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Investigation of energetic ion losses induced by long-lived saturated internal mode with energetic particle diagnostics in the HL-2A tokamak

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NUCLEAR FUSION 2023年第8期63卷 086014-086014页

作者： zhang, Jie zhang, Yipo Chen, Wei Cheng, Shikui Ogawa, Kunihiro He, Xiaofei Wang, Yongqin Liu, Yi Xu, Min Isobe, Mitsutaka Zhu, Yuxuan Zhan, xuwen Zhou, Jianhang zhang, Jinglong Liu, Liang He, Xiaoxue Li, Dong Li, Yonggao Guo, Wenping Yu, Liming Hao, Guangzhou Li, Bo Shi, Zhongbing Ji, Xiaoquan Zhong, Wulv Southwestern Inst Phys POB 432 Chengdu 610041 Peoples R China Natl Inst Fus Sci Natl Inst Nat Sci Toki Japan SOKENDAI Grad Univ Adv Studies Toki Japan Chengdu Univ Technol Coll Nucl Technol & Automation Engn Chengdu 610059 Peoples R China

Several sets of energetic particle diagnostics, including a set of neutron flux monitoring systems, a solid-state neutral particle analyzer and a fast ion loss probe (FILP), have been used to investigate the energetic ion losses induced by the long-lived saturated internal mode (LLM) in the HL-2A tokamak. Clear experimental evidence for different levels of energetic ion losses induced by LLM, sawtooth and minor disruption has been observed. A numerical calculation for the evolution of neutron emissions was carried out with the FBURN code, and it shows that the neutron emission drop rate linearly increases with the LLM amplitude and no threshold perturbation amplitude exists, illustrating that the loss mechanism for LLM induced energetic ion loss is dominantly convective. In addition, measurement results of the FILP demonstrate that LLM tends to expel energetic ions with relatively low energy (E < 27 keV) and high pitch angle (? > 60(?)), and can suppress the prompt loss of energetic ions with high energy and low pitch angle to a certain degree. Furthermore, the physical process for LLM induced energetic ion loss can be explained by orbit calculations, which show that LLM induced lost energetic ions will transport from center to peripheral region first, and then get lost out of plasma. The experimental observations are successfully reproduced by calculations using the ORBIT code combined with both the NUBEAM code and the MARS-K code. The paper clearly describes the whole physical process of LLM induced energetic ion loss for the first time in the HL-2A tokamak.

关键词： energetic ion loss long-lived saturated internal mode neutron flux measurement neutral particle analyzer fast ion loss probe

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全肠无神经节细胞症合并新的 SOX10突变1例

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临床小儿外科杂志 2025年第4期24卷 386-388页

作者：张骜戴春娟赵绪稳王金虎杜晓斌杨福江胡博天津市儿童医院新生儿外科天津

全肠无神经节细胞症是先天性巨结肠中十分罕见的类型, 其临床表现不典型, 诊疗上存在一定困难。SOX10基因突变被认为与先天性巨结肠症有关。本文报道1例合并新的SOX10突变的全肠无神经节细胞症患儿, 以提高临床对此罕见疾病的认识。

关键词：先天性巨结肠全肠无神经节细胞症 SOX10

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一例仔猪蓝耳病毒与细菌混合感染的诊治

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现代牧业 2024年第3期8卷 29-33页

作者：鲁绪文谭伟明张寄香王贵平湖南农业大学动物医学院湖南长沙410128 益阳职业技术学院湖南益阳413000

湖南省益阳市某养猪场仔猪出现发烧、呼吸急促以及咳嗽等临床症状。经剖检,发现病猪出现腹股沟淋巴结肿大和肺水肿等病变。为尽快对仔猪所患疾病进行确诊以便采取有效的防治措施,采集病猪的肺、肝、肾和肠系膜淋巴结,进行猪蓝耳病毒、... 详细信息

湖南省益阳市某养猪场仔猪出现发烧、呼吸急促以及咳嗽等临床症状。经剖检,发现病猪出现腹股沟淋巴结肿大和肺水肿等病变。为尽快对仔猪所患疾病进行确诊以便采取有效的防治措施,采集病猪的肺、肝、肾和肠系膜淋巴结,进行猪蓝耳病毒、猪圆环病毒(2型)、奇异变形杆菌、粪肠球菌及大肠杆菌的qPCR检测、细菌分离培养鉴定及药敏试验。结果显示,样品的猪蓝耳病毒qPCR检测为阳性,猪圆环病毒(2型)为阴性。病原菌的分离鉴定及药敏试验结果表明,分离得到奇异变形杆菌、粪肠球菌及大肠杆菌三株致病菌;三种菌均对多粘菌素B、呋喃唑酮和万古霉素敏感。本次病例检测结果说明,仔猪是在感染猪蓝耳病毒后继发感染多种细菌引起疾病的,防控首选药物为多粘菌素B、呋喃唑酮或万古霉素,猪场应加强疫苗免疫工作。本研究为该场仔猪细菌性呼吸道感染的防控提供理论基础。

关键词：断奶仔猪蓝耳病毒药敏试验继发感染

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A Computational Framework Towards Medical Image Explanation 7th

A Computational Framework Towards Medical Image Explanation

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AIME 7th Joint International Workshop on Knowledge Representation for Health Care and Process-Oriented Information Systems in Health Care (KR4HC/ProHealth) / 1st Workshop on Transparent, Explainable and Affective AI in Medical Systems (TEAAM)

作者： Wang, xuwen zhang, Yu Guo, Zhen Li, Jiao Chinese Acad Med Sci & Peking Union Med Coll Inst Med Informat & Lib Beijing 100020 Peoples R China Genertec Universal Med Grp Co Ltd Beijing 100000 Peoples R China

ISBN: (纸本)9783030374464;9783030374457

In this paper, a unified computational framework towards medical image explanation is proposed to promote the ability of computers on understanding and interpreting medical images. Four complementary modules are included, such as the construction of Medical Image-Text Joint Embedding (MITE) based on large-scale medical images and related texts;a Medical Image Semantic Association (MISA) mechanism based on the MITE multimodal knowledge representation;a Hierarchical Medical Image Caption (HMIC) module that is visually understandable to radiologists;and a language-independent medical imaging report generation prototype system by integrating the HMIC and transfer learning method. As an initial study of automatic medical image explanation, preliminary experiments were carried out to verify the feasibility of the proposed framework, including the extraction of large scale medical image-text pairs, semantic concept detection from medical images, and automatic medical imaging reports generation. However, there is still a great challenge to produce medical image interpretations clinically usable, and further research is needed to empower machines explaining medical images like a human being.

关键词： Medical image explanation Medical Image-Text Joint Embedding Medical Image Semantic Association Hierarchical Medical Image Caption Medical imaging reports generation

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艾滋病合并肠道马尔尼菲篮状菌感染1例

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传染病信息 2024年第4期37卷 381-384页

作者：李翔陈海云付旭文李海雯张乐昆明市第三人民医院/云南省传染性疾病临床医学中心 650041

小肠出血是较为常见的临床问题,且诊断具有一定的挑战性。本文报道了1例艾滋病合并肠道马尔尼菲篮状菌感染患者,表现为发热、腹痛、血便,CT提示空肠上段活动性出血,内镜提示空肠上段黏膜病变,血培养及内镜下活检提示马尔尼菲蓝状菌感染... 详细信息

小肠出血是较为常见的临床问题,且诊断具有一定的挑战性。本文报道了1例艾滋病合并肠道马尔尼菲篮状菌感染患者,表现为发热、腹痛、血便,CT提示空肠上段活动性出血,内镜提示空肠上段黏膜病变,血培养及内镜下活检提示马尔尼菲蓝状菌感染,行抗真菌治疗后,病情好转。这提示马尔尼菲蓝状菌可感染肠道,引起肠道出血等并发症,应用多种检查方法积极寻找出血部位,诊断明确后有效的抗真菌治疗,可取得良好疗效。

关键词：获得性免疫缺陷综合征马尔尼菲篮状菌真菌病空肠疾病

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Treatment of coking wastewater using oxic-anoxic-oxic process followed by coagulation and ozonation

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Carbon Resources Conversion 2019年第2期2卷 151-156页

作者： Jianbing Wang Yuxian Ji Fengyuan zhang Dongliang Wang xuwen He Chunrong Wang School of Chemical and Environmental Engineering China University of Mining and Technology-BeijingBeijing 100083China

An oxic-anoxic-oxic(O-A-O)system followed by coagulation and ozonation processes was used to study the treatment of coking *** the O-A-O process,the removals of NH4+-N,total nitrogen and COD were 91.5-93.3%,91.3-92.6%and 89.1-93.8%,respectively when employing hydraulic residence times of 60 h for the biochemical *** removal of NH4+-N was obtained due to the placement of an aerobic tank in front of A-O system which can mitigate the inhibitory effect of toxic compounds in coking wastewater on nitrifying *** of methanol into the anoxic reactor greatly increased the removal of total nitrogen,indicating that denitrifiers can hardly use organic compounds in coking wastewater as carbon source for *** values of the effluent from the O-A-O system were still higher than 260 mg/L even with a prolonged time of 160 h mainly due to the high refractory properties of residual compounds in the *** subsequent coagulation and ozonation processes resulted in the COD removal of 91.5%-93.3%and reduced the relative abundance of large molecular weight(MW)organics(>1 kDa)from 55.8%to 20.93%with the ozone,PAC and PAM dosages of 100,150 and 4 mg/L *** these conditions,the COD value and concentration of polycyclic aromatic hydrocarbons in the final effluent were less than 80 and 0.05 mg/L,respectively,which meet the requirement of the Chinese emission *** results indicate that the combined technology of O-A-O process,coagulation and ozonation is a reliable way for the treatment of coking wastewater.

关键词： Coking wastewater Activated sludge process Coagulation Ozonation Nitrification-denitrification

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Medical Image Labelling and Semantic Understanding for Clinical Applications 1

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10th International Conference of the CLEF-Association (CLEF)

作者： Wang, xuwen Guo, Zhen zhang, Yu Li, Jiao Chinese Acad Med Sci & Peking Union Med Coll Inst Med Informat Med Lib Beijing 100020 Peoples R China

ISBN: (数字)9783030285777

ISBN: (纸本)9783030285777;9783030285760

Semantic concept detection contributes to machine understanding and learning from medical images;it also plays an important role in image reading and image-assisted diagnosis. In this study, the problem of detecting high-frequency concepts from medical images was transformed into a multilabel classification task. The transfer learning method based on convolutional neural networks (CNNs) was used to recognize high-frequency medical concepts. The image retrieval-based topic modelling method was used to obtain the semantically related concepts from images similar to the given medical images. Our group participated in the concept detection subtasks that were launched by ImageCLEFcaption 2018 and ImageCLEFmed Caption 2019. In the 2018 task, the CNN-based transfer learning method achieved an F1 score of 0.0928, while the retrieval-based topic model achieved an F1 score of 0.0907. Although the latter method recalled some low-frequency concepts, it heavily depended on the image retrieval results. For the latter 2019 task, we proposed body part-based pre-classification strategies and achieved an F1 score of 0.2235. The results indicated that the transfer learning-based multi-label classification method was more robust in high-frequency concept detection across different data sets, but there is still much room for improvement in large-scale open semantic concept detection research.

关键词： Concept detection Transfer learning Multi-label classification Pre-classification Medical image retrieval

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Erratum to“Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Processes”[Engineering 18(2022)49-61]

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Engineering 2023年第3期22卷 233-233页

作者： Diling Yang xuwen Peng Qiongyao Peng Tao Wang Chenyu Qiao Ziqian Zhao Lu Gong Yueliang Liu Hao zhang Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada College of Petroleum Engineering China University of PetroleumBeijing 102249China

In Ref.[1],Eq.(8)has a typo,the following replacement should be done.γ_(bb)/2rδ/δr(rδ(r,t)/δr=2γ_(bb)/R_(bb)-Þ(t,t)-Ⅱ[h[r,t)](bubble=drop-bubble=drop)The publisher regrets an error in the original–article,and the sentence that explained the equation“Eqs.(8)–(10)show the augmented Young–Laplace equation for the interactions of gas bubbles or liquid droplets in different configurations,where Rb is the bubble/drop radius,Rp is the particle radius,Rbp=(1/Rb+1/Rp)1.

关键词： bubble radius equation

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基于网络药理学研究安石榴苷治疗炎症性肠病的作用机制

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世界科学技术-中医药现代化 2023年第7期25卷 2437-2449页

作者：毛旭文古丽若依·帕尔哈提张雍正阿米尔·泽布程路峰新疆医科大学药学院乌鲁木齐830017 新疆天然药物活性组分与释药技术重点实验室乌鲁木齐830017 新疆医科大学国际教育学院乌鲁木齐830017

目的运用网络药理学方法预测安石榴苷治疗炎症性肠病(IBD)的作用机制。方法通过数据库获取安石榴苷和IBD的交集基因,并进行PPI、GO功能和KEGG通路富集分析。安石榴苷和靶点通过分子对接验证。C57BL/6J小鼠采用葡聚糖硫酸钠建立IBD模型,... 详细信息

目的运用网络药理学方法预测安石榴苷治疗炎症性肠病(IBD)的作用机制。方法通过数据库获取安石榴苷和IBD的交集基因,并进行PPI、GO功能和KEGG通路富集分析。安石榴苷和靶点通过分子对接验证。C57BL/6J小鼠采用葡聚糖硫酸钠建立IBD模型,给予安石榴苷干预7天,给药过程中观察各组小鼠的体征并计算每天的疾病活动指数(DAI),给药结束后肠道通透性检测;取结肠组织苏木素-伊红染色法观察病理改变,并计算组织学损伤评分;ELISA法检测小鼠结肠组织中肿瘤坏死因子(TNF-α)、白细胞介素-10(IL-10)、髓过氧化物酶(MPO)、趋化因子1(CXCL1)等细胞因子水平。CCK8法测定安石榴苷对caco-2细胞增殖活性的影响。ELISA法检测脂多糖(LPS)诱导的caco-2细胞释放细胞因子水平。结果获得安石榴苷与IBD共同靶点14个,包括TNF、花生四烯酸-5-脂氧合酶(ALOX5)、血管内皮生长因子A(VEGFA)等;KEGG富集分析预测安石榴苷治疗IBD主要作用于花生四烯酸代谢、AGE-RAGE、VEGFA、Ras等信号通路;分子对接显示安石榴苷与TNF表现出较高的对接活性。与模型组比较,安石榴苷组小鼠体质量下降幅度减小(P<0.01);DAI显著降低(P<0.01);结肠黏膜充血、水肿明显减轻,组织学损伤评分显著降低(P<0.01);结肠组织TNF-α、IL-1β、MPO、CXCL1、IL-6、IL-18、IFN-γ水平显著降低(P<0.01);IL-10水平显著升高(P<0.01);20-300μmol·L^(-1)安石榴苷促进caco-2细胞增殖,抑制LPS诱导的TNF-α分泌,上调IL-10水平。结论安石榴苷通过抑制TNF-α等促炎因子分泌,上调抗炎因子IL-10水平,改善IBD小鼠的结肠炎症反应。

关键词：安石榴苷炎症性肠病网络药理学分子对接

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Knockdown of miR-130a-3p alleviates spinal cord injury induced neuropathic pain by activating IGF-1/IGF-1R pathway

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JOURNAL OF NEUROIMMUNOLOGY 2021年 351卷 577458-577458页

作者： Yao, Lan Guo, Ying Wang, Lei Li, Guoyan Qian, xuwen zhang, Jie Liu, Haiyan Liu, Guokai Peking Univ Int Hosp Dept Anesthesia Beijing 102206 Peoples R China Beijing Univ Chinese Medcine Dongzhimen Hosp Dept Anesthesia Beijing 100700 Peoples R China Peoples Liberat Army Gen Hosp Dujiakan Clin Beijing 100072 Peoples R China

Background: Recent studies have elucidated the instrumental role of microRNAs (miRNAs) in neuropathic pain (NP) progression. As one member of miRNAs, miR-130a-3p has been proved as a mediator in inflammation and neuronal maturation. The present study attempted to elucidate what effect miR-130a-3p exerts on NP. Materials and methods: The miR-130a-3p expression in the spinal cord tissues of rat with spinal cord compression injury (SCI) and LPS-induced BV2 microglia was determined with RT-PCR, which was further applied to analyze the clinical relevance between miR-130a-3p and neuropathic pain. Besides, the expression of IGF-1, IL-1 beta, IL-6, and TNF-alpha in the spinal cord tissues of rats was measured using RT-PCR and ELISA after intrathecal injection of miR-130a-3p inhibitors and tail vein injection of IGF-1 low-expression lentivirus (Lv-shIGF-1). Further, neuronal apoptosis (labeled by Caspase3) and microglial activation (labeled by Iba1) were examined by immunohistochemistry (IHC), and the levels of IGF-1, IGF-1R, NF-kappa B were determined by western blot. Additionally, bioinformatic was employed to analyze the potential target genes of miR-130a-3p. Furthermore, the dual luciferase activity assay and RNA immunoprecipitation assay were conducted to further substantiate whether miR-130a-3p targets IGF-1. Results: In comparison with the sham group, the miR-130a-3p expression was remarkably up-regulated in the spinal cord lesions of SCI rats. The ELISA results showed that inhibiting the miR-130a-3p significantly reduced NP symptoms of SCI rats, mitigated neuronal apoptosis, microglial activation, repressed NF-kappa B phosphorylation and the IL-1 beta, IL-6 and TNF-alpha expressions in SCI rats. Contrarily, downregulation of miR-130a-3p increased IGF-1 and IGF-1R expression. What's more, we observed the same effects in BV2 microglia. In addition, the bioinformatics analysis showed that miR-130-3p targeted at the 3'-untranslated region of IGF-1 and inhibiting its expr

关键词： Neuropathic pain miR-130a-3p IGF-1 Spinal cord injury Inflammation

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