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中国矿业 2019年第6期28卷 133-138页

作者：章丽萍马项阳吴胜念薛静雯郑洋何绪文中国矿业大学(北京)化学与环境工程学院

菱镁矿尾矿煅烧后产生的轻烧镁粉对于酸性矿井水的处理具有效果好、操作条件良好、沉渣少等优点。通过对轻烧镁粉的成分分析可知,主要成分氧化镁占比高于90%。以山西某煤矿酸性矿井水为研究对象,对其进行常规水质分析可知,总铁浓度为230... 详细信息

菱镁矿尾矿煅烧后产生的轻烧镁粉对于酸性矿井水的处理具有效果好、操作条件良好、沉渣少等优点。通过对轻烧镁粉的成分分析可知,主要成分氧化镁占比高于90%。以山西某煤矿酸性矿井水为研究对象,对其进行常规水质分析可知,总铁浓度为230.01mg/L、亚铁离子浓度为66.98mg/L、pH值为3.24。采用轻烧镁粉进行酸性矿井水处理,设计正交实验,分析初始pH值、药剂投加量、曝气量、曝气时间等对处理效果的影响。实验结果表明,在投加轻烧镁粉量为0.50~1.00g/L时,酸性矿井水初始pH值可由3.15~3.31提高到6~9左右,缓冲性能较好,较容易控制投加量使pH值控制在6~9;轻烧镁粉处理酸性矿井水时三个主要因素的影响程度大小为:投加量>搅拌时间>搅拌速度,当轻烧镁粉投加量为0.85g/L、搅拌速度为400r/min、搅拌时间为12min时,实验效果较好;利用轻烧镁粉提高酸性矿井水的pH值到7.48时,曝气5min,曝气量为0.5m3/h,聚合氯化铝(PAC)投加量为10mg/L时,经处理矿井水中亚铁离子和总铁浓度可分别降至0.07mg/L和0.17mg/L,满足排放或回用水对总铁的要求,且改善了沉渣的沉降性能,大大缩短了沉降时间。

关键词：轻烧镁粉酸性矿井水总铁 PAC 沉降性能创新实验

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基于男同社交媒体的无锡市市区男男性行为者规模估计研究

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中国艾滋病性病 2019年第5期25卷 468-471页

作者：孟晓军王旭雯尹寒露张轩邹华春顾静无锡市疾病预防控制中心江苏无锡214023 中山大学公共卫生学院(深圳) 广东深圳518107

目的估计无锡市市区男男性行为者(MSM)规模,为艾滋病疫情估计提供依据。方法利用乘数法结合MSM交友软件估计无锡市市区男男性行为人群规模。通过男同社交媒体Blued后台统计连续一周内每天登录过软件的人数,从而获得目标人群数r;通过RDS... 详细信息

目的估计无锡市市区男男性行为者(MSM)规模,为艾滋病疫情估计提供依据。方法利用乘数法结合MSM交友软件估计无锡市市区男男性行为人群规模。通过男同社交媒体Blued后台统计连续一周内每天登录过软件的人数,从而获得目标人群数r;通过RDS方法招募研究对象并开展问卷调查,获得乘数m,由此计算MSM规模估计数N=r×m。结果无锡市市区MSM规模估计数为25 460人[95%可信区间(CI):24 915～26 032]。其中,常住的MSM 21 717人(95%CI=21 310～22 252),流动的MSM有3 743人(95%CI=3 259～4 226);城镇MSM 16 218人(95%CI=14 945～17 618),农村的MSM有9 242人(95%CI=8 529～9 929);自认为同性恋的MSM有14 970人(95%CI=13 774～16 269),自认为双性恋的MSM有8 427人(95%CI=7 587～9 344);为同性提供过商业性服务的MSM 2 521人(95%CI=1 986～3 183)。结论利用乘数法结合MSM社交媒体估计MSM的规模具有一定的可行性和可信性。

关键词：乘数法规模估计男男性行为者社交媒体App

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Identification of Ly2 members as antimicrobial peptides from zebrafish Danio rerio

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BIOSCIENCE REPORTS 2017年第1期37卷 BSR20160265-BSR20160265页

作者： Liu, Xuemin Cao, xuwen Wang, Su Ji, Guangdong zhang, Shicui Li, Hongyan Ocean Univ China Inst Evolut & Marine Biodivers Dept Marine Biol Qingdao 266003 Peoples R China Ocean Univ China Dept Marine Biol Lab Evolut & Dev Qingdao 266003 Peoples R China

The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic of antimicrobial peptides (AMPs) and their expression were all significantly up-regulated after challenge with lipopolysaccharide (LPS). These strongly suggested that Ly2.1-3 are potential AMPs, but firm evidence are lacking. Here, we clearly showed that the recombinant proteins of Ly2.1-3 were capable of killing Gram-negative bacteria Aeromonas hydrophila and Escherichia coli, while they had little bactericidal activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. We also showed that recombinant proteins Ly2.1-3 (rLy2.1-3) were able to bind to the Gram-negative bacteria A. hydrophila, E. coli and the microbial signature molecule LPS, but not to the Gram-positive bacteria S. aureus and B. subtilis as well as the microbial signature molecule LTA. Moreover, the Scatchard analysis revealed that rLy2.1-3 could specifically bind to LPS. Finally, we found that Ly2.1-3 were not cytotoxic to mammalian cells. All these together indicate that Ly2.1-3 can function as AMPs.

关键词： zebrafish Danio rerio Ly6 gene cluster Antimicrobial peptides

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Paecilomyces variotii extracts（ZNC） enhance plant immunity and promote plant growth

Paecilomyces variotii extracts（ZNC） enhance plant immunity...

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中国植物病理学会2019年学术年会

作者： Lu Chongchong Liu Haifeng Jiang Depeng Wang Lulu Jiang Yanke Tang Shuya Hou xuwen Han Xinyi Liu Zhiguang zhang Min Chu Zhaohui Ding Xinhua State Key Laboratory of Crop Biology Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect PestsShandong Agricultural University Shandong Pengbo Biotechnology Co. LTD National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources College of Recourses and EnvironmentShandong Agricultural University

The crude extract of the endophytePaecilomyces variotii known as ZhiNengCong（ZNC）has function of promoting plant growth and enhancing disease resistance and is widely used in *** study aims to evaluate the molecular mechanisms of plant growth promotion and disease *** generated transcriptome profiles from ZNC-treated seedlings using RNA *** function of salicylic acid（SA） in ZNC-mediated immunity was examined using SA biosynthesis and signaling pathway *** concentrations of nitrogen（N） and phosphorus（P） in seedlings under ZNC treatment were *** effect of ZNC on the level of the hormone auxin in roots was tested using transgenic plants containing DR5:*** exhibited ultrahigh activity in promoting plant growth and enhancing disease resistance,even at concentrations as low as 1-10 ng/*** induced ROS accumulation,callose deposition,and expression of PR *** biosynthesis and signaling pathways were required for the ZNC-mediated defense ***,in improving plant growth,ZNC increased the level of auxin in root tips and regulated the absorption of N and *** to these results,ZNC is a highly effective plant elicitor that promotes plant growth by inducing auxin accumulation at the root tip at low concentrations and enhances plant disease resistance by activating the SA signaling pathway at high concentrations.

关键词： Plant elicitors Plant growth promotion Plant endophyte Disease resistance Auxin Salicylic acid

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芯片原子钟MEMS原子气室数字温控系统设计

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半导体技术 2019年第6期44卷 410-414,420页

作者：刘召军李坤李云超胡旭文闫树斌张彦军中北大学电子测试技术国防科技重点实验室太原030051 中北大学仪器科学与动态测试教育部重点实验室太原030051 北京动力机械研究所北京100074

芯片原子钟(CSAC)可以提供精准的时间基准,具有较好的应用前景。利用微型PIC~?单片机和增量式比例-微分-积分(PID)算法设计了一种CSAC微电子机械系统(MEMS)原子气室数字温控系统,并通过磁控溅射方法制作了MEMS原子气室专用的氧化铟锡(I... 详细信息

芯片原子钟(CSAC)可以提供精准的时间基准,具有较好的应用前景。利用微型PIC~?单片机和增量式比例-微分-积分(PID)算法设计了一种CSAC微电子机械系统(MEMS)原子气室数字温控系统,并通过磁控溅射方法制作了MEMS原子气室专用的氧化铟锡(ITO)加热玻璃。温度是影响CSAC稳定度的一个重要因素,解决了CSAC系统气室温控的加热不均匀问题,温控精度达到了0.10℃,达到了CSAC温控精度优于0.15℃的要求。通过饱和吸收光谱实验,获得了明显的饱和吸收谱线。实验结果为高性能CSAC的研究提供了参考。

关键词：芯片原子钟(CSAC) 数字温控饱和吸收微电子机械系统(MEMS)原子气室氧化铟锡(ITO)加热玻璃

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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds

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JOURNAL OF IMMUNOLOGY RESEARCH 2018年第1期2018卷 1-13页

作者： Deng, Zhuo Wang, Jing Lyu, Wentao Wieneke, xuwen Matts, Robert Ma, Xi zhang, Guolong Oklahoma State Univ Dept Anim & Food Sci Stillwater OK 74078 USA Beijing Acad Agr & Forestry Sci Inst Anim Husb & Vet Med Beijing 100097 Peoples R China Oklahoma State Univ Dept Biochem & Mol Biol Stillwater OK 74078 USA China Agr Univ State Key Lab Anim Nutr Beijing 100193 Peoples R China Oklahoma State Univ Ctr Vet Hlth Sci Dept Physiol Sci Stillwater OK 74078 USA

Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. Augmenting the synthesis of endogenous host defense peptides (HDPs) has emerged as a promising antibiotic-alternative approach to disease control and prevention. To facilitate the identification of HDP inducers for swine use, we developed a stable luciferase reporter cell line, IPEC-J2/PBD3-luc, through permanent integration of a luciferase reporter gene driven by a 1.1 kb porcine beta-defensin 3 (PBD3) gene promoter in porcine IPEC-J2 intestinal epithelial cells. Such a stable reporter cell line was employed in a high-throughput screening of 148 epigenetic compounds and 584 natural products, resulting in the identification of 41 unique hits with a minimum strictly standardized mean difference (SSMD) value of 3.0. Among them, 13 compounds were further confirmed to give at least a 5-fold increase in the luciferase activity in the stable reporter cell line, with 12 being histone deacetylase (HDAC) inhibitors. Eight compounds were subsequently observed to be comparable to sodium butyrate in inducing PBD3 mRNA expression in parental IPEC-J2 cells in the low micromolar range. Six HDAC inhibitors including suberoylanilide hydroxamine (SAHA), HC toxin, apicidin, panobinostat, SB939, and LAQ824 were additionally found to be highly effective HDP inducers in a porcine 3D4/31 macrophage cell line. Besides PBD3, other HDP genes such as PBD2 and cathelicidins (PG1-5) were concentration-dependently induced by those compounds in both IPEC-J2 and 3D4/31 cells. Furthermore, the antibacterial activities of 3D4/31 cells were augmented following 24 h exposure to HDAC inhibitors. In conclusion, a cell-based high-throughput screening assay was developed for the discovery of porcine HDP inducers, and newly identified HDP-inducing compounds may have potential to be developed as alternatives to antibiotics for applications in swine and possibly other anima

关键词： ANTIBIOTICS PEPTIDES LUCIFERASES DEFENSINS EPITHELIAL cells HISTONE deacetylase inhibitors HIGH throughput screening (Drug development)

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改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带胫骨止点撕脱骨折的疗效比较

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中华创伤骨科杂志 2019年第5期21卷 378-383页

作者：刘炜洁陈峰叶发刚戚超宫海峰张成栋王开钱源李绪文青岛大学附属医院创伤外科 266000

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕... 详细信息

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕脱骨折患者资料。男24例,女17例;年龄18~65岁,平均39岁;左膝22例,右膝19例;根据固定方式不同将患者分为2组:改良切开组23例(行改良Burks-Schaffer入路切开复位空心钉固定),关节镜组18例(行关节镜下Endobutton带袢钢板固定)。术后比较两组患者的手术时间、出血量、膝关节各项客观评分及膝关节活动度(ROM)等情况。结果41例患者术后获23~40个月(平均27.2个月)随访。所有患者均未出现切口感染、骨折畸形愈合或不愈合、固定装置松动等并发症。末次随访时膝关节X线片示撕脱骨折均已达到骨性愈合标准。改良切开组与关节镜组手术时间分别为(52.6±7.3)、(86.8±9.2)min,出血量分别为(63.9±12.7)、(19.7±10.2)mL,以上项目两组间比较差异均有统计学意义(P<0.05)。而两组患者在膝关节各项客观评分及ROM方面差异均无统计学意义(P>0.05)。结论改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗PCL胫骨止点撕脱骨折均能获得满意效果,后者出血少,但前者在手术时间方面更具优势。

关键词：膝关节关节镜检查骨折固定术,内后交叉韧带胫骨止点撕脱骨折改良Burks-Schaffer入路

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溶剂型氯丁橡胶胶粘剂研究进展

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材料开发与应用 2019年第5期34卷 83-87页

作者：李景瑞李煜张玲王绪文中国船舶重工集团公司第七二五研究所河南洛阳471023 河南省减振降噪材料工程技术中心河南洛阳471023

介绍了氯丁橡胶(CR)胶粘剂特点和溶剂型CR胶粘剂溶剂研究情况,并对溶剂型CR胶粘剂发展方向进行了展望。

关键词：氯丁橡胶胶粘剂混配型接枝型

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Correction: CEPC Technical Design Report: Accelerator

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Radiation Detection Technology and Methods 2024年第1期9卷 184-192页

作者： Abdallah, Waleed de Freitas, Tiago CarlosAdorno Afanaciev, Konstantin Ahmad, Shakeel Ahmed, Ijaz Ai, Xiaocong Aleem, Abid Altmannshofer, Wolfgang Alves, Fabio An, Weiming An, Rui Anderle, Daniele Paolo Antusch, Stefan Arai, Yasuo Arbuzov, Andrej Arhrib, Abdesslam Ashry, Mustafa Bai, Sha Bai, Yu Bai, Yang Bairathi, Vipul Balazs, Csaba Bambade, Philip Ban, Yong Bandyopadhyay, Triparno Bao, Shou-Shan Barber, Desmond P. Bat, Ays¸e Batozskaya, Varvara Behera, Subash Chandra Belyaev, Alexander Bertucci, Michele Bi, Xiao-Jun Bi, Yuanjie Bian, Tianjian Bianchi, Fabrizio Bieko¨tter, Thomas Biglietti, Michela Bilanishvili, Shalva Binglin, Deng Bodrov, Denis Bogomyagkov, Anton Bondarenko, Serge Boogert, Stewart Boonekamp, Maarten Borri, Marcello Bosotti, Angelo Boudry, Vincent Boukidi, Mohammed Boyko, Igor Bozovic, Ivanka Bozzi, Giuseppe Brient, Jean-Claude Budzinskaya, Anastasiia Bukhari, Masroor Bytev, Vladimir Cacciapaglia, Giacomo Cai, Hua Cai, Wenyong Cai, Wujun Cai, Yijian Cai, Yizhou Cai, Yuchen Cai, Haiying Cai, Huacheng Calibbi, Lorenzo Cang, Junsong Cao, Guofu Cao, Jianshe Chance, Antoine Chang, Xuejun Chang, Yue Chang, Zhe Chang, Xinyuan Chao, Wei Chatrabhuti, Auttakit Che, Yimin Che, Yuzhi Chen, Bin Chen, Danping Chen, Fuqing Chen, Fusan Chen, Gang Chen, Guoming Chen, Hua-Xing Chen, Huirun Chen, Jinhui Chen, Ji-Yuan Chen, Kai Chen, Mali Chen, Mingjun Chen, Mingshui Chen, Ning Chen, Shanhong Chen, Shanzhen Chen, Shao-Long Chen, Shaomin Chen, Shiqiang Chen, Tianlu Chen, Wei Chen, Xiang Chen, Xiaoyu Chen, Xin Chen, Xun Chen, Xurong Chen, Ye Chen, Ying Chen, Yukai Chen, Zelin Chen, Zilin Chen, Boping Chen, Chunhui Cheng, Hok Chuen Cheng, Huajie Cheng, Shan Cheng, Tongguang Chi, Yunlong Chimenti, Pietro Chiu, Wen Han Cho, Guk Chu, Ming-Chung Chu, Xiaotong Chu, Ziliang Coloretti, Guglielmo Crivellin, Andreas Cui, Hanhua Cui, Xiaohao Cui, Zhaoyuan D’Anzi, Brunella Dai, Ling-Yun Dai, Xinchen Dai, xuwen De Maria, Antonio De Filippis, Nicola De La Taille, Christophe De Mori, Francesca De Sio, Chiara Del Core, Elisa Deng, Cairo University Giza Egypt Xi’an Jiaotong-Liverpool University Suzhou China Institute of Power Engineering of National Academy of Sciences of Belarus Minsk Belarus Pakistan Institute of Nuclear Science and Technology (PINSTECH) Islamabad Pakistan Applied Physics Department Science and Technology Federal Urdu University of Arts Islamabad Pakistan Zhengzhou University Zhengzhou China Institute of High Energy Physics Chinese Academy of Sciences Beijing China University of California Santa Cruz Santa Cruz USA Nanjing University Nanjing China Beijing Normal University Beijing China Harvard University Cambridge USA South China Normal University Guangzhou China University of Basel Basel Switzerland High Energy Accelerator Research Organization (KEK) Tsukuba Japan Joint Institute for Nuclear Research Dubna Russia Faculty of Sciences and Techniques Université Abdelmalek Essaadi Tangier Morocco Southeast University Nanjing China Department of Physics University of Wisconsin–Madison Madison USA Instituto de Alta Investigación Universidad de Tarapacá Arica Chile Monash University Melbourne Australia Laboratoire de Physique des 2 infinis Irène Joliot-Curie – IJCLab Orsay France Peking University Beijing China Department of Physics and Nanotechnology SRM Institute of Science and Technology Kattankulathur India Shandong University Jinan China University of New Mexico Albuquerque USA Bandirma Onyedi Eylul University Bandırma Turkey National Centre for Nuclear Research Warsaw Poland Indian Institute of Technology Madras (IN) Chennai India University of Southampton Southampton UK INFN Milano - LASA Segrate Italy Sun Yat-Sen University Guangzhou China China Institute of Atomic Energy Beijing China INFN-University of Torino Turin Italy Karlsruhe Institute of Technology Institute for Theoretical Physics Karlsruhe Germany INFN-Sezione di Roma Tre Rome Italy Kutaisi International University Kutaisi Georgia Soochow University Suzhou China Budker Institute

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Chemical compositions of mussels and clams from the Tangyin and Yonaguni Knoll IV hydrothermal fields in the southwestern Okinawa Trough

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ORE GEOLOGY REVIEWS 2017年 87卷 172-191页

作者： Zeng, Zhigang Chen, Shuai Ma, Yao Yin, Xuebo Wang, Xiaoyuan zhang, Suping zhang, Junlong Wu, xuwen Li, Yang Dong, Dong Xiao, Ning Chinese Acad Sci Inst Oceanol Key Lab Marine Geol & Environm Seafloor Hydrothermal Act Lab 7 Nanhai Rd Qingdao 266071 Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Mineral Resources Qingdao 266071 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Qingdao Collaborat Innovat Ctr Marine Sci & Techn Qingdao 266061 Peoples R China Chinese Acad Sci Inst Oceanol Marine Biol Museum Qingdao 266071 Peoples R China

Studies of the chemical characteristics of mussels and clams in seafloor hydrothermal fields are important for understanding mass fluxes and elemental partitioning from hydrothermal vents into the biosphere, metal bioaccumulation of seafloor hydrothermal ecosystems, and the sources and sinks of biogeochemical and fluid cycles. We are the first to measure the mineral, major, trace and rare earth element, and carbon and oxygen isotope compositions of mussels (Bathymodiolus platifrons) and clams (Conchocele bisecta) from the Tangyin and Yonaguni Knoll IV hydrothermal fields in the southwestern Okinawa Trough. Mineralogical analysis shows that the carbonate shells of the mussel and clam samples are mainly composed of calcite and aragonite. Metal elements exhibit linear correlations in the shells (e.g., V and U) and tissues (e.g., Li and Rb) of the mussels and clams, suggesting that not all positive correlations of elements in tissues are inherited by the shells. V/As, Ca/Sr, and Fe/Cr ratios in the mussels and clams are close to those in the seawater, indicating that element ratios of seawater might be inherited by the mussels and clams. In addition, the Fe/Cr ratio of the shells of both mussels and clams can be used to trace the local seawater composition. The total LREE concentrations of mussel and clam tissue samples are higher than those of the mussel and clam shell samples, are similar to the hydrothermal fluids, exhibit LREE enrichment (La-CN/Nd-CN ratios = 1.86-32.1), and no or only slightly negative Eu anomalies, indicating that benthic animals are a sink of LREEs from hydrothermal fluids, and that the Eu/Eu* ratios of fluids change when fluids are incorporated into the tissues of the mussels and clams. In addition, the delta C-13 values of mussel shell samples are heavier than those of the clam shell samples in the hydrothermal field, indicating that more than one carbon source may be involved in defining the delta C-13 compositions of the shells. The majority

关键词： Mussel Clam C hemical composition Tangyin and Yonaguni Knoll IV hydrothermal fields

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