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山西化工 2024年第9期44卷 201-203页

作者：周松伟范俊豪郑旭文汪晓军佛山化尔铵生物科技有限公司广东佛山528300 华南理工大学环境与能源学院广东广州510006

本研究搭建了一套前置反硝化-亚硝化-厌氧氨氧化小试实验装置对PCB工业园废水进行了处理,实验结果表明,前置反硝化-亚硝化系统能够完成对PCB废水的除碳以及部分亚硝化处理,经过此套系统处理后的废水满足厌氧氨氧化进水要求。整套小试实... 详细信息

本研究搭建了一套前置反硝化-亚硝化-厌氧氨氧化小试实验装置对PCB工业园废水进行了处理,实验结果表明,前置反硝化-亚硝化系统能够完成对PCB废水的除碳以及部分亚硝化处理,经过此套系统处理后的废水满足厌氧氨氧化进水要求。整套小试实验装置在面对变化较大的进水水质的情况下,依然取得了较好的处理效果,平均出水氨氮质量浓度仅为6.5 mg/L,平均出水总氮质量浓度为20.1 mg/L,平均出水COD值为74.7 mg/L。在厌氧氨氧化反应器内出现了耦合反硝化现象,经过厌氧氨氧化处理后的出水硝氮浓度低于亚硝化出水。根据实验结果,作者也提出了利用厌氧氨氧化工艺处理PCB工业园废水的工程实施建议。

关键词： PCB工业园废水厌氧氨氧化亚硝化反硝化

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鸭肉发酵菌株筛选及发酵工艺研究

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中州大学学报 2023年第4期40卷 125-128页

作者：冯冲姚虹陈红锦乔书豪郑绪文郑州工程技术学院化工食品学院河南郑州450044

以鸭脯肉作为原料,以感官评分和pH值为指标,通过单因素和正交试验确定最佳菌株及发酵条件。结果表明,最佳条件为红曲霉菌和酿酒酵母菌的质量配比1:1、接种量0.06%、发酵时间8 h、发酵温度28℃。通过质构分析可知,鸭肉发酵产品比未发酵... 详细信息

以鸭脯肉作为原料,以感官评分和pH值为指标,通过单因素和正交试验确定最佳菌株及发酵条件。结果表明,最佳条件为红曲霉菌和酿酒酵母菌的质量配比1:1、接种量0.06%、发酵时间8 h、发酵温度28℃。通过质构分析可知,鸭肉发酵产品比未发酵产品具有硬度低、胶着性高,咀嚼性稍高,黏性高、弹性低等特点,口感品质更好。

关键词：鸭脯肉发酵工艺条件优化质构分析

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A CHARACTERIZATION OF CAPILLARY SPHERICAL CAPS BY A PARTIALLY OVERDETERMINED PROBLEM IN A HALF BALL

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PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY 2025年第1期153卷 161-170页

作者： Jia, Xiaohan Lu, zheng Xia, Chao Zhang, xuwen Southeast Univ Sch Math Nanjing 211189 Peoples R China Xiamen Univ Sch Math Sci Xiamen 361005 Peoples R China Albert Ludwigs Univ Freiburg Math Inst D-79104 Freiburg Germany Goethe Univ Inst Math D-60325 Frankfurt Germany Univ Freiburg Math Inst Ernst Zermelo Str1 D-79104 Freiburg Germany

In this paper, we study a Serrin-type partially overdetermined problem proposed by Guo-Xia [Calc. Var. Partial Differential Equations (2019), Paper No. 160, 15], and prove a rigidity result that characterizes capillar... 详细信息

关键词： Key words and phrases. Serrin's overdetermined problem mixed boundary value problem capillary hypersurfaces. capillary hypersurfaces

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Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping

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MODERN PATHOLOGY 2021年第6期34卷 1093-1103页

作者： Credle, Joel J. Robinson, Matthew L. Gunn, Jonathan Monaco, Daniel Sie, Brandon Tchir, Alexandra Hardick, Justin zheng, xuwen Shaw-Saliba, Kathryn Rothman, Richard E. Eshleman, Susan H. Pekosz, Andrew Hansen, Kasper Mostafa, Heba Steinegger, Martin Larman, H. Benjamin Johns Hopkins Univ Dept Pathol Immunol Div Inst Cell Engn Baltimore MD 21218 USA Johns Hopkins Univ Sch Med Dept Med Div Infect Dis Baltimore MD 21205 USA Johns Hopkins Univ Dept Emergency Med Sch Med Baltimore MD USA Johns Hopkins Univ Div Transfus Med Dept Pathol Baltimore MD USA Johns Hopkins Bloomberg Sch Publ Hlth W Harry Feinstone Dept Mol Microbiol & Immunol Baltimore MD USA Johns Hopkins Univ Dept Biostat Baltimore MD 21205 USA Johns Hopkins Univ Div Med Microbiol Dept Pathol Baltimore MD USA Seoul Natl Univ Biol Sci Seoul South Korea Seoul Natl Univ Inst Mol Biol & Genet Seoul South Korea

There is an urgent and unprecedented need for sensitive and high-throughput molecular diagnostic tests to combat the SARS-CoV-2 pandemic. Here we present a generalized version of the RNA-mediated oligonucleotide Annealing Selection and Ligation with next generation DNA sequencing (RASL-seq) assay, called "capture RASL-seq" (cRASL-seq), which enables highly sensitive (down to similar to 1-100 pfu/ml or cfu/ml) and highly multiplexed (up to similar to 10,000 target sequences) detection of pathogens. Importantly, cRASL-seq analysis of COVID-19 patient nasopharyngeal (NP) swab specimens does not involve nucleic acid purification or reverse transcription, steps that have introduced supply bottlenecks into standard assay workflows. Our simplified protocol additionally enables the direct and efficient genotyping of selected, informative SARS-CoV-2 polymorphisms across the entire genome, which can be used for enhanced characterization of transmission chains at population scale and detection of viral clades with higher or lower virulence. Given its extremely low per-sample cost, simple and automatable protocol and analytics, probe panel modularity, and massive scalability, we propose that cRASL-seq testing is a powerful new technology with the potential to help mitigate the current pandemic and prevent similar public health crises.

关键词： Diagnostic markers Viral infection

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In-Hospital Amantadine Does Not Improve Outcomes After Severe Traumatic Brain Injury: An 11-Year Propensity-Matched Retrospective Analysis

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WORLD NEUROSURGERY 2023年 177卷 E277-E287页

作者： Passman, Justin N. Cleri, Nathaniel A. Saadon, Jordan R. Naddaf, Nicki Gilotra, Kevin Swarna, Sujith Vagal, Vaibhav zheng, xuwen Zhang, Jason Wong, Jeffrey Asencio, Anthony Wang, Cassie Khalili, Andrew Hou, Wei Mofakham, Sima Mikell, Charles B. Renaissance Sch Med Dept Neurosurg Stony Brook NY 11794 USA SUNY Stony Brook Dept Family Populat & Prevent Med Stony Brook NY USA SUNY Stony Brook Dept Elect & Comp Engn Stony Brook NY USA

BACKGROUND: Disruption of dopamine neurotransmis-sion is associated with functional impairment after severe traumatic brain injury (sTBI). This has prompted the study of dopamine agonists, such as amantadine, to assist re-covery of consciousness. Randomized trials have mostly addressed the posthospital setting, with inconsistent findings. Therefore, we evaluated the efficacy of early amantadine administration on recovery of consciousness after ***: We searched the medical records of all pa-tients with sTBI admitted to our hospital between 2010 and 2021 who survived 10 days postinjury. We identified all patients receiving amantadine and compared them with all patients not receiving amantadine and a propensity score-matched nonamantadine group. Primary outcome measures included discharge Glasgow Coma Scale, Glasgow Outcome Scale-Extended score, length of stay, mortality, recovery of command-following (CF), and days to CF. -RESULTS: In our study population, 60 patients received amantadine and 344 did not. Compared with the propensity score-matched nonamantadine group, the amantadine group had no difference in mortality (86.67% vs. 88.33%, P = 0.783), rates of CF (73.33% vs. 76.67%, P = 0.673), or percentage of patients with severe (3-8) discharge Glas-gow Coma Scale scores (11.11% vs. 12.28%, P = 0.434). In addition, the amantadine group was less likely to have a favorable recovery (discharge Glasgow Outcome Scale-Extended score 5-8) (14.53% vs. 16.67%, P < 0.001), had a longer length of stay (40.5 vs. 21.0 days, P < 0.001), and had a longer time to CF (11.5 vs. 6.0 days, P = 0.011). No dif-ference in adverse events existed between ***: Our findings do not support the early administration of amantadine for sTBI. Larger inpatient randomized trials are necessary to further investigate amantadine treatment for sTBI.

关键词： Amantadine Coma Recovery of consciousness Severe traumatic brain injury TBI outcomes TBI treatment

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Rigidity and quantitative stability for partially overdetermined problems and capillary CMC hypersurfaces

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CALCULUS OF VARIATIONS AND PARTIAL DIFFERENTIAL EQUATIONS 2024年第5期63卷 125-125页

作者： Jia, Xiaohan Lu, zheng Xia, Chao Zhang, xuwen Southeast Univ Sch Math Nanjing 211189 Peoples R China Xiamen Univ Sch Math Sci Xiamen 361005 Peoples R China Albert Ludwigs Univ Freiburg Math Inst D-79104 Freiburg Im Breisgau Germany Goethe Univ Inst Math D-60325 Frankfurt Germany

In this paper, we first prove a rigidity result for a Serrin-type partially overdetermined problem in the half-space, which gives a characterization of capillary spherical caps by the overdetermined problem. In the second part, we prove quantitative stability results for the Serrin-type partially overdetermined problem, as well as capillary almost constant mean curvature hypersurfaces in the half-space.

关键词： 35N25 53A10 35B35 35A23

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Ultra-efficient sequencing of T Cell receptor repertoires reveals shared responses in muscle from patients with Myositis

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EBIOMEDICINE 2020年 59卷 102972-102972页

作者： Montagne, Janelle M. zheng, xuwen Alice Pinal-Fernandez, Iago Milisenda, Jose C. Christopher-Stine, Lisa Lloyd, Thomas E. Mammen, Andrew L. Larman, H. Benjamin Johns Hopkins Univ Sch Med Div Immunol Pathol Dept Baltimore MD 21218 USA Johns Hopkins Univ Sch Med Inst Cell Engn Baltimore MD 21218 USA NIAMSD Muscle Dis Unit Lab Muscle Stem Cells & Gene Regulat NIH Bethesda MD 20892 USA Johns Hopkins Univ Sch Med Dept Neurol Baltimore MD 21205 USA Univ Barcelona Hosp Clin Internal Med Dept Barcelona Spain Ctr Invest Med Red Enfermedades Raras Madrid Spain Johns Hopkins Univ Sch Med Div Rheumatol Baltimore MD USA

Background: Myositis, or idiopathic inflammatory myopathy (IIM), is a group disorders of unknown etiology characterized by the inflammation of skeletal muscle. The role of T cells and their antigenic targets in IIM initiation and progression is poorly understood. T cell receptor (TCR) repertoire sequencing is a powerful approach for characterizing complex T cell responses. However, current TCR sequencing methodologies are complex, expensive, or both, greatly limiting the scale of feasible studies. Methods: Here we present Framework Region 3 AmplifiKation sequencing ("FR3AK-seq"), a simplified multiplex PCR-based approach for the ultra-efficient and quantitative analysis of TCR complementarity determining region 3 (CDR3) repertoires. By using minimal primer sets targeting a conserved region immediately upstream of CDR3, undistorted amplicons are analyzed via short read, single-end sequencing. We also introduce the novel algorithm Inferring Sequences via Efficiency Projection and Primer Incorporation ("ISEPPI") for linking CDR3s to their associated variable genes. Findings: We find that FR3AK-seq is sensitive and quantitative, performing comparably to two different industry standards. FR3AK-seq and ISEPPI were used to efficiently and inexpensively characterize the T cell infiltrates of surgical muscle biopsies obtained from 145 patients with IIM and controls. A cluster of closely related TCRs was identified in samples from patients with sporadic inclusion body myositis (IBM). Interpretation: The ease and minimal cost of FR3AK-seq removes critical barriers to routine, large-scale TCR CDR3 repertoire analyses, thereby democratizing the quantitative assessment of human TCR repertoires in disease-relevant target tissues. Importantly, discovery of closely related TCRs in muscle from patients with IBM provides evidence for a shared antigen-driven T cell response in this disease of unknown pathogenesis. (C) 2020 The Authors. Published by Elsevier B.V.

关键词： TCR repertoire Myositis Idiopathic Inflammatory myopathy Autoimmunity

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Unbiased discovery of autoantibodies associated with severe COVID-19 via genome-scale self-assembled DNA-barcoded protein libraries

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NATURE BIOMEDICAL ENGINEERING 2022年第8期6卷 992-+页

作者： Credle, Joel J. Gunn, Jonathan Sangkhapreecha, Puwanat Monaco, Daniel R. zheng, xuwen Alice Tsai, Hung-Ji Wilbon, Azaan Morgenlander, William R. Rastegar, Andre Dong, Yi Jayaraman, Sahana Tosi, Lorenzo Parekkadan, Biju Baer, Alan N. Roederer, Mario Bloch, Evan M. Tobian, Aaron A. R. Zyskind, Israel Silverberg, Jonathan, I Rosenberg, Avi Z. Cox, Andrea L. Lloyd, Tom Mammen, Andrew L. Larman, H. Benjamin Johns Hopkins Univ Sch Med Dept Pathol Div ImmunolInst Cell Engn Baltimore MD 21205 USA Univ Birmingham Sch Biosci Inst Microbiol & Infect Birmingham W Midlands England Johns Hopkins Univ Sch Med Ctr Cell Dynam Baltimore MD USA Johns Hopkins Univ Sch Med Dept Cell Biol Baltimore MD USA Rutgers State Univ Dept Biomed Engn Piscataway NJ USA Johns Hopkins Univ Sch Med Dept Med Div Rheumatol Baltimore MD 21205 USA NIAID ImmunoTechnol Sect Vaccine Res Ctr NIH 9000 Rockville Pike Bethesda MD 20892 USA Johns Hopkins Univ Sch Med Dept Pathol Div Transfus Med Baltimore MD 21205 USA NYU Langone Med Ctr Dept Pediat New York NY USA Maimonides Hosp Dept Pediat Brooklyn NY 11219 USA George Washington Univ Sch Med & Hlth Sci Dept Dermatol Washington DC 20052 USA Johns Hopkins Univ Sch Med Dept Pathol Div Kidney Urol Pathol Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Med Div Infect Dis Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Neurol & Neurosurg Baltimore MD USA Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD USA Natl Inst Arthrit & Musculoskeletal & Skin Dis Muscle Dis Unit NIH Bethesda MD USA Johns Hopkins Univ Sch Med Dept Med Baltimore MD 21205 USA

Pathogenic autoreactive antibodies associated with severe COVID-19 can be identified via self-assembled genome-scale libraries of full-length proteins covalently coupled to uniquely identifying DNA barcodes for analysis by sequencing. Pathogenic autoreactive antibodies that may be associated with life-threatening coronavirus disease 2019 (COVID-19) remain to be identified. Here, we show that self-assembled genome-scale libraries of full-length proteins covalently coupled to unique DNA barcodes for analysis by sequencing can be used for the unbiased identification of autoreactive antibodies in plasma samples. By screening 11,076 DNA-barcoded proteins expressed from a sequence-verified human ORFeome library, the method, which we named MIPSA (for Molecular Indexing of Proteins by Self-Assembly), allowed us to detect circulating neutralizing type-I and type-III interferon (IFN) autoantibodies in five plasma samples from 55 patients with life-threatening COVID-19. In addition to identifying neutralizing type-I IFN-alpha and IFN-omega autoantibodies and other previously known autoreactive antibodies in patient plasma, MIPSA enabled the detection of as yet unidentified neutralizing type-III anti-IFN-lambda 3 autoantibodies that were not seen in healthy plasma samples or in convalescent plasma from ten non-hospitalized individuals with COVID-19. The low cost and simple workflow of MIPSA will facilitate unbiased high-throughput analyses of protein-antibody, protein-protein and protein-small-molecule interactions.

关键词： Antibodies

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Intelligent optimization of cold radial forging process for 20CrMnTiH alloy based on GA-BP and performance analysis

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2024年第9-10期135卷 4281-4307页

作者： Xu, Wenxia Wang, Zhaohui Zhu, xuwen Zhang, Bowen zheng, Zecheng Lv, Mi Wang, Hongxia Wuhan Univ Sci & Technol Key Lab Met Equipment & Control Technol Minist Educ Wuhan 430081 Hubei Peoples R China Wuhan Univ Sci & Technol Hubei Key Lab Mech Transmiss & Mfg Engn Wuhan 430081 Hubei Peoples R China Chongqing Construction Ind Grp Co Ltd Chongqing 400054 Peoples R China Hubei Univ Automot Technol Coll Mech Engn Shiyan 442002 Hubei Peoples R China

Cold radial forging (CRF) is recognized as one of the most effective manufacturing processes for the production of hollow components. Nonetheless, even minor alterations in the alloy composition during the cold deformation processing phase can significantly influence the material's manufacturability. This study addresses the challenges associated with high optimization costs, complex data acquisition, and the prediction of forming quality when integrating multiple processes, such as heat treatment and material composition. We propose the development of an intelligent predictive model aimed at forecasting the forming quality of the 20CrMnTiH alloy during CRF, utilizing a back-propagation neural network optimized by genetic algorithm (GA-BP). The assessment of forming quality is based on parameters such as damage, residual stress, and equivalent strain. The study investigates the impact of alloy composition and spheroidal annealing (SA) process parameters on forming quality. The performance of the three GA-BP prediction models is superior in terms of the coefficient of determination (R2) and mean square error (MSE), when compared to a conventional BP neural network and four other machine learning techniques, including gradient-boosted decision trees, random forests, support vector regression, and logistic regression. A comprehensive comparative analysis of the evaluation metrics across all three prediction models, alongside multi-objective optimization, indicates that the Pareto solution set generated by NSGA-II exhibits optimal distribution uniformity. The optimized process parameters (0.17%C-0.24%Si-0.81%Mn-0.03%P-0.03%S-1.15%Cr-0.05%Ni-0.06%Ti, Te: 60 degrees C, ATi: 4.57 h) resulted in a reduction of residual stresses by 12%, equivalent strain by 15%, and component damage by 30%. The results demonstrate that the methodology proposed in this paper not only enhances the quality of CRF molding but also significantly improves the accuracy of the predictive model for f

关键词： 20CrMnTiH alloy Cold radial forging Alloy composition Spheroidizing annealing GA-BP neural network

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Laser Ultrasonic Lamb Wave Damage Detection Method Based on the Single Transmitter and Multiple Receivers Circular Array 4th

Laser Ultrasonic Lamb Wave Damage Detection Method Based on ...

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4th International Conference on Intelligent Systems in Production Engineering and Maintenance, ISPEM 2023

作者： zheng, Shanpu Luo, Ying Wang, xuwen Xu, Chenguang Faculty of Civil Engineering and Mechanics Jiangsu University Zhenjiang212013 China Ganzhou Special Equipment Supervision and Inspection Center Jiangxi Ganzhou341000 China School of Physics and Electronic Engineering Jiangsu University Zhenjiang212013 China

ISBN: (纸本)9783031442810

Laser ultrasonic Lamb wave detection technology provides technical support for noncontact and online large plate/shell structure detection. Improving detection accuracy and efficiency has always been the goal of inspection personnel. In this paper, we have built a noncontact laser ultrasonic Lamb wave detection platform to achieve rapid localization of abnormal damage in aluminum alloy plates. First, analyze laser ultrasonic Lamb waves’ modal types and wavelength components. Design and optimize a circular laser array based on near-field beamforming theory, with a single transmitter at the center and multiple receivers around the circumference. After extracting single-frequency components using wavelet transform, the azimuth of the scattering wave is estimated using the near-field 2D multiple signal classification(2D-MUSIC). The advantage is that there is no need to collect the reference signal or add window filtering to intercept the wave packet. The results indicate that damage within the 900 cm2 area can be localized within 0.7 s, and the orientation error is within 6°. This method is an efficient method to achieve damage orientation in a large area. However, the problem of the low resolution and artifact interference in multi-damage estimation presented by this method is urgent to be solved in the future. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Beamforming

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