Screening a novel electrochemiluminescence (ECL) system is crucial to ECL evolution. Herein, an efficient ECL system with less interference and environmental concern under physiological condition is developed via a un...
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Screening a novel electrochemiluminescence (ECL) system is crucial to ECL evolution. Herein, an efficient ECL system with less interference and environmental concern under physiological condition is developed via a unique internal Cu(I)/Cu(II) couple cycling amplified strategy by employing the glutathione- and citrate-capped copper indium sulfide (CIS)/ZnS nanocrystals (NCs) as electrochemiluminophore and N2H4 center dot H2O as co-reactant. CIS/ZnS NCs can be electrochemically injected with valence band (VB) hole at 0.46 and 0.87 V (vs Ag/AgCl), and then achieve the same hole-injected states by relocalizing VB holes with the Cu(I) species inside of CIS/ZnS NCs to form internal Cu(II) defects, while each N2H4 center dot H2O molecule can be successively oxidized to two more reducing species N2H3 center dot and N2H2 around 0.10 V, and inject conduction band (CB) electron onto CIS/ZnS NCs for triple times. The internal Cu(I)/Cu(II) couple cycling involved radiative-charge recombination between these VB hole and CB electron eventually enables two efficient near-infrared ECL processes (around 731 nm) at 0.55 and 0.87 V, in which each single nanocrystal may participate in multiple ECL reaction cycles to produce multiple photons for amplified ECL, similar to the tris(bipyridyl)ruthenium(III) based ECL system. The low-triggering-potential ECL process at 0.55 V can be utilized to selectively determine Cu(II) with a wide linear range from 10 and 1500 nM and a limit of detection of 5 nM (S/N = 3). This work presents a NCs engineering and co-reactant selecting combined strategy for further ECL evolution.
Androgen receptor (AR) has proved to be a vital drug target for treating prostate cancer. Here, we reported the discovery of a novel AR antagonist 92 targeting the AR ligand-binding pocket, but distinct from the marke...
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Androgen receptor (AR) has proved to be a vital drug target for treating prostate cancer. Here, we reported the discovery of a novel AR antagonist 92 targeting the AR ligand-binding pocket, but distinct from the marketed drug enzalutamide (Enz), 92 demonstrated inhibition on the AR ligand-binding domain (LBD) dimerization, which is a novel mechanism reported for the first time. First, a novel hit (26, IC50 = 5.57 mu M) was identified through virtual screening based on a theoretical AR LBD dimer bound with the Enz model. Then, guided by molecular modeling, 92 was discovered with 32.7-fold improved AR antagonistic activity (IC50 = 0.17 mu M). Besides showing high bioactivity and safety, 92 can inhibit AR nuclear translocation. Furthermore, 92 inhibited the formation of the AR LBD dimer, possibly through attenuating the hydrogen-bonding network between the two monomers. This interesting finding would pave the way for the discovery of a new class of AR antagonists.
Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with Ti...
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Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with TiO2, producing V-O, titanium vacancies (V-Ti) and other point defects;the density and kind of defect is related to the neutron irradiation fluence. D-D neutron irradiation is used to regulate the concentration and type of defect, avoiding impurity elements. As the irradiation fluence increases, the saturation magnetization (M-s) first increases, then decreases and then increases. To verify the origin of RTFM, the CASTEP module was used to calculate the magnetic and structural properties of point defects in TiO2. V-O induces a 2.39 mu(B) magnetic moment, Ti3+ and F+ induce 1.28 mu(B) and 1.70 mu(B) magnetic moments, respectively, while V-Ti induces a magnetic moment of similar to 4 mu(B). Combining experimental and theoretical results, increases in V-O concentration lead to M-s increases;more V-O combine with electrons to form F+, inducing a smaller magnetic moment. V-O and V-Ti play a key role and M-s changes accordingly with larger fluence. V-O, F+ and V-Ti are the most likely origins of RTFM.
The present invention provides a concentrated winding axial cooling motor stator and a motor. The above concentrated winding axial cooling motor stator includes barriers and an axial oil feeding device, the barriers a...
标准号:
EP4044404(A4)
The present invention provides a concentrated winding axial cooling motor stator and a motor. The above concentrated winding axial cooling motor stator includes barriers and an axial oil feeding device, the barriers are in contact with stator windings and plug notches of a stator core, and the barrier and coils of two adjacent groups of the stator windings in slots of the stator core constitute a cooling medium communication cavity;the axial oil feeding device is arranged at any end part of the stator cores or is connected with a casing, and a location of the axial oil feeding device corresponds to any end of the stator cores;a side of the axial oil feeding device close to the stator windings is provided with a spray hole, an axis of the spray hole and an axis of the stator winding are intersected obliquely, a cooling medium is sprayed to the barrier and/or the stator winding and thus flows along an axial inner surface of the stator winding towards two ends of the stator winding. The present invention has the beneficial effect that the axial oil feeding device is arranged at a leading-out terminal or a non-leading-out terminal of a motor stator, thereby improving a heat exchange contact area between the cooling medium and the winding, and increasing heat dissipation capability.
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