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Extracellular Vesicles Separation and Biomedical Application Based on Affinity Recognition and Antifouling Coating Bifunctional Microsphere

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ANALYTICAL CHEMISTRY 2025年第8期97卷 4542-4548页

作者： He, Yuxing Kang, Jia Yang, xuwen Deng, Nan Hui, Lingyun Yu, Yunxuan Bian, Yangyang Tao, Fufang Duan, Xinrui zhang, Jing Shaanxi Normal Univ Sch Chem & Chem Engn Key Lab Analyt Chem Life Sci Shaanxi Prov Xian 710119 Shaanxi Peoples R China Xi An Jiao Tong Univ Instrumental Anal Ctr Xian 710049 Shaanxi Peoples R China Xi An Jiao Tong Univ Affiliated Hosp 1 Xian 710061 Shaanxi Peoples R China Northwest Univ Coll Life Sci Key Lab Resource Biol & Modern Biotechnol Western Xian 710069 Shaanxi Peoples R China Shaanxi Prov Drug Tech Evaluat Ctr Xian 710065 Shaanxi Peoples R China

Extracellular vesicles (EVs) are crucial mediators in various physiological and pathological processes, facilitating intercellular communication and offering potential as diagnostic disease markers. However, existing EVs separation methods have limitations that hinder their clinical application. In this study, we present a novel approach using bifunctional silica microspheres (SiO2-PTB-PS) for the specific, nondestructive isolation of EVs from complex biological media. The isolated EVs were subsequently used for direct cancer detection in clinical samples. The SiO2-PTB-PS microspheres, functionalized with a phosphatidylserine (PS) recognition peptide (PSpep), specifically bound to PS on the EVs surface. Additionally, an anti-adhesion coating on the silica microspheres minimized protein contamination, enhancing purity. This affinity-based recognition and antifouling strategy ensured high-purity EVs separation. Furthermore, we developed a detection system combining SiO2-PTB-PS microspheres with surface-enhanced Raman scattering (SERS) nanoprobes to identify protein tyrosine kinase 7 (PTK7) and epithelial cell adhesion (EpCAM) on the EVs membrane, achieving 80% precision in distinguishing cancer patients from healthy donors. The SiO2-PTB-PS microsphere system shows significant promise as a biotechnology tool, advancing the clinical application of EVs-based diagnostics.

关键词： Microspheres

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MONOTONICITY FORMULAS FOR CAPILLARY SURFACES

arXiv

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arXiv 2024年

作者： Wang, Guofang Xia, Chao zhang, xuwen Mathematisches Institut Universität Freiburg Ernst-Zermelo-Str.1 Freiburg79104 Germany School of Mathematical Sciences Xiamen University Xiamen361005 China

In this paper, we establish monotonicity formulas for capillary surfaces in the half-space R3+ and in the unit ball B3 and extend the result of Volkmann [27] for surfaces with free boundary. As applications, we obtain Li-Yau-type inequalities for the Willmore energy of capillary surfaces, and extend Fraser-Schoen’s optimal area estimate for minimal free boundary surfaces in B3 [10] to the capillary setting, which is different to another optimal area estimate proved by Brendle in [5].MSC Codes 53C42, 53A10, 49Q15 Copyright © 2024, The Authors. All rights reserved.

关键词： Capillarity

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Cascading oxidoreductases-like nanozymes for high selective and sensitive fiuorescent detection of ascorbic acid

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Chinese Chemical Letters 2025年第4期36卷 627-632页

作者： Ying Wang Hong Yang Caixia Zhu Qing Hong xuwen Cao Kaiyuan Wang Yuan Xu Yanfei Shen Songqin Liu Yuanjian zhang Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Devices Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189China

Compared with natural enzymes, nanozymes have the advantages of high stability and low cost;however,selectivity and sensitivity are key issues that prevent their further development. In this study, we report a cascade nanozymatic system with significantly improved selectivity and sensitivity that combines more substrate-specific reactions and sensitive fiuorescence detection. Taking detection of ascorbic acid(AA)as an example, a cascade catalytic reaction system consisting of oxidase-like N-doped carbon nanocages(NC) and peroxidase-like copper oxide(Cu O) improved the reaction selectivity in transforming the substrate into the target product by more than 1200 times against the interference of uric acid. The cascade catalytic reaction system was also applicable for transfer from open reactors into a spatially confined microfiuidic device, increasing the slope of the calibration curves by approximately 1000-fold with a linear detection range of 2.5 nmol/L to 100 nmol/L and a low limit of detection of 0.77 nmol/L. This work offers a new strategy that achieves significant improvements in selectivity and sensitivity.

关键词： Nanozyme Fluorescence Selectivity Sensitivity Ascorbic acid

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Research on alkali corrosion resistance and life prediction of glass fiber recycled concrete based on grey system theory

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STRUCTURES 2025年 75卷

作者： Yang, Wenrui Huang, Yuewen Wu, Weiwei Huang, Weihua Xiong, Xiaolong Li, Chengwei Zhong, xuwen Liu, Liai Zhou, Hai zhang, Xun East China Univ Technol Sch Civil & Architectural Engn Nanchang 330012 Peoples R China Hong Kong Polytech Univ Dept Civil & Environm Engn Hung Hom Kowloon Hong Kong Peoples R China Univ British Columbia Sch Engn Kelowna BC V1V 1V7 Canada Jiangxi Ganyue Expressway Co Ltd Nanchang Peoples R China Power China Jiangxi Elect Power Engn Co Ltd Nanchang Peoples R China

In this paper, four kinds of recycled concrete with 0 %, 0.5 %, 1.0 %, and 1.5 % glass fiber volume ratios were prepared to investigate the alkali corrosion resistance life of glass fiber recycled concrete in an alkaline environment. The alkali solution erosion test, uniaxial compression test, and scanning electron microscope (SEM) test were carried out, respectively. The results show that glass fiber can reduce the mass loss of recycled concrete in an alkaline environment, improve its compressive strength, and prolong its alkali resistance life. When the volume ratio of glass fiber was 1.0 %, the mass loss was reduced by 0.65 %, the compressive strength was increased by 11.22 %, and the alkali corrosion life was prolonged by 40 days, up to 183 days. Based on the grey degree theory GM(1,1), the compressive strength and corrosion resistance coefficient prediction models of glass fiber recycled concrete were established. The accuracy grade of the compressive strength prediction model and the corrosion resistance coefficient prediction model were level 1 (good), indicating that the accuracy of the prediction model was good, which provided a certain theoretical basis for the research in related fields of glass fiber recycled concrete in an alkaline environment.

关键词： Recycled concrete Glass fiber Gray prediction model GM(1,1) Alkaline environment Compressive strength

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CAPILLARY SCHWARZ SYMMETRIZATION IN THE HALF-SPACE

arXiv

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arXiv 2023年

作者： Lu, Zheng Xia, Chao zhang, xuwen School of Mathematical Sciences Xiamen University Xiamen361005 China Mathematisches Institut Albert-Ludwigs-Universität Freiburg Freiburg im Breisgau79104 Germany Institut für Mathematik Goethe-Universität Frankfurt60325 Germany

In this paper, we introduce a notion of capillary Schwarz symmetrization in the half-space. It can be viewed as the counterpart of the classical Schwarz symmetrization in the framework of capillary problem in the half-space. A key ingredient is a special anisotropic gauge, which enables us to transform the capillary symmetrization to the convex symmetrization introduced in [Alv+97].MSC Codes 35J25, 35J65, 49Q20 Copyright © 2023, The Authors. All rights reserved.

关键词： Anisotropy

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Occurrence, transfer rule, and dietary risk assessment of aflatoxins in medicinal and edible seeds

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FOOD BIOSCIENCE 2025年 63卷

作者： Lv, Jianxin zhang, Huiru Wang, xuwen Luo, Jiaoyang Wang, Yudan Kong, Dandan Wang, Chuang Guo, Mengyue Yang, Meihua Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst & Resources Utilizat Chinese Minist Educ Beijing 100193 Peoples R China Peking Union Med Coll Beijing 100193 Peoples R China Chinese Acad Med Sci Hainan Branch Inst Med Plant Dev Haikou 570311 Peoples R China

The last three decades have seen a rise in the use of herbal remedies and supplements, with more than 80% of the world's population relying on them for primary care. However, aflatoxin contamination in herbal remedies may constitute a risk to human health. In this study, a simple and robust method for the simultaneous detection of aflatoxins in four types of medicinal and edible seeds was developed by using UFLC-MS/MS combined with QuECHERS pretreatment. Meanwhile, the transfer rule of the aflatoxins in medicinal and edible seeds during the decoction process was explored, followed by dietary risk assessment based on Monte Carlo simulation. Results showed that aflatoxin contamination was found in 80.6% of the samples (62/77), with the contamination levels of 0.04-258.72 mu g/kg. Notably, high levels of aflatoxins were found in Ziziphi Spinosae Semen and Platycladi Semen, while low aflatoxin transfer rates (1.13%-11.86%) were observed during the decoction process. The estimated daily intake (EDI) of AFB1 could reach 15.314 and 0.333 ng/kg bw/day by ingesting aflatoxinsusceptible Ziziphi Spinosae Semen and Platycladi Semen, respectively. The population cancer risks ranged from 3.34 x 10- 8 to 2.86 x 10-4 hepatocellular carcinoma cases per 105 persons per year. The probabilistic risk assessment indicated a short-term and long-term health concern of intaking these two medicinal and edible seeds contaminated by aflatoxins. This study revealed the occurrence and transfer pattern of aflatoxins in the medicinal and edible seeds and evaluated the risks of their dietary exposure, providing a basis for their safe use.

关键词： Medicine food homology Aflatoxin Detection Transfer rule Risk assessment

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Finite element analysis of corn kernel damage: a viscoelastic model approach for impact-induced damage prediction

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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 2025年第7期105卷 3993-4004页

作者： Zhao, Xuelin zhang, Qiang Fang, xuwen zhang, Jinsong Feng, Weijing zhang, Li Zhou, Deyi Yu, Chunsheng Wang, Hao Gao, Xiaodi Zhou, Haigen Wu, Xinling Jilin Univ Coll Biol & Agr Engn Changchun 130022 Peoples R China

BACKGROUNDIn the present study, we address the quality degradation of corn during post-harvest processing by developing a viscoelastic composite model to predict kernel damage during post-harvest processing. The model, based on high-resolution scanning and inverse modeling techniques, provides an accurate representation of the complex internal components of corn kernels, which allows for the analysis of their stress response and damage susceptibility trends under different impact *** results show that the viscoelastic model has a relative error of 2.4% compared to the drop test data, thus demonstrating that the viscoelastic model has a very high accuracy in predicting impact damage and is able to accurately localize the flour-like endosperm as the main region of impact damage. The model showed a high correlation (0.99) between predicted and experimental damage rates by response surface *** damage during processing is reduced by reducing the proportion of flour-like endosperm in maize kernels. A new method for reducing damage during food handling and processing operations is proposed, providing an important reference for improving kernel durability and contributing to the development of gentler processing techniques to improve the quality of maize products. (c) 2025 Society of Chemical Industry.

关键词： viscoelastic composite model collision damage finite element method burgers model high moisture corn kernel

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Size and Charge Dual-Switchable Nanoparticles for Achieving Chemosensitization and Immune Infiltration against Pancreatic Ductal Adenocarcinoma

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ADVANCED FUNCTIONAL MATERIALS 2025年第1期35卷

作者： Song, Haolin Chen, Hongyi Chen, Qinjun Fan, Hongrui Li, Chufeng Wang, Yu zhang, Shilin Li, xuwen Su, Boyu Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Pancreatic ductal adenocarcinoma (PDAC), one of the most challenging cancers, is uniquely characterized by a biological barrier composed of multiple components in the extracellular matrix, preventing penetration of chemotherapeutic agents and hindering clinical drug treatment. Collagen I arrangement is critical. In this study, gemcitabine is chosen as the chemotherapeutic agent and dasatinib as the collagen-I-disrupting agent. When collagen I arrangement is disrupted, not only the chemotherapeutic drug enters the tumor area better, but the infiltration of CD8+ T cells into the tumor also increases. Therefore, a hypoxia-responsive linker-crosslinked polymer, DGD/L@GBI, is designed, which can be simultaneously loaded with two therapeutic agents, gemcitabine and dasatinib. The polymer is encapsulated by nucleic acid aptamers that target the PDAC stromal microenvironment and shield the surface. The aptamer is removed upon arrival at the PDAC hypoxic microenvironment, exposing the positively charged core to achieve charge reversal. Particle size transformation is achieved using linkers that respond to a hypoxic microenvironment. Increased intratumoral penetration is achieved using the dual transformation capabilities of the formulation. Pairing these two agents can result in a powerful efficacy in chemotherapy sensitization and immune infiltration.

关键词： charge reversal chemosensitization immune infiltration pancreatic ductal adenocarcinoma size reduction

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HEINTZE-KARCHER INEQUALITY FOR ANISOTROPIC FREE BOUNDARY HYPERSURFACES IN CONVEX DOMAINS

arXiv

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arXiv 2023年

作者： Jia, Xiaohan Wang, Guofang Xia, Chao zhang, xuwen School of Mathematical Sciences Xiamen University Xiamen361005 China Mathematisches Institut Universität Freiburg Ernst-Zermelo-Str.1 Freiburg79104 Germany Institut Für Mathematik Goethe-Universität Robert-Mayer-Str.10 Frankfurt60325 Germany

In this paper, we prove an optimal Heintze-Karcher-type inequality for anisotropic free boundary hypersurfaces in general convex domains. The equality is achieved for anisotropic free boundary Wulff shapes in a convex cone. As applications, we prove various Alexandrov-type *** Codes 53C45, 53A10, 53C42 Copyright © 2023, The Authors. All rights reserved.

关键词： Anisotropy

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A High-Performance n-Type Thermoelectric Polymer from C-H/C-H Oxidative Direct Arylation Polycondensation

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023年第20期62卷 e202219262-e202219262页

作者： Shi, Yibo zhang, xuwen Du, Tian Han, Yang Deng, Yunfeng Geng, Yanhou Tianjin Univ Collaborat Innovat Ctr Chem Sci & Engn Tianjin Sch Mat Sci & Engn Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Joint Sch Natl Univ Singapore & Tianjin Univ Int Campus Fuzhou 350207 Peoples R China

n-Type conjugated polymers (CPs) are crucial in the applications of organic electronics. Direct coupling of electron-deficient C-H monomer via selective C-H activation, namely C-H/C-H oxidative direct arylation polycondensation (Oxi-DArP), is an ideal approach toward such CPs. Herein, Oxi-DArP is firstly adopted to synthesize a high-performance n-type CP using a newly developed monomer, i.e., 3,6-di(thiazol-5-yl)-diketopyrrolopyrrole (Tz-5-DPP). Tz-5-DPP based homopolymer PTz-5-DPP with a molecular weight of 22 kDa has been synthesized via Oxi-DArP. After n-doping, PTz-5-DPP films exhibited electric conductivity values up to 8 S cm(-1) and power factors (PFs) up to 106 mu W m(-1) K-2. Notably, this PF value is the highest for n-type polymer thermoelectric materials to date. The Oxi-DArP synthesis and the excellent n-type performance of the polymer make this work an important step toward the straightforward and sustainable preparation of high-performance n-type polymer semiconductors.

关键词： Conjugated Polymer Diketopyrrolopyrrole Direct Arylation Polycondensation Electron Transport Organic Thermoelectrics

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