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Comparison of macro and micro-pollutants abatement from biotreated landfill leachate by single ozonation, O3/H2O2, and catalytic ozonation processes

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CHEMICAL ENGINEERING JOURNAL 2023年第Part4期452卷

作者： Wang, Hao zhang, Siyu He, xuwen Yang, Yongyuan Yang, Xuetong Van Hulle, Stijn W. H. China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China Univ Ghent Dept Green Chem & Technol LIWET Campus KortrijkGraaf Karel Goedelaan 5 B-8500 Kortrijk Belgium Tsinghua Univ Ctr Water & Ecol Sch Environm State Key Joint Lab Environm Simulat & Pollut Cont Beijing 100084 Peoples R China

Micropollutants (MPs) in landfill leachate have attracted increasing attention because they pose a potential threat to the aquatic environment and ecosystems once discharged into nearby aquifers without proper treat-ment. Although ozone-based oxidative techniques perform well for the removal of MPs in low-strength water streams, their role in leachate containing high dissolved organic matter (DOM) concentration requires further exploration. Moreover, it is unclear the mechanism of different ozone-based processes in advanced treatment for biotreated landfill leachate. This study compared the single ozonation and two ozone-based advanced oxidation processes (AOPs, heterogeneous catalytic ozonation and O3/H2O2 process) for polishing biotreated leachate. The mechanism of different ozone-based processes during leachate treatment was explored, which facilitates selecting of the appropriate process based on leachate quality and target treatment requirements. The removal efficiency and energy requirements of the macro and micro-pollutants were evaluated. The results revealed that the role of catalytic ozonation is mainly to enhance the direct ozone oxidation, whereas the O3/H2O2 process is to promote the indirect oxidation. The strengthening effect was most visible in the early stage (specific transferred ozone dose (STOD) < 2 gO3/gDOC) for catalytic ozonation, whereas it was more pronounced in the later stage for the O3/H2O2 process. The removal of UV-quenching substances correlated well with the elimination of MPs (R2 > 0.95), which provides a surrogate-based predictive model for the removal of MPs from high-strength leachate. Catalytic ozonation consumed the least amount of energy when the desired chemical oxygen demand (COD) removal was <= 35 %, otherwise, the O3/H2O2 process was the most energy-efficient. In any process, MPs with O3 or center dot OH reactivity could achieve more than 90 % elimination when the COD removal exceeded 30 %.

关键词： Landfill leachate Ozone-based AOPs Micropollutants Surrogate-based prediction OH yield Energy consumption

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Organic metal matrix Mil-88a nano-enzyme for joint repair in the osteoarthritis mouse model

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2023年 11卷 1164942页

作者： Hu, Hao Huang, Xu Dai, Yankun Zhu, Kairun Ye, xuwen Meng, Shengdong zhang, Qing Xie, Xueguan Huaian Second Peoples Hosp Huaian Peoples R China

Introduction: In this paper we tried to conduct a novel nanomaterial strategy to overcome osteoarthritis (OA) in a mouse model. Methods: In this regard, after synthesizing the Mil-88a nanozyme, as a certain Fe-MOF, its toxic effects were detected by CCK-8 method and live-dead staining. The OA model of mouse was constructed, and paraffin sections of joints were taken for histological evaluation. In addition, immunofluorescence and immunohistochemistry were used to identify the OA progression and OARSI was used to evaluate the OA grades. We observed that Mil-88a could be easily synthesized and has high biocompatibility. Results: We observed that Mil-88a could significantly promote the expression of OA anabolism-related genes such as Col2 and also significantly inhibit the expression of OA catabolism-related genes MMP13. Besides, we observed better OARSI score in animals treated with Mil-88a nano-enzyme loading on organic metal matrix. Discussion: Overall, Mil-88a nano-enzyme could be used as a novel strategy to treat OA.

关键词： nano-enzyme osteoarthritis mouse model Mil-88a organic metal

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Experimental Study on the Evolution of Hydrate Formation and Blockage in a Water-Dominated Bubbly Flow System

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SSRN 2023年

作者： Kong, Qingwen Qin, xuwen Wang, Zhiyuan zhang, Jianbo Tong, Shikun Sun, Baojiang Qingdao266580 China Department of Basic Investigation China Geological Survey Beijing100083 China National Engineering Research Center of Oil & Gas Drilling and Completion Technology Qingdao266580 China

During deepwater oil and gas drilling and hydrate production testing, water-dominated bubbly flow patterns may appear in the wellbore and drainage pipeline. Hydrate formation in bubbly flow may cause hydrate blockage and threaten the flow safety. In this study, a newly built high-pressure flow loop and a focused beam reflectance measurement device were used to investigate the evolution of hydrate formation and blockage in bubbly flow. The concentration and rate of hydrate rapid formation were mainly influenced by the initial flow velocity and maximum subcooling of the system. Considering the bubble breakage, coalescence and deformation, a kinetic model of hydrate rapid formation in bubbly flow was established based on the correction of the reaction rate factor K, and the model error was experimentally verified to be less than 15%. Hydrate aggregates in the range of 150–500 μm caused severe flow barriers, and three significant events were proposed to characterize the evolution degree of hydrate aggregation and blockage in bubbly flow. The critical initial flow velocity of 0.65±0.05 m/s determines whether hydrate aggregates with particle sizes larger than 150 μm will appear immediately when the hydrate is formed. And two main mechanisms of hydrate blockage in water-dominated bubbly flow were revealed. This study is expected to lay the foundation for hydrate flow assurance in wellbores and pipelines. © 2023, The Authors. All rights reserved.

关键词： Flow velocity

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Co-regulation of indole glucosinolates and camalexin biosynthesis by CPK5/CPK6 and MPK3/MPK6 signaling pathways^°°

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Journal of Integrative Plant Biology 2020年第11期62卷 1780-1796页

作者： Liuyi Vang Yan zhang Rongxia Guan Sen Li xuwen Xu Shuqun zhang Juan Xu State Key Lab oratory of Plant Physiology and Biochem istry College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Division of Biochemistry University of MissouriColumbiaMO 65211USA

Secondary plant metabolites,represented by indole glucosinolates(IGS)and camalexin,play important roles in Arabidopsis ***,we demonstrated the importance of MPK3 and MPK6,two closely related MAPKs,in regulating Botrytis cinerea(Bc)-induced IGS and camalexin *** we report that CPK5 and CPK6,two redundant calcium-dependent protein kinases(CPKs),are also involved in regulating the biosynthesis of these secondary *** loss-of-function of both CPK5 and CPK6 compromises plant resistance to *** profiling of CPK5-VK transgenic plants,in which a truncated constitutively active CPK5 is driven by a steroidinducible promoter,revealed that biosynthetic genes of both IGS and camalexin pathways are coordinately upregulated after the induction of CPK5-VK,leading to high-level accumulation of camalexin and 4-methoxyindole-3-ylmethylglucosinolate(4MI3G).Induction of camalexin and 4MI3G,as well as the genes in their biosynthesis pathways,is greatly compromised in cpks cpk6 mutant in response to *** a conditional cpk5 cpk6 mpk3 mpk6 quadruple mutant,Be resistance and induction of IGS and camalexin are further reduced in comparison to either cpks cpk6 or conditional mpk3 mpk6 double mutant,suggesting that both CPK5/CPK6 and MPK3/MPK6 signaling pathways contribute to promote the biosynthesis of 4MI3G and camalexin in defense against Be.

关键词： indole coordinate constitutive

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外剪内框结构体系力学计算与抗震性能

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东南大学学报(自然科学版) 2025年第1期55卷 1-8页

作者：张文津肖绪文肖建庄李水生丁陶吕凤悟周泉同济大学土木工程学院上海200092 中国建筑第八工程局有限公司上海200120 中国建筑第五工程局有限公司长沙410004

为灵活设计商场、库房等大开间建筑的内部空间,提出了一种外剪内框结构体系,即在普通框架结构四周布置剪力墙,将其作为主要抗侧力构件,内部框架结构主要承担竖向荷载。推导了外剪内框结构体系的内力分析方法,提出了框架与剪力墙相对刚... 详细信息

为灵活设计商场、库房等大开间建筑的内部空间,提出了一种外剪内框结构体系,即在普通框架结构四周布置剪力墙,将其作为主要抗侧力构件,内部框架结构主要承担竖向荷载。推导了外剪内框结构体系的内力分析方法,提出了框架与剪力墙相对刚度控制参数的计算公式与设计方法。基于某4层框架结构,设计了对应的外剪内框结构,评估了外剪内框结构体系的抗震性能与抗倒塌能力。结果表明,外剪内框结构体系内部框架柱截面面积相对较小,可以实现更大的建筑空间,框架-剪力墙相对刚度的设计方法可用于实际设计。材料用量相同时,外剪内框结构较框架结构抗震性能更好,其抗侧刚度提升30.3%,极限承载力提高7.3%,罕遇地震下基底剪力减小13.8%,顶点位移减小66.3%,最大层间位移角减小74.3%。

关键词：外剪内框结构体系剪力分担比弹性计算方法刚度设计抗震性能

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YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation

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HELIYON 2023年第8期9卷 e18876页

作者： Ma, Bo Cao, Pei zhang, Lichen Zhu, Hongyi Ye, xuwen Wang, Lingjun Chen, Liang Peking Univ Dept Trauma & Orthoped Peoples Hosp Beijing Peoples R China Nankai Univ Sch Med Tianjin Peoples R China Soochow Univ Affiliated Hosp 1 Dept Gen Surg Suzhou 215006 Jiangsu Peoples R China Soochow Univ Affiliated Hosp 1 Orthoped Inst Dept Orthoped Suzhou 215006 Jiangsu Peoples R China

As the most abundant internal mRNA modification, N6-methyladenosine (m6A) RNA methylation has been found to influence many biological events including bone mesenchymal stem cells (BMSCs) osteogenic differentiation. YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) is an m6A reading protein with the ability to mediate the decay of combined methylated mRNA, however its role in BMSCs osteogenic differentiation remains unknown. In this study, we first found an increase of RUNX family transcription factor 2 (RUNX2) expression and a decrease of YTHDC2 expression during the process of BMSCs osteogenic dif-ferentiation. Furthermore, we transfected BMSCs with YTHDC2 interference fragment, resulting in an increased content of RUNX2 mRNA and protein inside BMSCs. Finally, through RNA Immunoprecipitation experiments, we confirmed that YTHDC2 protein can bind to RUNX2 mRNA and accelerate its decomposition. Moreover, the immunofluorescence staining also showed a negative correlation between YTHDC2 and RUNX2. In conclusion, during BMSCs osteogenic differentiation, YTHDC2 protein showed decreased expression, resulting in a higher level of RUNX2 (mRNA and protein) expression inside cells, indicating YTHDC2 as a promising molecular target for the regulation of BMSCs osteogenic differentiation.

关键词： BMSCs Osteogenic differentiation m6A YTHDC2 RUNX2

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Enhanced aqueous stability and radiative-charge-transfer of CsPbBr3/Ag2S perovskite nanocrystal hybrids

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JOURNAL OF ELECTROANALYTICAL CHEMISTRY 2020年第0期858卷 113835-000页

作者： Fu, Kena He, Yupeng zhang, Bin Gao, xuwen Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

A convenient strategy to enhance the aqueous stability and radiative-charge-transfer of perovskite nanocrystals (PNCs) is developed via hybriding CsPbBr3 PNCs with Ag2S nanoparticles, which is conducted by directly decomposing silver diethyldithiocarbamate in CsPbBr3 PNCs crude. The obtained CsPbBr3-Ag2S hybrids are aqueous stable, and exhibit obviously enhanced aqueous photoluminescence (PL) with a quantum yield up to 82%in pure water as well as boosted electrochemical response for charge injection and 9-fold enhanced electrochemiluminescence (ECL) than CsPbBr3 PNCs in aqueous electrolyte. Both PL and ECL spectra of CsPbBr3-Ag2S hybrids are almost identical to the PL spectrum of CsPbBr3PNCs, indicating radiative-charge-transfer within CsPbBr3-Ag2S hybrids only occurs in CsPbBr3 segment. Annihilation ECL demonstrates that all the charges injected onto CsPbBr3-Ag2S hybrids at the redox potentials of Ag2S segment can be efficiently transferred into CsPbBr3 segment to enhance radiative-charge-transfer. This strategy is promising for the application of PNCs as well as the developing of novel electrochemiluminophores. (C) 2020 Elsevier B.V. All sights reserved.

关键词： Electrochemiluminescence CsPbBr3-Ag2S hybrids Aqueous stability Radiative charge transfer

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Effect of hydrogenation of liquefied heavy oil on direct coal liquefaction

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FUEL 2017年 194卷 291-296页

作者： Shan Xiangen Shu Geping Li Kejian zhang xuwen Wang Hongxue Cao Xueping Jiang Hongbo Weng Huixin East China Univ Sci & Technol Res Inst Petr Proc Shanghai 200237 Peoples R China Natl Engn Lab Direct Coal Liquefact Shanghai 201108 Peoples R China

The effect of hydrotreatment of liquefied heavy oil on direct coal liquefaction (DCL) was studied by hydrogenating the liquefied heavy oil (initial boiling point greater than 320 degrees C) in a 30 ml continuous hydrogenation apparatus at operating conditions of pressure (P) 13-19 MPa, temperature (T) 360-400 degrees C, liquid space velocity (LHSV) 0.6-1.4 h(-1). After hydrogenation, the properties and hydrocarbon composition of liquefied heavy oil were regulated, leading to the enhancement of hydrogen donating ability and 5.6% increase in oil yield of DCL as compared with non-hydrogenated raw oil. Based on the results, a new method of preparing recycle solvent for direct coal liquefaction by mixing hydrogenated heavy oil and un-hydrogenated middle oil in a suitable proportion was proposed, which has been verified to be effective and efficient to increase oil yield. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Direct coal liquefaction Hydrogenation Liquefied product Hydrogenated oil Hydrogen-donating ability

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Multi-Stage Task Allocation Strategy for Uav Cluster in Multi-Object Tracking

SSRN

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SSRN 2023年

作者： Liu, Yunping Niu, Tianyu zhang, Tingting Sun, xuwen Li, Liansheng Zhou, Li Jiangsu Province Atmospheric Environment and Equipment Technology Collaborative Innovation Center Nanjing University of Information Science and Technology Nanjing210044 China Army Engineering University of PLA Nanjing210001 China Dalian Naval Academy Dalian116018 China Beijing Institute of Control Engineering Beijing100094 China College of Marine Technology and Geomatics Jiangsu Ocean University Lianyungang Jiangsu222005 China

Multi-unarmed aerial vehicle (UAV) collaborative mission planning is a key technology for the intelligent development of UAV clusters at this stage, where mission assignment under multiple constraints is a core part of UAV mission planning technology. The poor planning ability of an UAV swarm often leads to resource waste and revenue reduction during mission execution, while the adoption of task allocation in the multi-target tracking of UAV clusters guarantees the highest profit. Algorithms of traditional pigeon-inspired optimization(PIO) and contract network protocol reflect defects of low timeliness and high time costs, respectively. Compared with these methods, the multilevel PIO algorithm maximizes the efficiency and profitability of the overall tracking task. A staged UAV cluster task allocation architecture was constructed to complete the global optimal initialization before tracking, and then a parallel auction contract network was employed to further perform the local optimal redistribution of each UAV. The simulation results suggest that this scheme not only guides cluster allocation in stages but also decreases the negotiatory time of a UAV cluster to in-crease the integral profitability under multiple constraints, such as prohibited areas. © 2023, The Authors. All rights reserved.

关键词： Profitability

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New biomarkers exploration and nomogram construction of prognostic and immune-related adverse events of advanced non-small cell lung cancer patients receiving immune checkpoint inhibitors

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RESPIRATORY RESEARCH 2023年第1期24卷 64-64页

作者： Lin, xuwen Chen, Xi Long, Xiang Zeng, Chao zhang, Zhihan Fang, Weiyi Xu, Ping Peking Univ Dept Pulm & Crit Care Med Shenzhen Hosp Shenzhen 518034 Guangdong Peoples R China Shantou Univ Med Coll Shantou 515041 Guangdong Peoples R China Southern Med Univ Canc Res Inst Sch Basic Med Sci Guangzhou 510515 Guangdong Peoples R China Southern Med Univ Integrated Hosp Tradit Chinese Med Canc Ctr Guangzhou 510315 Peoples R China

BackgroundImmune checkpoint inhibitors (ICIs) are regarded as the most promising treatment for advanced-stage non-small cell lung cancer (aNSCLC). Unfortunately, there has been no unified accuracy biomarkers and systematic model specifically identified for prognostic and severe immune-related adverse events (irAEs). Our goal was to discover new biomarkers and develop a publicly accessible method of identifying patients who may maximize benefit from *** retrospective study enrolled 138 aNSCLC patients receiving ICIs treatment. Progression-free survival (PFS) and severe irAEs were end-points. Data of demographic features, severe irAEs, and peripheral blood inflammatory-nutritional and immune indices before and after 1 or 2 cycles of ICIs were collected. Independent factors were selected by least absolute shrinkage and selection operator (LASSO) combined with multivariate analysis, and incorporated into nomogram construction. Internal validation was performed by applying area under curve (AUC), calibration plots, and decision *** nomograms with great predictive accuracy and discriminatory power were constructed in this study. Among them, two nomograms based on combined inflammatory-nutritional biomarkers were constructed for PFS (1 year-PFS and 2 year-PFS) and severe irAEs respectively, and one nomogram was constructed for 1 year-PFS based on immune indices. ESCLL nomogram (based on ECOG PS, preSII, changeCAR, changeLYM and postLDH) was constructed to assess PFS (1-, 2-year-AUC = 0.893 [95% CI 0.837-0.950], 0.828 [95% CI 0.721-0.935]). AdNLA nomogram (based on age, change-dNLR, changeLMR and postALI) was constructed to predict the risk of severe irAEs (AUC = 0.762 [95% CI 0.670-0.854]). NKT-B nomogram (based on change-CD3+CD56+CD16+NKT-like cells and change-B cells) was constructed to assess PFS (1-year-AUC = 0.872 [95% CI 0.764-0.965]). Although immune indices could not be modeled for severe irAEs prediction due to limited data, we were the

关键词： Immune Adverse events Lung cancer Biomarkers Nomogram

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