wu xuwen Liu Chaoling Tang Shiyin Lu Zhaoni Chen Fangming Song Junxiang Ruan Hongye Zhang Hui Song Wei Liu Hongwei Guo Yonghong Liang Zhiheng Su Pharmaceutical College Guangxi Medical UniversityNanning 530021China Medical Research Center Guangxi Medical UniversityNanning 530021Chin Pharmaceutical College Guangxi Medical UniversityNanning 530021China Department of Clinical Pharma

Rheumatoid arthritis(RA)is a chronic autoimmune disorder characterized by persistent joint inflammation leading to bone and cartilage damage and even ***,the pathogenesis of RA is multi-factorial and to a large degree,remains *** Sini decoction(DSD),a traditional Chinese medicine(TCM)formula,has been widely used as a remedy for rheumatoid arthritis(RA)in recent *** our study,1H-nuclear magnetic resonance(1H-NMR)based metabolomics analysis of 7 potential biomarkers,including taurine(1),urea(2),betaine(3),pyruvate(4),hippurate(5),succinate(6)and acetone(7)was performed to investigate the progression of RA and assess the efficacy of DSD in collagen-induced arthritis(CIA)*** to pathway analysis using identified metabolites and correlation construction,taurine and hypotaurine metabolism,gut microbiota metabolism,pyruvate metabolism,glycolysis/gluconeogenesis,the citrate cycle(TCA cycle)and lipid metabolism were recognized as being the most influenced metabolic pathways associated with *** a result,deviations of metabolites 1,3,4,5,6 and 7 in CIA rats were improved by DSD,which suggested that DSD mediated the abnormal metabolic pathways *** summary,the efficacy and its underlying therapeutic mechanisms of DSD on RA were systematically investigated and expect to provide a new insight in relevant studies of other TCM formulas.

关键词：

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20AA复方氨基酸联用大剂量维生素B6治疗创伤凝血障碍大鼠的实验研究

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中华卫生应急电子杂志 2015年第2期1卷 11-14页

作者：岳茂兴梁华平楚鹰包卿郑旭文刘政沈文明周培根李瑛卞晓星黄琴梅江苏大学附属武进医院常州213002 第三军医大学创伤烧伤与复合伤国家重点实验室重庆400042

目的：探讨20AA 复方氨基酸注射液（丰诺安）＋大剂量维生素 B6新疗法对创伤性凝血功能障碍动物模型凝血功能的影响。方法实验动物为雄性 SD 鼠24只，随机分为假手术组、生理盐水组以及新疗法治疗组，每组8只。采用 Feeney′s 自由落体... 详细信息

目的：探讨20AA 复方氨基酸注射液（丰诺安）＋大剂量维生素 B6新疗法对创伤性凝血功能障碍动物模型凝血功能的影响。方法实验动物为雄性 SD 鼠24只，随机分为假手术组、生理盐水组以及新疗法治疗组，每组8只。采用 Feeney′s 自由落体硬膜外撞击法加大腿骨折与放血制作大鼠多发伤模型，颈静脉插管输注20AA 复方氨基酸注射液（丰诺安）＋大剂量维生素 B6，生理盐水组输注等量的生理盐水，24 h 后，检测大鼠的凝血功能变化。结果治疗后新疗法治疗组与生理盐水组比较，血栓弹力图 R 值新疗法治疗组[（2．24±0．68）min]显著低于生理盐水组[（3．21±0．30）min]，（t ＝－0．98，P ＜0．05）；血栓弹力图 Angle 值新疗法治疗组[（81．98±1．78）deg]显著高于生理盐水组[（79．54±2．13）deg]，（t ＝2．43，P ＜0．05）。传统凝血试验结果：凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）新疗法治疗组均比生理盐水组低，而纤维蛋白原（FIB）新疗法治疗组高于生理盐水组，但其差异不显著。结论20AA 复方氨基酸注射液（丰诺安）＋维生素 B6联用能够明显改善创伤后大鼠凝血功能。

关键词：创伤和损伤凝血酶氨基酸类大鼠 Sprague—dawley

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Biomedical Network Regulated by Acanthopanacis Cortex (Wu-Jia-Pi) for Ossification

Biomedical Network Regulated by Acanthopanacis Cortex (Wu-Ji...

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International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery

作者： Junping Zhan Hongtao Guo Yun Yang Yutao Qi Miaofeng Li xuwen He Guang zheng The first affiliated hospital of Henan University of TCM The second affiliated hospital of Henan University of TCM School of Information Science & Engineering Lanzhou University

ISBN: (纸本)9781509040940

Acanthopanacis Cortex (AC) is a Chinese herbal medicine (Wu-Jia-Pi in PinYin) which is recognized with therapeutic effect of "strengthening bone and sinew", yet its regulating biological network is still obscure. In this study, started from AC's chemical compounds, their direct target proteins were filtered out. Then these targeted proteins were annotated with biological processes under the framework of Gene Ontology (GO) terms' hierarchical networks which were overrepresented and enriched with them with statistic significant p-value set to 0.05. In the biological process hierarchy networks, ossification formed a big one with bone formation associated biological processes. Further protein-protein interaction analysis with these targeted proteins and bone expressed ones formed a clear and concise protein-regulation network for ossification which should be responsible for the therapeutic effect of "strengthening bone and sinew". This study proposed a new approach of analyzing biological functions of a specified Chinese herbal medicine targeting certain therapeutic effect.

关键词： Acanthopanacis Cortex Ossification Chinese herbal medicine Protein-protein interaction Biomedical network

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Biological functional analysis of Chinese herbal medicines against wind-cold-dampness syndrome

Biological functional analysis of Chinese herbal medicines a...

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International Conference on Fuzzy Systems and Knowledge Discovery (FSKD)

作者： Guang zheng Yanjing Zhang He Zhang Miaofeng Li xuwen He Yutao Qi Junping Zhan Hongtao Guo School of Information Science & Engineering Lanzhou University Lanzhou P.R. China The second affiliated hospital of Henan University of TCM Zhengzhou P.R. China The first affiliated hospital of Henan University of TCM Zhengzhou P.R. China

ISBN: (纸本)9781509040940

Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical explorations, this syndrome can be treated with a group of herbal medicines in TCM. However, their molecular level biological functions are still not clear. In this study, a set of algorithms e.g., hypergeometric distribution, Jaccard index, and recursive programming for hierarchy network were deployed in the context gene/protein functional similarity and enrichment analysis. The analysis was mainly focused on the associated herbal medicines, their chemical compounds, target proteins' similarity, and gene ontology terms' hierarchical network overrepresentation through the enrichment analysis of hypergeometric distribution with P-value set to 0.05. As a result, these associated herbs share low level (

关键词： Proteins Biological processes Medical diagnostic imaging Chemical compounds Chemicals Indexes

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二溴海因对吉富罗非鱼血浆抗氧化酶基因表达的影响

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环境科学与技术 2017年第2期40卷 39-43页

作者：郑尧邴旭文裘丽萍范立民宋超孟顺龙刘涛孙博李丹丹张聪陈家长中国水产科学研究院淡水渔业研究中心农业部淡水鱼类遗传育种与养殖生物学重点开放实验室农业部长江下游渔业资源环境科学观测实验站中国水产科学研究院内陆渔业生态环境和资源重点开放实验室江苏无锡214081 南京农业大学无锡渔业学院江苏无锡214081

研究不同时间点(1、2、4、8、16 d)及修复期(26 d)、不同浓度(0、0.06、0.3、1.5 mg/L)二溴海因(DBDMH)对雄性吉富罗非鱼血浆中抗氧化酶基因的基因毒性,筛选稳定的生物标志物。实时荧光定量PCR方法检测DBDMH对超氧化物歧化酶(sod)、谷... 详细信息

研究不同时间点(1、2、4、8、16 d)及修复期(26 d)、不同浓度(0、0.06、0.3、1.5 mg/L)二溴海因(DBDMH)对雄性吉富罗非鱼血浆中抗氧化酶基因的基因毒性,筛选稳定的生物标志物。实时荧光定量PCR方法检测DBDMH对超氧化物歧化酶(sod)、谷胱甘肽-S-转移酶(gst)、谷胱甘肽还原酶(gr)、谷胱甘肽过氧化物酶1(gpx1)、过氧化氢酶(cat)基因表达的影响。中浓度组雄性吉富罗非鱼血浆抗氧化酶基因(除gr)表达受DBDMH胁迫诱导显著上调;各DBDMH浓度组1 d(sod,gst,gpx1),2 d(gst,gr)抗氧化基因表达呈现浓度依赖性下降,4 d sod,gpx1基因表达呈现浓度依赖性上升;8 d中浓度DBDMH处理组基因表达(gst,gr,gpx1)显著低于低浓度组;恢复试验阶段,中、高浓度DBDMH组各抗氧化酶基因表达均不能恢复到正常水平。0.3 mg/L DBDMH显著增强雄性吉富罗非鱼血浆所测抗氧化酶基因的表达(除1 d gpx1、cat,8和16 d gr),此浓度下抗氧化酶基因作为标志物较合适。

关键词：吉富罗非鱼二溴海因血浆抗氧化酶基因

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Correction: CEPC Technical Design Report: Accelerator

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Radiation Detection Technology and Methods 2024年第1期9卷 184-192页

作者： Abdallah, Waleed de Freitas, Tiago CarlosAdorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ays¸e Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Bieko¨tter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, Xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D’Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, Cairo University Giza Egypt Xi’an Jiaotong-Liverpool University Suzhou China Institute of Power Engineering of National Academy of Sciences of Belarus Minsk Belarus Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad Pakistan Applied Physics Department Science and Technology Federal Urdu University of Arts Islamabad Pakistan Zhengzhou University Zhengzhou China Institute of High Energy Physics Chinese Academy of Sciences Beijing China University of California Santa Cruz Santa Cruz USA Nanjing University Nanjing China Beijing Normal University Beijing China Harvard University Cambridge USA South China Normal University Guangzhou China University of Basel Basel Switzerland High Energy Accelerator Research Organization (KEK) Tsukuba Japan Joint Institute for Nuclear Research Dubna Russia Faculty of Sciences and Techniques Université Abdelmalek Essaadi Tangier Morocco Southeast University Nanjing China Department of Physics University of Wisconsin–Madison Madison USA Instituto de Alta Investigación Universidad de Tarapacá Arica Chile Monash University Melbourne Australia Laboratoire de Physique des 2 infinis Irène Joliot-Curie – IJCLab Orsay France Peking University Beijing China Department of Physics and Nanotechnology SRM Institute of Science and Technology Kattankulathur India Shandong University Jinan China University of New Mexico Albuquerque USA Bandirma Onyedi Eylul University Bandırma Turkey National Centre for Nuclear Research Warsaw Poland Indian Institute of Technology Madras (IN) Chennai India University of Southampton Southampton UK INFN Milano - LASA Segrate Italy Sun Yat-Sen University Guangzhou China China Institute of Atomic Energy Beijing China INFN-University of Torino Turin Italy Karlsruhe Institute of Technology Institute for Theoretical Physics Karlsruhe Germany INFN-Sezione di Roma Tre Rome Italy Kutaisi International University Kutaisi Georgia Soochow University Suzhou China Budker Institute

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PEDV亚单位疫苗免疫增强剂的筛选

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华北农学报 2016年第2期31卷 205-210页

作者：陈瑾黄春娟于晓明侯立婷乔绪稳郑其升侯继波江苏省农业科学院国家兽用生物制品工程技术研究中心江苏南京210014 江苏省动物重要疫病与人兽共患病防控协同创新中心江苏扬州225009

为了研究PEDV的新型亚单位疫苗,提高PEDV亚单位疫苗的免疫原性,选取免疫增强剂CVC1302、CVC1303与国家兽用生物制品工程技术研究中心构建的可溶性表达PEDV S蛋白核心表位COE的重组蛋白(p QZCOE-LTB)混合乳化制成疫苗,免疫4周龄的ICR小鼠... 详细信息

为了研究PEDV的新型亚单位疫苗,提高PEDV亚单位疫苗的免疫原性,选取免疫增强剂CVC1302、CVC1303与国家兽用生物制品工程技术研究中心构建的可溶性表达PEDV S蛋白核心表位COE的重组蛋白(p QZCOE-LTB)混合乳化制成疫苗,免疫4周龄的ICR小鼠,首免14 d后加免1次,随后采集首免14(加强免疫前),21,28,55 d的小鼠血清,分别用琼扩试验的方法定性检测血清IgG抗体以及用ELISA试剂盒定量检测小鼠血清IgG抗体滴度动态变化,肠组织sIgA抗体滴度。结果表明,重组蛋白与CVC1303配合使用免疫小鼠能产生显著高于灭活苗(CV777)阳性对照组的IgG和sIgA抗体水平,说明CVC1303免疫增强剂能有效增强该重组蛋白的免疫原性,提高亚单位疫苗免疫效果。

关键词：猪流行性腹泻病毒核心抗原表位免疫增强剂免疫效力

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