Rheumatoid arthritis(RA)is a chronic autoimmune disorder characterized by persistent joint inflammation leading to bone and cartilage damage and even ***,the pathogenesis of RA is multi-factorial and to a large degree...
Rheumatoid arthritis(RA)is a chronic autoimmune disorder characterized by persistent joint inflammation leading to bone and cartilage damage and even ***,the pathogenesis of RA is multi-factorial and to a large degree,remains *** Sini decoction(DSD),a traditional Chinese medicine(TCM)formula,has been widely used as a remedy for rheumatoid arthritis(RA)in recent *** our study,1H-nuclear magnetic resonance(1H-NMR)based metabolomics analysis of 7 potential biomarkers,including taurine(1),urea(2),betaine(3),pyruvate(4),hippurate(5),succinate(6)and acetone(7)was performed to investigate the progression of RA and assess the efficacy of DSD in collagen-induced arthritis(CIA)*** to pathway analysis using identified metabolites and correlation construction,taurine and hypotaurine metabolism,gut microbiota metabolism,pyruvate metabolism,glycolysis/gluconeogenesis,the citrate cycle(TCA cycle)and lipid metabolism were recognized as being the most influenced metabolic pathways associated with *** a result,deviations of metabolites 1,3,4,5,6 and 7 in CIA rats were improved by DSD,which suggested that DSD mediated the abnormal metabolic pathways *** summary,the efficacy and its underlying therapeutic mechanisms of DSD on RA were systematically investigated and expect to provide a new insight in relevant studies of other TCM formulas.
Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical ...
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ISBN:
(纸本)9781509040940
Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical explorations, this syndrome can be treated with a group of herbal medicines in TCM. However, their molecular level biological functions are still not clear. In this study, a set of algorithms e.g., hypergeometric distribution, Jaccard index, and recursive programming for hierarchy network were deployed in the context gene/protein functional similarity and enrichment analysis. The analysis was mainly focused on the associated herbal medicines, their chemical compounds, target proteins' similarity, and gene ontology terms' hierarchical network overrepresentation through the enrichment analysis of hypergeometric distribution with P-value set to 0.05. As a result, these associated herbs share low level (
Owing to relatively simplistic domestic hardware technology and a lack of on-orbit geometric calibration, particularly interior calibration, the positioning accuracies of Optical-1 HR satellites can vary greatly depen...
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ISBN:
(纸本)9781628418910
Owing to relatively simplistic domestic hardware technology and a lack of on-orbit geometric calibration, particularly interior calibration, the positioning accuracies of Optical-1 HR satellites can vary greatly depending on the presence of ground control points (GCPs). Without GCPs, accuracies are typically lower than 100 pixels, whereas when GCPs are plentiful, accuracy is higher than one pixel, demonstrating the potential for a large discrepancy between international optical satellites with the same image resolution. This study investigated a new method of geometric calibration for Optical-1 HR satellites. Experiments were conducted to demonstrate the positive effects on positioning accuracy achieved by the calibration method. After calibration by our method, a positioning accuracy of higher than one pixel was obtained with only a small number of GCPs, which is equivalent to the accuracy of advanced international optical satellites with the same image resolution.
Organic and inorganic sedimentary parameters in and off the Changjiang Estuary have been analyzed to reconstruct historical trends in eutrophication and hypoxia over the last century. The lipid biomarker concentration...
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Organic and inorganic sedimentary parameters in and off the Changjiang Estuary have been analyzed to reconstruct historical trends in eutrophication and hypoxia over the last century. The lipid biomarker concentrations in the Changjiang Estuary mud area,(CEMA) indicated eutrophication accelerated after the 1970s. Meanwhile, Mo/Al indicated hypoxia has increased since 1960s. Eutrophication and hypoxia in the CEMA are primarily a result of the dramatically increased load of terrestrial nutrients from the Changjiang to the East China Sea. The lipid biomarker concentrations in the southwest Cheju Island mud area (SCIMA) showed primary production is controlled mainly by changes in regional climate and marine current. No significant hypoxia occurred in the SCIMA over the past century as indicated by Mo/Al. Therefore, geochemical indicators of eutrophication and hypoxia revealed different patterns between the CEMA and SCIMA, suggesting the role of river-derived nutrients in sustaining eutrophication and hypoxia in the CEMA since the 1960s. (C) 2015 Elsevier Ltd. All rights reserved.
BACKGROUND: Fetal electrocardiography (FECG) places electrodes on the maternal abdomen to convert the fetal electrocardiosignals into fetal heart rate (FHR), improving the accuracy and comfort of pregnant woman. At th...
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BACKGROUND: Fetal electrocardiography (FECG) places electrodes on the maternal abdomen to convert the fetal electrocardiosignals into fetal heart rate (FHR), improving the accuracy and comfort of pregnant woman. At the same time, FECG simplifies the procedure of long term monitoring in the perinatal period. OBJECTIVE: Investigating the influence of gestational age and time of day on FHR features to distinguish between non-stress test (NST) normal fetuses and NST suspicious fetuses. METHODS: A novel method of FHR baseline estimation was presented;then baseline value and fetal heart rate variation (FHRV) were analyzed in the time domain using FHR signals recorded from 52 fetuses. RESULTS: Baseline values in 1: 00, 2: 00, 4: 00, 5: 00 and heart rate variation (HRV) distribution showed a significant difference (p < 0.05) between NST normal fetuses and NST suspicious fetuses. CONCLUSIONS: The results suggest that NST normal and suspicious fetuses had same outcome and different FHR features. Accurately distinguishing normal fetuses and suspicious fetuses is important for lowering the false positive rate and reducing unnecessary clinical intervention.
研究不同时间点(1、2、4、8、16 d)及修复期(26 d)、不同浓度(0、0.06、0.3、1.5 mg/L)二溴海因(DBDMH)对雄性吉富罗非鱼血浆中抗氧化酶基因的基因毒性,筛选稳定的生物标志物。实时荧光定量PCR方法检测DBDMH对超氧化物歧化酶(sod)、谷胱甘肽-S-转移酶(gst)、谷胱甘肽还原酶(gr)、谷胱甘肽过氧化物酶1(gpx1)、过氧化氢酶(cat)基因表达的影响。中浓度组雄性吉富罗非鱼血浆抗氧化酶基因(除gr)表达受DBDMH胁迫诱导显著上调;各DBDMH浓度组1 d(sod,gst,gpx1),2 d(gst,gr)抗氧化基因表达呈现浓度依赖性下降,4 d sod,gpx1基因表达呈现浓度依赖性上升;8 d中浓度DBDMH处理组基因表达(gst,gr,gpx1)显著低于低浓度组;恢复试验阶段,中、高浓度DBDMH组各抗氧化酶基因表达均不能恢复到正常水平。0.3 mg/L DBDMH显著增强雄性吉富罗非鱼血浆所测抗氧化酶基因的表达(除1 d gpx1、cat,8和16 d gr),此浓度下抗氧化酶基因作为标志物较合适。
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